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| 1 | Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism显示文摘The obstruction of post-insulin receptor signaling is the main mechanism of insulin-resistant diabetes.Progestin and adipoQ receptor 3(PAQR3),a key regulator of inflammation and metabolism,can negatively regulate the PI3 K/AKT signaling pathway.Here,we report that gentiopicroside(GPS),the main bioactive secoiridoid glycoside of Gentiana manshurica Kitagawa,decreased lipid synthesis and increased glucose utilization in palmitic acid(PA) treated HepG2 cells.Additionally,GPS improved glycolipid metabolism in streptozotocin(STZ) treated high-fat diet(HFD)-induced diabetic mice.Our findings revealed that GPS promoted the activation of the PI3 K/AKT axis by facilitating DNA-binding protein 2(DDB2)-mediated PAQR3 ubiquitinated degradation.Moreover,results of surface plasmon resonance(SPR),microscale thermophoresis(MST) and thermal shift assay(TSA) indicated that GPS directly binds to PAQR3.Results of molecular docking and cellular thermal shift assay(CETSA) revealed that GPS directly bound to the amino acids of the PAQR3 NH2-terminus including Leu40,Asp42,Glu69,Tyr125 and Ser129,and spatially inhibited the interaction between PAQR3 and the PI3 K catalytic subunit(P110α) to restore the PI3 K/AKT signaling pathway.In summary,our study identified GPS,which inhibits PAQR3 expression and directly targets PAQR3 to restore insulin signaling pathway,as a potential drug candidate for the treatment of diabetes. | Haiming Xiao Xiaohong Sun Zeyuan Lin Yan Yang Meng Zhang Zhanchi Xu Peiqing Liu Zhongqiu Liu Heqing Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 7 |
| 2 | A stable artificial protective layer for high capacity dendrite-free lithium metal anode显示文摘The metallic lithium(Li)is considered as the most promising anode material for high-e nergy batteries.Nevertheless,the uncon trollable growth of Li den drite and un stable electrolyte/electrode in terface still hin der the developme nt of Li-based battery.In this work,a no vel strategy has been proposed to stabilize Li anode by in-situ polymerizing polypyrrole(PPy)layer on Ni foam(PPy@Ni foam)as an artificial protective layer.The PPy protective layer can effectively decrease the contact between Li metal and electrolyte during cycling.In addition,the morphology characterization shows that the PPy layer can help the even Li deposition undemeath the layer,leading to a dendrite-free Li anode.As a result,when deposited 2 mAh-cm-2 Li metal,the PPy@Ni foam can keep stable Coulombic efficiency(99%)during nearly 250 cycles,much better than the pure Ni foam(100 cycles).Even in the case of the Li capacity of 10 mAh-cm-2,the stable cycling performance for 60 cycles can still be achieved.Furthermore,when assembled with LiFePO4 material as the cathode for a full cell,the PPy@Ni foam can keep high capacity retention of 85.5%at 500 cycles.In our work,we provide a simple and effective method to enhanee the electrochemical performances of Li metal-based batteries,and reveal a new avenue to design three-dimensional(3D)metallic curre nt collector for protecting the Li metal ano de. | Zhipeng Wen Yueying Peng Jianlong Cong Haiming Hua Yingxin Lin Jian Xiong Jing Zeng Jinbao Zhao | 2019 | Nano Research2019，12，10： | 6 |
| 3 | Machine Learning-Based Multi-Modal Information Perception for Soft Robotic Hands显示文摘This paper focuses on multi-modal Information Perception(IP)for Soft Robotic Hands(SRHs)using Machine Learning(ML)algorithms.A flexible Optical Fiber-based Curvature Sensor(OFCS)is fabricated,consisting of a Light-Emitting Diode(LED),photosensitive detector,and optical fiber.Bending the roughened optical fiber generates lower light intensity,which reflecting the curvature of the soft finger.Together with the curvature and pressure information,multi-modal IP is performed to improve the recognition accuracy.Recognitions of gesture,object shape,size,and weight are implemented with multiple ML approaches,including the Supervised Learning Algorithms(SLAs)of K-Nearest Neighbor(KNN),Support Vector Machine(SVM),Logistic Regression(LR),and the unSupervised Learning Algorithm(un-SLA)of K-Means Clustering(KMC).Moreover,Optical Sensor Information(OSI),Pressure