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| 1 | Genetic characterization and linkage disequilibrium mapping of resistance to gray leaf spot in maize(Zea mays L.)显示文摘Gray leaf spot(GLS),caused by Cercospora zeae-maydis,is an important foliar disease of maize(Zea mays L.)worldwide,resistance to which is controlled by multiple quantitative trait loci(QTL).To gain insights into the genetic architecture underlying the resistance to this disease,an association mapping population consisting of 161 inbred lines was evaluated for resistance to GLS in a plant pathology nursery at Shenyang in 2010 and 2011.Subsequently,a genome-wide association study,using 41,101 single-nucleotide polymorphisms(SNPs),identified 51 SNPs significantly(P<0.001)associated with GLS resistance,which could be converted into 31 QTL.In addition,three candidate genes related to plant defense were identified,including nucleotidebinding-site/leucine-rich repeat,receptor-like kinase genes similar to those involved in basal defense.Two genic SNPs,PZE-103142893 and PZE-109119001,associated with GLS resistance in chromosome bins 3.07 and 9.07,can be used for marker-assisted selection(MAS)of GLS resistance.These results provide an important resource for developing molecular markers closely linked with the target trait,enhancing breeding efficiency. | Liyu Shi Xiangling Lv Jianfeng Weng Hanyong Zhu Changlin Liu Zhuanfang Hao Yu Zhou Degui Zhang Mingshun Li Xiaoke Ci Xinhai Li Shihuang Zhang | 2014 | The Crop Journal2014，2，Z1： | 9 |
| 2 | Insight into fouling behavior of poly(vinylidene fluoride)(PVDF)hollow fiber membranes caused by dextran with different pore size distributions显示文摘Membrane fouling is the key problem that occurs in membrane process for water treatment. However, how membrane microstructure influences the fouling behavior is still not clear. In this study, fouling behavior caused by dextran was deeply and systematically investigated by employing four poly(vinylidene fluoride)(PVDF)membranes with different pore sizes, ranging from 24 to 94 nm. The extent of fouling by dextran was accurately characterized by pore reduction, flux decline, and the change of critical flux. The result shows that membrane with the smallest pore size of 24 nm experienced the smallest fouling rate and the lowest fouling extent. As the membrane pore size increased, the critical flux ranges were 105-114, 63-73, 38-44 and 34-43 L·m^(-2)·h^(-1),respectively. The critical flux and fouling resistances indicated that the fouling propensity increases with the increase of membrane pore size. Two pilot membrane modules with mean pore size of 25 nm and 60 nm were applied in membrane filtration of surface water treatment. The results showed that serious irreversible membrane fouling occurred on the membrane with pore size of 60 nm at the permeate flux of40.5 L·m^(-2)·h^(-1).On the other hand, membrane with pore size of 25 nm exhibited much better anti-fouling performance when permeate flux was set to 40.5,48 and 60 L·m^(-2)·h^(-1). | Kailiang Zeng Jie Zhou Zhaoliang Cui Yue Zhou Chuan Shi Xiaozu Wang Liyue Zhou Xiaobin Ding Zhaohui Wang Enrico Drioli | 2018 | Chinese Journal of Chemical Engineering2018，26，2： | 9 |
| 3 | Reworking effects in the Holocene Zhuye Lake sediments:A case study by pollen concentrates AMS ^(14)C dating显示文摘Transported by wind and water,the relatively old sediments can deposit in the terminal lake of an inland drainage basin.The reworking effect can affect the lake sediments 14 C dating and explanations for proxies.The Zhuye Lake is the terminal lake of the Shiyang River Basin.Previous studies indicated that sediments in different locations of the lake basin showed different climatic change patterns.And then,some radiocarbon dates were inverted for some Late Pleistocene sections.Whether this phenomenon is related with the reworking effect? The pollen concentrates 14 C dating can avoid the reservoir effect,which is an ideal method for studying the reworking effect.In this study,we used the pollen concentrates as dating materials and dated five Holocene sections in the Zhuye Lake Basin.Based on the 14 C dates comparison between the pollen concentrates,organic matter,and shells,the pollen concentrates dates are relatively older than other dating materials.Based on the result,the reworking effect worked in the Zhuye Lake Basin during the Holocene;however,in different locations of the lake basin the reworking effects were in different levels.Furthermore,the Holocene lacustrine deposits were formed mostly during the early and middle Holocene.This study provided clues for reworking effect studies of other lakes in arid China. | LIYu WANG NaiAng LI ZhuoLun ZHANG ChengQi ZHOU XueHua | 2012 | Science China Earth Sciences2012，55，10： | 7 |
