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| 1 | Performance of RegCM4 over Major River Basins in China显示文摘A long-term simulation for the period 1990–2010 is conducted with the latest version of the International Centre for Theoretical Physics' Regional Climate Model(RegCM4), driven by ERA-Interim boundary conditions at a grid spacing of 25 km. The Community Land Model(CLM) is used to describe land surface processes, with updates in the surface parameters,including the land cover and surface emissivity. The simulation is compared against observations to evaluate the model performance in reproducing the present day climatology and interannual variability over the 10 main river basins in China,with focus on surface air temperature and precipitation. Temperature and precipitation from the ERA-Interim reanalysis are also considered in the model assessment. Results show that the model reproduces the present day climatology over China and its main river basins, with better performances in June–July–August compared to December–January–February(DJF).In DJF, we find a warm bias at high latitudes, underestimated precipitation in the south, and overestimated precipitation in the north. The model in general captures the observed interannual variability, with greater skill for temperature. We also find an underestimation of heavy precipitation events in eastern China, and an underestimation of consecutive dry days in northern China and the Tibetan Plateau. Similar biases for both mean climatology and extremes are found in the ERA-Interim reanalysis, indicating the difficulties for climate models in simulating extreme monsoon climate events over East Asia. | Xuejie GAO Ying SHI Zhenyu HAN Meili WANG Jia WU Dongfeng ZHANG Ying XU Filippo GIORGI | 2017 | Advances in Atmospheric Sciences2017，34，4： | 33 |
| 2 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 3 | Potential role of maternal serum microRNAs as a biomarker for fetal congenital heart defects显示文摘 | Zhangbin Yu Shuping Han Ping Hu Chun Zhu Xuejie Wang Lingmei Qian Xirong Guo | 2010 | Medical Hypotheses2010，，3： | 1 |
| 4 | Strata behavior in extra-thick coal seam mining with upward slicing backfilling technology显示文摘Based on the character of upward slicing backfilling mining and the condition of Gonggeyingzi coal mine in Inner Mongolia,this paper describes the studies of the strata behavior and the stress distribution in the process of backfilling mining in extra-thick coal seams.This was achieved by setting up and analyzing the elastic foundation beam model using the ABAQUS software.The results show that:(1) With the gradual mining of different slices,the roof appears to bend continuously but does not break.The vertical stress in the roof decreases and the decreasing amplitude reduces,while the tensile stress in the roof grows with the mining slices and the maximum tensile stress will not exceed the allowable tensile stress.(2) The front vertical stress at the working face exceeds the rear vertical stress and both show a trend of decrease with decreasing amplitude of decrease.(3) The slices mined early have more influence on the surrounding rock than the later ones.Similarly,the strata behavior experiences the same trend.The field measured data show that the roof does not break during the mining process,which is consistent with the conclusion. | Deng Xuejie Zhang Jixiong Kang Tao Han Xiaole | 2016 | International Journal of Mining Science and Technology2016，26，4： | 1 |
| 5 | Assessing the sensitivity of RegCM4 to cumulus and ocean surface schemes over the Southeast Asia domain of the coordinated regional climate downscaling experiment显示文摘东南亚地区开展的区域气候模式模拟较少。为评估并确认RegCM4最新版本(4.7)在这一地区的模式配置,本文进行了三组水平分辨率为25km的多年模拟试验,分别为使用Emanuel和使用Tiedtke (Tiedtke-1)对流参数化方案,以及引入了海表面蒸发效应的Tiedtke (Tiedtke-2)方案,模拟范围为CORDEX-东南亚区域。分析表明,模式对该区域当代DJF和JJA陆地气温的气候态特征具有较好的模拟能力;冷偏差在两个季节均普遍存在,但冬季模拟中部分地区存在暖偏差。对降水而言,各个试验均能够在整体上再现不同季节降水的空间分布,降水量以及季节演变特征,但Tiedtke-1与Tiedtke-2的模拟结果均要明显的好于Emanuel,特别是在海上。这一区域的RegCM4设置由此确认为使用Tiedtke-2及其他模式缺省的物理参数化过程,并将应用于未来的气候变化模拟之中。 | WANG Zhengqi GAO Xuejie HAN Zhenyu WU Jia XU Ying JUNENG Liew | 2020 | Atmospheric and Oceanic Science Letters2020，13，1： | 1 |
| 6 | Molten salt electrolyte based on alkali bis(fluorosulfonyl)imides for lithium batteries显示文摘 | Yali Liu Sisi Zhou Hongbo Han Hong Li Jin Nie Zhibin Zhou Liquan Chen Xuejie Huang | 2013 | Electrochimica Acta2013，，： | 1 |
| 7 | Pathogenesis and preventive measures of environment-related cardiovascular disease in northern China显示文摘Cardiovascular diseases(CVDs)have been the top-ranked cause of human death in the world for years,according to the World Health Organization.Accumulating evidence from epidemiological data supports the view that the risk of CVDs is higher in northern China than in southern area.There is no doubt that living environment has become a crucial factor contributing to the occurrence and progression of CVDs in northern region.However,there have not been any clinical guidelines for the prevention strategy of environment-related CVDs,especially for cold exposure.Thus,there is an urgent need for better understanding of the clinical characteristics and underlying mechanisms of cold-induced CVDs in order to formulate and implement proper and effective measures for minimizing the risk of CVDs for people residing in low-temperature area.Cold exposure,air pollution,lack of sunlight and irrational diet are believed to be crucial factors responsible for environment-related CVDs,and preventive measures might be carried out accordingly to decrease the high risk of CVDs in northern China. | Yukai Cao Xuejie Han Xinbo Zhao Jiuxu Kan Yue Yuan Yue Li | 2022 | Frigid Zone Medicine2022，2，3： | 0 |
