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| 1 | rMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated Tool for Genome-wide Association Study显示文摘Along with the develoipment of high-throughput sequencing technologies,both sample size and SNP number are increasing rapidly in genome-wide association studies(GWAS),and the associated computation is more challenging than ever.Here,we present a memory-efficient,visualization-enhanced,and parallel-accelerated R package called“r MVP”to address the need for improved GWAS computation.r MVP can 1)effectively process large GWAS data,2)rapidly evaluate population structure,3)efficiently estimate variance components by Efficient Mixed-Model Association e Xpedited(EMMAX),Factored Spectrally Transformed Linear Mixed Models(Fa ST-LMM),and Haseman-Elston(HE)regression algorithms,4)implement parallel-accelerated association tests of markers using general linear model(GLM),mixed linear model(MLM),and fixed and random model circulating probability unification(Farm CPU)methods,5)compute fast with a globally efficient design in the GWAS processes,and 6)generate various visualizations of GWASrelated information.Accelerated by block matrix multiplication strategy and multiple threads,the association test methods embedded in r MVP are significantly faster than PLINK,GEMMA,and Farm CPU_pkg.r MVP is freely available at http://gffzz188fe103f8f1460asofwv6kcqccw06wuk.ffgz.tsg.suse.edu.cn/xiaolei-lab/r MVP. | Lilin Yin Haohao Zhang Zhenshuang Tang Jingya Xu Dong Yin Zhiwu Zhang Xiaohui Yuan Mengjin Zhu Shuhong Zhao Xinyun Li Xiaolei Liu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 12 |
| 2 | A Ka-band Solid-state Transmitter Cloud Radar and Data Merging Algorithm for Its Measurements显示文摘This study concerns a Ka-band solid-state transmitter cloud radar, made in China, which can operate in three different work modes, with different pulse widths, and coherent and incoherent integration numbers, to meet the requirements for cloud remote sensing over the Tibetan Plateau. Specifically, the design of the three operational modes of the radar(i.e., boundary mode M1, cirrus mode M2, and precipitation mode M3) is introduced. Also, a cloud radar data merging algorithm for the three modes is proposed. Using one month's continuous measurements during summertime at Naqu on the Tibetan Plateau,we analyzed the consistency between the cloud radar measurements of the three modes. The number of occurrences of radar detections of hydrometeors and the percentage contributions of the different modes' data to the merged data were estimated.The performance of the merging algorithm was evaluated. The results indicated that the minimum detectable reflectivity for each mode was consistent with theoretical results. Merged data provided measurements with a minimum reflectivity of -35 dBZ at the height of 5 km, and obtained information above the height of 0.2 km. Measurements of radial velocity by the three operational modes agreed very well, and systematic errors in measurements of reflectivity were less than 2 dB. However,large discrepancies existed in the measurements of the linear depolarization ratio taken from the different operational modes.The percentage of radar detections of hydrometeors in mid- and high-level clouds increased by 60% through application of pulse compression techniques. In conclusion, the merged data are appropriate for cloud and precipitation studies over the Tibetan Plateau. | Liping LIU Jiafeng ZHENG Jingya WU | 2017 | Advances in Atmospheric Sciences2017，34，4： | 7 |
| 3 | Recent Advances in Space-Deployable Structures in China显示文摘Deployable space structure technology is an approach used in building spacecraft,especially when realizing deployment and folding functions.Once in orbit,the structures are released from the fairing,deployed,and positioned.With the development of communication,remote-sensing,and navigation satellites,space-deployable structures have become cutting-edge research topics in space science and technology.This paper summarizes the current research status and development trend of spacedeployable structures in China,including large space mesh antennas,space solar arrays,and deployable structures and mechanisms for deep-space exploration.Critical technologies of space-deployable structures are addressed from the perspectives of deployable mechanisms,cable-membrane form-finding,dynamic analysis,reliable environmental adaptability analysis,and validation.Finally,future technology developments and trends are elucidated in the fields of mesh antennas,solar arrays,deployable mechanisms,and on-orbit adjustment,assembly,and construction. | Xiaofei Ma Tuanjie Li Jingya Ma Zhiyi Wang Chuang Shi Shikun Zheng Qifeng Cui Xiao Li Fan Liu Hongwei Guo Liwu Liu Zuowei Wang Yang Li | 2022 | Engineering2022，，10： | 6 |
