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| 1 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 7 |
| 2 | CNN-Based Intelligent Safety Surveillance in Green IoT Applications显示文摘Safety surveillance is considered one of the most important factors in many constructing industries for green internet of things(IoT)applications.However,traditional safety monitoring methods require a lot of labor source.In this paper,we propose intelligent safety surveillance(ISS)method using a convolutional neural network(CNN),which is an autosupervised method to detect workers whether or not wearing helmets.First,to train the CNN-based ISS model,the labeled datasets mainly come from two aspects:1)our labeled datasets with the full labeled on both helmet and pedestrian;2)public labeled datasets with the parts labeled either on the helmet or pedestrian.To fully take advantage of all datasets,we redesign CNN structure of network and loss functions based on YOLOv3.Then,we test our proposed ISS method based on the specific detection evaluation metrics.Finally,experimental results are given to show that our proposed ISS method enables the model to fully learn the labeled information from all datasets.When the threshold of intersection over union(IoU)between the predicted box and ground truth is set to 0.5,the average precision of pedestrians and helmets can reach 0.864 and 0.891,respectively. | Wengang Cao Jianing Zhang Changxin Cai Quan Chen Yu Zhao Yimo Lou Wei Jiang Guan Gui | 2021 | China Communications2021，18，1： | 4 |
| 3 | A modified domain reduction method for numerical simulation of wave propagation in localized regions显示文摘A modified domain reduction method(MDRM) that introduces damping terms to the original DRM is presented in this paper. To verify the proposed MDRM and compare the computational accuracy of these two methods, a numerical test is designed. The numerical results of the MDRM and DRM are compared using an extended meshed model. The results show that the MDRM significantly improved the computational accuracy of the DRM. Then, the MDRM is compared with two existing conventional methods, namely Liao's transmitting boundary and viscous-spring boundary with Liu's method. The MDRM shows its great advancement in computational accuracy, stability and range of applications. This paper also discusses the influence of boundary location on computational accuracy. It can be concluded that smaller models tend to have larger errors. By introducing two dimensionless parameters, φ_1 and φ_2, the rational distance between the observation point and the MDRM boundary is suggested. When φ_1 >2 or φ_2>13, the relative PGA error can be limited to 5%. In practice, the appropriate model size can be chosen based on these two parameters to achieve desired computational accuracy. | Luo Chao Lou Menglin Gui Guoqing Wang Hao | 2019 | Earthquake Engineering and Engineering Vibration2019，18，1： | 4 |
| 4 | Patient-specific modeling of facial soft tissue based on radial basis functions transformations of a standard three-dimensional finite element model显示文摘 | LOU Hang-di CHEN Si CHEN Gui XU Tian-min RONG Qi-guo | 2012 | Chinese Medical Journal2012，，22： | 2 |
| 5 | Phenylpropanoid Derivatives Are Essential Components of Sporopollenin in Vascular Plants显示文摘The outer wall of pollen and spores,namely the exine,is composed of sporopollenin,which is highly resistant to chemical reagents and enzymes.In this study,we demonstrated that phenylpropanoid pathway derivatives are essential components of sporopollenin in seed plants.Spectral analyses showed that the autofluorescence of Lilium and Arabidopsis sporopollenin is similar to that of lignin.Thioacidolysis and NMR analyses of pollen from Lilium and Cryptomeria further revealed that the sporopollenin of seed plants contains phenylpropanoid derivatives,including p-hydroxybenzoate(p-BA),p-coumarate(p-CA),ferulate(FA),and lignin guaiacyl(G)units.The phenylpropanoid