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| 1 | Two Comparable Earthquakes Produced Greatly Different Coseismic Landslides:The 2015 Gorkha,Nepal and 2008 Wenchuan,China Events显示文摘The 2015 Gorkha Earthquake in Nepal and the 2008 Wenchuan Earthquake in China occurred at the south and southeast margins of the Tibetan Plateau, respectively. Both earthquakes had similar magnitudes of Mw 7.8 and 7.9, caused catastrophic loss of life and damage to property, and generated tens of thousands of landslides. Comparisons of pre- and post-quake satellite images supported by field investigations show that the Gorkha Earthquake triggered at least 2 064 large landslides(defined as covering an area ≥10 000 m^2) over a ~35 600 km^2 region with a volume of(444–584)×10~6(average 509×10~6) m^3 and total area of 44.78×10~6 m^2. In contrast, the Wenchuan Earthquake triggered 25 580 large landslides over a region of ~44 000 km^2 with a volume of(7 128–9 479)×10~6(average 8 219×10~6) m^3 and a total area of about 670.65×10~6 m^2. Several controlling factors including topographic relief, slope steepness, and regional peak ground acceleration(PGA) were investigated to try to explain the great differences between the number, volume and area of the coseismic landslides associated with the two similar earthquakes. We found that the differences primarily arose from an unexpected factor, the dip angle of the seismogenic fault. This discovery should aid understanding the failure mechanisms of quake-triggered landslides, and suggests that more factors should be taken into consideration in estimating coseismic landslide volumes from earthquake magnitudes. | Chong Xu Xiwei Xu Yingying Tian Lingling Shen Qi Yao Xueqiang Huang Junxue Ma Xi Chen Siyuan Ma | 2016 | Journal of Earth Science2016，27，6： | 14 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | Comparative Transcriptome Analysis Reveals Different Host Cell Responses to Acute and Persistent Foot-and-Mouth Disease Virus Infection显示文摘Foot-and-mouth disease virus(FMDV) rapidly causes cytopathic effects in susceptible cells. Incomplete viral clearance during the acute infection leads to persistent infection. The relationship between host gene expression and the persistent infection remains unclear. In this study, we analyzed the transcriptome profiles of BHK-21 cells acutely and persistently infected with FMDV to identify differences in gene expression. GO and KEGG enrichment analyses showed that the 8,378 differentially expressed genes were significantly enriched in categories including metabolism, biosynthesis, ribosome function, and endocytosis. In persistently infected BHK-21 cells, ribosome-and translation-related genes were significantly down-regulated. There were more differentially expressed immune-related genes during persistent infection than during acute infection. Two hundred and seventy-four genes were differentially expressed in both acutely and persistently infected BHK-21 cells. Among these genes, heat shock protein family B member 1(Hspb1) knockdown significantly inhibited FMDV replication. Our research provides a basis for further research to understand the mechanisms of persistent FMDV infection including the genes involved in FMDV replication. | Jiadai Li Lingling Han Yao Hao Yuncong Yuan Mingzhen Wang Xiu Xin Hailong Wang Fang Yu Congyi Zheng Chao Shen | 2020 | Virologica Sinica2020，35，1： | 4 |
| 4 | Interaction among controlling factors for landslides triggered by the 2008 Wenchuan, China Mw 7.9 earthquake显示文摘2008 年 5 月 12 日 Mw 7.9 Wenchuan,中国地震触发了大约 200,000 山崩,它被很多个因素控制。这研究检验五个因素:斜坡角度,斜坡方面,岩性学,山峰地面加速(针网阵列),和差错站在一起( seismogenic 差错上的相对位置,即,挂的墙或矿脉基卒下盘),决定这些因素怎么并且是否控制co地震的山崩出现至少一个因素,独自或在音乐会行动,涉及支持或压制山崩。我们执行了一个多因素用从 2008 Wenchuan 地震的数据的统计分析。结果在陡峭的地形学描绘的区域显示出那或在充分的理由摇晃发生在地震期间的地方,比另外的区域在斜坡方面和山崩数字密度(LND ) 之间有一种更靠近的关系。在岩性学和 LND 价值之间的关系取决于针网阵列。接着,在 LND 价值和针网阵列之间的关系被岩性学也影响。另外, seismogenic 差错的挂的墙上的 co 地震的山崩上的岩性学的控制效果在矿脉基卒下盘上比那大。在这些因素之中检验相互作用能改进 co 地震的山崩出现的机制的理解。 | Lingling SHEN Chong XU Lianyou LIU | 2016 | Frontiers of Earth Science2016，10，2： | 4 |