| 4 | Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94显示文摘A bicyclic depsipeptide, chromopeptide A(1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K_α radiation(λ ? 0.71073 ?) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC_(50) values of 7.7, 7.0, and 16.5 nmol/L, respectively. | Zhenfang Zhou Xin Wang Hui Zhang Jingya Sun Linghui Zheng Hongchun Liu Jidong Wang Aijun Shen Meiyu Geng Yuewei Guo | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 6 |
| 5 | The five major autoimmune diseases increase the risk of cancer:epidemiological data froma large-scale cohort study in China显示文摘Background:Cancer incidence and mortality have received critical attention during the long-term management of morbidities in patients with autoimmune diseases(AIDs).This study aimed to investigate and compare the risk of cancer associated with five major AIDs in a large-scale Chinese cohort.Methods:A total of 8,120 AID patients consecutively admitted to a national tertiary referral center in China were included and followed-up for 38,726.55 patient-years,including those with systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),Sjoren’s syndrome(SS),systemic scleroderma(SSc),and idiopathic inflammatory myositis(IIM).Demographic data,cancer incidence,predilecting sites and cancer onset time were recorded and compared among the five AIDs.Results:Four hundred and thirty(5.3%)patients developed cancer.Their median agewas 57.5 years and AID durationwas 79.8 months.The estimated total standardized incidence ratio(SIR)of cancer in AIDs patients was 3.37,with the highest SIR observed in IIM(4.31),followed by RA(3.99),SSc(3.77),SS(2.88)and SLE(2.58).The increased SIR of cancers in AID patients showed a female predominance(female vs.male:3.59 vs.2.77)and younger patient involvement(age<50 vs.≥50 years:4.88 vs.3.04).Patientswith SLE had increased SIRs for developing hematologic malignancies and solid tumors located in the urinary bladder,corpus uteri and cervix uteri.Patients with SS had a significantly high SIR for developing non-Hodgkin’s lymphoma.Within 3 years of IIM diagnosis,74.6%of the patients developed cancer and they had a high risk of ovarian cancer.RA was associated with a wide distribution of scancers,including non-Hodgkin’s lymphoma,gynecologic,urinary tract,thyroid gland and lung cancers.SSc patients had increased SIRs for developing cervical uterine,lung,and breast cancers.Conclusion:Patients with five major AIDs in China had an increased risk of developing cancer,with a predominance in women and younger patients,although cancer incidence,predilection sites and cancer onset time may vary greatly in each AID entity. | Ziyue Zhou Huazhen Liu Yiying Yang Jingya Zhou Lidan Zhao Hua Chen Yunyun Fei Wen Zhang Mengtao Li Yan Zhao Xiaofeng Zeng Fengchun Zhang Huaxia Yang Xuan Zhang | 2022 | Cancer Communications2022，42，5： | 4 |
| 6 | Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function显示文摘The AMP-activated protein kinase(AMPK)is a central regulator of energy homeostasis.Although much has been learned on how low energy status and glucose starvation activate AMPK,how AMPK activity is properly controlled in vivo is still poorly understood.Here we report that UHRF1,an epigenetic regulator highly expressed in proliferating and cancer cells,interacts with AMPK and serves to suppress AMPK activity under both basal and stressed conditions.As a nuclear protein,UHRF1 promotes AMPK nuclear retention and strongly suppresses nuclear AMPK activity toward substrates H2B and EZH2.Importantly,we demonstrate that UHRF1 also robustly inhibits AMPK activity in the cytoplasm compartment,most likely as a consequence of AMPK nucleocytoplasmic shuttling.Mechanistically,we found that UHRF1 has no obvious effect on AMPK activation by upstream kinases LKB1 and CAMKK2 but inhibits AMPK