Sensor Information(PSI),and Double-Sensor Information(DSI)are adopted to compare the recognition accuracies.The experiment results demonstrate that the proposed sensors and recognition approaches are feasible and effective.The recognition accuracies obtained using the above ML algorithms and three modes of sensor information are higer than 85 percent for almost all combinations.Moreover,DSI is more accurate when compared to single modal sensor information and the KNN algorithm with a DSI outperforms the other combinations in recognition accuracy. | Haiming Huang Junhao Lin Linyuan Wu Bin Fang Zhenkun Wen Fuchun Sun | 2020 | Tsinghua Science and Technology2020，25，2： | 4 |
| 4 | Local electronic structure and magnetic properties of (Ga,Cr)N显示文摘The local electronic structure and mag- netic properties of diluted magnetic semiconductor (Ga,Cr)N have been studied by using discrete varia- tional method (DVM) based on density functional theory. The magnetic moments per Cr atom vary significantly with Cr concentration, and the trend of variation is in agreement with that of the experiment. The coupling between Cr atoms in the system with two Cr atoms considered is found to be ferromagnetic, and the magnetic moment per Cr atom is similar to the case in which only one Cr atom is considered in the same doping concentration. For all doping con- centrations, the coupling between Cr and the nearest neighbor N is found to be antiferromagnetic, and the Cr 3d states hybridize strongly with N 2p states, which are in agreement with the band calculations. | LIN He DUAN Haiming | 2006 | Chinese Science Bulletin2006，51，13： | 3 |
| 5 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 6 | Joint association analysis method to dissect complex genetic architecture of multiple genetically related traits显示文摘Genome-wide association study(GWAS)has been a standard approach to discover the genetic determinants underlying complex traits.It is a major challenge in GWAS how to improve analysis power,uncover complex genetic correlation,and reveal gene-gene and gene-environment interactions through integrated analysis of multiple genetically related traits.To combat these challenges,we proposed a mixed linear model-based joint association analysis method for multiple traits,which include epistasis and geneenvironment interaction in the mapping model and utilize within-trait variance and between-trait covariance simultaneously;A F-statistics based on Wilks statistics is used to test the significance of each SNP and paired interacted SNPs,each genetic effects of QTS are estimated and tested by the MCMC method based on a QTS full model.Simulations showed that the multi-trait GWAS method could provide increased power in detecting pleiotropic loci affecting more than one trait,and can unbiasedly estimate effects of QTS.To demonstrate the performance of the proposed method,we analyzed four blood lipid traits in Multi-Ethnic Study of Atherosclerosis(MESA)Cohort and two yield-related traits in a rice immortalized F2 dataset.A software package was developed for the proposed method. | Feng Lin Guoan Qi Ting Xu Xiangyang Lou Yongbo Hong Haiming Xu | 2020 | The Crop Journal2020，8，5： | 2 |
| 7 | Exact three-wave solutions for the KP equation显示文摘 | Zhengde Dai Songqing Lin Haiming Fu Xiping Zeng | 2010 | Applied Mathematics and Computation2010，，5： | 1 |
| 8 | Anchoring polysulfide with artificial solid electrolyte interphase for dendrite-free and low N/P ratio Li-S batteries显示文摘Lithium sulfur batteries are regarded as a promising candidate for high-energy-density energy storage devices.However,the lithium metal anode in lithium-sulfur batteries encounters the problem of lithium dendrites and lithium metal consumption caused by polysulfide corrosion.Herein we design a dualfunction PMMA/PPC/LiNO3composite as an artificial solid electrolyte interphase(PMCN-SEI)to protect Li metal anode.This SEI offers multiple sites of C=O for polysulfide anchoring to constrain corrosion of Li metal anode.The lithiated polymer group and Li3N in PMCN-SEI can homogenize lithium-ion deposition behavior to achieve a dendrite-free anode.As a result,the PMCN-SEI protected Li metal anode enables the Li||Li symmetric batteries to maintain over 300 cycles(1300 h)at a capacity of 5 m Ah cm^(-2),corresponding to a cumulative capacity of 3.25 Ah cm^(-2).Moreover,Li-S batteries assembled with 20μm of Li metal anode(N/P=1.67)still deliver an initial capacity of 1166 m A h g-1at 0.5C.Hence,introducing polycarbonate polymer/inorganic composite SEI on Li provides a new solution for achieving the high energy density of Li-S batteries. | Wei Lu Zhao Wang Guiru Sun Shumin Zhang Lina Cong Lin Lin Siru Chen Jia Liu Haiming Xie Yulong Liu | 2023 | Journal of Energy Chemistry2023，，5： | 1 |