| 5 | Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2-and CDKNIA-interacting protein (BCCIP) in cells显示文摘 | Jiaming Su Yi Sui Jian Ding Fuqiang Li Shuang Shen Yang Yang Zeming Lu Fei Wang Lingling Cao Xiaoxia Liu Jingji Jin Yong Cai | 2016 | Protein & Cell2016，7，10： | 3 |
| 6 | Optimization of compression formulation and load of food-grade tracers for grain traceability using central composite design显示文摘Food-grade tracers have been developed as an identification technology for grain traceability from original harvest to final destination for transportation.The characteristics of food-grade tracers must be able to satisfy the environmental demands for grain traceability.To optimize the food-grade tracer production process,the effects of direct compression formulation and load on the mechanical characteristics were studied using response surface methodology(RSM)with central composite design(CCD).Among the four tested formulations,Formulations#2(consisting of 35.00%lactose 100 mesh,64.50%microcrystalline cellulose 102 and 0.50%magnesium stearate)and#4(consisting of 38.00%lactose 100 mesh,50.00%microcrystalline cellulose 102,11.00%pregelatinized starch and 1.00%magnesium stearate)were selected for tracer production based on their physical properties as powders.The value of Carr’s flowability index was 68 for both Formulations#2 and#4,which was the highest among all the formulations.Therefore,Formulations#2 and#4 also had the best powder flowability.The magnesium stearate ratio(1.00%-3.00%)and pressure(6.00-16.00 kgf)were used as independent variables to detect changes in the breaking rate,peak shear force and friction coefficient of tracers compressed by the selected formulations.The optimal production parameters could be achieved at a magnesium stearate ratio of 2.25%and pressure of 16.00 kgf for Formulation#2 and at a magnesium stearate ratio of 1.02%and pressure of 16.00 kgf for Formulation#4.Under these optimal conditions,the tracers had good impact characteristics(breaking rate),compression characteristics(peak shear force)and frictional characteristics(friction coefficient).Moreover,Formulation#2 was more suitable for production because compared to Formulation#4,its breaking rate and friction coefficient values were lower,and its peak shear force value was higher. | Liang Kun Zhang Lingling Lu Wei Cedric Sean Okinda Shen Mingxia | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 2 |
| 7 | Creating Mesopores in ZSM-5 Zeolite by Alkali Treatment: A New Way to Enhance the Catalytic Performance of Methane Dehydroaromatization on Mo/HZSM-5 Catalysts显示文摘 | Lingling Su Lin Liu Jianqin Zhuang Hongxia Wang Yonggang Li Wenjie Shen Yide Xu Xinhe Bao | 2003 | Catalysis Letters (-)2003，，3： | 1 |
| 8 | Lycium barbarum polysaccharide stimulates proliferation of MCF-7 cells by the ERK pathway显示文摘 | Lingling Shen Guang Du | 2012 | Life Sciences . 2012 (9-10)2012，，9： | 1 |
| 9 | Creating Mesopores in ZSM-5 Zeolite by Alkali Treatment: A New Way to Enhance the Catalytic Performance of Methane Dehydroaromatization on Mo/HZSM-5 Catalysts显示文摘 | Lingling Su Lin Liu Jianqin Zhuang Hongxia Wang Yonggang Li Wenjie Shen Yide Xu Xinhe Bao | 2003 | Catalysis Letters (-)2003，，3： | 1 |