activity by acting as a bridging factor targeting phosphatase PP2A to dephosphorylate AMPK.Hepatic overexpression of UHRF1 showed profound effects on glucose and lipid metabolism in wild-type mice but not in those with the liver-specific knockout of AMPKα1/α2,whereas knockdown of UHRF1 in adipose tissue led to AMPK activation and reduced sizes of adipocytes and lipogenic activity,highlighting the physiological significance of this regulation in glucose and lipid metabolism.Thus,our study identifies UHRF1 as a novel AMPK gate-keeper with critical roles in cellular metabolism. | Xiang Xu Guangjin Ding Caizhi Liu Yuhan Ding Xiaoxin Chen Xiaoli Huang Chen-Song Zhang Shanxin Lu Yunpeng Zhang Yuanyong Huang Zhaosu Chen Wei Wei Lujian Liao Shu-Hai Lin Jingya Li Wei Liu Jiwen Li Sheng-Cai Lin Xinran Ma Jiemin Wong | 2022 | Cell Research2022，32，1： | 3 |
| 7 | Enrichment factors of movable hydrocarbons in lacustrine shale oil and exploration potential of shale oil in Gulong Sag,Songliao Basin,NE China显示文摘The geological characteristics and production practices of the major middle-and high-maturity shale oil exploration areas in China are analyzed.Combined with laboratory results,it is clear that three essential conditions,i.e.economic initial production,commercial cumulative oil production of single well,and large-scale recoverable reserves confirmed by the testing production,determine whether the continental shale oil can be put into large-scale commercial development.The quantity and quality of movable hydrocarbons are confirmed to be crucial to economic development of shale oil,and focuses in evaluation of shale oil enrichment area/interval.The evaluation indexes of movable hydrocarbon enrichment include:(1)the material basis for forming retained hydrocarbon,including TOC>2%(preferentially 3%-4%),and typeⅠ-Ⅱkerogens;(2)the mobility of retained hydrocarbon,which is closely related to the hydrocarbon composition and flow behaviors of light/heavy components,and can be evaluated from the perspectives of thermal maturity(Ro),gas-oil ratio(GOR),crude oil density,quality of hydrocarbon components,preservation conditions;and(3)the reservoir characteristics associated with the engineering reconstruction,including the main pore throat distribution zone,reservoir physical properties(including fractures),lamellation feature and diagenetic stage,etc.Accordingly,13 evaluation indexes in three categories and their reference values are established.The evaluation indicates that the light shale oil zones in the Gulong Sag of Songliao Basin have the most favorable enrichment conditions of movable hydrocarbons,followed by light oil and black oil zones,containing 20.8×10^(8) t light oil resources in reservoirs with R_(0)>1.2%,pressure coefficient greater than 1.4,effective porosity greater than 6%,crude oil density less than 0.82 g/cm^(3),and GOR>100 m/m^(3).The shale oil in the Gulong Sag can be explored and developed separately by the categories(resource sweet spot,engineering sweet spot,and tight oil sweet spot)depending on shale oil flowability.The Gulong Sag is the most promising area to achieve large-scale breakthrough and production of continental shale oil in China. | ZHAO Wenzhi BIAN Congsheng LI Yongxin ZHANG Jinyou HE Kun LIU Wei ZHANG Bin LEI Zhengdong LIU Chang ZHANG Jingya GUAN Ming LIU Shijul | 2023 | Petroleum Exploration and Development2023，50，3： | 2 |
| 8 | Interest rate liberalization and pass-through of monetary policy rate to bank lending rates in China显示文摘We examine whether the effectiveness of the monetary policy rate transmission differs before and after interest rate liberalization in China using the autoregressive distributed lag (ARDL) bound test and an error correction model (ECM). The results show that after liberalization the mark-up is lower, and both the Iong-run and shortrun interest rate pass-through has become faster and more complete. We attribute our findings to the ongoing reforms of China's banking system, which has improved the competitiveness of Chinese commercial banks. | Jingya Li Ming-Hua Liu | 2019 | Frontiers of Business Research in China2019，13，2： | 2 |
