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| 1 | Early Permian Tarim Large Igneous Province in northwest China显示文摘Tarim Large Igneous Province(TLIP)is the second Late Paleozoic LIPs in China after the recognition of Emeishan LIP,and is a hot research topic in geosciences.On the basis of the analysis of research history about TLIP,this paper summarizes the research result during last twenty years and suggests the key research area in the future.The residual distribution range of TLIP is up to 250000 km2,and the largest residual thickness is 780 m.The eruption of basalt happened during 290–288 Ma and belongs to LIPs magmatic event with fast eruption of magma.The lithological units of the TLIP include basalt,diabase,layered intrusive rock,breccia pipe mica-olivine pyroxenite,olivine pyroxenite,gabbro,ultramafic dyke,quartz syenite,quartz syenite porphyry and bimodal dyke.The basalt and diabase of TLIP exhibit OIB-like trace element patterns and enrichment of LILE and HFSE,and mainly belong to high TiO2series.There is an obvious difference in isotope among the basalt from Keping and the basalt and dibase from the northern Tarim Basin.The basalt from Keping with negative Nd and high REE value derives from enriched mantle,and the diabase and basalt from the northern Tarim Basin with positive Nd and low REE value are related to depleted mantle.The crust uplifting in the Early Permian and the development of picrite and large scale dyke and formation of large scale V-Ti-Magnetite deposit in Wajilitag area support the view that the TLIP is related to mantle plume.The TLIP has a temporal-spatial relationship with Permian basic to ultra-basic igneous rock,which is distributed widely in Central Asia,and they represent a tectono-magmatic event with very important geodynamic setting.This paper also suggests that the deep geological process,the relation with mantle plume,mineralization,the relation with environmental change and biological evolution,and the geodynamics of the TLIP will be the key research topics in the future. | YANG ShuFeng CHEN HanLin LI ZiLong LI YinQi YU Xing LI DongXu MENG LiFeng | 2013 | Science China Earth Sciences2013，56，12： | 12 |
| 2 | MiR-181a-5p regulates 3T3-L1 cell adipogenesis by targeting Smad7 and Tcf7I2显示文摘 | Dan Ouyang Lifeng Xu Lihua zhang Dongguang Guo Xiaotong Tan Xiaofang Yu Junjie Qi Yaqiong Ye Qihong Liu Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 9 |
| 3 | Synthesis and kinetics investigation of meso-microporous Cu-SAPO-34 catalysts for the selective catalytic reduction of NO with ammonia显示文摘A series of meso-microporous Cu-SAPO-34 catalysts were successfully synthesized by a one-pot hydrothermal crystallization method, and these catalysts exhibited excellent NH_3-SCR performance at low temperature. Their structure and physic chemical properties were characterized by means of X-ray diffraction patterns(XRD), Scanning electron microscopy(SEM), Transmission electron microscopy(TEM), N_2 sorption-desorption, nuclear magnetic resonance(NMR), Inductively Coupled Plasma-Atomic Emission spectrometer(ICP-AES), X-ray absorption spectroscopy(XPS),Temperature-programmed desorption of ammonia(NH_3-TPD), Ultraviolet visible diffuse reflectance spectroscopy(UV-Vis DRS) and Temperature programmed reduction(TPR).The analysis results indicate that the high activities of Cu-SAPO-34 catalysts could be attributed to the enhancement of redox property, the formation of mesopores and the more acid sites. Furthermore, the kinetic results verify that the formation of mesopores remarkably reduces diffusion resistance and then improves the accessibility of reactants to catalytically active sites. The 1.0-Cu-SAPO-34 catalyst exhibited the high NO conversion(> 90%) among the wide activity temperature window in the range of 150–425℃. | Jixing Liu Fuhong Yu Jian Liu Lifeng Cui Zhen Zhao Yuechang Wei Qianyao Sun | 2016 | Journal of Environmental Sciences2016，28，10： | 8 |