| 10 | Antibody-engineered red blood cell interface for high-performance capture and release of circulating tumor cells显示文摘Circulating tumor cells(CTCs),as important liquid biopsy target,can provide valuable information for cancer progress monitoring and individualized treatment.However,current isolation platforms incapable of balancing capture efficiency,specificity,cell viability,and gentle release have restricted the clinical applications of CTCs.Herein,inspired by the structure and functional merits of natural membrane interfaces,we established an antibody-engineered red blood cell(RBC-Ab)affinity interface on microfluidic chip for high-performance isolation and release of CTCs.The lateral fluidity,pliability,and anti-adhesion property of the RBC microfluidic interface enabled efficient CTCs capture(96.5%),high CTCs viability(96.1%),and high CTCs purity(average 4.2-log depletion of leukocytes).More importantly,selective lysis of RBCs by simply changing the salt concentration was utilized to destroy the affinity interface for efficient and gentle release of CTCs without nucleic acid contamination.Using this chip,CTCs were successfully detected in colon cancer samples with 90%sensitivity and 100%specificity(20 patients and 10 healthy individuals).After the release process,KRAS gene mutations of CTCs were identified from all the 5 cancer samples,which was consistent with the results of tissue biopsy.We expect this RBC interface strategy will inspire further biomimetic interface construction for rare cell analysis. | Haicong Shen Rui Su Jiao Peng Lin Zhu Kunyue Deng Qi Niu Yanling Song Liu Yang Lingling Wu Zhi Zhu Chaoyong Yang | 2022 | Bioactive Materials2022，7，5： | 1 |
| 11 | Near-infrared chemiluminescent carbon nanogels for oncology imaging and therapy显示文摘Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-infrared chemiluminescence(CL)emission and distinctive photodynamic capacity,the H2O2-driven chemiluminescent CNGs are further designed by assembling the polymeric conjugate and CL donors,enabling an in vitro and in vivo ROS bioimaging capability in animal inflammation models and a high-performance therapy for xenograft tumors.Mechanistically,ROS generated in inflammatory sites or tumor microenvironment can trigger the chemically initiated electron exchange luminescence in the chemical reaction of peroxalate and H2O2,enabling in vivo CL imaging.Meanwhile,part of the excited-state electrons will transfer to the ambient H2O or dissolved oxygen and in turn lead to the type I and type II photochemical ROS production of hydroxyl radicals or singlet oxygen,endowing the apoptosis of tumor cells and thus enabling cancer therapy.These results open up a new avenue for the design of multifunctional nanomaterials for bioimaging and antienoplastic agents. | Chenglong Shen Tianci Jiang Qing Lou Wenbo Zhao Chaofan Lv Guangsong Zheng Hangrui Liu Pengfei Li Lingling Dai Kaikai Liu Jinhao Zang Feng Wang Lin Dong Songnan Qu Zhe Cheng Chongxin Shan | 2022 | SmartMat2022，3，2： | 1 |
| 12 | Role of JNK Activation and Mitochondrial Bax Translocation in Allicin-Induced Apoptosis in Human Ovarian Cancer SKOV3 Cells显示文摘 | Ling Xu Jin Yu Dongxia Zhai Danying Zhang Wei Shen Lingling Bai Zailong Cai Chaoqin Yu Leo M. Lee | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 1 |
| 13 | Studies on the biosynthesis of arteannuin显示文摘In previous communications we have reported that arteannuic acid(1,Scheme1)is a common precursor of the biosynthesis of both arteannuin(2)and arteannuinB(3)by the leaf homogenate of the plant Qinghao(Artemesia annua L.).It seemsthat most likely the oxidation of allylic tertiary carbon atom,C-6,may occur early inthe biosynthetic path of 2 and 3 from 1.Natural 6-epi-deoxyarteannuin B(4) | Ⅴ.The role of 6-epi-deoxyarteannuin B in arteannuin biosynthesisWANG,Yu SHEN,Zheng-Wu XIA,Zhi-Qiang ZHOU,Feng-Yi Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Lu,Shanghai 200032 | 1993 | Chinese Journal of Chemistry1993，11，5： | 1 |
