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| 1 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 2 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 3 | STRUCTURE DESIGN OF THE BEIJING SPECTROMETERⅢBEAM PIPE显示文摘The Beijing spectrometerⅢ(BESⅢ)beam pipe is in the center of the BESⅢ,which is the detector of the upgrade project of Beijing electron and positron collider(BEPCⅡ).Electrons and positrons collide in the BESⅢbeam pipe.According to the demands of the BEPCⅡ,a key program of Chinese Academy of Sciences,the BESⅢbeam pipe is designed based on the finite elements analysis.The BESⅢbeam pipe is installed in the inner cylinder of the BESⅢdrift chamber.As a vacuum tube,the BESⅢbeam pipe is designed as 1000 mm in length,63 mm in inner diameter and 114 mm in outer diameter,respectively.The BESⅢbeam pipe consists of a central beryllium pipe cooled by EDM-1,the oil No.1 for electric discharge machining,and two extended copper pipes cooled by deionized water(DW).The three parts are jointed by vacuum welding.Factors taken into account in the design are as follows.①The wall thickness of the central beryllium pipe should be designed as small as possible to reduce the multi-scattering and improve the particle momentum resolution.And the wall thickness of the extended copper pipe should be designed as large as possible to protect the detectors from the backgrounds.②The BESⅢbeam pipe must be sufficiently cooled to avoid the damage and prevents its influence to the BESⅢdrift chamber(DC)operation.The inner surface temperature of the DC inner cylinder must be maintained at 293±2 K.③The magnetic permeability of the materials used in the BESⅢbeam pipe must be less than 1.05 H/m to avoid large magnetic field distortions.④The static pressure of the vacuum chamber of the BESⅢbeam pipe must be less than 800μPa.The simulating results show that the designed structure oftbe BESⅢbeam pipe satisfies the requirements mentioned above.The structure design scheme is evaluated and adopted by the headquarters of BEPCⅡ. | ZHENG Lifang JI Quan WANG Li LI xunfeng XU Shaowang DONG Sujun ZHAO Libin LIU Jianping | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 3 |
| 4 | Limiting the deterioration of mango fruit during storage at room temperature by oxalate treatment显示文摘 | Xiaolin Zheng Libin Ye Tianjia Jiang Guoxin Jing Jianrong Li | 2011 | Food Chemistry2011，，2： | 1 |
| 5 | A Related-Key Boomerang Distinguishing Attack of Threefish-256显示文摘The block cipher Threefish is the main component of Skein, which is based on ARX. Based on the efficient algorithms for calculating the differential of modular addition, we extend local collisions of Threefish-256 to more round by using related-key differential of addition in this paper. A related-key boomerang distinguish attack is proposed on 31-round Threefish-256 with a time complexity of 2^(234). | LIU Shusheng WANG Libin GONG Zheng | 2012 | Wuhan University Journal of Natural Sciences2012，17，5： | 0 |
| 6 | A novel nomogram for prognosis stratification in salvage liver transplantation:a national-wide study with propensity score matching analysis in China显示文摘Background:Salvage liver transplantation(SLT)has been reported to be an efficient treatment option for patients with recurrent hepatocellular carcinoma(HCC)after liver resection(LR).However,for recipients who underwent liver transplantation(LT)due to recurrent HCC after LR in China,the selection criteria are not well established.Methods:In this study,data from the China Liver Transplant Registry(CLTR)of 4,244 LT performed from January 2015 to December 2019 were examined,including 3,498 primary liver transplantation(PLT)and 746 SLT recipients.Propensity score matching(PSM)analysis was used to minimize between-group imbalances.The overall survival(OS)and disease-free survival(DFS)between PLT and SLT in recipients fulfilling the Milan or Hangzhou criteria were compared based on the multivariate analysis,nomograms were plotted to further classify the SLT group into low-and high-risk groups.Results:In this study,the 1-,3-and 5-year OS and DFS of SLT recipients fulfilling Milan criteria(OS,P=0.01;DFS,P<0.001)or Hangzhou criteria(OS,P=0.03;DFS,P=0.003)were significantly reduced when compared to that of PLT group after PSM analysis.Independent risk factors,including preoperative transarterial chemoembolization(TACE),alpha fetoprotein(AFP)level,tumor maximum size and tumor total diameter were selected to draw a prognostic nomogram.The low-risk SLT recipients(1-year,95.34%;3-year,84.26%;5-year,77.20%)showed a comparable OS with PLT recipients fulfilling Hangzhou criteria (P=0.107). Conclusions: An optimal nomogram model for prognosis stratification and clinical decision guidance of SLT was established. The low-risk SLT recipients based on the nomograms showed comparable survival with those fulfilling Hangzhou criteria in PLT group. | Kai Wang Fengqiang Gao Siyi Dong Jialu Ding Libin Dong Chuxiao Shao Zhoucheng Wang Xun Qiu Xuyong Wei Zhengxin Wang Jiayin Yang Qiang Xia Shusen Zheng Xiao Xu | 2023 | Hepatobiliary Surgery and Nutrition2023，12，6： | 0 |
