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| 1 | Paleoclimate Modeling in China: A Review显示文摘This paper provides a review of paleoclimate modeling activities in China. Rather than attempt to cover all topics, we have chosen a few climatic intervals and events judged to be particularly informative to the international community. In historical climate simulations, changes in solar radiation and volcanic activity explain most parts of reconstructions over the last millennium prior to the industrial era, while atmospheric greenhouse gas concentrations play the most important role in the20 th century warming over China. There is a considerable model–data mismatch in the annual and boreal winter temperature change over China during the mid-Holocene [6000 years before present(ka BP)], while coupled models with an interactive ocean generally perform better than atmospheric models. For the Last Glacial Maximum(21 ka BP), climate models successfully reproduce the surface cooling trend over China but fail to reproduce its magnitude, with a better performance for coupled models. At that time, reconstructed vegetation and western Pacific sea surface temperatures could have significantly affected the East Asian climate, and environmental conditions on the Qinghai–Tibetan Plateau were most likely very different to the present day. During the late Marine Isotope Stage 3(30–40 ka BP), orbital forcing and Northern Hemisphere glaciation, as well as vegetation change in China, were likely responsible for East Asian climate change. On the tectonic scale,the Qinghai–Tibetan Plateau uplift, the Tethys Sea retreat, and the South China Sea expansion played important roles in the formation of the East Asian monsoon-dominant environment pattern during the late Cenozoic. | JIANG Dabang YU Ge ZHAO Ping CHEN Xing LIU Jian LIU Xiaodong WANG Shaowu ZHANG Zhongshi YU Yongqiang LI Yuefeng JIN Liya XU Ying JU Lixia ZHOU Tianjun YAN Xiaodong | 2015 | Advances in Atmospheric Sciences2015，32，2： | 12 |
| 2 | Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS显示文摘The activity and stability of the adapter protein MAVS (also known as VISA, Cardif and IPS-1), which critically mediates cellular antiviral responses, are extensively regulated by ubiquitination. However, the process whereby MAVS is deubiquitinated is unclear. Here, we report that the ovarian tumor family deubiquitinase 4 (OTUD4) targets MAVS for deubiquitination. Viral infection leads to the IRF3/7-dependent upregulation of OTUD4 which interacts with MAVS to remove K48-linked polyubiquitin chains, thereby maintaining MAVS stability and promoting innate antiviral signaling. Knockout or knockdown of OTUD4 impairs RNA virus-triggered activation of IRF3 and NF-κB, expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo. Consistently, Cre-ER Otud4fl/fl or Lyz2-Cre Otud4fl/fl mice produce decreased levels of type I interferons and proinflammatory cytokines and exhibit increased sensitivity to VSV infection compared to their control littermates. In addition, reconstitution of MAVS into OTUD4-deficient cells restores virus-induced expression of downstream genes and cellular antiviral responses. Together, our findings uncover an essential role of OTUD4 in virus-triggered signaling and contribute to the understanding of deubiquitination-mediated regulation of innate antiviral responses. | Tianzi Liuyu Keying Yu Liya Ye Zhidong Zhang Man Zhang Yujie Ren Zeng Cai Qiyun Zhu Dandan Lin Bo Zhong | 2019 | Cell Research2019，29，1： | 7 |
| 3 | Ore-controlling effect of structure and distribution of deep rock mass on Pb-Zn deposit in Qingchengzi ore concentration area,Liaoning显示文摘Qingchengzi ore concentration area in Liao-Ji rift is an important lead-zinc ore area of China,and the deep prospecting in this area has great prospects.Based on the spatial occurrence of ore bodies the Pb-Zn deposit can be divided into three types:layered,vein-shaped and pinnate.The deep geological conditions in this area are deduced by analyzing the tectonic evolution process and rock mass gravity inversion.The tectonic evolution of Liao-Ji rift can be divided into three stages:Paleoproterozoic extension period,Mesoproterozoic compression period and Mesozoic reactivation period.The magmatic activities in the Indosinian epoch led to the distribution pattern of the present deposits.According to the gravity inversion,Shuangdinggou-and Xinling rock masses on the north and south sides of the mining area are connected in the deep.The connected rock body might be distributed in the entire mining area.Xinling rock mass may be a branch extending from Shuangdinggou rock mass along the northeast trending fault,the connected rocks provide magmatic hydrothermal fluid for the final,folds and faults result in different types of ore body shapes. | NIU Mingxuan YU Yunliang TIAN Liya NIU Wenqing XU Haibo | 2020 | Global Geology2020，23，2： | 4 |
