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| 1 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 2 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 3 | Naringenin reduces lung metastasis in a breast cancer resection model显示文摘Metastasis is the main cause of death in cancer patients. To improve the outcomes of patients undergoing a surgery, new adjuvant therapies that can effectively inhibit metastases have to be developed. Studies have shown that flavonoid naringenin, a natural product that is mainly present in grapes and citrus, may contribute to cancer prevention. It has many advantages compared to traditional chemotherapeutic drugs, such as low toxicity. To determine whether naringenin can also inhibit metastases, a breast cancer resection model that mimics clinical situations was established. We found that orally administered naringenin significantly decreased the number of metastatic tumor cells in the lung and extended the life span of tumor resected mice. Flow cytometry analysis revealed that T cells displayed enhanced antitumor activity in naringenin treated mice, with an increased proportion of IFN-γ and IL-2 expressing T cells. In vitro studies further demonstrated that relief of immunosuppression caused by regulatory T cells might be the fundamental mechanism of metastasis inhibition by naringenin. These results indicate that orally administered naringenin can inhibit the outgrowth of metastases after surgery via regulating host immunity. Thus, naringenin can be an ideal surgical adjuvant therapy for breast cancer patients. | Lei Qin Lingtao Jin Linlin Lu Xiaoyan Lu Chunling Zhang Fayun Zhang Wei Liang | 2011 | Protein & Cell2011，2，6： | 12 |
| 4 | Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins显示文摘蛋白质治疗,治疗学的蛋白质在那里被交付对待混乱,为治疗疾病被认为最安全、很直接的途径。然而,它的应用被有效策略的少量高度为在他们的管理以后在 vivo 交付蛋白质和治疗学的蛋白质的快速的清理限制。这里,我们表明能显著地延长治疗学的蛋白质的发行量时间以及最小化他们的 immunogenicity 的新奇策略。这被与抵抗蛋白质吸附的 crosslinked phosphorylcholine 聚合物的薄层包含单个蛋白质分子完成。通过广泛的细胞的研究,我们证明 crosslinked phosphorylcholine 聚合物壳有效地阻止包含的蛋白质是由巨噬细胞的 phagocytosed,它在 vivo 在 nanoparticles 的清理起一个必要作用。而且,聚合物壳阻止包含的蛋白质被有免疫力的房间识别。作为结果,对治疗学的蛋白质的有免疫力的回答有效地被压制。这个工作描述一个可行方法延长循环时间并且减少治疗学的蛋白质的 immunogenicity,它可以在多样的疾病的治疗支持新奇蛋白质治疗的发展和申请。 | Sheng Liang Yang Liu Xin Jin Gan Liu Jing Wen Linlin Zhang Jie Li Xubo Yuan Irvin S.Y. Chen Wei Chen Hui Wang Linqi Shi Xinyuan Zhu Yunfeng Lu | 2016 | Nano Research2016，9，4： | 11 |
| 5 | Research and application of a power-flow-calculation method in multiterminal VSC-HVDC power grid显示文摘For demonstrating a multiterminal voltage-source converter(VSC)-based high-voltage DC(HVDC)(VSCHVDC) project, this study puts forward a technical route for calculating the power flow in a 500-kV VSC-HVDC power grid in comparison with that of an AC power grid. The Jacobian matrix used in the power-flow calculation was deduced through methods such as Newton–Laphson iteration and Taylor series expansion. Further, the operation effect of powerflow calculation on a true bipolar VSC-HVDC power grid was analyzed briefly. The elements of the Jacobian matrix corresponding to VSC were studied under the mode of droop control and the control strategy of VSC-HVDC power grid was analyzed in detail. The power-flow calculation model for VSC-HVDC power grid of the master–slave control mode was simplified using the PQ decomposition method of the power-flow calculation of an AC power grid. Moreover, a four-terminal model of the Zhangbei VSC-HVDC demonstration project was established and tested on MATLAB. The simulation results under two kinds of operating conditions were analyzed and compared to the results of BPA; the deviation between the power-flow results was studied. The results show that the proposed calculation method can provide a feasible support for calculating the power flow in VSC-HVDC grids. | Linlin Wu Xiaowei Fan Man Xu Zhendong Li Xiao Wang Xiaofei Zhang Haiwang Jin | 2019 | Global Energy Interconnection2019，2，1： | 8 |
