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| 1 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 2 | Effect of dietary supplementation with protease on growth performance,nutrient digestibility, intestinal morphology, digestive enzymes and gene expression of weaned piglets显示文摘This study was conducted to investigate the effect of dietary protease supplementation on the growth performance, nutrient digestibility, intestinal morphology, digestive enzymes and gene expression in weaned piglets. A total of 300 weaned piglets(21 days of age Duroc x Large White x Landrace; initial BW = 6.27 ± 0.45 kg) were randomly divided into 5 groups. The 5 diets were: 1) positive control diet(PC), 2) negative control diet(NC), and 3) protease supplementations, which were 100, 200, and 300 mg per kg NC diet. Results indicated that final BW, ADG, ADFI, crude protein digestibility, enzyme activities of stomach pepsin, pancreatic amylase and trypsin, plasma total protein, and intestinal villus height were higher for the PC diet and the supplementations of 200 and 300 mg protease per kg NC diet than for the NC diet(P < 0.05). Supplementations of 200 and 300 mg protease per kg NC diet significantly increased the ratio of villus height to crypt depth(VH:CD) of duodenum, jejunum and ileum compared with NC diet(P < 0.05). Feed to gain ratio, diarrhea index, blood urea nitrogen, and diamine oxidase were lower for the PC diet and supplementations of 200 and 300 mg protease per kg NC diet than for the NC diet(P < 0.05). Piglets fed the PC diet had a higher peptide transporter 1(PepTl) mRNA abundance in duodenum than piglets fed the NC diet(P < 0.05), and supplementations of 100, 200 and 300 mg protease per kg NC diet increased the PepTl mRNA abundance in duodenum(P < 0.05) comparing with the NC diet. Piglets fed the PC diet had a higher b0,+AT mRNA abundance in jejunum than piglets fed the NC diet(P < 0.05), and supplementations of 200 and 300 mg protease per kg NC diet increased the b0,+AT mRNA abundance in jejunum and ileum comparing with the NC diet(P < 0.05). In summary, dietary protease supplementation increases growth performance in weaned piglets, which may contribute to the improvement of intestinal development, protein digestibility, nutrient transport efficiency, and health status of piglets when fed low digestible protein sources. | Jianjun Zuo Baoming Ling Lina Long Tiejun Li Ludovic Lahaye Chengbo Yang Dingyuan Feng | 2015 | Animal Nutrition2015，，4： | 18 |
| 3 | A review of the end-effector of large space manipulator with capabilities of misalignment tolerance and soft capture显示文摘The space manipulator which has advantages of high dexterity and universality, is used to the space capturing usually. According to the different types of mechanical interfaces of targets, the on orbit capturing operation includes capturing of cooperative target and capturing of uncooperative target. The performances of the famous large space manipulators named space shuttle remote manipulator system(SRMS), the space station remote manipulator system(SSRMS) and the Europe robotic arm(ERA) are reviewed and studied respectively. Moreover, the space manipulators being developed by China for space station is also surveyed. Based on the performance analysis of the large space manipulators and end-effectors, which are adapted to the construction and daily maintenance for the large space structure such as the space station, the basic requirements of large misalignment tolerance capability, soft capturing capability and hard docking capability for the end-effector of large space manipulator are proposed in this paper. According to these requirements, the capture mechanism and methods that can enable the end-effector to have the capability of misalignment tolerance and soft capturing are presented. The development trend and key technologies of the large space manipulators and the end-effectors are also reviewed. | FENG Fei TANG LiNa XU JianFeng LIU Hong LIU YiWe | 2016 | Science China(Technological Sciences)2016，59，11： | 15 |