| 4 | Adenocarcinoma transformed into squamous cell carcinoma in non-small cell lung cancer显示文摘Non-small cell lung cancer(NSCLC)is the most common form of lung cancer which remains the deadliest malignancy worldwide(Siegel et al.,2019).In general,NSCLC can be divided into several subtypes,including adenocarcinoma(ADC),squamous cell carcinoma(SCC),adeno-squamous cell carcinoma(AD-SCC)and large cell carcinoma(LCC). | Yueqiang Jiang Jun Zhang Jin Feng Yaping Lu Yuan Fan Ling Cheng Xin Liao Liya Hu Shiying Yu Tiejun Yin | 2021 | Journal of Genetics and Genomics2021，48，7： | 1 |
| 5 | Genome Analyses of Single Human Oocytes显示文摘 | Yu Hou Wei Fan Liying Yan Rong Li Ying Lian Jin Huang Jinsen Li Liya Xu Fuchou Tang X. Sunney Xie Jie Qiao | 2013 | Cell2013，，7： | 1 |
| 6 | Effects of rare earth compounds on growth and apoptosis of leukemic cell lines显示文摘 | Yucheng Dai Jian Li Jie Li Li Yu Ge Dai Aiguo Hu Liya Yuan Zhu Wen | 2002 | In Vitro Cellular & Developmental Biology - Animal2002，，7： | 1 |
| 7 | Degradation of paracetamol in aqueous solutions by TiO 2 photocatalysis显示文摘 | Liming Yang Liya E. Yu Madhumita B. Ray | 2008 | Water Research2008，，13： | 1 |
| 8 | Genome Analyses of Single Human Oocytes显示文摘 | Yu Hou Wei Fan Liying Yan Rong Li Ying Lian Jin Huang Jinsen Li Liya Xu Fuchou Tang X. Sunney Xie Jie Qiao | 2013 | Cell2013，，7： | 1 |
| 9 | Effects of rare earth compounds on growth and apoptosis of leukemic cell lines显示文摘 | Yucheng Dai Jian Li Jie Li Li Yu Ge Dai Aiguo Hu Liya Yuan Zhu Wen | 2002 | In Vitro Cellular & Developmental Biology - Animal2002，，7： | 1 |
| 10 | Degradatlon of paracetamol in aqueous solutions by TiO2 photocatalysis显示文摘 | YANG Liming YU Liya RAY M | 2008 | Water Research2008，42，13： | 1 |
| 11 | Ultrasonic synthesis and photocatalytic performance of metal-ions doped Ti()2 cata- lysts under solar light irradiation显示文摘 | Feng Huajun Yu Liya E Zhang Minhong | 2013 | Materials Research Bulle- tin2013，48，2： | 1 |
| 12 | Photocatalytic degradation of particulate pollutants and self-cleaning performance of TiO 2 -containing silicate coating and mortar显示文摘 | Padmaja Krishnan Min-Hong Zhang Liya Yu Huajun Feng | 2013 | Construction and Building Materials2013，，： | 1 |
| 13 | Syntheses and crystal structures of rare earth (Nd, Gd) 1-D chain com-plexes with N-p-tolylsulfonyl-β-alanine显示文摘Two rare earth complexes of Ts-β-AlaH with the formula of [Ln2(H2O)4(Ts-β-AlaH)6]n·4nH2O (where Ln = Nd(1), Gd(2); Ts-β-AlaH = N-p-tolylsulfonyl-β-Alanine) have been synthesized and characterized by elemental analysis, IR, and X-ray diffraction. The results show that the two complexes are isostructural. They crystallize in a monoclinic system with P21/n space group. Crystal data for 1: a = 0.95149(19) nm, b = 1.9012(4) nm, c = 2.2863(5) nm, β = 100.37(3)°, Z = 4, Dc = 1.509 mg/cm3, F(000) = 1880, R1 = 0.0560, wR2 = 0.1564 [I > 2σ (I)]; for 2: a = 0.9495(2) nm, b = 1.9037(4) nm, c = 2.2987(5) nm, β = 99.87(3)°, Z = 4, Dc= 1.541 mg/cm3, F(000) = 1916, R1 = 0.0515, wR2 = 0.1566 [I>2σ (I)]. The two complexes are one-dimensional chains and the coordination number of the Nd3+ or Gd 3+ ion is nine. | MA Lufang LI Xiaodong WANG Liya LIANG Fupei ZHANG Manbo YU Kaibei | 2005 | Rare Metals2005，24，4： | 1 |
| 14 | AHNAK2 is a biomarker and a potential therapeutic target of adenocarcinomas显示文摘Adenocarcinoma is the second largest histological type of cervical cancer,second only to cervical squamous cell carcinoma.At present,despite the clinical treatment strategies of cervical adenocarcinoma and cervical squamous cell carcinoma being similar,the outcome and prognosis of cervical adenocarcinoma are significantly poor.Therefore,it is urgent to find specific biomarker and therapeutic target for cervical adenocarcinoma.In this study,we aim to reveal and verify the potential biomarkers and therapeutic targets of cervical adenocarcinoma.Weighted correlation network analysis(WGCNA)reveals the differentially-expressed genes significantly related to the histological characteristics of the two cervical cancer subtypes.We select the genes with the top 20 significance for