| 14 | Bilateral inferior petrosal sinus sampling for the treatment of Cushing's disease Data from 52 cases from one institute over an eight-year period显示文摘The present study analyzed data from 108 Cushing's disease patients,who underwent trans-sphenoidal surgery in one hospital between January 2003 and April 2010,to investigate the performance value of bilateral inferior petrosal sinus sampling (BIPSS).Of the 108 patients,52 underwent BIPSS prior to surgery and 56 did not.Results showed that BIPSS accuracy for the diagnosis of Cushing's disease was 86.5% (45/52),and accuracy for adenoma lateralization during surgery was 76.9% (40/52).In addition,early remission rate was significantly greater compared to patients without BIPSS.Results demonstrated that BIPSS facilitated localization and diagnosis of Cushing's disease and helped to predict adenoma lateralization. | Changyan Fan Xiuhua Shi Qingfang Sun Liuguan Bian Weiguo Zhao Jiankang Shen Hua Zhang Tingwei Su Weiqing Wang Xiaoying Li Guang Ning Liang Kong Lingling Hu | 2011 | Neural Regeneration Research2011，6，28： | 1 |
| 15 | Yangtze River Delta Aerosol liquid water in PM_(2.5)and its roles in secondary aerosol formation at a regional site of Yangtze River Delta显示文摘Aerosol liquid water content(ALWC)plays an important role in secondary aerosol formation.In this study,a whole year field campaign was conducted at Shanxi in north Zhejiang Province during 2021.ALWC estimated by ISORROPIA-Ⅱ was then investigated to explore its characteristics and relationship with secondary aerosols.ALWC exhibited a highest value in spring(66.38μg/m^(3)),followed by winter(45.08μg/m^(3)),summer(41.64μg/m^(3)),and autumn(35.01μg/m^(3)),respectively.It was supposed that the secondary inorganic aerosols(SIA)were facilitated under higher ALWC conditions(RH>80%),while the secondary organic species tended to form under lower ALWC levels.Higher RH(>80%)promoted the NO_(3)^(-)formation via gas-particle partitioning,while SO_(4)^(2-)was generated at a relative lower RH(>50%).The ALWC was more sensitive to NO_(3)^(-)(R=0.94)than SO_(4)^(2-)(R=0.90).Thus,the self-amplifying processes between the ALWC and SIA enhanced the particle mass growth.The sensitivity of ALWC and OX(NO_(2)+O_(3))to secondary organic carbon(SOC)varied in different seasons at Shanxi,more sensitive to aqueous-phase reactions(daytime R=0.84;nighttime R=0.54)than photochemical oxidation(daytime R=0.23;nighttime R=0.41)in wintertime with a high level of OX(daytime:130-140μg/m^(3);nighttime:100-140μg/m^(3)).The self-amplifying process of ALWC and SIA and the aqueous-phase formation of SOC will enhance aerosol formation,contributing to air pollution and reduction of visibility. | Ruifang Shi Fei Zhang Yemin Shen Jiasi Shen Bingye Xu Binyu Kuang Zhengning Xu Lingling Jin Qian Tang Xudong Tian Zhibin Wang | 2024 | Journal of Environmental Sciences2024，，4： | 1 |
| 16 | The heterogeneity and dynamic equilibrium of rat embryonic stem cells显示文摘 | Yan Shen Cheng Shi Wei Wei Weidong Yu Wenlin Li Yang Yang Jun Xu Wenqin Ying Xin Sui Lingling Fang Weiwei Lin Huan Yang Sheng Ding Huan Shen Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，7： | 1 |
| 17 | Research capacity and training needs of nurses’in Shanghai,China:A multicenter,cross-sectional survey显示文摘Aims:The aim of this study is to investigate nurses’research capacity and related training needs in Shanghai to provide evidence to further nursing research training.Materials and Methods:A cross-sectional design with a convenience sample of 1226 clinical registered nurses,including the Nursing Research Capacity of Self-Evaluation Questionnaire and Research Training Needs Form,was recruited from 14 public hospitals in Shanghai,China.And the influencing factors of nurses’research capacity were analyzed.Results:The mean score of nurses’research capacity was(46.25±22.90)in Shanghai,that was at a low-to-medium level.The influencing factors of nurses’research capacity including age(F=15.983,P<0.001),education(F=20.738,P<0.001),professional title(F=6.993,P=0.001),working years(F=7.803,P<0.001),department(F=8.545,P<0.001),and position(F=−3.354,P=0.001).The most critical factor is the time to participate a study(P<0.001).And what the nurses demanded were writing skills,special lectures,and participating in colleagues’projects mostly.Conclusion:Nurse’s scientific research capacity still needs to be improved in Shanghai.The key to improving this situation is the individualized scientific research training and education for nurses and the practice of more participation in scientific research projects. | Huajiao XU Ying SHEN Lingling WU Weihong SHEN | 2022 | Journal of Integrative Nursing2022，4，3： | 0 |
