|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Structure and regulatory function of plant transcription factors显示文摘The expression of inducible genes in plants is regulated by specific transcription factors at the transcrip-tional level. A typical transcription factor usually contains a DNA-binding domain, a transcription regulation domain, a dimerization site and a nuclear localization domain. These functional domains define the characteristic, localization and regulatory role of a transcription factor. Transcription factors recognize and bind to specific cis-acting elements or interact with other proteins, and then activate or repress the transcription of target genes by their functional domains. In recent years, elucidation on the structure and function of transcription factors has become an important subject in plant molecular biology. | LIU Qiang, ZHANG Guiyou & CHEN ShouyiDepartment of Biological Science and Biotechnology, Tsinghua Univorsity, Beijing 100084, China Department of Biological Science and Biotechnology, State Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China | 2001 | Chinese Science Bulletin2001，46，4： | 36 |
| 2 | Erosion of the prismatic layer by the organic matrix during the formation of the nacre-prism transition layer in the shell of Pinctada fucata (Bivalvia, Mollusca)显示文摘Three variants of the sequence of formation of the nacre-prism transition layer were observed in Pinctada fucata (Bivalvia, Mollusca) shells. In each case, the layer was formed by the organic matrix secreted by the mantle, together with the interprismatic organic envelope. The continuity of the organic phase throughout the shell was maintained as the new nacreous layer was formed on the nacre-prism transition layer. Changes in the interprismatic organic envelopes on either side of the nacre-prism transition zone indicated that the organic matrix of the nacre-prism transition layer becomes embedded into the organic phase of the prismatic layer. It is concluded that penetration and erosion of the prisms by the organic matrix generates a strong bond between the prismatic and nacreous layers. | LIU XiaoJun LIU Chang SUN Juan ZHOU YuJuan ZHENG GuiLan ZHANG GuiYou WANG HongZhong XIE LiPing ZHANG RongQing | 2011 | Chinese Science Bulletin2011，56，9： | 3 |
| 3 | Protection of 3'-methoxy-puerarin against focal brain ischemia and its association with c-fos expression显示文摘The present study established a rat model of focal brain ischemia by occlusion of the middle cerebral artery covered with FeCl3, and investigated the protective effect of 3'-methoxy-puerarin. Hippocampal and cortical c-fos gene expression was determined using in situ hybridization. Results showed that 3'-methoxy-puerarin reduced neurological deficit scores, cerebral infarcted zone and water content of brain tissues, dramatically increased the activity of catalase and glutathione peroxidase in the ischemia zone of the hippocampus, increased the activity of catalase in the cortex, decreased lipid peroxide and lactic acid contents in the hippocampus and cerebral cortex, and down-regulated c-fos gene expression in brain ischemic rats. Results demonstrated that 3'-methoxy-puerarin exhibited cerebroprotective effects against focal brain ischemia, which involved c-fos gene expression. | Sha Liu Yibing Zhang Guiyou Du Yong Zhao Haifeng Cui Chunyu Cao | 2011 | Neural Regeneration Research2011，6，27： | 2 |
| 4 | Parkinson's Disease Risk Variant rs1109303 Regulates the Expression of INPP5K and CRK in Human Brain显示文摘Dear Editor,Parkinson’s disease (PD) is the second most common neurodegenerative disease in the elderly (1, 2)PD affects1%–2%of the world’s population older than 65 years(3–5)In recent years, large-scale genome-wide association studies (GWAS) have been widely conducted to identify the common genetic risk genes for PD. A number of PD susceptibility genes have been identified, including SNCA,MAPT, NUCKS1, the HLA region, GAK, BST1, GBA,WNT3, RIT2, and LRRK2 [3–5]. | Guiyou Liu Yi Zhao Jing-yi Sun Bao-liang Sun | 2019 | Neuroscience Bulletin2019，35，2： | 1 |
| 5 | Intervention of rosiglitazone on myoeardium Glut4-mRNA expression during ischemia-reperfusion injury in cardiopulmonary bypass in dogs显示文摘 | Bin Liu Guiyou Liang Gang Xu | 2013 | Mol Cell Biochem2013，373，1： | 1 |