| 4 | Polarized holographic lithography system for high-uniformity microscale patterning with periodic tunability显示文摘Periodic microscale array structures play an important role in diverse applications involving photonic crystals and diffraction gratings.A polarized holographic lithography system is proposed for patterning high-uniformity microscale two-dimensional crossed-grating structures with periodic tunability.Orthogonal two-axis Lloyd’s mirror interference and polarization modulation produce three sub-beams,enabling the formation of two-dimensional crossed-grating patterns with wavelength-comparable periods by a single exposure.The two-dimensional-pattern period can also be flexibly tuned by adjusting the interferometer spatial positioning.Polarization states of three sub-beams,defining the uniformity of the interference fringes,are modulated at their initial-polarization states based on a strict full polarization tracing model in a three-dimensional space.A polarization modulation model is established considering two conditions of eliminating the unexpected interference and providing the desired identical interference intensities.The proposed system is a promising approach for fabricating high-uniformity two-dimensional crossed gratings with a relatively large grating period range of 500–1500 nm.Moreover,our rapid and stable approach for patterning period-tunable two-dimensional-array microstructures with high uniformity could be applicable to other multibeam interference lithography techniques. | Gaopeng Xue Qihang Zhai Haiou Lu Qian Zhou Kai Ni Liyu Lin Xiaohao Wang Xinghui Li | 2021 | Microsystems & Nanoengineering2021，7，2： | 2 |
| 5 | Direct growth of special-shape graphene on different templates by remote catalyzation of Cu nanoparticles显示文摘A novel method avoiding the complex transfer process is proposed to directly grow low-defect and few-layer graphene on different insulating substrates(SiO_2, Al_2O_3, etc.) by remote catalyzation of Cu nanoparticles(NPs) using ambient pressure chemical vapor deposition(APCVD). The insulating substrates with special structure are used as templates to grow wrapped graphene sheets with special shapes.Hollow graphene species are obtained by removing the substrates. The prime feature of the proposed method is using Cu NPs as catalyst rather than metal foils. The Cu NPs play an important role in the remote catalyzation during the nucleation of graphene. This method can improve the quality and relatively decrease the growth temperature of the graphene on the insulating substrates, which displays the great potential of APCVD direct growth of graphene on dielectric substrates for electronic and photovoltaic applications. | Shuangshuang Han Fan Yang Liyue Liu Mi Zhou Yongkui Shan Dezeng Li | 2017 | Journal of Materials Science & Technology2017，33，8： | 1 |
| 6 | Virtual&augmented reality for biological microscope in experiment education显示文摘Background Mixed-reality technologies,including virtual reality(VR)and augmented reality(AR),are considered to be promising potential tools for science teaching and learning processes that could foster positive emotions,motivate autonomous learning,and improve learning outcomes.Methods In this study,a technology-aided biological microscope learning system based on VR/AR is presented.The structure of the microscope is described in a detailed three-dimensional(3D)model,each component being represented with their topological interrelationships and associations among them being established.The interactive behavior of the model was specified,and a standard operating guide was compiled.The