pathway is expressed in the tapetum in Arabidopsis,consistent with the fact that the sporopollenin precursor originates from the tapetum.Further germination and comet assays showed that this pathway plays an important role in protection of pollen against UV radiation.In the pteridophyte plant species Ophioglossum vulgatum and Lycopodium clavata,phenylpropanoid derivatives including p-BA and p-CA were also detected,but G units were not.Taken together,our results indicate that phenylpropanoid derivatives are essential for sporopollenin synthesis in vascular plants.In addition,sporopollenin autofluorescence spectra of bryophytes,such as Physcomitrella and Haplocladium,exhibit distinct characteristics compared with those of vascular plants,indicating the diversity of sporopollenin among land plants. | Jinp-Shi Xue Baocai Zhang HuaDong Zhan Yong-Lin Lv Xin-Lei Jia TianHua Wang Nai-Ying Yang Yu-Xia Lou Zai-Bao Zhang Wen-Jing Hu Jinshan Gui Jianguo Cao Ping Xu Yihua Zhou Jin-Feng Hu Laigeng Li Zhong-Nan Yang | 2020 | Molecular Plant2020，13，11： | 2 |
| 6 | Uniqueness and nonunique ness of coexistence states in the Lotka-Voherra competi- tion model 显示文摘 | Gui Changfeng Lou Yuan | 1994 | Communications on Pure and Applied Mathematics1994，47，： | 1 |
| 7 | Uniqueness and nonuniqueness of coexistence state in the Lotka-Volterra competition model显示文摘 | Gui C F Lou Y | 1994 | Communications on Pure and Applied Mathematics1994，47，： | 1 |
| 8 | Wavefront reconstruction through a paraxial optical system in color digital holography显示文摘 | Junchang Li Caojin Yuan Qinghe Song Jinbing Gui Yuli Lou | 2013 | Optics Communications2013，，： | 1 |
| 9 | First Report in China on the Identification and Drug Sensitivity of Mycobacterium elephantis Isolated from the Milk of a Cow with Mastitis显示文摘Objective In this study, milk from a cow with mastitis was analyzed to determine the presence of mycobacterial infection. Milk quality and security problems pertaining to the safe consumption of dairy products were also discussed in this study. Methods Milk was preprocessed with 4% Na OH. Then, mycobacteria were isolated from the milk sample on L-J medium. The isolate was identified using multiple loci Polymerase Chain Reaction(PCR) and multi-locus sequence analysis with 16 S r RNA, sod A, hsp65, and ITS genes. The drug sensitivity of the isolate to 27 antibiotics was tested through alamar blue assay. Results Smooth, moist, pale yellow colonies appeared on the L-J medium within a week after inoculation. Based on the results of multiple loci PCR analysis, the isolate was preliminarily identified as non-tuberculous mycobacteria. The 16 S r RNA, Sod A, hsp65, and ITS gene sequences of the isolate exhibited 99%, 99%, 99%, and 100% similarities, respectively, with those of the published reference strains of Mycobacterium elephantis(M. elephantis). The drug sensitivity results showed that the strain is resistant to isoniazid, p-aminosalicylic acid, and trimesulf but is sensitive to ofloxacin, rifampicin, amikacin, capreomycin, moxifloxacin, kanamycin, levofloxacin, cycloserine, ethambutol, streptomycin, tobramycin, rifabutin, ciprofloxacin, linezolid, cefoxitin, clarithromycin, and minocycline. Conclusion To the best of our knowledge, this study is initially to report the isolation of M. elephantis from the milk of a cow with mastitis in China. | JI Ling Yun XU Dong Lei YIN Shu Peng LIU Hai Can LI Gui Lian JIANG Yi WEI Jian Hao ZENG Hao LOU Yong Liang LYU Jian Xin WAN Kang Lin | 2017 | Biomedical and Environmental Sciences2017，30，7： | 1 |