| 6 | Hydrogen sulfide promotes flowering in heading Chinese cabbage by S-sulfhydration of BraFLCs显示文摘Heading Chinese cabbage(Brassica rapa L.syn.B.campestris L.ssp.chinensis Makino var.pekinensis(Rupr.)J.Cao et Sh.Cao)is a cruciferous Brassica vegetable that has a triplicate genome,owing to an ancient genome duplication event.It is unclear whether the duplicated homologs have conserved or diversi fied functions.Hydrogen sulfide(H_(2)S)is a plant gasotransmitter that plays important physiological roles in growth,development,and responses to environmental stresses.The modification of cysteines through S-sulfhydration is an important mechanism of H_(2)S,which regulates protein functions.H?S promotes flowering in Arabidopsis and heading Chinese cabbage.Here we investigated the molecular mechanisms of H_(2)S used to promote flowering in the latter.Four,five,and four BraFLC,BraSOC I,and BraFT homologs were identi fi ed in heading Chinese cabbage.Different BraFLC proteins were bound to different CArG boxes in the promoter regions of the BraSOC I and BraFT homologs,producing different binding patterns.Thus,there may be functionally diverse BraFLC homologs in heading Chinese cabbage.Exogenous H_(2)S at 100μmol L^(-1) significantly promoted flowering by compensating for insuf fi cient vernalization.BraFLC 1 and BraFLC_(3) underwent S-sulfhydration by H_(2)S,after which their abilities to bind most BraSOC I or BraFT promoter probes weakened or even disappeared.These changes in binding ability were consistent with the expression pattern of the BraFT and BraSOC I homologs in seedlings treated with H_(2)S.These results indicated that H_(2)S signaling regulates flowering time.In summary,H_(2)S signaling promoted plant flowering by weakening or eliminating the binding abilities of BraFLCs to downstream promoters through S-sulfhydration. | Xiaoli Ma Liping Zhang Zhuoya Pei Linlin Zhang Zhiqiang Liu Danmei Liu Xuefeng Hao Zhuping Jin Yanxi Pei | 2021 | Horticulture Research2021，8，1： | 6 |
| 7 | Optimal power allocation for secure directional modulation networks with a full-duplex UAV user显示文摘This paper makes an investigation of a secure unmanned aerial vehicle(UAV)-aided communication network based on directional modulation(DM). In this network, ground base station(GBS) acts as a control center to transmit confidential message and artificial noise(AN). The UAV user, moving along a linear flight trajectory, is intended to receive the useful information from GBS. At the same time, it also sends AN signals to further interference eavesdropper’s channel. Aiming at maximizing secrecy rate during the UAV flight process, a joint optimization problem is formulated with respect to power allocation(PA)factors, beamforming vector and AN projection matrices. For simplicity, maximum rate transmission, nullspace projection and the leakage-based method are applied to form the transmit beamforming vector, AN projection matrix at GBS, and AN projection vector at UAV user, respectively. Following this, the optimization problem reduces to a bivariate optimization programme with two PA factors. An alternating iterative algorithm(AIA) is proposed to optimize the two PA factors. Simulation results demonstrate that, compared to the half-duplex(HD) mode, the proposed strategy for full-duplex(FD) mode achieves a higher secrecy rate(SR) and outperforms the FD mode with fixed PA strategy. | Zaoyu LU Linlin SUN Shuo ZHANG Xiaobo ZHOU Jinyong LIN Wenlong CAI Jin WANG Jinhui LU Feng SHU | 2019 | Science China(Information Sciences)2019，62，8： | 6 |
| 8 | Adenosine A 2A R modulates cardiovascular function by activating ERK1/2 signal in the rostral ventrolateral medulla of acute myocardial ischemic rats显示文摘 | Meiyan Jiang Chengrong Zhang Jin Wang Jun Chen Chunmei Xia Dongshu Du Na Zhao Yinxiang Cao Linlin Shen Danian Zhu | 2011 | Life Sciences2011，，5： | 4 |