| 8 | CRISPR-powered optothermal nanotweezers:Diverse bio-nanoparticle manipulation and single nucleotide identification显示文摘Optothermal nanotweezers have emerged as an innovative optical manipulation technique in the past decade,which revolutionized classical optical manipulation by efficiently capturing a broader range of nanoparticles.However,the optothermal temperature field was merely employed for in-situ manipulation of nanoparticles,its potential for identifying bio-nanoparticles remains largely untapped.Hence,based on the synergistic effect of optothermal manipulation and CRIPSR-based bio-detection,we developed CRISPR-powered optothermal nanotweezers(CRONT).Specifically,by harnessing diffusiophoresis and thermo-osmotic flows near the substrate upon optothermal excitation,we successfully trapped and enriched DNA functionalized gold nanoparticles,CRISPR-associated proteins,as well as DNA strands.Remarkably,we built an optothermal scheme for enhancing CRISPR-based single-nucleotide polymorphism(SNP)detection at single molecule level,while also introducing a novel CRISPR methodology for observing nucleotide cleavage.Therefore,this innovative approach has endowed optical tweezers with DNA identification ability in aqueous solution which was unattainable before.With its high specificity and feasibility for in-situ bio-nanoparticle manipulation and identification,CRONT will become a universal tool in point-of-care diagnosis,biophotonics,and bio-nanotechnology. | Jiajie Chen Zhi Chen Changle Meng Jianxing Zhou Yuhang Peng Xiaoqi Dai Jingfeng Li Yili Zhong Xiaolin Chen Wu Yuan Ho-Pui Ho Bruce Zhi Gao Junle Qu Xueji Zhang Han Zhang Yonghong Shao | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 9 | A common variant in AAK1 reduces risk of noise-induced hearing loss显示文摘Noise-induced hearing loss(NIHL)is one of the most common types of hearing loss and contributes to significant morbidity worldwide,as well as being the major cause of age-related hearing loss and tinnitus.The World Health Organization(WHO)estimates that 10%of the world's population is exposed to sound levels that could potentially cause NIHL[1].It has been widely accepted that NIHL is a multifactorial genetic disorder with estimated heritability of 36%to 40%[2].Ideally,identification of the modifying genetic variants would help protect individuals at high risk of NIHL.For decades,many geneticists have searched for genes that either predispose or protect from NIHL.Howeve r,the majority of genetic studies for NIHL were conducted in independent known candidate genes[3]. | Qixuan Wang Xueling Wang Tao Yang Lu Yang Huihui Liu Yihang Zheng Guixian Jiang Hongchao Liu Chenhui Huang Juan Chen Zhentao Wang Zhaoyan Wang Wei Zhao Jiannan Lin Xuejie Zhang Junbo Shi Kun Han Xingyu Le Yan Ren Yun Li Yingying Hong Wentao Shi Dongqi Cui Minfei Qian Jun Xu Xiaofei Zheng Yunge Gao Chen Li James Lin Zhiwu Huang Hao Wu | 2023 | National Science Review2023，10，7： | 0 |
| 10 | SD-RLK28 positively regulates pollen hydration on stigmas as a PCP-Bβ receptor in Arabidopsis thaliana显示文摘Pollen hydration on dry stigmas is strictly regulated by pollen–stigma interactions in Brassicaceae. Although several related molecular events have been described, the molecular mechanism underlying pollen hydration remains elusive. Multiple B-class pollen coat proteins(PCP-Bs) are involved in pollen hydration. Here, by analyzing the interactions of two PCP-Bs with three Arabidopsis thaliana stigmas strongly expressing S-domain receptor kinase(SD-RLK), we determined that SD-RLK28 directly interacts with PCP-Bβ. We investigated pollen hydration, pollen germination, pollen tube growth, and stigma receptivity in the sd-rlk28 and pcp-bβ mutants. PCP-Bβ acts in the pollen to regulate pollen hydration on stigmas. Loss of SD-RLK28 had no effect on pollen viability, and sd-rlk28 plants had normal life cycles without obvious defects. However,pollen hydration on sd-rlk28 stigmas was impaired and pollen tube growth in sd-rlk28 pistils was delayed. The defect in pollen hydration on sd-rlk28 stigmas was independent of changes in reactive oxygen species levels in stigmas. These results indicate that SD-RLK28 functions in the stigma as a PCP-Bβ receptor to positively regulate pollen hydration on dry stigmas. | Li Guo Ziya Huang Xingyu Chen Min Yang Miaomiao Yang Ziwei Liu Xuejie Han Xiangjie Ma Xiaoli Wang Qiguo Gao | 2023 | Journal of Integrative Plant Biology2023，65，10： | 0 |
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