| 9 | Glacier variations and their response to climate change in an arid inland river basin of Northwest China显示文摘Glaciers are a critical freshwater resource of river recharge in arid areas around the world.In recent decades,glaciers have shown evidence of retreat due to climate change,and the accelerated ablation of glaciers and associated impacts on water resources have received widespread attention.Glacier variations result from climate change,so they can serve as an indicator of climate change.Considering the climatic differences in different elevation ranges,it is worthwhile to explore whether different responses exist between glacier area and air temperature in each elevation zone.In this study,we selected a typical arid inland river basin(Sugan Lake Basin)in the western Qilian Mountains of Northwest China to analyze the glacier variations and their response to climate change.The glacier area data from 1989 to 2016 were delineated using Landsat Thematic Mapper(TM),Enhanced TM+(ETM+)and Operational Land Imager(OLI)images.We compared the relationships between glacier area and air temperature at seven meteorological stations in the glacier-covered areas and in the Sugan Lake Basin,and further analyzed the relationship between glacier area and mean air temperature of the glacier surfaces in July–August in the elevation range of 4700–5500 m a.s.l.by the linear regression method and correlation analysis.In addition,based on the linear regression relationship established between glacier area and air temperature in each elevation zone,we predicted glacier areas under future climate scenarios during the periods of 2046–2065 and 2081–2100.The results indicate that the glaciers experienced a remarkable shrinkage from 1989 to 2016 with a shrinkage rate of–1.61 km^2/a(–0.5%/a),and the rising temperature is the decisive factor dominating glacial retreat;there is a significant negative linear correlation between glacier area and mean air temperature of the glacier surfaces in July–August in each elevation zone from 1989 to 2016.The variations in glaciers are far less sensitive to changes in precipitation than to changes in air temperature.Due to the influence of climate and topographic conditions,the distribution of glacier area and the rate of glacier ablation first increased and then decreased in different elevation zones.The trend in glacier shrinkage will continue because air temperature will continue to increase in the future,and the result of glacier retreat in each elevation zone will be slightly slower than that in the entire study area.Quantitative glacier research can more accurately reflect the response of glacier variations to climate change,and the regression relationship can be used to predict the areas of glaciers under future climate scenarios.These conclusions can offer effective references for assessing glacier variations and their response to climate change in arid inland river basins in Northwest China as well as other similar regions in the world. | ZHOU Zuhao HAN Ning LIU Jiajia YAN Ziqi XU Chongyu CAI Jingya SHANGYizi ZHU Jiasong | 2020 | Journal of Arid Land2020，12，3： | 2 |
| 10 | Enhanced catalysis of ultrasmall Au-MoS_2 clusters against reactive oxygen species for radiation protection显示文摘Ionizing radiation produces excessive reactive oxygen species(ROS) which impose detrimental effects on biological systems. Thus, it is important to explore clinically safe and efficacious radioprotection agents to scavenge ROS and reduce the risks of radiotherapy. Recently, emerging catalytic nanomaterials such as sulfide nanomaterials have shown capability of clearing ROS in vivo by unique electron transfers between atoms, but their catalytic activities are yet suboptimal. As such, there is an unmet need to improve catalytic properties for stronger antioxidant activities and radiation protection. Herein, we prepared ultrasmall Au-MoS_2 clusters(~2.5 nm) and they showed enhanced catalytic properties via gold intercalation facilitating increased active sites and synergistic effects. Electrocatalysis results revealed that the catalytic activity of Au-MoS_2 towards H2O_2 was superior to ultrasmall MoS_2 without Au. As a result, we found that improving the electrocatalytic property of Au-MoS_2 can effectively enhance corresponding antioxidant activities and radioprotection effects in vivo. In addition, Au-MoS_2 also showed significant radioprotection in vitro and dramatically reduced the excess of radiation-induced adverse ROS. It also rescued radiation-induced DNA damages and protected the bone marrow hematopoietic system from ionizing radiation. | Peixian Bian Jinxuan Zhang Junying Wang Jiang Yang Jingya Wang Haile Liu Yuanming Sun Meixian Li Xiao-Dong Zhang | 2018 | Science Bulletin2018，63，14： | 2 |