| 4 | Laser direct writing and characterizations of flexible piezoresistive sensors with microstructures显示文摘Functional materials with high viscosity and solid materials have received more and more attentions in flexible pressure sensors,which are inadequate in the most used molding method.Herein,laser direct writing(LDW)method is proposed to fabricate flexible piezoresistive sensors with microstructures on PDMS/MWCNTs composites with an 8%MWCNTs mass fraction.By controlling laser energy,microstructures with different geometries can be obtained,which significantly impacts the performances of the sensors.Subsequently,curved microcones with excellent performance are fabricated under parameters of f=40 kHz and v=150 mm·s^(-1).The sensor exhibits continuous multi-linear sensitivity,ultrahigh original sensitivity of 21.80%kPa^(-1),wide detection range of over 20 kPa,response/recovery time of~100 ms and good cycle stability for more than 1000 times.Besides,obvious resistance variation can be observed when tiny pressure(a peanut of 30 Pa)is applied.Finally,the flexible piezoresistive sensor can be applied for LED brightness controlling,pulse detection and voice recognition. | Chenying Zhang Wei Zhou Da Geng Cheng Bai Weida Li Songyue Chen Tao Luo Lifeng Qin Yu Xie | 2021 | Opto-Electronic Advances2021，4，4： | 7 |
| 5 | High mobility group box 1 protein (HMGB1) as an immune-modulating factor for polarization of human T lymphocytes显示文摘Objective This study was performed to investigate the effect of high mobility group box-1 protein (HMGB1) on immune function of human T lymphocytes in vitro and explore its potential role in cell-mediated immune dysfunction. Methods Fresh blood was obtained from healthy adult volunteers and peripheral blood mononuclear cells (PBMCs) were isolated, then rhHMGB1 was added to PBMCs. Four-color flow cytometric (FCM) analysis was used for the measurement of intracellular cytokine including interleukin IL-4 and interferon IFN- ? ELISA kits were employed for the determination of IL-2 and sIL-2R protein levels in cell culture supernatants. Results (1) Different stimulating time and dosage of rhHMGB1 did not alter the number of IFN- αpositive cells (Th1). rhHMGB1 stimulation provoked a dose-dependent and time-dependent increase in Th2 subset and decrease in ratio of Th1 to Th2. (2) Compared with the untreated cells, when the cells were coincubated with rhHMGB1 (10-100ng/ml) for 12 hrs, protein release of IL-2 and sIL-2R were significantly up-regulated. At 48 hrs, in contrast, protein production was relatively lower in cells after exposure to 100-1000 ng/ ml rhHMGB1. Conclusions These findings demonstrated that HMGB1 has a dual influence on immune functions of human T lymphocytes. | Lifeng Huang Yongming Yao Haidong Meng Xiaodong Zhao Ning Dong Yan Yu | 2008 | Journal of Geriatric Cardiology2008，5，2： | 6 |
| 6 | Urban Expansion in China Based on Remote Sensing Technology:A Review显示文摘Urban areas and its evolution are important anthropogenic indicators and human ecological footprints, and play decisive roles in environmental change analysis, global geo-conditional monitoring, and sustainable development. China has the highest rate of urban expansion and has emerged as an urban expansion hotspot worldwide. In this paper, the progress of studies on Chinese urban expansion based on remote sensing technology are summarized and analyzed from the aspects of urban area definition, remotely sensed imagery applied in urban expansion, monitoring methods of urban expansion, and urban expansion applications. Existing issues and future directions of Chinese urban expansion are discussed and proposed. Results indicate that: 1) The fusion of multi-source remotely sensed imagery is imperative to meet the needs of urban expansion with various monitoring terms and frequencies on different scales and dimensions. 