| 9 | Enhancement of MoTe2 near-infrared absorption with gold hollow nanorods for photodetection显示文摘Infrared(IR)light photodetection based on two dimensional(2D)materials of proper bandgap has attracted increasing attention.However,the weak IR absorption in 2D materials,due to their ultrathin attribute and indirect bandgap in multilayer structures,degrades their performance when used as IR photodetectors.In this work,we utilize the fact that few-layer MoTe2 flake has a near-IR(NIR)bandgap and demonstrate a^60-fold enhancement of NIR response by introducing a gold hollow nanorods on the surface.Such gold hollow nanorods have distinct absorption peak located also at the NIR regime,therefore induces strong resonance,benefitting NIR absorption in MoTe2,resulting in strong near-field enhancement.With the evidence from steady and transient state optical spectra,we confirm that the enhancement of NIR response originates only photon absorption,rather than electron transport at interfaces as observed in other heterostructures,therefore,precluding the requirement of high-quality interfaces for commercial applications. | Jiawen You Ye Yu Kai Cai Dongming Zhou Haiming Zhu Renyan Wang Qingfu Zhang Hongwei Liu Yuting Cai Dong Lu Jang-Kyo Kim Lin Gan Tianyou Zhai Zhengtang Luo | 2020 | Nano Research2020，13，6： | 1 |
| 10 | Pathogenesis of premature coronary artery disease:Focus on risk factors and genetic variants显示文摘The development of premature coronary artery disease(PCAD)is dependent on both genetic predisposition and traditional risk factors.Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies.Genome-wide association studies(GWASs)have identified a considerable number of common genetic variants that are associated with PCAD.Most of these genetic variants are attributable to lipid and blood pressure-related single-nucleotide polymorphisms(SNPs).The genetic variants that predispose individuals to developing PCAD may depend on race and ethnicity.Some characteristic genetic variants have been identified in Chinese populations.Although translating this genetic knowledge into clinical applications is still challenging,these genetic variants can be used for CAD phenotype identification,genetic prediction and therapy.In this article we will provide a comprehensive review of genetic variants detected by GWASs that are predicted to contribute to the development of PCAD.We will highlight recent findings regarding CAD-related genetic variants in Chinese populations and discuss the potential clinical utility of genetic variants for preventing and managing PCAD. | Haiming Wang Zifan Liu Junjie Shao Min Jiang Xuechun Lu Lejian Lin Lin Wang Qiang Xu Haomin Zhang Xin Li Jingjing Zhou Yundai Chen Ran Zhang | 2022 | Genes & Diseases2022，9，2： | 1 |
| 11 | Simultaneous desulfurization and denitrification by microwave reactor with ammonium bicarbonate and zeolite显示文摘 | Zaishan Wei Zhehang Lin Hejingying Niu Haiming He Yongfeng Ji | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 12 | Research on key technologies of deduction of multinational power trading in the context of Global Energy Interconnection显示文摘When transnationalized electricity trade is conducted in the context of Global Energy Interconnection(GEI),the transaction settlement usually has a long cycle and high cost and is influenced by the volatility of the exchange rate.It is thus necessary to overcome the problems associated with the transaction settlement,change in the trading model data,and trading strategy in the transnational transaction deduction.To overcome the problem of trade settlement,this paper proposes the use of a digital currency(energy currency)for the cross-border electricity trading settlement based on the special drawing