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| 1 | Centro-parietal N200: An event-related potential component specific to Chinese visual word recognition显示文摘Almost all written languages currently used in the world are alphabetic or phonologically-based scripts (e.g., English) whose word recognition involves discrimination of one-dimensional linear combinations of several dozens of letters or phonological units, except written Chinese whose vocabulary consists of a large number of block characters, the analysis of which relies on the extraction of 2-dimensional form information at multiple levels including radical, character, and multiple-character word. Whether the dramatic contrast between the 2 types of orthography leads to distinctive mental processes is a fundamental question in psycholinguistic research unanswered in the past three decades. Using event-related potentials and visual lexical decision tasks, we asked native Chinese speakers to discriminate between real Chinese words and pseudoor non-words and observed a widespread negative deflection with centro-parietal focus elicited 200 ms post-stimulus onset. This N200 response showed a clear and large amplitude enhancement upon word repetition and seems to be specific to Chinese as no similar effects had been reported in word recognition studies involving alphabetic scripts under similar experimental conditions. Further evidence showed that this N200 could not be attributed to non-linguistic sensori-perceptual processes, nor phonological or semantic processes, but likely reflects very early identification of the orthography of individual words involving extensive and higher-level visual analysis. Recently the first author proposed a meaning-spelling theory of written Chinese vocabulary proposing that the Chinese and alphabetic scripts are the only 2 possible logical types of mature human writing systems, and that the former is more thoroughly a visual language compared with the latter and thus shall emphasize more of visual processing. Reinforcing each other, the meaning-spelling theory and the discovery of the centro-parietal N200 reveal the uniqueness of Chinese both theoretically and empirically, and provide strong arguments for the intrinsic distinction between written Chinese and alphabetic scripts. | ZHANG John X FANG Zhuo DU YingChun KONG LingYue ZHANG Qin XING Qiang | 2012 | Chinese Science Bulletin2012，57，13： | 6 |
| 2 | Genetic Analysis and Mapping of the Purple Gene in Purple Heading Chinese Cabbage显示文摘To analyze genetic linkage and map purple gene(Br Pur) controlling purple inner leaves trait of Chinese cabbage, a F2 population was constructed by selfing a F1 plant from homozygous purple heading line ‘14S839' and homozygous orange heading line ‘14S162'. The phenotype investigation of head color showed that the segregation ratio of purple to non-purple individuals was consistent with the expected ratio of 3:1,which indicated that purple inner leaves trait is controlled by a single dominant gene. A total of 297 SSRs in whole genome of Chinese cabbage were tested by modified Bulked Segregant Analysis(BSA) method. Two linked markers flanking Br Pur, A710 and A714, were obtained and Br Pur was mapped on linkage group A07 based on the sequence of these two markers. Subsequently, two new markers flanking Br Pur, CL-12 and B214-87, were developed based on two known anthocyanins-related genes, Br4CL3 and Bra004214. Genetic mapping of all markers in the F2 mapping population showed CL-12 and B214-87 linked to Br Pur with the genetic distance of 3.1 c M and 3.5 c M, respectively. | WU Junqing ZHAO Jing QIN Meiling REN Yanjing ZHANG Huamin DAI Zihui HAO Lingyu ZHANG Lugang | 2016 | Horticultural Plant Journal2016，2，6： | 3 |