2) To guarantee the classification accuracy and efficiency and describe urban expansion and its influences on local land use simultaneously, the combination of visual interpretation and automatic classification is the tendency of future monitoring methods of urban areas. 3) Urban expansion data have become the prerequisite for recognizing the urban development process, excavating its driving forces, simulating and predicting the future development directions, and also is conducive to revealing and explaining urban ecological and environmental issues. 4) In the past decades, Chinese scholars have promoted the application of remote sensing technology in the urban expansion field, with data construction, methods and models developing from the quotation stage to improvement and innovation stage; however, an independent and consistent urban expansion data on the national scale with long-term and high-frequency(such as annual monitoring) monitoring is still lacking. | ZHANG Zengxiang LIU Fang ZHAO Xiaoli WANG Xiao SHI Lifeng XU Jinyong YU Sisi WEN Qingke ZUO Lijun YI Ling HU Shunguang LIU Bin | 2018 | Chinese Geographical Science2018，28，5： | 6 |
| 7 | The effects of EGR and ignition timing on emissions of GDI engine显示文摘The effects of EGR and ignition timing on engine emissions and combustion were studied through an experiment carried out on an air-guided GDI engine.The test results showed that the ignition timing significantly affected the GDI engine emissions,that the NOx emissions significantly reduced when the ignition timing was retarded,and that NOx emissions decreased with the EGR level increasement.A higher EGR rate could reduce CO emissions while the CO emissions were less affected by the ignition timing.The HC emissions decreased at a lower EGR rate.At 2500 r/min,an appropriate EGR rate could cut down CO emissions.The exhaust gas temperature could significantly decrease with improving the EGR rate,and the exhaust gas temperature at 2500 r/min was clearly higher than that at 1850 r/min.The nucleation mode particles increased clearly,the accumulation mode particle number decreased gradually with the increase of EGR rate,and the typical particle size of nucleation mode particle was in the range of 10–25 nm. | ZHAO LiFeng YU XiuMin QIAN DingChao DONG Wei SUN Ping HE Ling YANG Song | 2013 | Science China(Technological Sciences)2013，56，12： | 5 |
| 8 | Selection of DNA aptamer that specific binding human carcinoembryonic antigen in vitro显示文摘客观: 选择 carcinoembryonic 抗原(CEA ) 的特定的恰当的 amer,为癌症的最吸引人的分子之一指向治疗和成像。方法:在 vitro 选择的七个回合对净化的 CEA 蛋白质被执行。调停 Ligand 的目标纯化和 Co-immunoprecipitation 被采用验证恰当的 amer 的特定的绑定到净化并且本国的蛋白质独立。能绑两个的 ResultsrThe CEA 特定的恰当的 amer 净化,有高特性的本国的蛋白质被获得。结论: 这是 CEA 特定的 apatmer 被生产的第一次。在这的结果学习以后为 CEA-aptamer 的进一步的调查和申请提供初步的证据。 | Lifeng Wang Baorui Liu Haitao Yin Jia Wei Xiaoping Qian Lixia Yu | 2007 | Journal of Nanjing Medical University2007，21，5： | 5 |
| 9 | Ionic liquids containing the urea moiety for recognition of halides and complex anions显示文摘A series of novel imidazolium based ionic liquids containing the urea moiety were designed and synthesized for anion recognition. 1-Ethylurea-3-methylimidazolium acetate ([Eumim]OAc) was used as the receptor for the halides and complex anions (BF4-, PF6-, BPh4-). 1H NMR spectra showed that the urea protons and imidazolium C(2) proton of the receptor ([Eumim]OAc) moved upfield on addition of various anions. A Job plot showed that the [Eumim]OAc receptor formed a 1:1 complex with BPh4-. X-ray diffraction analysis and the molecular modeling study revealed that the conformations of [Eumim]OAc and [Eumim]BPh4 were different. The conformational change of the cation was caused by anion exchange, and may provide an alternative to current methods for recognition of anions. | DONG ZhiYun YANG Yu ZHANG LiFeng XUE YunRong FENG MeiYun GAO GuoHua | 2012 | Chinese Science Bulletin2012，57，5： | 3 |