| 11 | A Review of Co-processing of Kitchen Waste and Municipal Residual Sludge显示文摘In this paper,the methods of kitchen waste disposal in recent years were summed up,and the advantages and disadvantages of the current treatment methods were analyzed. At the same time,it has been found that the co-processing of kitchen waste and residual sludge not only has dealt with both kitchen waste and residual sludge,but also the carbon and nitrogen ratio and moisture content of the mixture are balanced,and increases the processing efficiency significantly. It has a certain processing advantage. At present,most research is about the anaerobic digestion of kitchen waste and residual sludge,and the process is more mature,but the study of VFAs accumulation is still insufficient. Aerobic composting is still in the early stage of development,and there are few studies on it at home and abroad. Meanwhile,prospects for the kitchen waste recycling were made in this article. | Han Houfeng Zhuang Pingfang Liu Mei Rong Zhenying Weng Yisong Chen Qingguo Sun Jingya | 2018 | Meteorological and Environmental Research2018，9，4： | 2 |
| 12 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 13 | Molten salt as ultrastrong polar solvent enables the most straightforward pyrolysis towards highly efficient and stable single-atom electrocatalyst显示文摘Currently,pyrolysis as the most widely used method still has some key issues not well resolved for synthesis of carbon-supported single-atom catalysts(C-SACs),e.g.,the sintering of metal atoms at high temperature as well as the high cost and complicated preparations of precursors.In this report,molten salts are demonstrated to be marvellous medium for preparation of C-SACs by pyrolysis of small molecular precursors(ionic liquid).The ultrastrong polarity on one hand establishes robust interaction with precursor and enables better carbonization,resulting in largely enhanced yield.On the other hand,the aggregation of metal atoms is effectively refrained while no nanoparticle or cluster is formed.By this strategy,a C-SAC with atomically dispersed Fe-N_(4) sites and a high specific area over 2000 m^(2) g^(-1) is obtained,which illustrates high ORR activity in both acid and alkaline media.Moreover,this SAC exhibits superior methanol tolerance and stability after acid soaking at 85℃ for 48 h.It is believed that the molten-salts-assisted pyrolysis can be developed into a routine strategy as it not only can largely simply the synthesis of C-SACs,but also can be extended to prepare other types of SACs. | Nannan Li Wei Liu Chao Zhu Ce Hao Jingya Guo Hongyu Jing Jinwen Hu Cuncun Xin Danyang Wu Yantao Shi | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 14 | Generation and investigation of a new cycloid drive with double contact 显示文摘 | CHEN Bingkui ZHONG Hui LIU Jingya | 2012 | Mechanism and Machine Theory2012，49，4： | 1 |
| 15 | Analysis of Formation and Mechanisms of Black and Smelly River Water in Island Cities显示文摘The causes of formation of black and smelly river water were summarized,including the entry of organic pollutants into rivers,such as domestic waste,three industrial wastes,thermal pollution caused by industrial hot drainage,pollution of the river bottom and resuspension movement,and so on. The existing modes and valence changes of iron,sulfur and other elements in black and smelly water were discussed. It is clear that the formation of the black and stink is mainly caused by blackening factors and stink-causing factors. It is concluded that the main blackening factors are ferrous sulfide,manganese sulphide,and the main stink-causing factors are hydrogen sulfide,ammonia or sulfides( VOSCs),josamidine and 2-dimethyl isobenol based on sulfur elements. It provides theoretical reference for the control of black and smelly river water in island cities. | Wang Peng Weng Yisong Zhuang Pingfang Liu Mei Sun Jingya Zhang Fusheng | 2018 | Meteorological and Environmental Research2018，9，6： | 1 |
