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| 1 | Clue to a thorough understanding of terahertz pulse generation by femtosecond laser filamentation显示文摘In this work, it has been demonstrated that in order to fully understand the terahertz(THz) pulse generation process during femtosecond laser filamentation, the interaction between THz wave and air plasma has to be taken into account. This interaction is mainly associated with the spatial confinement of the THz pulse by the plasma column, which could be described by the one-dimensional negative dielectric(1DND) waveguide model. By combining the 1 DND model with the conventional four-wave mixing(4WM) and photocurrent(PC) models,the variation of THz spectral amplitude and width obtained in experiments could be better understood. Finally, a three-step procedure, with 1DND bridging 4WM and PC processes, has been established for the first time to describe the underlying mechanism of THz radiation from plasma sources. | JIAYU ZHAO WEIWEI LIU SHICHANG LI DAN LU YIZHU ZHANG YAN PENG YIMING ZHU SONGLIN ZHUANG | 2018 | Photonics Research2018，6，4： | 9 |
| 2 | Spaceflight and simulated microgravity suppresses macrophage development via altered RAS/ERK/NFκB and metabolic pathways显示文摘Spaceflight-associated immune system weakening ultimately limits the ability of humans to expand their presence beyond the earth's orbit. A mechanistic study of microgravity-regulated immune cell function is necessary to overcome this challenge. Here, we demonstrate that both spaceflight (real) and simulated microgravity significantly reduce macrophage differentiation, decrease macrophage quantity and functional polarization, and lead to metabolic reprogramming, as demonstrated by changes in gene expression profiles. Moreover, we identified RAS/ERK/NFκB as a major microgravity-regulated pathway. Exogenous ERK and NFκB activators significantly counteracted the effect of microgravity on macrophage differentiation. In addition, microgravity also affects the p53 pathway, which we verified by RT-qPCR and Western blot. Collectively, our data reveal a new mechanism for the effects of microgravity on macrophage development and provide potential molecular targets for the prevention or treatment of macrophage differentiation deficiency in spaceflight. | Lu Shi Hongling Tian Peng Wang Ling Li Zhaoqi Zhang Jiayu Zhang Yong Zhao | 2021 | Cellular & Molecular Immunology2021，18，6： | 7 |
| 3 | ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer显示文摘The Serine-Glycien-One-Carbon(SGOC)pathway is pivotal in multiple anabolic processes.Expression levels of SGOC genes are deregulated under tumoeigenic condltions,suggesting panicipation of oncogenes in deregulating the SGOC biosynthetic pathway.However,the underlying mechanism remains elusive.Here,we identifed that Interleukin enfiarccer-binding factor 3(ILF3)is overexpressed in primary CRC patient specimens and correlates with poor progroosis.ILF3 is critical in regulating the SGOC pathway by directly regulating the mRNA stability of SGOC genes,thereby increasing SGOC genes expression and facilitating tumor growth.Mehhanktic studies showed that the EGF-MIEK-ERK pathway nnediates ILF3 phosphorylation,which hin ders E3 ligase speckle-type POZ protein(SPOP)-mediated poly-ubiquitination and degradation of ILF3.Sign iftca ntly,combination of SGOC inhibitor and the anti-EGFR monoclonal antibody cetuximab can hinder the growth of patient-derived xenografts that sustain high ERK-ILF3 levels.Taken together,deregutation of ILF3 via the EGF-ERK signaling plays an important role in systemic serine metabolic reprogramming and confers a predilection toward CRC development.Our findings indicate that clinical evaluation of SCOC inhibitor is warranted for CRC patients with ILF3 overexpression. | Kai Li Jian-lin Wu Baifu Qin Zongmin Fan Qin Tang Weisi Lu Haipeng Zhang Fan Xing Manqi Meng Shaomin Zou Wenxia Wei Honglei Chen Jian Cai Huaiming Wang Hui Zhang Jiayue Cai Ling Fang Xiqing Bian Chuangqi Chen Ping Lan Bart Ghesquiere Lekun Fang Mong-Hong Lee | 2020 | Cell Research2020，30，2： | 6 |
| 4 | Exploring BH_2CN-based hydrophobic hypergolic fuels and effective fuel“additives”: Imidazolylidene cyanoborane complexes显示文摘Two hydrophobic imidazolylidene-cyanoborane complexes were prepared by the introduction of{BH2 CN} into the molecular formula via treatment of imidazolium iodide and Na BH3 CN avoiding literature's tedious and hazardous procedures. These two complexes were fully characterized using IR spectroscopy,~1 H NMR and^(13)C NMR spectroscopy and high-resolution mass spectrometer. The X-Ray structure of NHC-1 has been determined. NHC-2 was proved to be hypergolic with WFNA and displayed the attractive properties such as water immiscibility, wide liquid range(Tg= -22C), short ignition delay time(13 ms), high density(0.98 g/cm3), good density impulse(r Isp, 347 s g cm^(-3)), showing the promising application potential as a fuel and an efficient fuel additive. | Xingye Li Jiayu Nan Tian Lu Hongyu Huo Yanqiang Zhang Haibo Li Fude Nie Hongquan Yin Fu-Xue Chen | 2018 | Chinese Chemical Letters2018，29，6： | 3 |