| 18 | A reflective display based on the electro-microfluidic assembly of particles within suppressed water-in-oil droplet array显示文摘Reflective displays have stimulated considerable interest because of their friendly readability and low energy consumption.Herein,we develop a reflective display technique via an electro-microfluidic assembly of particles(eMAP)strategy whereby colored particles assemble into annular and planar structures inside a dyed water droplet to create'open'and'closed'states of a display pixel.Water-in-oil droplets are compressed within microwells to form a pixel array.The particles dispersed in droplets are driven by deformation-strengthened dielectrophoretic force to achieve fast and reversible motion and assemble into multiple structures.This eMAP based device can display designed information in three primary colors with≥170°viewing angle,~0.14 s switching time,and bistability with an optimized material system.This proposed technique demonstrates the basis of a high-performance and energy-saving reflective display,and the display speed and color quality could be further improved by structure and material optimization;exhibiting a potential reflective display technology. | Shitao Shen Haoqiang Feng Yueming Deng Shuting Xie Zichuan Yi Mingliang Jin Guofu Zhou Paul Mulvaney Lingling Shui | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 19 | Chromosome 6q deletion mapping in human ovarian tumor: a common deletion region between D6S1649 and D6S311显示文摘Objective: To explore the loss of heterozygosity(LOH) on chromosome 6q in ovarian cancer, and localize a minimum area in deletion region. Methods: 93 ovarian tumors were analyzed for LOH studies with 10 microsatellite markers spanning chromosome 6q. To further localize a minimum area in deletion region. Nineteen microsatellite markers were used to refined a minimum area. Results: Forty three tumors(46%) were demonstrated allelic losses, which spanned less than two megabase areas, franked by a distal marker D6S311 and a proximal marker D6S1649, and likely harbored ovarian tumor suppressor gene(s). With analysis of density of LOH, increased DNA copy number at loci of 6q was demonstrated between D6S1649 and D6S311. Conclusion: It is possible that duplication after the allelic loss might be a main mechanism that leads to carcinogenesis in ovarian tumor. The refinement of these candidate tumor suppressor genes loci might facilitate future loss of heterozygosity studies and enable the isolation of candidate genes from this region. | Yufei Shen Lingling Xu Yongning Zhai Jing Tian Hong Xia Lasko W | 2006 | Journal of Nanjing Medical University2006，20，5： | 0 |
| 20 | Theoretical Study on the Hydrogen Bonding Interactions in Complexes of 5-Hydroxytryptamine with Water显示文摘精力,几何学和泛音 1:1 5-hydroxytryptamine-water (5-HT-H2O ) 的震动的频率建筑群在 MP2/6-311++G 被学习(d, p ) 水平。自然债券轨道(NBO ) ,在分子(QTAIM ) 的原子的量子论分析和局部性的分子的轨道的精力分解分析(LMO-EDA ) 被执行在这些建筑群探索结合氢的相互作用的性质。氢契约(H 契约) 的各种各样的类型在这些 5-HT-H2O 建筑群被形成。分子间的 C4H55-HT ?? 嗷在 HTW3 的 H 契约由于 cooperativity 被加强,而没有如此的 cooperativity 在另外的 5-HT-H2O 建筑群被发现。在氮原子的 H 契约在作为质子施主扮演的 5-HT 氨基比另外的 H 契约强壮。我们研究表演结合的相互作用玩的氢 5-HT-H2O 建筑群的相对稳定性上的一个重要角色。 | Lingfei Guo Zhengguo Huang Tingting Shen Lingling Ma Xiqian Niu | 2013 | Chinese Journal of Chemistry2013，31，8： | 0 |
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