motion control of components was simulated based on collision detection.Combined with immersive VR equipment and AR technology,we developed a virtual microscope subsystem and a mobile virtual microscope guidance system.Results The system consisted of a VR subsystem and an AR subsystem.The focus of the VR subsystem was to simulate operating the microscope and associated interactive behaviors that allowed users to observe and operate the components of the 3D microscope model by means of natural interactions in an immersive scenario.The AR subsystem allowed participants to use a mobile terminal that took a picture of a microscope from a textbook and then displayed the structure and functions of the instrument,as well as the relevant operating guidance.This flexibly allowed students to use the system before or after class without time and space constraints.The system allowed users to switch between the VR and AR subsystems.Conclusions The system is useful for helping learners(especially K-12 students)to recognize a microscope's structure and grasp the required operational skills by simulating operations using an interactive process.In the future,such technology-assisted education would be a successful learning platform in an open learning space. | Xiang ZHOU Liyu TANG Ding LIN Wei HAN | 2020 | Virtual Reality & Intelligent Hardware2020，2，4： | 1 |
| 7 | Vaccination of Goats with 31 kDa and 32 kDa Schistosoma japonicum Antigens by DNA Priming and Protein Boosting显示文摘Two Schistosoma japonicum vaccine candidate antigens Sj 31 and Sj 32, which have shown particular promise to induce protective immunity in mice, were used to immunize goats by using a DNA priming-protein boosting strategy in present work. DNA vaccine formulations of the two antigens (VRSj31 and VRSj32) were produced and injected intramuscularly twice at a 2-week interval and then recombinant proteins (rSj31 and rSj32) together with Freund Complete Adjuvant (FCA) were used to boost the goats. The experiment was repeated in different batche cercariae. A strong anamnestic antibody response was induced after boost. A significant reduction of liver egg counts and miracidial hatching was showed in both experiments. Significant protections against challenge infection were elicited with 31.6% of percentage reduction for worm recovery in the second experiment and 20.9% in the first experiment, respectively. | Lianfei Tang Zhijun Zhou Yuxiao Chen Yonghui Luo Linqian Wang Liyu Chen Fushen Huang Xianfang Zeng Xinyuan Yi | 2007 | Cellular & Molecular Immunology2007，4，2： | 1 |
| 8 | The epidemiology of civilian inpatients’ burns in Chinese military hospitals, 2001–2007显示文摘 | Yuan Yao Yuncheng Liu Jihong Zhou Jun Qiu Liang Zhang Danfeng Yuan Liyu Zhou Zhengguo Wang Jiashun Ren Jianguo Shi | 2011 | Burns2011，，6： | 1 |
| 9 | Theoretical simulation of performances in CIGS thin-film solar cells with cadmiumfree buffer layer显示文摘Copper indium gallium selenium(CIGS) thin film solar cells have become one of the hottest topics in solar energy due to their high photoelectric transformation efficiency.To real applications,CIGS thin film is covered by the buffer layer and absorption layer.Traditionally,cadmium sulfide(CdS) is inserted into the middle of the window layer(ZnO) and absorption layer(CIGS) as a buffer layer.However,the application of the GIGS/CdS thin film solar cells has been limited because of the environmental pollution resulting from the toxic cadmium atom.Although zinc sulfide(ZnS) has been proposed to be one of the candidates,the performance of such battery cells has not been investigated.Here,in this paper,we systematically study the possibility of using zinc sulfide(ZnS) as a buffer layer.By including the effects of thickness,concentration of a buffer layer,intrinsic layer and the absorbing layer,we find that photoelectric transformation efficiency of ZnO/ZnS(n)/CIGS(i)/CIGS(p) solar cell is about 17.22%,which is qualified as a commercial solar cell.Moreover,we also find that the open-circuit voltage is ~0.60 V,the short-circuit current is ~36.99 mA/cm^2 and the filled factor is ~77.44%.Therefore,our results suggest that zinc sulfide may be the potential candidate of CdS as a buffer layer. | Kang Luo Yulin Sun Liyu Zhou Fang Wang Fang Wu | 2017 | Journal of Semiconductors2017，38，8： | 0 |