| 6 | A possible mechanism for the formation of annual growth lines in bivalve shells显示文摘We report a unique shell margin that differed from the usual shell structure of Pinctada fucata.We observed empty organic envelopes in the prismatic layer and the formation of the nacreous layer in the shell margin.All the characteristics of the growing margin indicated that the shell was growing rapidly.To explain this anomaly,we propose the concept of 'jumping development'.During jumping development,the center of growth in the bivalve shell jumps forward over a short time interval when the position of the mantle changes.Jumping development explains the unusual structure of the anomalous shell and the development of annual growth lines in typical shells.Annual growth lines are the result of a discontinuity in the shell microstructure induced by jumping development. | LIU XiaoJun YAN ZhenGuang ZHENG GuiLan ZHANG GuiYou WANG HongZhong XIE LiPing ZHANG RongQing | 2011 | Science China(Life Sciences)2011，54，2： | 1 |
| 7 | The Study of a Method of Regional Environmental Risk Assessmem 显示文摘 | Xu Linyu Liu Guiyou | 2009 | Journal of Environmental Management2009，90，11： | 1 |
| 8 | The study of a method of regional environmental risk assessment显示文摘 | Linyu Xu Guiyou Liu | 2009 | Journal of Environmental Management2009，，11： | 1 |
| 9 | The study of a method of regional environmental risk assessment显示文摘 | Linyu Xu Guiyou Liu | 2009 | Journal of Environmental Management2009，，11： | 1 |
| 10 | The study of a method of regional environmental risk assessment 显示文摘 | XU Linyu LIU Guiyou | 2009 | J Environ Manage2009，90，1： | 1 |
| 11 | Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)显示文摘The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic burdens.Abnormal metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβantibodies.Nonetheless,the cognitive benefits of the current treatments are limited.The etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive impairment.Hence,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve cognition.To attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD patients.The Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat AD.The aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline. | Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja Malm Xiaobo Mao Joaquim Miguel Oliveira Mike M.Modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou Marietta Zille Colin L.Masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang | 2023 | Neuroprotection2023，1，2： | 0 |
| 12 | MAPK4 facilitates angiogenesis by inhibiting the ERK pathway in non-small cell lung cancer显示文摘Background:Angiogenesis plays an important role in the occurrence and development of non-small cell lung cancer(NSCLC).The atypical mitogen-activated protein kinase 4(MAPK4)has been shown to be involved in the pathogenesis of various diseases.However,the potential role of MAPK4 in the tumor angiogenesis of NSCLC remains unclear.Methods:Adult male C57BL/6 wild-type mice were randomly divided into the control group and p-siMAPK4 intervention group,respectively.The cell proliferation was analyzed with flow cytometry and immunofluorescence staining.The vascular density in tumor mass was analyzed by immuno-fluorescence staining.The expressions of MAPK4 and related signaling molecules were detected by western blot analysis and immunofluorescence staining,and so on.Results:We found that the expression of MAPK4,which was dominantly expressed in local endothelial cells(ECs),was correlated with tumor angiogenesis of NSCLC.Furthermore,MAPK4 silencing inhibited the proliferation and migration abilities of human umbilical vein ECs(HUVECs).QKHZC-2020-4Y156,QKH-JC-2018-1428,QKH-RC-2019-5612;Collaborative Innovation Center of Chinese Ministry of Education,Grant/Award Number:2020-39;Program for Science and Technology Joint Fund Project in Zunyi Science and Technology Bureau and Zunyi Medical University,Grant/Award Numbers:ZSKH-RPT-2020-6,ZSKH-HZ-2021-193;Graduate Research Fund of Zunyi Medical University,Grant/Award Number:2023-ZYK-171 Global gene analysis showed that MAPK4 silencing altered the expression of multiple genes related to cell cycle and angiogenesis pathways,and that MAPK4 silencing increased transduction of the extracellular regulated protein kinases 1/2(ERK1/2)pathway but not Akt and c-Jun n-terminal kinase pathways.Further analysis showed that MAPK4 silencing inhibited the proliferation and migration abilities of HUVECs cultured in tumor cell supernatant,which was accompanied with increased transduction of the ERK1/2 pathway.Clinical data analysis suggested that the higher expression of MAPK4 and CD34 were associated with poor prognosis of patients with NSCLC.Targeted silencing of MAPK4 in ECs using small interfering RNA driven by the CD34 promoter effectively inhibited tumor angiogenesis and growth of NSCLC in vivo.Conclusion:Our results reveal that MAPK4 plays an important role in the angiogenesis and development of NSCLC.MAPK4 may thus represent a new target for NSCLC. | Jing Chen Jing Yang Yufang Liu Xu Zhao Juanjuan Zhao Lin Tang Mengmeng Guo Ya Zhou Chao Chen Dongmei Li Zhenke Wen Guiyou Liang Lin Xu | 2024 | Cancer Innovation2024，3，3： | 0 |