| 16 | BrΦnsted acid-promoted ‘on-water’ C(sp^3)-H functionalization fot the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction显示文摘The isoindolinone and biaryl scaffolds are prevalent in natural products and drug molecules,which have showed broad and interesting biological activities.The efficient construction of such hybridized molecules and biological evaluation are of great interest to medicinal chemistry community.In this communication,we report an efficient BrΦnsted acid-promoted C(sp^3)-H functionalization approach that enables the rapid construction of biologically important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine,2-formylbenzoic acid and various anilines.The title compounds were generated in high to excellent yields(up to 96%)regardless of the electronic nature and steric effects of the substituents.In this reaction,an isoindolinone scaffold,one C-C single bond,and two C-N bonds were formed simultaneously with high atom economy.In this work,we have envisioned that the methyl group linked to the electron-deficient Nheterocycles could be used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chemistry.Besides,the title compounds have exhibited promising activity against the SKP2-CKS1 interaction. | Shuo Yuan Sixi Wang Min Zhao Danqing Zhang Jinjie Chen Jian-Xin Li Jingya Zhang Yihui Song Jinyi Wang Bin Yu Hongmin Liu | 2020 | Chinese Chemical Letters2020，31，2： | 1 |
| 17 | Torsional stiffness calculation of double-enveloping cy- cloid drive显示文摘 | Liu Jingya Matsumura Shigeki Chen Bingkui | 2012 | Journal of Advanced Mechanical Design2012，6，1： | 1 |
| 18 | Effects of Phosphorus Concentration on the Treatment of Domestic Wastewater by a Combination of Hydrolytic Acidification and Biological Aerated Filter Filled with Mussel Shells显示文摘The combination of hydrolytic acidification and biological aerated filter( BAF) filled with mussel shells was used to treat domestic wastewater,and the removal rates of chemical oxygen demand( COD),ammonia nitrogen( NH_3-N) and total phosphorus( TP) by the system were analyzed under different TP concentrations. When TP concentration ranged from 12. 39 to 14. 69 mg / L,the removal rate of COD was the best,over 90. 92%; as TP concentration varied from 2. 26 to 2. 61 mg / L,the removal rates of NH_3-N and TP were the best,up to 100. 00% and76. 38% respectively. The results show that it is feasible to use mussel shells as the media of BAF,and TP concentration has certain influence on the performance of the system dealing with domestic wastewater. | Sun Huiling Liu Mei Chen Qingguo Rong Zhenying Jiang Yu Sun Jingya | 2016 | Meteorological and Environmental Research2016，7，1： | 1 |
| 19 | Torsional Stiffness ealeulation of double-enveloping eyeloid drive 显示文摘 | LIU Jingya MATSUMURA Shigeki CHEN Bingkui | 2012 | Journal of Advanced Mechanical De- sign2012，6，1： | 1 |
| 20 | Whole genome variants across 57 pig breeds enable comprehensive identification of genetic signatures that underlie breed features显示文摘Background:A large number of pig breeds are distributed around the world,their features and characteristics vary among breeds,and they are valuable resources.Understanding the underlying genetic mechanisms that explain across-breed variation can help breeders develop improved pig breeds.Results:In this study,we performed GWAS using a standard mixed linear model with three types of genome variants(SNP,InDel,and CNV)that were identified from public,whole-genome,sequencing data sets.We used 469 pigs of 57 breeds,and we identified and analyzed approximately 19 million SNPs,1.8 million InDels,and 18,016 CNVs.We defined six biological phenotypes by the characteristics of breed features to identify the associated genome variants and candidate genes,which included coat color,ear shape,gradient zone,body weight,body length,and body height.A total of 37 candidate genes was identified,which included 27 that were reported previously(e.g.,PLAG1 for body weight),but the other 10 were newly detected candidate genes(e.g.,ADAMTS9 for coat color).Conclusion:Our study indicated that using GWAS across a modest number of breeds with high density genome variants provided efficient mapping of complex traits. | Jingya Xu Yuhua Fu Yan Hu Lilin Yin Zhenshuang Tang Dong Yin Mengjin Zhu Mei Yu Xinyun Li Yang Zhou Shuhong Zhao Xiaolei Liu | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 1 |
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