| 4 | Walnut-inspired microsized porous silicon/graphene core-shell composites for high-performance lithium-ion battery anodes显示文摘 | Wei Zhai Qing Ai Lina Chen Shiyuan Wei Deping Li Lin Zhang Pengchao Si Jinkui Feng Lijie Ci | 2017 | Nano Research2017，10，12： | 12 |
| 5 | Effects of Different Land-Use Types on Soil Erosion Under Natural Rainfall in the Loess Plateau, China显示文摘黄土高原,位于中国的干旱、半干旱的区域,由于强烈人的活动和土壤 erodibility 经历重要土壤侵蚀。探索并且识别能控制土壤侵蚀并且完成某些农业生产能力的陆地使用类型或陆地使用模式是必要的。这研究在 Yan'an 的北方与二个斜坡坡度(5 °
和 15 °
) 建立了流量阴谋,黄土高原的一个区域,与 3 单身者一起,陆地使用打字(栽培土地, CL;switchgrass, SG;并且放弃了土地, AL ) 并且 2 种合成陆地使用类型(CL-SG 和 CL-AL ) 。从 2006 ~ 2012,我们连续地监视了降雨特征,流量深度,土壤损失,植被范围,和土壤物理性质。结果为 5 种陆地使用类型在流量和土壤损失事件的数字显示了一个一般趋势:CL = CL-SG > CL-AL > SG > AL。为流量深度,土壤损失,他们变化的大小,和降雨流量回归方程的斜坡的一般趋势是 CL > CL-SG > CL-AL > SG > AL,而为流量产生的降雨阀值展出了相反的趋势。nonparametric 的结果关于流量 depth/EI 30 和 EI 30 在 30 min,和关系回归显示了的流量深度土壤损失上是降雨动能和最大的降雨紧张的产品的土壤 loss/EI 30, 测试 CL-AL 的效果类似于 SG 的;SG 类似于 AL;并且 CL-AL, SG,和 AL 比关于土壤和水保存的 CL 优异。显著地作为斜坡坡度增加的流量深度和土壤损失增加了。流量深度和土壤损失显著地分别地与土壤粒子尺寸作文和体积密度被相关。最强壮的重要关联在流量深度和植被范围之间以及在土壤损失和植被范围之间被发现,它证明那篇植被报道是控制土壤侵蚀的主要因素。因此,因为土壤保存和农业生产的某个度在学习区域是必要的,合成陆地使用类型 CL-AL 和人工的草地(SG ) 是适当选择。 | FENG Qiang ZHAO Wenwu WANG Jun ZHANG Xiao ZHAO Mingyue ZHONG Lina LIU Yuanxin FANG Xuening | 2016 | Pedosphere2016，26，2： | 11 |
| 6 | DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways显示文摘Background:Gastric cancer(GC)is one of the most common malignancies worldwide,particularly in China.DNA damage-inducible transcript 4(DDIT4)is a mammalian target of rapamycin inhibitor and is induced by various cellular stresses;however,its critical role in GC remains poorly understood.The present study aimed to investigate the poten-tial relationship and the underlying mechanism between DDIT4 and GC development.Methods:We used western blotting,real-time polymerase chain reaction,and immunohistochemical or immunoflu-orescence to determine DDIT4 expression in GC cells and tissues.High-content screening,cell counting kit-8 assays,colony formation,and in vivo tumorigenesis assays were performed to evaluate cell proliferation.Flow cytometry was used to investigate cell apoptosis and cell cycle distribution.Results:DDIT4 was upregulated in GC cells and tissue.Furthermore,downregulating DDIT4 in GC cells inhibited proliferation both in vitro and in vivo and increased 5-fluorouracil-induced apoptosis and cell cycle arrest.In contrast,ectopic expression of DDIT4 in normal gastric epithelial cells promoted proliferation and attenuated chemosensitivity.Further analysis indicated that the mitogen-activated protein kinase and p53 signaling pathways were involved in the suppression of proliferation,and increased chemosensitivity upon DDIT4 downregulation.Conclusion:DDIT4 promotes GC proliferation and tumorigenesis,providing new insights into the role of DDIT4 in the tumorigenesis of human GC. | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2018 | Cancer Communications2018，38，1： | 10 |
| 7 | FXYD6: a novel therapeutic target toward hepatocellular carcinoma显示文摘FXYD6, FXYD 领域包含离子运输管理者 6,被报导了影响 Na 的活动 < 啜 class= “ a-plus-plus ” >+/K+-ATPase 并且与心理疾病被联系。这里,我们证明 FXYD6 在 hepatocellular 癌(HCC ) 是起来调整的并且提高 HCC 房间的迁居和增长。FXYD6 的起来规定不仅断然随 Na 的增加相关 < 啜 class= “ a-plus-plus ” >+/K 有它发信号的下游的 Src 英皇家空军之阶级最低之兵的激活的 +-ATPase 而且坐标小径。更重要地,显著地由它的功能的抗体堵住 FXYD6 在老鼠禁止 xenografted HCC 肿瘤的生长潜力,显示 FXYD6 代表向 HCC 的一个潜在的治疗学的目标。总的来说,我们的结果在 HCC 前进建立 FXYD6 的一个关键角色并且建议指向 FXYD6 的治疗能向 HCC 病人有益于临床的治疗。 | Qian Gao Xiongfei Chen Hongxia Duan Zhaoqing Wang Jing Feng Dongling Yang Lina Song Ningxin Zhou Xiyun Yan | 2014 | Protein & Cell2014，5，7： | 7 |