| 10 | Multi-Modality Medical Image Fusion Based on Wavelet Analysis and Quality Evaluation显示文摘Multi-modality medical image fusion has more and more important applications in medical image analysis and understanding. In this paper, we develop and apply a multi-resolution method based on wavelet pyramid to fuse medical images from different modalities such as PET-MRI and CT-MRI. In particular, we evaluate the different fusion results when applying different selection rules and obtain optimum combination of fusion parameters. | Yu Lifeng & Zu Donglin Institute of Heavy Ion Physics, Peking University, 100871, P. R. China Wang Weidong General Hospital of PLA, Beijing 100853, P. R. China Bao Shanglian Institute of Heavy Ion Physics, Peking University, 100871, P. R. China | 2001 | Journal of Systems Engineering and Electronics2001，12，1： | 3 |
| 11 | The electromechanical features of LiNbO_(3) crystal for potential high temperature piezoelectric applications显示文摘Lithium niobate(LiNbO_(3),LN)crystal is a multi-functional material with favorable piezoelectric,nonlinear optical and electro-optic properties.In this study,the electromechanical properties of the radial extensional(RE)and the thickness extensional(TE)modes of the congruent LN are studied and the temperature dependent behaviors are revealed.The RE mode electromechanical coupling factors(kp)for the Y-and Z-oriented discs are calculated and found to be 3.8%and 24.7%,respectively,which are nearly the same as the experimental results of 3.8%and 25.2%,respectively.The maximum RE and thickness shear(TS)modes electromechanical coupling factors are obtained to be 47.6%and 68.5%for the Yx/25and Yx/167crystal cuts,respectively.The LN crystal possesses good temperature stability of the electromechanical coupling factors(RE and TE modes)from 20℃ to 500℃,where the variations of kp and kt for the Y-oriented discs are<8.0%and<1.8%,respectively. | Feifei Chen Lingfeng Kong Wei Song Chao Jiang Shiwei Tian Fapeng Yu Lifeng Qin Xian Zhao | 2019 | Journal of Materiomics2019，5，1： | 3 |
| 12 | Integration of homogeneous and heterogeneous nucleation growth via 3D alloy framework for stable Na/K metal anode显示文摘Sodium/Potassium(Na/K)metal anodes have been considered as the promising anodes for next-generation Na/K secondary batteries owing to their ultrahigh specific capacity,low redox potential and low cost.However,their practical application is still hampered due to unstable solid electrolyte interphase,infinite volume change,and dendrite growth.Herein,we design a 3D-Na_(3)Bi/3D-K_(3)Bi alloy host which enables the homogeneous and heterogeneous nucleation growth of Na/K metal.The unique structure with periodic alternating of electron and ion conductivity improves the mass transfer kinetics and prevents the volume expansion during cycling.Meanwhile,the sodiophilicity of Na_(3)Bi/potassiophilicity of K_(3)Bi framework can avoid dendritic growth.Cycling lifespans over 700 h with 1 mAh cm^(−2)for 3D-Na_(3)Bi@Na electrode and about 450 h with 1 mAh cm^(−2)for 3D-K_(3)Bi@K electrode are achieved,respectively.3D-Na_(3)Bi@Na||Na_(3)V_(2)(PO_(4))3 full battery shows sustainable cycle performance over 400 cycles.This design provides a simple but effective approach for achieving safety of sodium/potassium metal anodes. | Shufen Ye Lifeng Wang Fanfan Liu Pengcheng Shi Yan Yu | 2021 | eScience2021，1，1： | 3 |