| 3 | GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies显示文摘Cancer cells are usually characterized by hyperactive glucose metabolism,which can often lead to glucose scarcity;thus,alternative pathways to rewire cancer metabolism are required.Here,we demonstrated that GLUT3 was highly expressed in colorectal cancer(CRC)and negatively linked to CRC patient outcomes,whereas GLUT1 was not associated with CRC prognosis.Under glucoselimiting conditions,GLUT3 expedited CRC cell growth by accelerating glucose input and fuelling nucleotide synthesis.Notably,GLUT3 had a greater impact on cell growth than GLUT1 under glucose-limiting stress.Mechanistically,low-glucose stress dramatically upregulated GLUT3 via the AMPK/CREB1 pathway.Furthermore,high GLUT3 expression remarkably increased the sensitivity of CRC cells to treatment with vitamin C and vitamin C-containing regimens.Together,the results of this study highlight the importance of the AMPK/CREB1/GLUT3 pathway for CRC cells to withstand glucose-limiting stress and underscore the therapeutic potential of vitamin C in CRC with high GLUT3 expression. | Weixing Dai Ye Xu Shaobo Mo Qingguo Li Jun Yu Renjie Wang Yanlei Ma Yan Ni Wenqiang Xiang Lingyu Han Long Zhang Sanjun Cai Jun Qin Wen-Lian Chen Wei Jia Guoxiang Cai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 4 | Cell-penetrating peptides mediated protein cross-membrane delivery and its use in bacterial vector vaccine显示文摘 | Jimei Ma Jinmei Xu Lingyu Guan Tianjian Hu Qin Liu Jingfan Xiao Yuanxing Zhang | 2014 | Fish and Shellfish Immunology2014，，1： | 1 |
| 5 | AWAITING THE RETURN OF THE GREEN PEACOCK显示文摘The beautiful Heihui River,a tributary of the Lancang River,runs through the lofty mountains of Qinghua Township in Weishan Yi and Hui Autonomous County in Dali Bai Autonomous Prefecture,Yunnan Province.The Qinghua Green Peacock Nature Reserve in Weishan on the banks of the Heihui River is the only provincial nature reserve for green peacocks in China.Twenty to thirty years ago,the place was home to flocks of green peacocks,but none of their feathers have been found since 2006.Since the Administration of Qinghua Green Peacock Nature Reserve(Provinciallevel)of Weishan(hereinafter“the Administration”)was established,efforts towards green peacock protection have intensified,and the natural environment suitable for green peacocks has been restored,making it possible for green peacocks to come back. | Qin Menglin Zhou Lingyu | 2021 | China Report ASEAN2021，6，10： | 0 |
| 6 | Review of Modern Research on Toxicity of Traditional Chinese Medicine Aconm Lateralis Radix Praeparaia显示文摘The traditional Chinese medicine Aconm Lateralis Radix Praeparaia(Fuzi)is pungent and sweet in taste,hot in nature,and has high toxicity.It governs the meridians of the heart,kidney and spleen.It has the functions of restoring yang to save from collapse,dispersing cold and removing dampness,and warming the middle to relieve pain.It is often used for the treatment of yang collapse,cold limbs,weak pulse,heart yang deficiency,heart pain due to chest impediment,abdominal cold-pain,kidney yang deficiency,impotence and cold in womb,and syndrome of exogenous disease due to yang deficiency,etc.Its great yang qi and strong medicinal properties often bring about toxic and adverse effects.However,after processing or combination with other medicinal materials,the effects of Aconm Lateralis Radix Praeparaia are quite different.Not only the toxicity is greatly reduced,but also the curative effects are strengthened.Through searching related literature,this paper reviewed the researches about the toxicity reduction and curative effect improvement of Aconm Lateralis Radix Praeparaia,in order to provide a certain theoretic reference for future further research of Aconm Lateralis Radix Praeparaia. | Lingyu DENG Si LIN Huizhen QIN Hua ZHU | 2021 | Medicinal Plant2021，12，3： | 0 |