| 7 | UAV search-and-rescue planning using an adaptive memetic algorithm显示文摘The use of unmanned aerial vehicles(UAVs) is becoming more commonplace in search-and-rescue tasks,but UAV search planning can be very complex due to limited response time, large search area, and multiple candidate search modes. In this paper, we present a UAV search planning problem where the search area is divided into a set of subareas and each subarea has a prior probability that the target is present in it. The problem aims to determine the search sequence of the subareas and the search mode for each subarea to maximize the probability of finding the target. We propose an adaptive memetic algorithm that combines a genetic algorithm with a set of local search procedures and dynamically determines which procedure to apply based on the past performance of the procedures measured in fitness improvement and diversity improvement during problem-solving. Computational experiments show that the proposed algorithm exhibits competitive performance compared to a set of state-of-the-art global search heuristics, non-adaptive memetic algorithms, and adaptive memetic algorithms on a wide set of problem instances. | Libin HONG Yue WANG Yichen DU Xin CHEN Yujun ZHENG | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，11： | 0 |
| 8 | Chinese herbal medicine combined with cognitive–behavioural therapy for avoidant paruresis:a controlled trial显示文摘Background Avoidant paruresis is a common clinical condition in urology and psychosomatic medicine.However,it has limited treatment options that are safe and effective with few side effects.Aims Our study aimed to investigate the effectiveness and safety of the Chinese herbal Yangxin Tongquan decoction combined with cognitive-behavioural therapy(CBT)for avoidant paruresis.Methods Sixty-eight patients with avoidant paruresis were divided into a treatment group(33 patients)and a control group(35 patients).The control group was assigned 10 weeks of CBT and systematic desensitisation.In addition to CBT and systematic desensitisation,the treatment group was given the Chinese herbal Yangxin Tongquan decoction during the 10-week study.The Shy Bladder Syndrome Scale(SBS)and the Self-rating Anxiety Scale(SAS)were administered before and after treatment to measure any change.Results The overall efficacy in the treatment group(n=30)was 80.0%vs 62.5%in the control group(n=33).Comparing pretreatment and post-treatment measures,both groups showed improvement in SBS scores and SAS scores(treatment group:t_((SBS))=8.397,p_((SBS))<0.001,t_((SAS))=8.216,p_((SAS))<0.001;control group:t_((SBS))=6.802,p_((SBS))<0.001,t_((SAS))=5.171,p_((SAS))<0.001).Moreover,both groups’SBS and SAS scores changed significantly over time(SBS scores:F_(time)=118.299,p<0.001;SAS scores:F_(time)=92.114,p<0.001).However,the treatment group performed better than the control group(SBS scores:F_(time*group)=5.709,p=0.020;SAS scores:F_(time*group)=7.235,p=0.009).Conclusions The Chinese herbal Yangxin Tongquan decoction combined with cognitive-behavioural psychotherapy positively affects the treatment of avoidant paruresis without significant adverse effects. | Shijie Liang Ying Zhou Chao Yu Xiang Gao Fangbin Ji Qianyuan Fang Zhihang Zhang Libin Yang Youkang Zhao Yuhui Zhao Renwu Yin Kaimin Chen Zheng Lu | 2023 | General Psychiatry2023，36，5： | 0 |