| 5 | Optimized Design Method of Sharing Two Grounding Electrodes by Multi UHVDC Converter Stations显示文摘 | GUO Jian LU Jiayu ZHANG Wenliang | 2012 | 高电压技术2012，38，12： | 3 |
| 6 | Impact of Ion Current on Total Electric Field Measurement Under HVDC Transmission Line显示文摘The total electric field(TEF) at ground level induced by high-voltage direct current(HVDC) overhead transmission lines is one of the important indexes for evaluating the lines' electromagnetic environment.Based on analyzing the existing TEF sensors and the measurement principle of ion-current density,the influence from ions on TEF measurements is quantitively studied.The results show that the ions generated by the corona from a HVDC transmission line in operation cause errors in the measurement of TEF.This error is determined through analyzing the component of total measuring current on the filed mill's sensing electrode: if no appropriate approach taken,the maximum measurement error reaches up to 4.3%.Furthermore,a method that can eliminate such error,and hence improve the accuracy of TEF sensors is designed. | CUI Yong YUAN Haiwen LU Jiayu JU Yong LIU Yingyi | 2013 | 高电压技术2013，39，10： | 2 |
| 7 | Electric Field Calculations of Residential Houses near UHVDC Lines Using 3D Reconstruction Method显示文摘Prediction of electric field impact on residential houses is required in the design of UHVDC transmission lines.The calculation of electric field distribution on houses is a 3D problem,however,the effectiveness of some 2D calculation meth-ods has been validated by specific reduced-scale experimental models.The 2D methods are simple in operation and quick in computation compared with the 3D methods.In this paper,the deviation ranges of 2D electric field calculation results on houses are discussed.Then,a 3D electric field reconstruction method is proposed to correct the 2D results according to the size and location of the houses.The 3D electric field distribution on the houses can be obtained based on efficient 2D calculations,and a direct 3D calculation is avoided.Finally,the validity of the calculation methods is verified by the measurement results of a full-scale experimental system. | Donglai Wang Tiebing Lu Xiang Cui Li Xie Luxing Zhao Yong Ju Jiayu Lu | 2019 | CSEE Journal of Power and Energy Systems2019，5，4： | 2 |
| 8 | The role of varied metal protrusions on the conductor surfaces in corona discharge subjected to DC high voltages显示文摘Conductor corona performance is significant in the evaluation of electromagnetic environment for high voltage power transmission lines. The influence of artificial contaminated conductors on corona discharge was studied and turned out to be complicated. The ionized field strength on the corona cage was measured by field mill. Meanwhile, photos of corona plumes were photographed and grayed to quantitate the corona discharge intensity. Subsequently, a calculation model for equivalent electric field strength coefficient was established to evaluate the discharge intensity of conductors in coaxial cylindrical electrode. It could be found the computational results achieved an agreement with the observed experimental phenomena. By means of simulation results, a reasonable explanation was given to the finding that the closer the distance between the two protrusions was, the lower the corona discharge intensity and higher corona inception voltage of the conductors would be. In summary, the distributions of corona sources played an important role in the corona discharge and this work would provide an important reference for the evaluation of corona effects on the surface of contaminated conductors. | XU JiaYu XU Peng ZHANG Qian CUI Xiang BIAN XingMing LU TieBing LI HaiBing | 2018 | Science China(Technological Sciences)2018，61，8： | 2 |
| 9 | A calculation method for the electric field under double-circuit HVDC transmis- sion lines显示文摘 | YONG Yang LU Jiayu LEI Yinzhao | 2008 | IEEE Transactions on Power Delivery2008，23，4： | 1 |
| 10 | Interfacial Degradation and Optimization of Li-rich Cathode Materials显示文摘High-energy and safe lithium ion batteries(LIBs)are in increasing need as the rapid development of electronic devices,electric vehicles,as well as energy storage station.Li-rich oxides have attracted a lot of attention due to their high capacity and low cost as cathode material for LIBs.However,they still suffer from the vulnerable cathode/electrolyte interface,which presents the huge challenges of surface degradation and gas release,particularly at high state of charge.Some issues of Li-rich cathode materials,such as moderate cycle stability and voltage decay,are in tight connection with electrode-electrolyte interfacial side reactions.Research in the area of interfacial degradation mechanism and optimization strategies is of great significance as for Li-rich cathode,and extensive efforts have been poured.This review aims to understand the degradation mechanism of Li-rich cathode materials,and summarize the corresponding valuable and effective optimization strategies.Based on these considerations,we also have discussed the remaining challenges and the future research direction. | Yuefeng Su Jiayu Zhao Lai Chen Ning Li Yun Lu Jinyang Dong Youyou Fang Shi Chen Feng Wu | 2021 | Chinese Journal of Chemistry2021，39，2： | 1 |