rights of the International Monetary Fund,which is controlled by the Global Energy Interconnection Development and Cooperation Organization(GEIDCO),to enable the proposed currency to become a stable digital currency.The traders can use the energy coins as a unit of currency for quotes,combined with the data pertaining to the changes in the energy information obtained from the GEI framework and data regarding the optimally extrapolated reference trading indicators.To realize the implementation of the multi-trader concurrent transaction deduction using a microservice architecture,this paper proposes a method of computing the microservice and synchronous interaction among the traders,based on the database table data,because the large amount of computation is required to be accomplished asynchronously with a single process.The key technology behind these cross-national electricity trading simulations can not only enable the GEI transnational traders to performed daily real-time trading,but it also demonstrates the advantages of the rapid settlement of the energy currency and the realization of a stable payment in the global energy interconnection cross-border electricity trading. | Jijie Huang Changnian Lin Haiming Zhou Zhengqing Xu Chunzhe Lin | 2019 | Global Energy Interconnection2019，2，6： | 1 |
| 13 | Introgression of chromosome 6PL terminal segment from Agropyron cristatum to increase both grain number and grain weight in wheat显示文摘Agropyron cristatum(2n=4x=28,PPPP),which harbours many high-yield and disease-resistance genes,is a promising donor for wheat improvement.Narrow genetic diversity and the trade-off between grain weight and grain number have become bottlenecks for increasing grain yield in wheat.In this study,a novel translocation line,WAT650l,was derived from the chromosome 6P addition line 4844–12,which can simultaneously increase both grain number per spike(GNS)and thousand-grain weight(TGW).Cytological analysis and molecular marker analysis revealed that WAT650l was a 5BL.5BS-6PL(bin 12–17)translocation line.Assessment of agronomic traits and analysis of the BC4F2 and BC5F2 populations suggested that the 6PL terminal chromosome segment in WAT650l resulted in increased grain number per spike(average increased by 14.07 grains),thousand-grain weight(average increased by 4.31 g),flag leaf length,plant height,spikelet number per spike and kernel number per spikelet during the two growing seasons of 2020–2021 and 2021–2022.Additionally,the increased GNS locus and high-TGW locus of WAT650l were mapped to the bins 16–17 and 12–13,respectively,on chromosome 6PL by genetic population analysis of three translocation lines.In summary,we provide a valuable germplasm resource for broadening the genetic base of wheat and overcoming the negative relationship between GNS and TGW in wheat breeding. | Yida Lin Shenghui Zhou Xuezhong Liang Bing Han Junli Yang Baojin Guo Jinpeng Zhang Haiming Han Weihua Liu Xinming Yang Xiuquan Li Lihui Li | 2023 | The Crop Journal2023，11，3： | 1 |
| 14 | Impact of living donor liver with steatosis and idiopathic portal inflammation on clinical outcomes in pediatric liver transplantation:Beijing experience显示文摘Background:To evaluate the impact of steatosis and/or idiopathic portal inflammation(IPI)in living donor livers on recipients’clinical outcomes.Methods:We assessed 305 qualified donor liver samples from June 2013 to December 2018.Donors and recipients’clinical characteristics,including follow-up data were retrieved.The graft and overall survival with/without steatosis or portal inflammation were compared by Kaplan-Meier analysis.Results:For living donors,the medium age of was 31.2(28,35.8)years old;liver histopathology showed macrovesicular steatosis:0-5%264/305(86.6%)and 5-30%41/305(13.4%),IPI:no 220/305(72.1%)and mild 85/305(27.9%).For recipients,the medium age was 1.0(0.6,1.5)years old;the median pediatric-end-stage-liver-disease score was 16(5.0,26.0)and medium follow-up time was 32.8(24.8,52.0)months.Biliary atresia(69.5%)was the main indication for liver transplantation(LT).Conclusions:The presence of steatosis and portal inflammation of the donor liver did not impact the clinical outcomes including transaminase or bilirubin normalization,short-/long-term