| 9 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform under construction at IMP.It is a 5 year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in Material Sciences,Astrophysics,Atomic Physics and Highly Charged Ion Physics,LEAF has been designed and constructed with the state of the art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals. | Sun Liangting Yang Yao Lu Liang Guo Yuhui Liu Xiaojun Jing Long Li Libin Sun Liepeng Gao Zheng Ma Hongyi Jin Xiaofeng Zhai Yuhan Xu Xianbo Shi Longbo Xing Chaochao Liu Yuting Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jia Huan Zhang Bin Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Zhu Li Li Jiaqing Lu Wang Guo Junwei Li Chenxing Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 10 | Im m unoregulatory Effects of Triptergium W ilfordii Hook at Antifertility Dose on Splenic NK Cells Activityin Male Mice显示文摘Effects of Tripterypium Wilfordii Hook f (TWH) on sperm atozoa in the epi- didym is and splenic NK cells activity in m ale m ice w ere observed using MTT assay and silver impregnation m ethods. The results show ed that the density, viability and m otility of the epididym alsperm atozoa in the experim entalgroupstreated w ith TWH w ere m ore significantly reduced than those in the controlgroup (P< 0.01). The head sw elling, head separation from tailin the groups treated w ith TWH w ere observed. The inhibition of splenicNK cellsactivity in m iceby TWH w asdose-dependent. Inhi- bition by TⅡand TWH athigh dose on the NK cells activity w as significant (P< 0.01 and P< 0.05), w hileinhibitory effectsof TWH atinterm ediateand low doseson the NK cells activity w ere notobserved (P> 0.05). Itw as concluded thatTWH at low er antifertility dose did not significantly inhibit the splenic NK cells activity. It m ightbe usefulforevaluating thetherapeuticeffectsof TWH in futureclinicalprac- tice. | XU Zheng(徐铮) LU Xiu-ying(路秀英) XIU He-m ing(修贺明) LIBin(李彬) JIA Tai-he(贾太和) Clinical Research Center for Reproduction, Bethune International Peace Hospital, Shijiazhuang 050082, China | 1999 | Journal of Reproduction and Contraception1999，10，1： | 0 |
| 11 | A software-defined MAPE-K architecture for unmanned systems显示文摘Dear editor,With the advances in software,sensors,and communication technologies,there is rapid development in unmanned systems.An unmanned system consists of unmanned vehicles,a control system and a communication system among its components.These kinds of systems,due to their specific autonomy and high mobility,ofer a wide range of applications and have been used as important tools in various domains. | Mingyue JIANG Libin ZHENG Zuohua DING Zhi JIN | 2023 | Science China(Information Sciences)2023，66，5： | 0 |
| 12 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform constructing at IMP.It is a 5-year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in material sciences,astrophysics,atomic physics and highly charged ion physics,LEAF has been designed and constructed with the state-of-the-art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals.The layout of LEAF is given in Fig.1. | Sun Liangting Lu Liang Jia Huan Yang Yao Zhang Bin Guo Yuhui Gao Zheng Ma Hongyi Jin Xiaofeng Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jing Long Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Liu Xiaojun Li Jiaqing Lu Wang Guo Junwei Yang Long Li Libin Sun Liepeng Shi Longbo Li Chenxing Ma Wei Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 13 | Effects of hydraulic retention time on net present value and performance in a membrane bioreactor treating antibiotic production wastewater显示文摘A cost sensitivity analysis was performed for an industrial membrane bioreactor to quantify the effects of hydraulic retention times and related operational parameters on cost.Different hydraulic retention times(72-24 h)were subjected to a flat-sheet membrane bioreactor updated from an existing 72 h oxidation ditch treating antibiotic production wastewater.Field experimental data from the membrane bioreactor,both full-scale(500 m/d)and pilot(1.0 m3/d),were used to calculate the net present value(NPV),incorporating both capital expenditure(CAPEX)and operating expenditure.The results showed that the tank cost was estimated above membrane cost in the 38.2%,where capital expenditure contributed 24.2%more than operational expenditure.Tank construction cost was decisive in determining the net present value contributed 62.1%to the capital expenditure.The membrane bioreactor has the advantage of a longer lifespan flat-sheet membrane,while flux decline was tolerable.The antibiotics decreased to 1.87±0.33 mg/L in the MBR effluent.The upgrade to the membrane bioreactor also benefited further treatments by 10.1%-44.7%lower direct investment. | Dawei Yu Jianxing Wang Libin Zheng Qianwen Sui Hui Zhong Meixue Cheng Yuansong Wei | 2020 | Frontiers of Environmental Science & Engineering2020，14，6： | 0 |
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