| 10 | Safety and immunogenicity of a modified COVID-19 mRNA vaccine,SYS6006,as a fourth-dose booster following three doses of inactivated vaccines in healthy adults:an open-labeled Phase 1 trial显示文摘The continuous emergence of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants led to a rapid decline in protection efficacy and neutralizing titers even after three doses of COVID-19 vaccines.Here,we report an open-labeled Phase I clinical trial of a modified mRNA vaccine(SYS6006)as a fourth-dose booster in healthy adults.Eighteen eligible participants,who had completed three doses of inactivated COVID-19 vaccines,received a fourth boosting dose of SYS6006-20μg.Eighteen convalescent COVID-19 patients were enrolled for the collection of serum samples as a comparator of immunogenicity.The primary endpoint of this trial was titers of anti-receptor binding domain of spike glycoprotein(RBD)antibodies of the Omicron strain(BA.2 and BA.4/5)in serum;titers of neutralizing antibodies against pseudovirus of the Omicron strain(BA.2 and BA.4/5).The secondary endpoint was the incidence of adverse events within 30 days after the boosting.The exploratory endpoint was the cellular immune responses(interferon gamma,IFN-γ).This trial was registered with the Chinese Clinical Trial Registry website.No serious adverse events were reported within 30 days after vaccination.No Grade 3 fever or serious adverse event was reported in the SYS6006 group.Notably,SYS6006 elicited higher titers and longer increases in anti-RBD antibodies and neutralizing antibodies(>90 days)compared with the convalescent group(P<0.0001)against Omicron strain(BA.2 and BA.4/5).Besides,higher positive spots of T-cell-secreting IFN-γwere observed in the SYS6006 group than those in the convalescent group(P<0.05).These data demonstrated that SYS6006 was well tolerated and highly immunogenic,generating a stronger and more durable immune response against different variants of SARS-CoV-2. | Yuzhou Gui Ye Cao Jiajin He Chunyang Zhao Wei Zheng Ling Qian Jie Cheng Chengyin Yu Chen Yu Kun Lou Gangyi Liu Jingying Jia | 2023 | Life Metabolism2023，2，3： | 1 |
| 11 | A phaseⅡStudy of paclitaxel and nedaplatin as first–line chemotherapy in patients with advanced esophageal cancer显示文摘 | Cao Wei Xu Chun Lou Guying | 2009 | Jpn J Clin Oncol2009，39，9： | 1 |
| 12 | A Phase II Study of paclitaxel and nedaplatin as first-line chemotherapy in patients with advanced esophageal cancer显示文摘 | Weiguo Cao Chun Xu Guying Lou | 2009 | Jpn J Clin Oncol2009，39，9： | 1 |
| 13 | Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity显示文摘The endocrine regulatory roles of the hypothalamic-pituitary-adrenocortical axis on anxiety-like behavior and metabolic status have been found throughout animal taxa.However,the precise effects of the balancing adrenal corticosteroid biosynthesis under the influence of adrenocorticotrophic hormone(ACTH),a pro-opiomelanocortin(POMC)-derived peptide,on animal energy expenditure and somatic growth remain unknown.POMC has also been identified as one of the candidate loci for polycystic ovary syndrome,which features hyperandrogenism and some prevalence of obesity in patients.Here we show that zebrafish lacking functional POMCa exhibit similar phenotypes of stress response and body weight gain but not obesity as observed in mammalian models.In contrast with the impaired anorexigenic signaling cascade of melanocyte-stimulating hormones and leptin,which are responsible for their obesity-prone weight gain observed in various pome mutant mammals,analyses with our pomca mutant series indicate that ACTH is the key regulator for the phenotype with enhanced somatic growth without obesity in pomca-deficient zebrafish.Hypocortisolism associated with hyperandrogenism has been observed in the pomca-deficient zebrafish,with enhanced activation of mammalian target of rapamycin complex 1;reutilization of amino acids and fatty acid^-oxidation are observed in the muscle tissue of the pomca-deficient fish.After reducing hyperandrogenism by crossing our pomca mutant fish with a cy p l 7a 1-deficient background,the phenotype of enhanced somatic growth in pomca-deficient fish was no longer observed.Thus,our work also demonstrated that the role of POMCa in stress response seems to be conserved in vertebrates,whereas its effect on adipostasis is unique to teleosts. | Chuang Shi Yao Lu Gang Zhai Jianfei Huang Guohui Shang Qiyong Lou Dongliang Li Xia Jin Jiangyan He Zhenyu Du Jianfang Gui Zhan Yin | 2020 | Journal of Molecular Cell Biology2020，12，4： | 1 |