| 7 | Research Progress in Toxicity and Toxicity-reducing and Efficacy-enhancing Compatibility of Radix Aconiti Lateralis Praeparata显示文摘Radix Aconiti Lateralis Praeparata contains alkaloids,flavonoids,polysaccharides,organic acids and organic alkalis,among which diester alkaloids are important effective ingredients,which can be used for treating heart failure,rheumatic heart disease,coronary heart disease,hypotension,shock and other diseases.However,it also contains the main ingredients that produce toxic effects and are highly toxic to the cardiovascular system,nervous system,digestive system,reproductive system,embryos,and livers and kidneys.In this study,we analyzed the toxicity-reducing and efficacy-enhancing effects of the compatibility of Radix Aconiti Lateralis Praeparata with with single herbs Glycyrrhiza uralensis Fisch.,Panax ginseng C.A.Meyer,Zingiber ojjicinale Rosc.and Rheum palmatum L.,aiming to provide references for further exploring the appropriate compatibility conditions of traditional Chinese medicine in the future and improving the safety of the clinical application of Radix Aconiti Lateralis Praeparata. | Si LIN Huizhen QIN Lingyu DENG Hua ZHU | 2021 | Agricultural Biotechnology2021，10，3： | 0 |
| 8 | Selective Carbon-Carbon Bond Amination with Redox-Active Aminating Reagents:A Direct Approach to Anilines显示文摘The structure of Montelukast-derivatives(12)in Table 2 and the structure of its product 25 in page s24 are wrong,and they should be Montelukast-derivatives(12)methyl(R,E)-2-(1-(1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)thio)methyl)cyclopropyl)acetate and methyl(R,E)-2-(1-(3-(2-aminophenyl)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)thio)-methyl)cyclopropyl)acetate(25). | Xu Qiu Yachong Wang Lingyu Su Rui Jin Song Song Qixue qin Junhua Li Baoning Zong Ning Jiao | 2023 | Chinese Journal of Chemistry2023，41，18： | 0 |
| 9 | Research Progress of Herb Pair Rhizoma Coptidis-Fructus Evodiae显示文摘The herb pair is the basic form of compatibility and application of traditional Chinese medicine.Herb pairs have the advantages of simple structure,clear compatibility and effective characteristics,and are suitable for scientific research.Rhizoma Coptidis-Fructus Evodiae is a relatively fixed combination of two herbs commonly used in clinical Chinese medicine.Chinese medicine uses it to treat various diseases caused by damp-heat accumulation in the liver and gallbladder,and spleen and stomach.The two medicines in the herb pair are opposite in nature but complement each other,and can achieve a great effect based on simple combination.Modern research shows that the herb pair has a wide range of pharmacological effects and good anti-tumor,analgesic,bacteriostatic and anti-inflammatory activity,and show good curative effects on stress ulcers,functional dyspepsia,chronic colitis,etc.This paper reviewed the research progress on the herb pair of Rhizoma Coptidis-Fructus Evodiae. | Lingyu DENG Huizhen QIN Si LIN Jing LUO Anda WEI Fengfeng XIE Hua ZHU | 2022 | Agricultural Biotechnology2022，11，4： | 0 |
| 10 | Clinical Application of Traditional Chinese Medicine in the Treatment of Ovarian Cancer显示文摘Ovarian cancer is one of the most common gynecological malignancies and can occur at any time in a woman's life.This paper analyzed the etiology and pathogenesis of ovarian cancer in traditional Chinese medicine,and simply sorted out the methods and means of oral administration and external application of traditional Chinese medicine in the treatment of ovarian cancer,hoping to provide new therapeutic ideas for the treatment of the disease. | Jing LUO Si LIN Lingyu DENG Huizhen QIN Hua ZHU | 2022 | Agricultural Biotechnology2022，11，4： | 0 |
| 11 | IGF2BP3 Enhances the Growth of Hepatocellular Carcinoma Tumors by Regulating the Properties of Macrophages and CD8^(+)T Cells in the Tumor Microenvironment显示文摘Background and Aims:Overexpression of IGF2BP3 is associated with the prognosis of hepatocellular carcinoma(HCC).However,its role in regulating tumor immune microenvironment(TME)is not well characterized.Here,we investigated the effects of IGF2BP3 on macrophages and CD8^(+)T cells within the TME of HCC.Methods:The relationship between IGF2BP3 and immune cell infiltration was analyzed using online bioinformatics tools.Knockout of IGF2BP3 in mouse hepatoma cell line Hepa1-6 was established using CRISPR/Cas9 