further investigation.Through microarray and immunohistochemical(IHC)analyses of a variety of tumor tissues,we find that among these 20 genes,AHNAK2 is highly expressed not only in cervical adenocarcinoma,but also in multiple of adenocarcinoma tissues,including esophagus,breast and colon,while not in normal gland tissues.In vitro,AHNAK2 knockdown significantly inhibits cell proliferation and migration of adenocarcinoma cell lines.In vivo,AHNAK2 knockdown significantly inhibits tumor progression and metastasis of various adenocarcinomas.RNA-sequencing and bioinformatics analyses suggest that the inhibitory effect of AHNAK2 knockdown on tumor progression is achieved by regulating DNA replication and upregulating Bim expression.Together,we demonstrate that AHNAK2 is a biomarker and a potential therapeutic target for adenocarcinomas. | Meng Xu Anyi Cheng Liya Yu Wei Wei Jinpeng Li Cheguo Cai | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 0 |
| 15 | The Effects of Intracellular Glutathione Content on the Sensitivity of Methylseleninic Acid to Human High-metastatic Large Cell Lung Cancer Cell Line L9981显示文摘Background and Objective Lung cancer has the fastest increasing rate of morbidity and mortality all over the world and appears to be one of the most dangerous malignant tumors | Chengfei LIU Jun CHEN Liya SUN Yu ZHU Ting WANG Na-galakshmi NADIMINTY Allen C. GAO Qinghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 16 | Three-dimensional geological modelling and direction of hydrothermal alteration of Horne deposit, Blake River Group, Quebec, Canada显示文摘The Horne deposit with rich Cu and Au in Noranda region of Black River Group in Quebec has high economic significance.Current researches on Horne deposit are mostly based on two-dimensional maps and statistical data.It is hard to reflect the spatial structure and characteristics of Horne orebody directly.In this paper,GIS was used to digitize the mining plan-view maps at different depths,stope maps,the boundary of the massive sulfide in drilling trajectories as well as the grade data of Au and Cu of Horne deposit.Meanwhile,the authors established the grade attribute database.Subsequently the three-dimensional(3D)geological model and grade attribute model of Horne orebody were established by Geological Object Computer Aided Design(GOCAD).Positions of two vents and directions of hydrothermal alteration in Horne deposit were inferred based on the property of the major fault,characteristics of hydrothermal alteration,the enrichment morphology and spatial distribution of high-grade Cu in the Cu attribute model. | TIAN Liya YU Yunliang XU Haibo | 2021 | Global Geology2021，24，1： | 0 |
| 17 | Effects of Milling Methods on Rice Flour Properties and Rice Product Quality:A Review显示文摘High-quality rice flour is the foundation for the production of various rice-based products.Milling is an essential step in obtaining rice flour,during which significant changes occur in the physicochemical and quality characteristics of the flour.Although rice flour obtained through mainstream wet milling methods exhibits superior quality,low production efficiency and wastewater discharge limit the development of the industry.Dry milling,on the other hand,conserves water resources,but adversely affects flour performance due to excessive heat generation.As an emerging powder-making technique,semi-dry milling offers a promising solution by enhancing flour quality and reducing environmental impact.This is achieved by minimizing soaking time through hot air treatment while reducing mechanical energy consumption to reach saturated water absorption levels.However,continuous production remains a challenge.This comprehensive review summarizes the effects of various milling technologies on rice flour properties and product qualities.It also discusses key control indicators and technical considerations for rice flour processing equipment and processes. | TIAN Yu SUN Jing LI Jiaxin WANG Aixia NIE Mengzi GONG Xue WANG Lili LIU Liya WANG Fengzhong TONG Litao | 2024 | Rice science2024，31，1： | 0 |