| 9 | Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1显示文摘As a leading cause of respiratory disease, influenza A virus(IAV) presents a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapies, there remains to be a requirement for new drugs. Compound Yi-Zhi-Hao pellet(CYZH) is a famous traditional Chinese medicine(TCM) used in the clinic, whose formula has been recorded in Complication of National Standard for Traditional Chinese Medicine to treat common cold. In this study, we found that CYZH exhibited a broad-spectrum anti-influenza activity and inhibited the expression of viral RNA and proteins in vitro. Mechanistically, CYZH had no inhibitory activities against viral protein hemagglutinin and IAV RNA-dependent RNA polymerase. Instead, it induced activation of erythroid 2-related factor 2(Nrf2) and nuclear factor kappa B(NF-κB), which subsequently upregulated heme oxygenase-1(HO-1) expression.Also, CYZH protected cells from oxidative damage induced by reactive oxygen series. In conclusions,CYZH inhibits IAV replication in vitro, at least partly by activating expression of the Nrf2/HO-1 pathway. | Jinqiu Yin Linlin Ma Huiqiang Wang Haiyan Yan Jin Hu Wen Jiang Yuhuan Li | 2017 | Acta Pharmaceutica Sinica B2017，7，6： | 4 |
| 10 | Serum Ferritin Concentration Predicts Mortality in Patients with Hepatitis B Virus-related Acute on Chronic Liver Failure显示文摘 | Linlin Chen Jianpin Wu Yuemei Chen Dingqian Wu Jin Yang | 2014 | Archives of Medical Research2014，，： | 2 |
| 11 | Functional delivery vehicle of organic nanoparticles in inorganic crystals显示文摘Encapsulation of bioactive substances for extended shelf life and controlled,targeted release is critical for their applications in food and drug delivery.Here,a new method has been developed to encapsulate bioactive molecules in the crystal composites,showing greatly enhanced stability and unique pHtriggered response.Chlorophyll,a model bioactive,is first loaded in shellac nanoparticles via coprecipitation with a high encapsulation efficiency,and then the chlorophyll-loaded nanoparticles are incorporated into calcite crystals grown from a gel media containing the nanoparticles.Under the protection of shellac nanoparticles and calcite crystals,chlorophyll shows excellent stability even under light.Encapsulated chlorophyll could only be released by first dissolving the calcite crystals under acidic condition and then dissolving the shellac nanoparticles under alkaline condition.The unique pHtriggered release mimics the pH change from acidic in the stomach to alkaline in the intestine and is thus well suited for controlled,targeted intestinal release.This work suggests that the crystal composites are an ideal delivery vehicle for the functional design of bioactive molecules. | Linlin Kong Xinyi Jin Dapeng Hu Leyun Feng Dong Chen Hanying Li | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 12 | Weakly-Supervised Single-view Dense 3D Point Cloud Reconstruction via Differentiable Renderer显示文摘In recent years,addressing ill-posed problems by leveraging prior knowledge contained in databases on learning techniques has gained much attention.In this paper,we focus on complete three-dimensional(3D)point cloud reconstruction based on a single red-green-blue(RGB)image,a task that cannot be approached using classical reconstruction techniques.For this purpose,we used an encoder-decoder framework to encode the RGB information in latent space,and to predict the 3D structure of the considered object from different viewpoints.The individual predictions are combined to yield a common representation that is used in a module combining camera pose estimation and rendering,thereby achieving differentiability with respect to imaging process and the camera pose,and optimization of the two-dimensional prediction error of novel viewpoints.Thus,our method allows end-to-end training and does not require supervision based on additional ground-truth(GT)mask annotations or ground-truth camera pose annotations.Our evaluation of synthetic and real-world data demonstrates the robustness of our approach to appearance changes and self-occlusions,through outperformance of current state-of-the-art methods in terms of accuracy,density,and model completeness. | Peng Jin Shaoli Liu Jianhua Liu Hao Huang Linlin Yang Michael Weinmann Reinhard Klein | 2021 | Chinese Journal of Mechanical Engineering2021，34，5： | 2 |