| 11 | A calculation method for the hybrid electric field under UHVAC and UHVDC transmission lines in the same corridor显示文摘 | Yang Yong Lu Jiayu Lei Yinzhao | 2010 | IEEE Transaction on Power Delivery2010，25，2： | 1 |
| 12 | A calculation method for the electricfield under double-circuit HVDC transmission lines显示文摘 | Yang Yong Lu Jiayu Lei Yinzhao | 2008 | IEEE Trans on Power Delivery2008，23，4： | 1 |
| 13 | Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer显示文摘Reversal of cancer drug resistance remains a critical challenge in chemotherapy.Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer.To overcome the intrinsic limitations in conventional mitochondrial targeting strategies,we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin(DOX)resistance in lung cancer.Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors.As a consequence,thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice.This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance. | Lifo Ruan Jun Chen Chuanchao Du Huiru Lu Jiayu Zhang Xiaomeng Cai Rui Dou Wenchu Lin Zhifang Chai Guangjun Nie Yi Hu | 2022 | Bioactive Materials2022，7，7： | 1 |
| 14 | Design of the UHVDC Corona Cage in China显示文摘For the purpose of testing and analysing the corona characteristics of UHVDC bundle conductors, UHVDC corona cage would be built in China. Corona cage is one of the indispensable equipments for conductor corona performance researches. Tests of conductor co- rona characteristics in corona cages can overcome the shortages of those with test lines.The dimensions of several corona cages constructed overseas were introduced in this paper. Based on foreign experiences and the requirement of State Grid Corporation of China, the UHVDC corona cage was designed as double-cage, double-layer, three-sections, and catenary shape with the size of 70 m×22 m×13 m. The corona loss measurement system, radio interference measuring system, and the audible noise measuring system are also detailed, including the measurement theory, connection with the cage, the parameters and the designing basis. The UHVDC corona cage has been put into service. It now undergoes a large amount of audible noise and radio frequency interference tests. | GUO Jian LU Jiayu ZHANG Wenliang | 2013 | 高电压技术2013，39，8： | 1 |
| 15 | Growth of ~4' Li2B407 single crystals by multi-crucible Bridgman method 显示文摘 | XU Jiayue LU Baoliang FAN Shiji | 2004 | J Cryst Growth2004，264，13： | 1 |
| 16 | Genetic determinants of high on-treatment platelet reactivity in clopidogrel treated Chinese patients显示文摘 | Lanning Zhang Yanming Chen Ying Jin Fei Qu Jiayue Li Cong Ma Jie Yang Bin Xu Hongjuan Wang Xiaoqi Li Yang Li Yuxiao Zhang Caiyi Lu Tong Yin | 2013 | Thrombosis Research2013，，： | 1 |
| 17 | Single fre-quency admittance spectroscopy measurements of band offsets in a Se/Si1-xGex/Si quantum well显示文摘 | Lu Fang Jiang Jiayu Sun Henghui | | 0，，： | 1 |
| 18 | Bridgman Growth of Sr3NbGa3Si2O14 Single Crystal 显示文摘 | Wu Anhua Xu Jiayue Lu Baoliang | 2006 | Materials Research Bulletin2006，41，： | 1 |
| 19 | Rapid visual detection of Vibrio parahaemolyticus by combining LAMP-CRISPR/Cas12b with heat-labile uracil-DNA glycosylase to eliminate carry-over contamination显示文摘Vibrio parahaemolyticus is a major pathogen frequently found in seafood.Rapid and accurate detection of this pathogen is important for the control of bacterial foodborne diseases and to ensure food safety.In this study,we established a one-pot system that combines uracil-DNA glycosylase(UDG),loopmediated isothermal amplification(LAMP),and clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 12b(Cas12b)for detecting V.parahaemolyticus in seafood.This detection system can effectively perform identification using a single tube and avoid the risk of carryover contamination. | Fang WU Chen LU Wenhao HU Xin GUO Jiayue CHEN Zhidan LUO | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，8： | 1 |
| 20 | Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients显示文摘A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. | Linlin Cheng Xiaomei Zhang Yu Chen Dan Wang Dong Zhang Songxin Yan Hongye Wang Meng Xiao Te Liang Haolong Li Meng Xu Xin Hou jiayu Dai Xian Wu Mingyuan Li Minya Lu Dong Wu Ran Tian Jing Zhao Yan Zhang Wei Cao Jinglan Wang Xiaowei Yan Xiang Zhou Zhengyin Liu Yingchun Xu Fuchu He Yongzhe Li Xiaobo Yu Shuyang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
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