| 10 | Predicting the pathological status of mammographic microcalcifications through a radiomics approach显示文摘Objective The study aimed to develop a machine learning(ML)-coupled interpretable radiomics signature to predict the pathological status of non-palpable suspicious breast microcalcifications(MCs).Methods We enrolled 463 digital mammographical view images from 260 consecutive patients detected with non-palpable MCs and BI-RADS scored at 4(training cohort,n=428;independent testing cohort,n=35)in the First Affiliated Hospital of Nanjing Medical University between September 2010 and January 2019.Subsequently,837 textures and 9 shape features were subsequently extracted from each view and finally selected by an XGBoostembedded recursive feature elimination technique(RFE),followed by four machine learning-based classifiers to build the radiomics signature.Results Ten radiomic features constituted a malignancy-related signature for breast MCs as logistic regression(LR)and support vector machine(SVM)yielded better positive predictive value(PPV)/sensitivity(SE),0.904(95%CI,0.865–0.949)/0.946(95%CI,0.929–0.977)and 0.891(95%CI,0.822–0.939)/0.939(95%CI,0.907–0.973)respectively,outperforming their negative predictive value(NPV)/specificity(SP)from 10-fold crossvalidation(10FCV)of the training cohort.The optimal prognostic model was obtained by SVM with an area under the curve(AUC)of 0.906(95%CI,0.834–0.969)and accuracy(ACC)0.787(95%CI,0.680–0.855)from 10FCV against AUC 0.810(95%CI,0.760–0.960)and ACC 0.800 from the testing cohort.Conclusion The proposed radiomics signature dependens on a set of ML-based advanced computational algorithms and is expected to identify pathologically cancerous cases from mammographically undecipherable MCs and thus offer prospective clinical diagnostic guidance. | Min Li Liyu Zhu Guangquan Zhou Jianan He Yanni Jiang Yang Chen | 2021 | Intelligent Medicine2021，1，3： | 0 |
| 11 | The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers显示文摘Adenosine-to-inosine(A-to-I)RNA editing,constituting nearly 90%of all RNA editing events in humans,has been reported to contribute to the tumorigenesis in diverse cancers.However,the comprehensive map for functional A-to-I RNA editing events in cancers is still insufficient.To fill this gap,we systematically and intensively analyzed multiple tumorigenic mechanisms of A-to-I RNA editing events in samples across 33 cancer types from The Cancer Genome Atlas.For individual candidate among1,500,000 quantified RNA editing events,we performed diverse types of downstream functional annotations.Finally,we identified 24,236 potentially functional A-to-I RNA editing events,including the cases in APOL1,IGFBP3,GRIA2,BLCAP,and miR-589-3p.These events might play crucial roles in the scenarios of tumorigenesis,due to their tumor-related editing frequencies or probable effects on altered expression profiles,protein functions,splicing patterns,and microRNA regulations of tumor genes.Our functional A-to-I RNA editing events(http://gffzz53f2f6c9ddf14a6bsvoknuuxvoxxb6055.ffgz.tsg.suse.edu.cn/CAeditome/)will help better understand the cancer pathology from the A-to-I RNA editing aspect. | Sijia Wu Zhiwei Fan Pora Kim Liyu Huang Xiaobo Zhou | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 12 | From tuberculosis bedside to bench:UBE2B splicing as a potential biomarker and its regulatory mechanism显示文摘Alternative splicing(AS)is an important approach for pathogens and hosts to remodel transcriptome.However,tuberculosis(TB)-related AS has not been sufficiently explored.Here we presented the first landscape of TB-related AS by long-read sequencing,and screened four AS events(S100A8-intron1-retention intron,RPS20-exon1-alternaitve promoter,KIF13B-exon4-skipping exon(SE)and UBE2B-exon7-SE)as potential biomarkers in an in-house cohort-1.The validations in an in-house cohort-2(2274 samples)and public datasets(1557 samples)indicated that the latter three AS events are potential promising biomarkers for TB diagnosis,but not for TB progression and prognosis.The excellent performance of