| 13 | Integrative analysis for the role of long non-coding RNAs in radiation-induced mouse thymocytes responses显示文摘长非编码的 RNA (lncRNAs ) 是涉及许多生物函数的规章的分子的一个批评的类;然而,他们在对放射的有免疫力的房间反应的角色是未知的。因此,在这研究,我们使用了综合分析响应放射在鼠标 thymocytes 和 lncRNAs 的潜在的函数决定 lncRNAs 的表达式侧面。介绍的 Microarray 数据显示了那 53 lncRNAs (36 起来调整并且 17 下面调整) 并且 74 编码基因(39 起来调整并且 35 下面调整) 高度,差别与控制组相比在高剂量放射(HDR ) 表示了组。在低剂量放射(LDR ) 组织,仅仅一 lncRNA 是下面调整的。而且作为与控制组相比,在 HDR 组的 109 条 lncRNA 小径和在 LDR 的 14 条 lncRNA 小径组织,差别被表示。我们的数据在鼠标 thymocytes 揭示了 lncRNAs 的表达式模式并且预言他们的潜力响应 LDR 和 HDR 工作。在 HDR 组,去分析证明在到 HDR 的 thymocytes 的损坏回答的 lncRNAs 的角色主要包含了染色质组织和房间死亡。这些调查结果可能在导致 LDR 、导致 HDR 的有免疫力的房间改进我们 lncRNAs 的角色的理解并且为进一步的调查提供一个新试验性的基础。 | Hui Gao Zhuo Dong Wei Wei Lihong Shao Linlin Jin Yahui Lv Gang Zhao Shunzi Jin | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 2 |
| 14 | A stable and efficient La-doped MIL-53(Al)/ZnO photocatalyst for sulfamethazine degradation显示文摘Photocatalytic technology can solve various environmental pollution problems,especially antibiotic pollution.A novel La-doped MIL-53(Al)/ZnO composite material was successfully synthesized by a combination of hydrothermal method and calcination,showing high photocatalytic degradation percent of sulfamethazine(SMT).The 2 mol%La MIL-53(Al)/ZnO photocatalyst shows the highest degradation efficiency toward SMT(92%)within 120 min,which is 4.1 times higher than pure ZnO(increased from 18%to 92%).In addition,the degradation analysis of SMT by high performance liquid chromatography proves that the products are CO_(2) and H_(2)O.The improved photocatalytic activity is mostly caused by the following factors.(1)Doping La ions can decrease the band gap of ZnO,enhance light response,and effectively enhance the separation rate of photo-generated holes and electrons.(2)MIL-53(Al)can adsorb SMT and promote the separation of electron.This work shows that the synthesized La-doped MIL-53(Al)/ZnO photocatalyst is expected to be used as a green and effective method for treatment of environment water pollution. | Qiuming Wei Wei Li Chun Jin Yasi Chen Linlin Hou Zhiliang Wu Zhongliang Pan Qinyu He Yinzhen Wang Dingyuan Tang | 2022 | Journal of Rare Earths2022，40，4： | 2 |
| 15 | UBE3A alleviates isoproterenol-induced cardiac hypertrophy through the inhibition of the TLR4/MMP-9 signaling pathway显示文摘Cardiac hypertrophy is considered to be a leading factor in heart function-related deaths.In this study,we explored the potential mechanism underlying cardiac hypertrophy induced by isoproterenol.Our results showed that isoproterenol induced cardiac hypertrophy in AC16 cells,as reflected by the increased cell surface area and increased hypertrophic markers,which was accompanied by increased ubiquitin-protein ligase E3a(UBE3A)expression.Moreover,UBE3A knockdown by siRNAs accelerated cardiac hypertrophy,suggesting that increased UBE3A expres sion induced by isoproterenol might be a protective response and UBE3A might be a protective factor against cardiac hypertrophy.Our study also revealed that UBE3A knockdown increased the protein expression of the TLR4/MMP-9 pathway that has been shown to be associated with cardiac hypertrophy,which suggested that UBE3A-mediated protection is likely to be associated with the blockade of the TLR4/MMP-9 signaling pathway.UBE3A might be thus a potential target gene for the treatment of cardiac hypertrophy. | Yanfei Li Linlin Ma Sijie Gu Jiewen Tian Yilin Cao Zi Jin Jingyi Chen Bingbing Gu Jiayin Tu Zhixiao Wang Xinming Li Zhongping Ning Yueling Jin | 2020 | Acta Biochimica et Biophysica Sinica2020，52，1： | 1 |
| 16 | Electrospun Porous NiCo<sub>2</sub>O<sub>4</sub> Nanotubes as Advanced Electrodes for Electrochemical Capacitors显示文摘 | Linlin Li Shengjie Peng Yanling Cheah Peifen Teh Jin Wang Grace Wee Yahwen Ko Chuiling Wong Madhavi Srinivasan | 2013 | Chem Eur J2013，，19： | 1 |