| 13 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 14 | Interdecadal change of winter SST variability in the Kuroshio Extension region and its linkage with Aleutian atmospheric low pressure system显示文摘由从为最后 100 年可得到的各种各样的来源利用多重数据集,为冬季海表面温度(SST ) 的 interdecadal 变化的存在在自台湾东面的菲律宾海流向日本的暖流延期(KE ) 区域的可变性被调查。并且它有阿留申群岛之土人的连接低(AL ) 活动变化也被讨论。结果发现 KE SST 可变性展出重要 6 一 and 10 一有明显的 interdecadal 的摆动变化。6 一摆动主要在 1930-1950 期间被检测,它被强迫的异常表面热流动和与 AL 紧张变化联系的 Ekman 热运输大部分影响。10 一摆动在 1980 年代以后是很明显的,它被 AL 纵贯的移动主要通过海洋的 Rossby 波浪的桥触发。 | YU Peilong ZHANG Lifeng ZHANG Yongchui DENG Bing | 2016 | Acta Oceanologica Sinica2016，35，5： | 3 |
| 15 | MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7显示文摘MiR-195 在在肿瘤的不同类型禁止房间增长被含有。它是否贡献 thymic 的过程上皮的房间(侦探) 增长仍然保持不清楚。在这研究,我们发现 miR-195a-5p 在从变老的老鼠孤立的侦探是高度起来调整的。进一步的实验证明 miR-195a-5p 模仿禁止的 transfection 老鼠的增长髓的 thymic 第 1 行上皮的房间(MTEC1 ) ,而在 MTEC1 的 miR-195a-5p 禁止者的 transfection 有相反的效果。另外, miR-195a-5p 没在 MTEC1 apoptosis 上有明显的效果。而且, Smad7,转变生长因素小径的一个否定管理者,被酶试金作为 miR-195a-5p 的一个直接目标证实。一起拿,我们的结果显示 miR-195a-5p 禁止 MTEC1 增长,至少部分地,经由 Smad7 的下面规定。 | Dongguang Guo Yaqiong Ye Junjie Qi Lifeng Xu Lihua Zhang Xiaolong Tan Zhigang Tan Xiaofang Yu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 3 |
| 16 | Conformal and continuous deposition of bifunctional cobalt phosphide layers on p-silicon nanowire arrays for improved solar hydrogen evolution显示文摘垂直地排列的 p 硅 nanowire (SiNW ) 数组广泛地为太阳开车的氢进化作为有希望的光阴极在最近的年里被调查了。然而,有用一条简单、买得起的途径的两项高 photoelectrocatalytic 活动和长期的运作的稳定性的 SiNW 光阴极的制造是一项挑战性的任务。此处,我们报导 di 钴磷化物的保角、连续的免职(公司 2 P ) 经由一个划算的扔落下的方法的平版印刷术有图案的高度订的 SiNW 数组上的层由一个低温度的 phosphorization 处理列在后面。同样扔的公司 2 P 层由水晶的 nanoparticles 组成并且与 SiNWs 有亲密接触,形成明确的 SiNW@Co 2 P 核心 / 壳 nanostructure。保角、连续的公司 2 P 层作为能够实质地为氢进化反应改进 photoelectrocatalytic 活动的高度有效的催化剂工作(她的) 并且有效地使钝化保护他们免受相片氧化的伤害的 SiNWs,因此延长电极的一生。作为 aconsequence, SiNW@Co 2 有优化公司 2 P 层厚度展出一个高光电流密度 of-21.9 妈 ? 獡愠 ? 汥' 虪箳椰嬑郢 G? 祢愠猠牴楡桧晴牯慷摲洠汯整 ?慳瑬猠湹桴獥獩愠灰潲捡 | Sitaramanjaneva Mouli Thalluri Jerome Borme Kang Yu Junyuan Xu Isilda Amorim Joao Gaspar Liang Qiao Paulo Ferreira Pedro Alpuim Lifeng Liu | 2018 | Nano Research2018，11，9： | 2 |
| 17 | Arg462Gln and Asp541Glu polymorphisms in ribonuclease L and prostate cancer risk:a meta-analysis显示文摘Objective:The association between ribonuclease L(RNASEL)gene polymorphisms and prostate cancer risk has been widely reported,but the results of these studies remained controversial and underpowered.We performed a meta-analysis of 28 studies to evaluate the association between Arg462Gln and Asp541Glu polymorphisms in the RNASEL gene and prostate cancer risk.Methods:Odds ratios(ORs)with 95%confidence intervals(CIs) were estimated to assess the association between RNASEL polymorphisms and prostate cancer risk.Results:A significantly increased prostate cancer risk was found for the Arg462Gln polymorphism in Africans(Gln/Gln vs Arg/Arg:OR=2.50,95%CI=1.28-4.87;Gln/Gln vs Gln/Arg+Arg/Arg:OR=2.54,95%CI=1.30-4.95),but not in Europeans and Asians.Additionally,the Asp541Glu polymorphism was associated with increased total prostate cancer risk(Glu-allele vs Asp-allele:OR=1.04,95%CI=1.01-1.07;Glu/Glu vs Asp/Asp:OR=1.22,95%CI= 1.03-1.46;Glu/Glu vs Glu/Asp+Asp/Asp:OR=1.09,95%CI=1.02-1.16).In the stratified analysis for the Asp541Glu polymorphism,there was a significantly increased prostate cancer risk in Africans and Europeans,and in hospital-based prostate cancer cases.Conclusion:The meta-analysis results showed evidence that RNASEL Arg462Gln and Asp541Glu polymorphisms are associated with prostate cancer risk and could be low-penetrance prostate cancer susceptibility biomarkers. | Yuanyuan Mi Qianqian Yu Zhichao Min Bin Xu Lifeng Zhang Wei Zhang Ninghan Feng L ixin Hua | 2010 | The Journal of Biomedical Research2010，24，5： | 2 |