technology.In vitro cell coculture and subcutaneously implanted hepatoma mice model were used to explore the effects of IGF2BP3 on immune cells.Expression of CCL50l transforming growth factor beta 1(TGF-β1)was detected with quantitative real-time polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay.The binding of IGF2BP3 and its target RNA was verified by trimolecular fluorescence complementation system and RNA immunoprecipitation followed by quantitative or semiquantitative polymerase chain reaction.Results:IGF2BP3 expression was elevated in HCC and was positively correlated with macrophage infiltration.Patients with higher IGF2BP3 expression and lower macrophage infiltration had a better survival rate.We found that IGF2BP3 could bind to the mRNA of CCL5 or TGF-β1,increasing their expression,and inducing macrophage infiltration and M2 polarization while inhibiting the activation of CD8^(+)T cells.Furthermore,inhibition of IGF2BP3 combined with anti-CD47 antibody treatment significantly suppressed the growth of hepatoma in Hepa1-6 xenograft tu-mor mice.Conclusions:IGF2BP3 promoted the infiltration and M2-polarization of macrophages and suppressed CD8^(+)T activation by enhancing CCL5 and TGF-β1 expression,which facilitated the progression of Hepa1-6 xenograft tumor. | Lingyu Ma Jiayu Jiang Qin Si Chong Chen Zhaojun Duan | 2023 | Journal of Clinical and Translational Hepatology2023，11，6： | 0 |
| 12 | Selective Carbon-Carbon Bond Amination with Redox-Active Aminating Reagents:A Direct Approach to Anilines显示文摘Amines are among the most fundamental motifs in chemical synthesis,and the introduction of amine building blocks via selective C-C bond cleavage allows the construction of nitrogen compounds from simple hydrocarbons through direct skeleton modification.Herein,we report a novel method for the preparation of anilines from alkylarenes via Schmidt-type rearrangement using redox-active amination reagents,which are easily prepared from hydroxylamine.Primary amines and secondary amines were prepared from corresponding alkylarenes or benzyl alcohols under mild conditions.Good compatibility and valuable applications of the transformation were also displayed. | Xu Qiu Yachong Wang Lingyu Su Rui Jin Song Song Qixue Qin Junhua Li Baoning Zong Ning Jiao | 2021 | Chinese Journal of Chemistry2021，39，11： | 0 |
| 13 | Key-dependent cube attack on reduced Frit permutation in Duplex-AE modes显示文摘Dear editor,Recently,the permutation-based cryptology becomes a good topic in symmetric-key research groups.Many dedicated ciphers are permutation-based,and researchers introduced lots of cryptographic permutations which were suitable for different applications(collision-resistant hashing,preimageresistant hashing,message authentication,message encryption,etc.).Frit(fault-resistant iterative transformation)is a new lightweight 384-bit cryptographic permutation proposed by Simon et al. | Lingyue QIN Xiaoyang DONG Keting JIA Rui ZONG | 2021 | Science China(Information Sciences)2021，64，3： | 0 |
| 14 | Atramacronoids A-C,three eudesmanolide sesquiterpene-phenol hybrids with an unprecedented C-C linkage from the rhizomes of Atractylodes macrocephala显示文摘Three eudesmanolide sesquiterpene-phenol hybrids,atramacronoids A-C(1-3),featuring an unusual6/6/5/5/6 skeleton furnished by forming an unexpected C-8-C-16 linkage,were obtained from the rhizomes of Atractylodes macrocephala.Their structures and absolute configurations were elucidated by spectroscopic data analysis,chemical calculations,combined with X-ray diffractions.The plausible biosynthetic pathways for compounds 1-3 are proposed.Surprisingly,compound 1 exhibited cytotoxicity against SGC-7901 cells by inducing cells apoptosis,which might relate to the promotion of synthesis of neutrophil elastase. | Haixin Zhang Jingrong Li Jinguang Si Chengya Dong Qi Li Meng Yu Lingling Qin Lingyu Li Chenxu Zhao Tao Zhang Zhongmei Zou | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
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