| 8 | A Local Cluster of Omicron Variant COVID-19 Likely Caused by Internationally Mailed Document——Beijing Municipality,China,January 2022显示文摘On January 15,2022,a 26 years old female(Case A)went to a sampling site for coronavirus disease 2019(COVID-19)testing due to excessive fatigue and fever for two days.This patient preliminarily tested positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)using a quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR)method. | Daitao Zhang Shuangsheng Wu Zhenyong Ren Ying Sun Xiangfeng Dou Zhaomin Feng Fu Li Yi Tian Shujuan Cui Baiwei Liu Bing Lyu Xiaoli Wang Feng Liu Lina Jin Chu Jiang Lina Tian Zhenjiang Xin Zhichao Liang Lei Jia Quanyi Wang Yang Pan Peng Yang | 2022 | China CDC weekly2022，4，14： | 6 |
| 9 | Impaired tumor angiogenesis and VEGF- induced pathway in endothelial CD146 knockout mice显示文摘 | Qiqun Zeng Zhenzhen Wu Hongxia Duan Xuan Jiang Tao Tu Di Lu Yongting Luo Ping Wang Lina Song Jing Feng Dongling Yang Xiyun Yan | 2014 | Protein & Cell2014，5，6： | 6 |
| 10 | In situ synthesis and modification of calcium carbonate nanoparticles via a bobbling method显示文摘Modified calcium carbonate (CaCO3) nanoparticles with cubic- and spindle-like configuration were synthesized in situ by the typical bobbling (gas-liquid-solid) method. The modifiers, such as sodium stearate, octadecyl dihydrogen phosphate (ODP) and oleic acid (OA), were used to obtain hydrophobic nanoparticles. The different modification effects of the modifiers were investigated by measuring the active ratio, whiteness and the contact angle. Moreover, transmission electron microscopy (TEM), X-ray diffraction (XRD) and thermogravimetry analysis (TGA analysis) were employed to characterize the obtained products. A preliminary reaction mechanism was discussed. According to the results, the active ratio of CaCO3 modified by ODP was ca. 99.9% and the value of whiteness was 97.3% when the dosage of modifiers reached 2%. The contact angle was 122.25° for the CaCO3 modified in the presence of sodium stearate, ODP and OA. When modified CaCO3 was filled into PVC, the mechanical properties of products were improved greatly such as rupture intensity, pull intensity and fuse temperature. The compatibility and affinity between the modified CaCO3 nanoparticles and the organic matrixes were greatly improved. | ZHAO LiNa FENG JingDong WANG ZiChen | 2009 | Science China Chemistry2009，52，7： | 5 |
| 11 | Decomposition of acid dissolved titanium slag from Australia by sodium hydroxide显示文摘The kinetics of the decomposition of acid dissolved titanium slag with a sodium hydroxide system under atmospheric pressure was studied. The effect of reaction temperature, particle size and NaOH-to-slag mass ratio on titanium extraction was investigated. The results show that temperature and particle size have significant influence on titanium extraction. The experimental data of titanium extraction show that the shrinking core model with chemical reaction controlled process is most applicable for the decomposition of slag, with an apparent activation energy of 62.4 kJ·mol-1. Approximately 85 wt.%-90 wt.% of the titanium can be extracted from the slag under the optimal conditions. In addition, the purity of titanium dioxide obtained in the product is up to 98.5 wt.%. | FENG Yang WANG Jinggang WANG Lina QI Tao XUE Tianyan CHU Jinglong | 2009 | Rare Metals2009，28，6： | 5 |
| 12 | Occurrence of bisphenol A in surface and drinking waters and its physicochemical removal technologies显示文摘Bisphenol A (BPA ) ,内分泌的破坏混合物,在环境和有害效果由于它的宽出现引起了宽公共担心。BPA 与最大的集中在许多表面水和喝的水里被检测了直到十 | Liping LIANG Jing ZHANG Pian FENG Cong LI Yuying HUANG Bingzhi DONG Lina LI Xiaohong GUAN | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 5 |