complications and recipients’survival.However,recipients with high pediatric-end-stage-liver-disease score(>16)receiving donor liver with portal inflammation,but not steatosis,had trend negative effect on recipients’survival.In conclusion,donor livers with mild steatosis and portal inflammation were qualified for pediatric living donor LT.However,donor liver with mild portal inflammation would better not be allocated to recipients with high pediatric-end-stage-liver-disease score.This study provided new evidence in pediatric living donor liver allocation. | Xinyan Zhao Yafei He Jimin Liu Qian Zhang Liwei Liu Wei Qu Ying Liu Zhigui Zeng Haiming Zhang Jidong Jia Liying Sun Lin Wei Zhijun Zhu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 1 |
| 15 | Macroscopic assembled graphene nanofilms based room temperature ultrafast mid-infrared photodetectors显示文摘Graphene with linear energy dispersion and weak electron-phonon interaction is highly anticipated to harvest hot electrons in a broad wavelength range.However,the limited absorption and serious backscattering of hot-electrons result in inadequate quantum yields,especially in the mid-infrared range.Here,we report a macroscopic assembled graphene(nMAG)nanofilm/silicon heterojunction for ultrafast mid-infrared photodetection.The assembled Schottky diode works in 1.5-4.0μm at room temperature with fast response(20-30 ns,rising time,4 mm2 window)and high detectivity(1.61011 to 1.9109 Jones from 1.5 to 4.0μm)under the pulsed laser,outperforming single-layer-graphene/silicon photodetectors by 2-8 orders.These performances are attributed to the greatly enhanced photo-thermionic effect of electrons in nMAG due to its high light absorption(~40%),long carrier relaxation time(~20 ps),low work function(4.52 eV),and suppressed carrier number fluctuation.The nMAG provides a long-range platform to understand the hot-carrier dynamics in bulk 2D materials,leading to broadband and ultrafast MIR active imaging devices at room temperature. | Li Peng Lixiang Liu Sichao Du Srikrishna Chanakya Bodepudi Lingfei Li Wei Liu Runchen Lai Xiaoxue Cao Wenzhang Fang Yingjun Liu Xinyu Liu Jianhang Lv Muhammad Abid Junxue Liu Shengye Jin Kaifeng Wu Miao-Ling Lin Xin Cong Ping-Heng Tan Haiming Zhu Qihua Xiong Xiaomu Wang Weida Hu Xiangfeng Duan Bin Yu Zhen Xu Yang Xu Chao Gao | 2022 | InfoMat2022，4，6： | 1 |
| 16 | THE SYSTEMATIC DYNAMIC EMULATION ON THE AGRICULTURAL DEVELOPMENT ON THE LOESS PLATEAU显示文摘The Loess Plateau, covered with thick loess, lies in the middle reaches of the YellowRiver to the west of the Taihangshan Mountains, east of the Wuqiao Mountains south ofYinshan Mountains and north of the Qinling Mountains with a total area of 56×10~4km^2.The plateau is 1000--2500m above sea level and has loess as thick as 100--200 metres, be- | Lin Haiming Huang Gaobao Chen Yuan Yu Shiming Gansu Agricultural University, Lanzhou, 730070 | 1993 | 干旱区资源与环境1993，7，Z1： | 0 |
| 17 | Community Authenticity Experience of Shared Accommodation Consumers显示文摘By constructing a research framework of theoretical concepts such as leisure involvement, authenticity experience, place attachment, and willingness to revisit, the aim is to explore the authenticity experience and its influencing mechanisms in shared accommodation consumption. Research data are collected by using questionnaire survey method, and statistical analysis of data is conducted using SPSS 21.0. Research has found that leisure involvement has a significant positive impact on authenticity experience, place attachment, and willingness to revisit;authenticity experience has a significant positive impact on place attachment and willingness to revisit;place attachment has a significant positive impact on willingness to revisit. Therefore, shared accommodation owners need to strengthen the editing and publishing of leisure strategies on we media to enhance customers sense of leisure involvement;pay attention to enhancing the local authentic cultural experience of tenants, in order to increase their sense of attachment to the place and thereby enhance their willingness to stay. | Haiming CHEN Mengting DENG Yiyu CHEN Xuejuan KONG Shaoling GUO Jiaxin SHEN Zihao LIN | 2023 | Meteorological and Environmental Research2023，14，6： | 0 |