| 14 | A miniaturized transit-time ultrasonic flowmeter based on ScAIN piezoelectric micromachined ultrasonic transducers for small-diameter applications显示文摘Transit-time ultrasonic flowmeters(TTUFs)are among the most widely used devices for flow measurements.However,traditional TTUFs are usually based on a bulk piezoelectric transducer,which limits their application in small-diameter channels.In this paper,we developed a miniaturized TTUF based on scandium-doped aluminum nitride(ScAIN)piezoelectric micromachined ultrasonic transducers(PMUTs).The proposed TTUF contains two PMUT-based transceivers and a T-type channel.The PMUTs contain 13×13 square cells with dimensions of 2.8×2.8 mm^(2).To compensate for the acoustic impedance mismatch with liquid,a layer of polyurethane is added to the surface of the PMUTs as a matching layer.The PMUT-based transceivers show good transmitting sensitivity(with 0.94 MPaN surface pressure)and receiving sensitivity(1.79 mV/kPa)at a frequency of 1 MHz in water.Moreover,the dimensions of the Ttype channel are optimized to achieve a measurement sensitivity of 82 ns/(m/s)and a signal-to-noise ratio(SNR)better than 15 dB.Finally,we integrate the fabricated PMUTs into the TDC-GP30 platform.The experimental results show that the developed TTUF provides a wide range of flow measurements from 2 to 300 L/h in a channel of 4 mm diameter,which is smaller than most reported channels.The accuracy and repeatability of the TTUF are within 0.2%and 1%,respectively.The proposed TTUF shows great application potential in industrial applications such as medical and Chemical applications. | Yunfei Gao Minkan Chen Zhipeng Wu Lei Yao Zhihao Tong Songsong Zhang Yuandong Alex Gui Liang Lou | 2023 | Microsystems & Nanoengineering2023，9，2： | 0 |
| 15 | Genomic polymorphisms at the crhr2 locus improve feed conversion efficiency through alleviation of hypothalamus-pituitary-interrenal axis activity in gibel carp(Carassius gibelio)显示文摘Improvement in fish feed conversion efficiency(FCE)is beneficial for sustaining global food fish supplies.Here,we show that a set of polymorphisms at locus of the corticotropin releasing hormone receptor 2(crhr2),which is involved in hypothalamuspituitary-interrenal(HPI)axis signaling,is associated with improved FCE in farmed allogynogenetic gibel carp strain CAS Ⅲ compared with that in the wild gibel carp strain Dongting(DT).This set of polymorphisms downregulates the expression levels of crhr2 mRNA in the brain and pituitary tissues in gibel carp strain CAS Ⅲ compared with those in strain DT.Furthermore,compromised HPI axis signaling is observed in gibel carp strain CAS Ⅲ,such as decreased α-melanocyte stimulating hormone protein levels,plasma cortisol content,and stress responses.Moreover,enhanced activation of protein kinase B/mammalian target of rapamycin complex 1 signaling observed in the muscle tissue of strain CAS Ⅲ in comparison to that in strain DT indicated elevated anabolic metabolism in strain CAS Ⅲ.Thus,these studies demonstrate that the genetic markers associated with compromised HPI axis signaling,such as crhr2,are potentially useful for genetic selection toward improvement in farmed fish growth and FCE,which would reduce fishmeal consumption and thereby indirectly facilitate sustainable fisheries. | Chuang Shi Qiyong Lou Beide Fu Junyan Jin Jianfei Huang Yao Lu Xia Jin Jiangyan He Gang Zhai Shouqi Xie Jingou Tong Jianfang Gui Zhan Yin | 2022 | Science China(Life Sciences)2022，65，1： | 0 |
| 16 | 中国应加快人民币升值显示文摘【美国《远东经济评论》】7月8日许多支持或反对人民币加快升值的常见理由都是错误的。事实上,加快人民币升值确实有利于中国。这不仅可以缓解国际压力,也有利于中国经济本身。在分析人民币加快升值的“真正”理由之前,首先应该讨论关于中国汇率问题的一些常见误解。 | Jerry Lou Kate Zhu Allen Gui | 2007 | 海外经济评论2007，，30： | 0 |
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