classifiers further underscored the diagnostic value of these three biomarkers.Subgroup analyses indicated that UBE2B-exon7-SE splicing was not affected by confounding factors and thus had relatively stable performance.The splicing of UBE2B-exon7-SE can be changed by heat-killed mycobacterium tuberculosis through inhibiting SRSF1 expression.After heat-killed mycobacterium tuberculosis stimulation,231 ubiquitination proteins in macrophages were differentially expressed,and most of them are apoptosis-related proteins.Taken together,we depicted a global TB-associated splicing profile,developed TB-related AS biomarkers,demonstrated an optimal application scope of target biomarkers and preliminarily elucidated mycobacterium tuberculosis-host interaction from the perspective of splicing,offering a novel insight into the pathophysiology of TB. | Mengyuan Lyu Jian Zhou Yanbing Zhou Weelic Chong Wei Xu Hongli Lai Lu Niu Yang Hai Xiaojun Yao Sheng Gong Qinglan Wang Yi Chen Yili Wang Liyu Chen Zengwanggema Jiongjiong Zeng Chengdi Wang Binwu Ying | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
| 13 | Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response显示文摘Epstein-Barr virus(EBV)and human papillomavirus(HPV)infection is the risk factors for nasopharyngeal carcinoma and cervical carcinoma,respectively.However,clinical analyses demonstrate that EBV or HPV is associated with improved response of patients,although underlying mechanism remains unclear.Here,we reported that the oncoproteins of DNA viruses,such as LMP1 of EBV and E7 of HPV,inhibit PERK activity in cancer cells via the interaction of the viral oncoproteins with PERK through a conserved motif.Inhibition of PERK led to increased level of reactive oxygen species(ROS)that promoted tumor and enhanced the efficacy of chemotherapy in vivo.Consistently,disruption of viral oncoprotein-PERK interactions attenuated tumor growth and chemotherapy in both cancer cells and tumor-bearing mouse models.Our findings uncovered a paradoxical effect of DNA tumor virus oncoproteins on tumors and highlighted that targeting PERK might be an attractive strategy for the treatment of NPC and cervical carcinoma. | Jiang He Liyu Liu Feiyu Tang You Zhou Huan Liu Can Lu Deyun Feng Hong Zhu Yitao Mao Zhi Li Lu Zhang Yuemei Duan Zhi Xiao Musheng Zeng Liang Weng Lun-Quan Sun | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 0 |
| 14 | Alternating current stimulation promotes neurite outgrowth and plasticity in neurons through activation of the PI3K/AKT signaling pathway显示文摘As a commonly used physical intervention,electrical stimulation(ES)has been demonstrated to be effective in the treatment of central nervous system disorders.Currently,researchers are studying the effects of electrical stimu-lation on individual neurons and neural networks,which are dependent on factors such as stimulation intensity,duration,location,and neuronal properties.However,the exact mechanism of action of electrical stimulation remains unclear.In some cases,repeated or prolonged electrical stimulation can lead to changes in the morphology or function of the neuron.In this study,immunofluorescence staining and Sholl analysis are used to assess changes in the neurite number and axon length to determine the optimal pattern and stimulation parameters of ES for neurons.Neuronal death and plasticity are detected by TUNEL staining and microelectrode array assays,respec-tively.mRNA sequencing and bioinformatics analysis are applied to predict the key targets of the action of ES on neurons,and the identified targets are validated by western blot analysis and qRT-PCR.The effects of alternating current stimulation(ACS)on neurons are more significant than those of direct current stimulation(DCS),and the optimal parameters are 3μA and 20 min.ACS stimulation significantly increases the number of neurites,the length of axons and the spontaneous electrical activity of neurons,significantly elevates the expression of growth-asso-ciated protein-43(GAP-43)without significant changes in the expression of neurotrophic factors.Furthermore,application of PI3K/AKT-specific inhibitors significantly abolishes the beneficial effects of ACS on neurons,con-firming that the PI3K/AKT pathway is an important potential signaling pathway in the action of ACS. | Hao Zhong Cong Xing Mi Zhou Zeyu Jia Song Liu Shibo Zhu Bo Li Hongjiang Yang Hongpeng Ma Liyue Wang Rusen Zhu Zhigang Qu Guangzhi Ning | 2023 | Acta Biochimica et Biophysica Sinica2023，55，11： | 0 |