| 13 | Relationship of gelatinases-tight junction proteins and blood-brain barrier permeability in the early stage of cerebral ischemia and reperfusion显示文摘Gelatinases matrix metalloproteinase-2 and matrix metalloproteinase-9 have been shown to mediate claudin-5 and occludin degradation, and play an important regulatory role in blood-brain barrier permeability. This study established a rat model of 1.5-hour middle cerebral artery occlusion with reperfusion. Protein expression levels of claudin-5 and occludin gradually decreased in the early stage of reperfusion, which corresponded to the increase of the gelatinolytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9. In addition, rats that received treatment with matrix metalloproteinase inhibitor N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpenthanoyl]-L- tryptophan methylamide (GM6001) showed a significant reduction in Evans blue leakage and an inhibition of claudin-5 and occludin protein degradation in striatal tissue. These data indicate that matrix metalloproteinase-2 and matrix metalloproteinase-9-mediated claudin-5 and occludin degradation is an important reason for blood-brain barrier leakage in the early stage of reperfusion. The leakage of the blood-brain barrier was present due to gelatinases-mediated degradation of claudin-5 and occludin proteins. We hypothesized that the timely closure of the structural component of the blood-brain barrier (tight junction proteins) is of importance. | Haolin Xin Wenzhao Liang Jing Mang Lina Lin Na Guo Feng Zhang Zhongxin Xu | 2012 | Neural Regeneration Research2012，7，31： | 4 |
| 14 | Primed macrophages directly and specifically reject allografts显示文摘Monocytes and macrophages have long been associated with acute and chronic allograft rejection;this is mediated by their abilities to promote inflammation,kill target cells via antibody-dependent cytotoxicity and modulate adaptive immunity.Our present study showed that allogeneic antigen-primed macrophages acutely rejected skin grafts with specificity after adoptive transfer into MHC-matched immunodeficient mice.The ability of primed macrophages to reject allografts essentially requires the help of CD4^(+) T cells and does not require the help of CD8^(+) T cells.Moreover,the primed,perforin-deficient macrophages rejected the skin grafts in a significantly delayed pattern compared with WT macrophages,indicating that the perforin pathway of the primed macrophages is likely involved in the rejection process.Thus,primed macrophages are endowed with adaptive immunitylike features,such as specificity,with the help of CD4^(+) T cells during the immune response to allografts.The present study challenges our traditional views of macrophage functions and highlights the biological functions of macrophages beyond innate immunity in mammals. | Zhulang Chu Chenming Sun Lina Sun Chang Feng Fan Yang Yanan Xu Yong Zhao | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 15 | Short-term link quality prediction using nonparametric time series analysis显示文摘Wireless link quality prediction(LQP) is the foundation for proactive operations and is therefore a key technique in alleviating network performance degradation. However, accurate LQP is difficult because of the dynamic nature of wireless environments. A recent study found that fluctuations in intermediate quality links often show dynamics on a sub-second granularity, making the task even more challenging. In order to leverage the intermediate links, as well as fine-tune upper-layer protocols, we propose to use nonparametric modeling in nonlinear time series analysis that predicts