| 13 | Genetic Insights into Glycine’s Protective Role Against CAD—European and East Asia,2015 and 2020显示文摘Introduction:The purpose of this study is to examine the potential causal relationship between levels of circulating glycine and coronary artery disease(CAD)using a two-step Mendelian randomization(MR)analysis.Methods:We analyzed data from genome-wide association studies(GWAS)conducted on European and East Asian populations.To assess the causal effects of circulating glycine levels on the risk of CAD.We used the inverse-variance weighting(IVW),weighted median(WM),MR-Egger,and Mendelian Randomization Pleiotropy RESidual Sum and Outlier(MR-PRESSO)methods.Furthermore,we conducted mediation analysis to investigate the contribution of blood pressure and other cardiovascular disease-related traits.Results:The two-step Mendelian randomization analysis revealed that higher levels of glycine in the blood were associated with a reduced risk of CAD in Europeans[odds ratio(OR)=0.84,95%confidence interval(CI):0.72,−0.98;P=0.029]and East Asians:(OR=0.76,95%CI:0.66,−0.89;P=3.57×10−4).Sensitivity analysis confirmed the robustness of these findings.Additionally,our results suggest that about 6.06%of the observed causal effect is mediated through genetically predicted systolic blood pressure(SBP)in the European population.Discussion:Our results contribute to the current knowledge regarding the involvement of glycine in the progression of CAD,and provide valuable methodological insights for the prevention and treatment of this condition. | Jiaying Yu Zhuolin Zhu Ting Wang Yuanhao Wei Lianjie Huang Qianru Zhang Yuting Zhang Yiran Wang Guiyou Liu Xiang Shu Rennan Feng | 2024 | China CDC weekly2024，6，9： | 0 |
| 14 | Design and construction of size-controlled CoO/CS catalysts for Fischer–Tropsch synthesis显示文摘The use of supported Co-based catalysts is widespread in various catalytic reactions due to their unique structures.The structural sensitivity of these catalysts is closely linked to their particle size and crystal form.Consequently,comprehending the structure–activity relationship requires the development of well-defined Co-based catalysts.Herein,we employed a colloidal wet chemical process and a heterogeneous nucleation method to prepare well-defined Co-based catalysts supported by inert carbon nanospheres.The nanospheres’surface possesses abundant functional groups that efficiently capture metal complexes and facilitate the nucleation and growth of CoO nanoparticles.By adjusting the Co source concentration,solvent molar ratio,and nucleation growth kinetics,we successfully prepared CoO/carbon sphere(CS)catalysts with different particle sizes and crystal forms.The influence of metallic face-centered cubic(fcc)-Co^(0) particle size in the range of 6.6–17.6 nm on the performance of Fischer–Tropsch synthesis(FTS)using well-defined CoO/CS catalysts has been investigated.The result demonstrated that the turnover frequency(TOF)remained constant for CoO/CS catalysts with metallic fcc-Co^(0) particle size larger than 7.7 nm.However,both the selectivity and the activity changed for CoO/CS catalysts with smaller particles(<7.7 nm).Significantly,when metallic fcc-Co^(0) particle size was reduced from 17.6 to 7.7 nm,the cobalt time yield increased to 6.7μmolCO·gCo^(-1)·s^(-1),indicating improved catalytic activity.At the same time,the CH_(4) selectivity decreased to 4.9%,suggesting a higher preference for hydrocarbon production.These findings demonstrate the importance of particle size in Co catalyzed Fischer–Tropsch synthesis.The use of well-defined CoO/CS catalysts offers valuable insights into the structure–activity relationship,leading to a better understanding of Co catalyzed Fischer–Tropsch synthesis. | Wei Sun Ting Kuang Guiyou Wei Yue Li Yaqin Liu Shuai Lyu Yuhua Zhang Jinlin Li Li Wang | 2024 | Nano Research2024，17，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员