| 17 | Functional copolymer binder for nickel-rich cathode with exceptional cycling stability at high temperature through coordination interaction显示文摘Nickel-rich layered oxide LiNi_(1-x-y)Co_(x)Al_yO_(2)(NCA) with high theoretical capacity is a promising cathode material for the next-generation high-energy batteries.However,it undergoes a rapid capacity fading when operating at high temperature due to the accelerated cathode/electrolyte interfacial reactions and adhesive efficacy loss of conventional polyvinylideneffuoride(PVdF) binder.Herein,poly(acrylonitrile-co-methyl acrylate) copolymer is designed with electron-rich-C≡N groups as a novel binder for LiNi_(0.8)Co_(0.1)Al_(0.1)O_(2) cathode at high temperature.The electron-rich-C≡N groups are able to coordinate with the active Ni^(3+) on the surface of NCA,alleviating electrolyte decomposition and cathode structure degradation.Moreover,the strong adhesive ability is conducive to maintain integrity of electrodes upon cycling at 55℃.In consequence,the NCA electrodes with this functional binder display improved cycling stability(81.5% capacity retention after 100 cycles) and rate performance at 55℃. | Mihan Jin Bing Li Linlin Hu Peiyu Zhao Qilu Zhang Jiangxuan Song | 2021 | Journal of Energy Chemistry2021，30，9： | 1 |
| 18 | Alteration of gut microbiota in type 2 diabetes complicated with cholelithiasis patients显示文摘To the Editor:Type 2 diabetes(T2D)and cholelithiasis are both common diseases with a high,prevalence.In China,the,prevalence of T2D,is.0.90% and that offadult cholelithiasis is 6.83%. | Jiajia Chen Linlin Yan Xingfan Ma Ping Yuan Fan Zhao Zihan Han Jingshan Liu Wenbo Wang Donghai Zhou Hongyu Zhao Nan Feng Dandan Huang Shoukui Hu Jin Gui | 2022 | Chinese Medical Journal2022，135，17： | 1 |
| 19 | Identification and determination of the major constituents in Traditional Chinese Medicinal formula Danggui-Shaoyao-San by HPLC–DAD–ESI-MS/MS显示文摘 | Linlin Chen Jin Qi Yan-xu Chang Danni Zhu Boyang Yu | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，，2： | 1 |
| 20 | Different Proteomics of Ca^(2+) on SA-induced Resistance to Botrytis cinerea in Tomato显示文摘This study aims to comprehensively study the effects of Ca^(2+) on the SA-induced resistance Botrytis cinerea in tomato through proteomics analysis.A proteomic approach was used to uncover the inducible proteins of tomato in the susceptible tomato cultivars ‘L402' against Botrytis cinerea after salicylic acid(SA) and a combination treatment of CaCl_2 and SA.The results showed that the use of combination treatment of CaCl_2 and SA significantly enhanced tomato resistance against Botrytis cinerea.In total,46 differentially expressed protein spots from 2-DE gel maps were detected,of which 41 were identified by mass spectrometry.All the identified proteins were categorized into eight groups according to their putative functions:defense response(14.00%),antioxidative protein(9.75%),photosynthesis(24.39%),molecular chaperone(4.88%),energy(17.01%),metabolism(21.95%),protein synthesis(4.88%) and signal transduction(0.2%).Of the proteins in the eight function groups,the effect of stress/defense and reactive oxygen species on Ca^(2+) -regulated SA-induced resistance may be the most important one in induced resistance by RT-PCR.The expression level of pathogenesis-related proteins(PRs) and chitinase was upregulated by a combination treatment of CaCl_2 and SA.The characterization of these proteins greatly helped to reveal the induced proteins involved in the regulation of Ca^(2+) on SA-induced resistance to Botrytis cinerea.In the combination treatment of CaCl_2 and SA,the defense response and antioxidative protein were clearly upregulated much more than SA alone or the control treatment by the method of proteomics and RT-PCR.The present findings suggest that susceptible tomato cultivars treated by the combination treatment of CaCl_2 and SA might possess a more sensitive SA signaling system or effective pathway than SA treatment alone.In addition,results indicated that SA could coordinate other cellular activities linked with photosynthesis and metabolism to facilitate defense response and recovery,indicating that the self-defense capability of tomato was improved by the combination treatment of CaCl_2 and SA. | LI Linlin GUO Peng JIN Hua LI Tianlai | 2016 | Horticultural Plant Journal2016，2，3： | 1 |
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