short-term link quality online. Unlike existing studies,we do not define any new experimental or hypothetical models, or train models using a set of training data.Functional-coefficient autoregression is employed to predict the link dynamics at high time resolutions. We apply our approach and a local linear regression-based LQP(a typical parametric modeling approach) to both NS-2 simulation and empirical packet traces. The results indicate that the proposed method has much higher prediction accuracy and convergence speed than the local linear regression-based LQP under dynamic network conditions. | WENG LiNa ZHANG Ping FENG ZhiYong CHENG HongWei LIAN Hao FU Bin | 2015 | Science China(Information Sciences)2015，58，8： | 4 |
| 16 | Nutrient Composition of Different Foxtail Millet Seeds显示文摘Ten millet cultivars from China and abroad were analyzed for their crude fat,amylose and amylopectin,crude protein and amino acid content. A wide variation was observed in amylopectin contain,ranging from 54. 47% to 69. 26%,while amylose content ranged from 11. 26% to 23. 22%. The average crude fat in all cultivates was 3. 46%,and most cultivates ranged from 3. 1% to 3. 7%. Protein contents ranged from 8. 61% to 15. 54% with a mean value of 11. 94%. For amino acid composition,the ten cultivates were particularly rich in leucine,and the mean was 34. 57 mg/g. The millet cultivars were also high in glycine,glutamic acid and cysteine. Millet was known to be limiting in the essential amino lysine,and the mean was 5. 18 mg/g. Other amino acids,tyrosine,histidine and arginine were also very low in the ten cultivars. In general,significant nutrient composition differences were observed between the different millet cultivars,and A2( a kind of mother line of the hybrid millet) and hybrid millet registered a higher level of protein and amino acid composition which would be useful in millet breeding. | Guangyu FAN Jincheng YUAN Lina ZHANG Xiaojie LIU Xiaoming WANG Feng WANG Xiaolei FENG Guoliang SONG Haiying ZHANG Qian WANG Zhihai ZHAO Yinghui LIU | 2018 | Agricultural Biotechnology2018，7，5： | 4 |
| 17 | Improved oxygen reduction reaction via a partially oxidized Co-CoO catalyst on N-doped carbon synthesized by a facile sand-bath method显示文摘High active and durable non-noble metal electrocatalysts are urgently developed to satisfy the high performance oxygen reduction reaction(ORR). We successfully synthesized Co-CoOx anchored on nitrogen-doped carbon via a facile sand-bath method(SBM), i.e., Co-CoOx/N-C(SBM). The as-obtained Co-CoOx/N-C(SBM) exhibited overwhelming superiorities to Co-CoO/N-C prepared by conventional heat treatment(CHT), particularly in electrochemical performance of ORR. Although Co-CoOx/N-C(SBM)showed smaller specific surface area of 276.8 m^2/g than that of 939.5 m^2/g from Co-CoO/N-C(CHT), the Co-CoOx/N-C(SBM) performed larger pore diameter and more Co_3O_4 active component resulting in better ORR performance in 0.1 mol/L KOH solution. The Co-CoO_x/N-C(SBM) delivered onset potential of 0.91 V vs. RHE, mid-wave potential of 0.85 V vs. RHE and limited current density of 5.46 mA/cm^2 much better than those of the Co-CoO/N-C(CHT). Furthermore, Co-CoOx/N-C(SBM) showed greater stability and better methanol tolerance superior to the commercial 20 wt% Pt/C. | Libing Hu Feng Yu Huifang Yuan Gang Wang Mincong Liu Lina Wang Xueyan Xue Banghua Peng Zhiqun Tian Bin Dai | 2019 | Chinese Chemical Letters2019，30，3： | 4 |