| 15 | Examined lymph node numbers influence prognosis in rectal cancer treated with neoadjuvant therapy显示文摘Background:The number of lymph nodes examined(LNe)is often insufficient in patients with rectal cancer(RC)treated with neoadjuvant therapy;however,its prognostic value remains controversial.Thus,we retrospectively explored whether LNe had an influence on staging and prognosis and investigated whether there was a cut-off value for better prognosis in patients with RC treated with neoadjuvant therapy.Methods:Data were collected from seven prospective hospital databases in China from July 2002 to May 2018.Binary logistic regression models were used to predict lymph node metastasis.The cut-off value for LNe was determined using X-tile 3.6.1.Survival outcomes and risk factors were analyzed using the log-rank test and Cox regression model.Results:A total of 482 patients were included,of whom 459 had complete overall survival(OS)information.Using the percentile method,the total number of lymph nodes examined(TLNe)was 14-16(40th-60th percentile),and the proportion of patients with lymph node metastasis reached a maximum of 48.1%.Cox multivariate analysis showed that the odds ratio(OR)remained the highest when TLNe was 14-16(OR=3.379,P=0.003).The 3-year and 5-year OS were 85.4% and 77.8%,respectively.Negative lymph nodes examined(NLNe)of≤6 was an independent risk factor for 3-year and 5-year OS(3-year OS 71.1%vs.85.9%,P=0.004;5-year OS 66.3%vs.74.3%,P=0.035).Subgroup analysis for patients with ypN+showed that higher 3-year and 5-year OS were achieved when the TLNe was>10,78.8%vs.54.0%(P=0.005),and 60.8%vs.36.0%(P=0.012),respectively.Patients with ypN0M0 had a higher 5-year OS when the TLNe was>19(P=0.055).Conclusion:The TLNe and NLNe influenced the staging accuracy and demonstrated prognostic value in patients with RC treated with neoadjuvant therapy. | Liyu Zhu Lin Wang Zhidong Gao Yujian Zeng Kaixiong Tao Quan Wang Xinming Li Huanhu Zhang Zhanlong Shen Jing Zhou Kai Shen Yingjiang Ye Aiwen Wu | 2023 | Cancer Pathogenesis and Therapy2023，1，3： | 0 |
| 16 | The Improvement of the Teaching Method in Intensive Reading Class显示文摘TheImprovementoftheTeachingMethodinIntensiveReadingClassZhuLiyuⅠ.IntroductionIntensivereadingcourseisthemaincourseinEnglishte... | Zhou Liyu | 1996 | 辽东学院学报(社会科学版)1996，1，1： | 0 |
| 17 | Layer-structured Cr/Cr_(x)N coating via electroplating-based nitridation achieving high deuterium resistance as the hydrogen permeation barrier显示文摘Hydrogen isotope permeation through structural materials is a key issue for developing nuclear fusion energy,which will cause fuel loss and radioactive pollution.Developing ceramic coatings with high thermal shock and hydrogen resistance is an effective strategy to solve this issue.In this work,a layer-structured Cr/Cr_(x)N coating was successfully fabricated by a facile electroplatingbased nitridation technique,which is easy,facile,and applicable to coating complex-shaped substrates.The Cr/Cr_(x)N coating,composed of a bottom Fe/Cr interdiffusion zone,a middle Cr layer,and a top Cr_(x)N layer,exhibits high bonding strength,high anti-thermal-shock ability,and high deuterium permeation resistance.Its bonding strength achieves 43.6 MPa.The Cr/Cr_(x)N coating remains intact even after suffering 300 thermal shock cycles under a 600℃–water condition.Through optimizing the nitridation temperature,the Cr/Cr_(x)N coating achieves a deuterium permeation reduction factor(PRF)as high as 3599 at 500℃.Considering its scalable fabrication technique and considerable properties,the developed Cr/Cr_(x)N coating may serve as a novel high-performance hydrogen permeation barrier in various fields. | Liyu ZHENG Heping LI Jun ZHOU Xinluo TIAN Zhongyang ZHENG Long WANG Xinyun WANG Youwei YAN | 2022 | Journal of Advanced Ceramics2022，11，12： | 0 |
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