| 18 | MicroRNA-181a-5p enhances cell proliferation in medullary thymic epithelial cells via regulating TGF-β signaling显示文摘在从不同年龄的老鼠的胸腺纸巾的 miRNAs 的表示侧面在我们的以前的学习被表明了。在 miRNA 表达式侧面的综合分析以后,我们证明 miR-181a-5p 的表达式显著地在 thymic 被减少从 10- 的上皮的房间(侦探) 到 19-month-old 鼠标当与那相比在从 1-month-old 的侦探由量的反向的 transcriptase 聚合酶的鼠标锁住反应时。我们在侦探假设了那 miR-181a-5p 可能通过调整一些基因或发信号的小径与年龄相关的胸腺复杂物被联系。测试这个假设,老鼠髓的 thymic 上皮的房间(MTEC1 ) 被使用。有 miR-181a-5p 的 Transfection 模仿支持了 MTEC1 房间的增长,但是没影响 apoptosis。效果被颠倒 miR-181a-5p 的表示什么时候在 MTEC1 房间被压制。而且,转变生长因素贝它受体(Tgfbr1 ) 我被酶试金作为 miR-181a-5p 的一个直接目标证实。而且,它被发现 miR-181a-5p 的那 overexpression 下面调整 Smad3 的 phosphorylation 并且堵住了发信号的转变生长因素贝它的激活。不过,一相反地,关联在 Tgfbr1 的表示之间被观察,在侦探的 miR-181a-5p 源于不同年龄的老鼠。一起,我们提供 miR-181a-5p 可以是在侦探,和表示的增长的一个重要内长的管理者的证据在侦探的 miR-181a-5p 的层次可以与年龄相关的胸腺复杂物被联系。 | Dongguang Guo Yaqiong Ye Junjie Qi Lihua Zhang Lifeng Xu Xiaotong Tan Xiaofang Yu Qihong Liu Jilong Liu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 2 |
| 19 | The RALF1-FERONIA complex interacts with and activates TOR signaling in response to low nutrients显示文摘Target of rapamycin(TOR)kinase is an evolutionarily conserved major regulator of nutrient metabolism and organismal growth in eukaryotes.In plants,nutrients are remobilized and reallocated between shoots and roots under low-nutrient conditions,and nitrogen and nitrogen-related nutrients(e.g.,amino acids)are key upstream signals leading to TOR activation in shoots under low-nutrient conditions.However,how these forms of nitrogen can be sensed to activate TOR in plants is still poorly understood.Here we report that the Arabidopsis receptor kinase FERON IA(FER)interacts with the TOR pathway to regulate nutrient(nitrogen and amino acid)signaling under low-nutrient conditions and exerts similar metabolic effects in response to nitrogen deficiency.We found that FER and its partner,RPM1-induced protein kinase(RIPK),interact with the TOR/RAPTOR complex to positively modulate TOR signaling activity.During this process,the receptor complex FER/RIPK phosphorylates the TOR complex component RAPTOR1B.The RALF1 peptide,a ligand of the FER/RIPK receptor complex,increases TOR activation in the young leaf by enhancing FER-TOR interactions,leading to promotion of true leaf growth in Arabidopsis under lownutrient conditions.Furthermore,we showed that specific amino acids(e.g.,Gin,Asp,and Gly)promote true leaf growth under nitrogen-deficient conditions via the FER-TOR axis.Collectively,our study reveals a mechanism by which the RALF1-FER pathway activates TOR in the plant adaptive response to low nutrients and suggests that plants prioritize nutritional stress response over RALF1-mediated inhibition of cell growth under low-nutrient conditions. | Limei Song Guoyun Xu Tingting Li Huina Zhou Qinlu Lin Jia Chen Long Wang Dousheng Wu Xiaoxu Li Lifeng Wang Sirui Zhu Feng Yu | 2022 | Molecular Plant2022，15，7： | 2 |
| 20 | Estrogen upregulates DNA2 expression through the PI3K-AKT pathway in endometrial carcinoma显示文摘Endometrial cancer is the most common gynecological malignancy,affecting up to 3%of women at some point during their lifetime(Morice et al.,2016;Li and Wang,2021).Based on the pathogenesis and bio‑logical behavioral characteristics,endometrial cancer can be divided into estrogen-dependent(I)and non-estrogen-dependent(II)types(Ulrich,2011).Type I accounts for approximately 80%of cases,of which the majority are endometrioid carcinomas,and the remaining are mucinous adenocarcinomas(Setiawan et al.,2013). | Xinyan WANG Xiuling XU Ting ZHANG Yang JIN Sheng XU Lifeng CHEN Yucheng LAI Ling ZHANG Ruolang PAN Yan YU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 2 |
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