| 18 | Human embryonic stem cells-derived endothelial cell therapy facilitates kidney regeneration by stimulating renal resident stem cell proliferation in acute kidney injury显示文摘Endothelial cell therapy has been implicated to enhance tissue regeneration and vascularization in ischemic kidney. However, no published study has yet examined direct effects of endothelial cell treatment in kidney recovery. This study investigated the therapeutic efficacy of endothelial cells in a mouse model with acute kidney injury (AKI). Thus, human embryonic stem cells-derived endothelial cells (hESC-ECs) labeled with a reporter system encoding a double fusion reporter gene for firefly luciferase (Fluc) and green fluorescent protein (GFP) were characterized by Fluc imaging and immunofluoresence staining. Cultured hESC-ECs (1×106) were injected into ischemic kidney shortly after AKI. Survival of the transplanted hESC-ECs was monitored in vivo from day 1 to 14 after endothelial cell transplantation and potential impact of hESC-EC treatment on renal regeneration was assessed by histological analyses. We report that a substantial level of bioluminescence activity was detected 24 h after hESC-EC injection followed by a gradual decline from 1 to 14 d. Human ESC-ECs markedly accelerated kidney cell proliferation in response to ischaemia-induced damage, indicated by an elevated number of BrdU+ cells. Co-expression of Sca-1, a kidney stem cell proliferation marker, and BrdU further suggested that the observed stimulation in renal cell regeneration was, at least in part, due to increased proliferation of renal resident stem cells especially within the medullary cords and arteriole. Differentiation of hESC-ECs to smooth muscle cells was also observed at an early stage of kidney recovery. In summary, our results suggest that endothelial cell therapy facilitates kidney recovery by promoting vascularization, trans-differentiation and endogenous renal stem cell proliferation in AKI. | JIA XiaoHua L He LI Chen FENG GuoWei YAO XinPeng MAO LiNa KE TingYu CHE YongZhe XU Yong LI ZongJin KONG DeLing | 2013 | Chinese Science Bulletin2013，58，23： | 4 |
| 19 | Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma:an exploratory study显示文摘Background:Previous studies have shown that macrophage migration inhibitory factor(MIF)is involved in the pathogenesis of asthma.This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma.Methods:We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls,analyzing the parameter levels of serum MIF,serum total immunoglobulin E(tIgE),peripheral blood eosinophil percentage(EOS%),and fractional exhaled nitric oxide(FeNO).Lung function indices were used to identify disease severity and therapeutic response.Results:Our study showed that all measured parameters in patients were at higher levels than those of controls.After one week of treatment,most parameter levels decreased significantly except for serum tIgE.Furthermore,we found that serum MIF positively correlated with EOS%as well as FeNO,but negatively correlated with lung function indices.Receiver operator characteristic(ROC)curve analysis indicated that among the parameters,serum MIF exhibited a higher capacity to evaluate therapeutic response.The area under the curve(AUC)of MIF was 0.931,with a sensitivity of 0.967 and a specificity of 0.800.Conclusions:Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations. | Huiyuan ZHU Shaochun YAN Jingshuo WU Zhong ZHANG Xiaolin LI Zheng LIU Xing MA Lina ZHOU Lin ZHANG Mingming FENG Yiwei GENG Aixin ZHANG Sabina JANCIAUSKIENE Aiguo XU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 3 |
| 20 | Results of docetaxel plus oxaliplatin (DOCOX) ± cetuximab in patients with metastatic gastric and/or gastroesophageal junction adenocarcinoma: results of a randomized phase 2 study显示文摘 | Donald Richards Darren M. Kocs Alexander I. Spira A. David McCollum Sami Diab Lanny I. Hecker Allen Cohn Feng Zhan Lina Asmar | 2013 | European Journal of Cancer2013，，： | 3 |
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