| 18 | Assessment of the Capability of ENSEMBLES Hindcasts in Predicting Spring Climate in China显示文摘Using the hindcasts provided by the Ensemble-Based Predictions of Climate Changes and Their Impacts(ENSEMBLES) project for the period of 1980–2005, the forecast capability of spring climate in China is assessed mainly from the aspects of precipitation, 2-m air temperature, and atmospheric circulations. The ENSEMBELS can reproduce the climatology and dominant empirical orthogonal function(EOF) modes of precipitation and 2-m air temperature, with some differences arising from different initialization months. The multi-model ensemble(MME) forecast of interannual variability is of good performance in some regions such as eastern China with February initialization.The spatial patterns of the MME interannual and inter-member spreads for precipitation and 2-m air temperature are consistent with those of the observed interannual spread, indicating that internal dynamic processes have major impacts on the interannual anomaly of spring climate in China. We have identified two coupled modes between intermember anomalies of the 850-hPa vorticity in spring and sea surface temperature(SST) both in spring and at a lead of 2 months, of which the first mode shows a significant impact on the spring climate in China, with an anomalous anticyclone located over Northwest Pacific and positive precipitation and southwesterly anomalies in eastern China.Our results also suggest that the SST at a lead of two months may be a predictor for the spring climate in eastern China. A better representation of the ocean–atmosphere interaction over the tropical Pacific, Northwest Pacific, and Indian Ocean can improve the forecast skill of the spring climate in eastern China. | Yitong LIN Haiming XU Jing MA Haijun LI | 2019 | Journal of Meteorological Research2019，33，2： | 0 |
| 19 | 3-[3-(3-florophenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate,a novel xanomeline derivative,improves neural cells proliferation and survival in adult mice显示文摘The present study analyzed the influence of 3-[3-(3-florophenyl-2-propyn-1-ylthio)-1, 2, 5-thiadiazol-4-yl]-1, 2, 5, 6-tetrahydro-1-methylpyridine oxalate (EUK1001), a novel xanomeline derivative of the M1/M4 receptor agonist, on hippocampal neurogenesis in adult C57BL6 mice. Results showed that 15-day EUK1001 treatment via intraperitoneal injection promoted neural cell proliferation in the dentate gyrus, although cell differentiation did not change. The majority of bromodeoxyuridine-positive cells co-expressed the immature neuronal marker doublecortin. In addition, the level of neurogenesis in the subventricular zone was not altered. Brain-derived neurotrophic factor mRNA expression was up-regulated following EUK1001 treatment, but no change was observed in expression of camp-responsive element binding protein 1, paired box gene 6, vascular endothelial growth factor alpha, neurogenic differentiation factor 1, and wingless-related mouse mammary tumor virus integration site 3A mRNA. These experimental findings indicated that EUK1001 enhanced proliferation and survival of hippocampal cells, possibly by increasing brain-derived neurotrophic factor expression. | Xiaoliang Zhang Qiang Gong Shuang Zhang Lin Wang Yinghe Hu Haiming Shen Suzhen Dong | 2012 | Neural Regeneration Research2012，7，1： | 0 |
| 20 | Investigating the reason for high FF from ternary organic solar cells显示文摘Organic solar cells(OSCs)have attracted huge attention because of their unique merits[1−3].In last few years,thanks to the design of new materials and device engineering,the power conversion efficiencies(PCEs)of OSCs have surpassed 18%[4−8].The PM6:Y6 cells are efficient binary cells,offering high PCEs over 16%[9−11].The high performance originates from the efficient free charge generation and the ground state dipole field at the donor-acceptor interface that promotes the exciton dissociation[12]. | Danqin Li Yihan Zeng Zeng Chen Shifeng Leng Zuo Xiao Qifan Xue Tianyu Hao Meng Lv Hongbo Wu Lina Lin Jianming Yang Zaifei Ma Jinquan Chen Rong Huang Feng Liu Haiming Zhu Xianjie Liu Liming Ding Mats Fahlman Qinye Bao | 2021 | Journal of Semiconductors2021，42，9： | 0 |
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