| 18 | Spiro-based triphenylamine molecule with steric structure as a cathode material for high-stable all organic lithium dual-ion batteries显示文摘Redox p-type organic compounds are promising cathode materials for dual-ion batteries.However,the triphenylamine-based polymers usually with agglomerate and intertwined molecular chain nature limit the maximum reaction of their active sites with large-sized anions.Herein,we demonstrate the application of a small molecule with rigid spirofluorene structu re,namely 2,2’,7,7’-tetrakis(diphenylamine)-9,9’-spirobifluorene(Spiro-TAD),as a cathode material for lithium dual-ion batteries.The inherent sterical structure endows the Spiro-TAD with good chemical stability and large internal space for fast diffusion kinetics of anions in the organic electrolyte.As a result,the Spiro-TAD electrode shows significant insolubility and less steric hindrance,and gives a high actual capacity of 109 mA h g^(-1)(active groups utilization ratio approximately 100%) at 50 mA g^(-1)with a high discharge voltage of 3.6 V(vs.Li+/Li),excellent rate capability(60 mA h g^(-1)at 2000 mA g^(-1)) and extremely stable cycling life(98.4% capacity retention after 1400 cycles at 500 mA g^(-1)) in half cells.Such good electrochemical performance is attributed to the robust and rapid adsorption/desorption of ClO4-anions,which can be proved by the in-situ FTIR and XPS.Moreover,an all-organic lithium dual-ion battery(a-OLDIBs) is constructed using the Spiro-TAD as cathode and 3,4,9,10-Perylenetetracarboxylic diimide(PTCDI) as anode and displays long-term cycling performance of 87.5 mA h g^(-1)after 800 cycles.This study will stimulate further developments in designing all organic battery systems. | Liya Huang Zehao Yu Liubin Wang Bin Qin Fengshi Cai Zhihao Yuan Zhiqiang Luo | 2023 | Journal of Energy Chemistry2023，，8： | 0 |
| 19 | The transcription factor HBF1 directly activates expression of multiple flowering time repressors to delay rice flowering显示文摘Flowering time(or heading date)is an important agronomic trait that determines the environmental adaptability and yield of many crops,including rice(Oryza sativa L.).Hd3a BINDING REPRESSOR FACTOR 1(HBF1),a basic leucine zipper transcription factor,delays flowering by decreasing the expression of Early heading date 1(Ehd1),Heading date 3a(Hd3a),and RICE FLOWERING LOCUS T 1(RFT1),but the underlying molecular mechanisms have not been fully elucidated.Here,we employed the hybrid transcriptional factor(HTF)strategy to enhance the transcriptional activity of HBF1 by fusing it to four copies of the activation domain from Herpes simplex virus VP16.We discovered that transgenic rice lines overexpressing HBF1-VP64(HBF1V)show significant delays in time to flower,compared to lines overexpressing HBF1-MYC or wild-type plants,via the Ehd1–Hd3a/RFT1 pathway,under both long-day and short-day conditions.Transcriptome deep sequencing analysis indicated that 19 WRKY family genes are upregulated in the HBF1V overexpression line.We demonstrate that the previously unknown gene,OsWRKY64,is a direct downstream target of HBF1 and represses flowering in rice,whereas three known flowering repressor genes,Days to heading 7(DTH7),CONSTANS 3(OsCO3),and OsWRKY104,are also direct target genes of HBF1 in flowering regulation.Taking these results together,we propose detailed molecular mechanisms by which HBF1 regulates the time to flower in rice. | Cong Li Liya Zhang Xin Wang Chunsheng Yu Tao Zhao Bin Liu Hongyu Li Jun Liu Chunyu Zhang | 2023 | aBIOTECH2023，4，3： | 0 |
| 20 | Effects of Different Water Treatment on Yield and Agronomic Traits of Wheat显示文摘In order to make clear the effects of water on yield and agronomic traits of wheat in Cangzhou,18 wheat cultivars from north part of Huanghuai Plain were collected for spring irrigation. The indoor and field surveys were used to analyze the effects of irrigation frequency on stem tiller situation,leaf area coefficient,yield and other traits of different wheat cultivars. The results indicated that the average yield of irrigation 1 increased by 68. 07 kg compared with that of irrigation 0,while the average yield of irrigation 2 increased by 60. 00 kg compared with that of irrigation 1. The survey of flag leaf area of wheat cultivars at the grain filling stage showed that the leaf area of irrigation 0 was the smallest( 18. 15 cm^2 on average),the leaf area of irrigation 1 was 20. 34 cm^2,and the leaf area of irrigation 2 was 24. 05 cm^2. With the increase in the irrigation times,the volume weight of wheat cultivars declined,the number of infertile spikelet dropped,and the plant height gradually increased. In conclusion,every decrease of one time of irrigation times,there will be loss of yield about 60. 00 kg. | Weiwei WANG Liang YU Liya NIU Wei WANG Li LU Fengzhi WANG Songshan ZHAO | 2018 | Asian Agricultural Research2018，10，3： | 0 |
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