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| 1 | Stability improvement under high efficiency—next stage development of perovskite solar cells显示文摘With efficiency of perovskite solar cells(PSCs) overpassing 23%, to realize their commercialization, the biggest challenge now is to boost the stability to the same level as conventional solar cells. Thus, tremendous effort has been directed over the past few years toward improving the stability of these cells. Various methods were used to improve the stability of bulk perovskites,including compositional engineering, interface adjustment, dimensional manipulation, crystal engineering, and grain boundary decoration. Diverse device configurations, carrier transporting layers, and counter electrodes are investigated. To compare the stability of PSCs and clarify the degradation mechanism, diverse characterization methods were developed. Overall stability of PSCs has become one central topic for the development of PSCs. In this review, we summarize the state-of-the-art progress on the improvement of device stability and discuss the directions for future research, hoping it provides an overview of the current status of the research on the stability of PSCs and guidelines for future research. | Danni Yu Yue Hu Jiangjian Shi Haoying Tang Wenhao Zhang Qingbo Meng Hongwei Han Zhijun Ning He Tian | 2019 | Science China Chemistry2019，62，6： | 7 |
| 2 | Synthesis and mesomorphism of diacetylene-bridged triphenylene discotic liquid crystal dimers显示文摘Connecting two discotic mesogens via a spacer not only stabilizes the columnar mesophase but also leads to the formation of glass columnar phase, and therefore improves the physical properties of discotic liquid crystals as organic semiconductor. Here, we report the synthesis of eight diacetylene-bridged triphenylene discotic liquid crystal dimers, [C18H6(OCnH2n+1)4(OMe)O2C-C8H16-C≡≡ C-]2, 3(n), (n = 4-8), [C18H6(OC6H13)5O2C-C8H16-C≡≡ C-]2, 6 and [C18H6(OC6H13)5O-(CH2)m-C≡≡ C-]2, 8(m), (m = 1, 3) by Eglinton coupling reaction. The thermotropic liquid crystal properties were studied by differential scanning calorimetry and polarized optical microscopy. The results are showed as follows: the length of peripheral alkyl chains of triphenylene influenced properties of liquid crystal dimers; dimers 3(n) (n = 5-8) and 6 had glass columnar phase, and no crystallization was observed above -50℃ for all the triphenylene dimers; compared with 3(6), 6 showed higher molecular symmetry, more stable columnar mesophase and wider mesophase range. The connecting group, length and rigidity of spacer had important influence on the mesomorphism of diacetylene-bridged triphenylene discotic liquid crystal dimers. | JI Hong ZHAO KeQing YU WenHao WANG BiQin HU Pin | 2009 | Science China Chemistry2009，52，7： | 6 |
| 3 | COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation. | Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 4 |
| 4 | Genomic landscapes of Chinese sporadic autism spectrum disordersrevealed by whole-genome sequencing显示文摘Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical and genetic heterogeneity.In this study,we identified all classes of genomic variants from whole-genome sequencing (WGS) dataset of 32 Chinese trios with ASD,including de novo mutations,inherited variants,copy number variants (CNVs) and genomic structural variants.A higher mutation rate (Poisson test,P<2.2×10^(-16)) in exonic (1.37×10^(-8)) and 3'-UTR regions (1.42×10^(-8)) was revealed in comparison with that of whole genome (1.05×10^(-8)).Using an integrated model,we identified 87 potentially risk genes (P<0.01) from 4832 genes harboring various rare deleterious variants,including CHD8 and NRXN2,implying that the disorders may be in favor to multiple-hit.In particular,frequent rare inherited mutations of several microcephaly-associated genes (ASPM,WDR62,and ZNF335)were found in ASD.In chromosomal structure analyses,we found four de novo CNVs and one de novo chromosomal rearrangement event,including a de novo duplication of UBE3A-containing region at 15q11.2-q13.1,which causes Angelman syndrome and microcephaly,and a disrupted TNR due to de novo chromosomal translocation t (1;5) (q25.1;q33.2).Taken together,our results suggest that abnormalities of centrosomal function and chromatin remodeling of the microcephaly-associated genes may be implicated in pathogenesis of ASD.Adoption of WGS as a new yet efficient technique to illustrate the full genetic spectrum in complex disorders,such as ASD,could provide novel insights into pathogenesis,diagnosis and treatment. | Jinyu Wu Ping Yu Xin Jin Xiu Xu Jinchen Li Zhongshan Li Mingbang Wang Tao Wang Xueli Wu Yi Jiang Wanshi Cai Junpu Mei Qingjie Min Qiong Xu Bingrui Zhou Hui Guo Ping Wang Wenhao Zhou Zhengmao Hu Yingrui Li Tao Cai Yi Wang Kun Xia Yong-Hui Jiang Zhong Sheng Sun | 2018 | Journal of Genetics and Genomics2018，45，10： | 3 |
| 5 | Effect of strain on DRX of 7050 aluminum alloy during extrusion at high temperature显示文摘Extrusion experiments with different filling contents at the temperature of 440 ℃ were conducted for solution treated 7050 aluminum alloy.The microstructure of typical regions with different filler contents were described qualitatively and characterized quantitatively by electron backscattered diffraction technique(EBSD) and TEM.Fraction of deformed structure decrease continuously since ε=0.72.Second phase particles distribute dispersively and interact with dislocations when ε=0.66,which delays the occurrence of DRX.As the strain increases,particles dissolve into the matrix,and their number reduces rapidly.The influence of particles on dislocation accumulation is impaired,so dislocations accumulate on the subgrain boundaries continuously,and lead to the transformation of subgrain boundaries into high angle grain boundaries(HAGBs).The continuous dynamic recrystallization(CDRX) occurrs at the strain of 0.81~0.85.At ε=0.92,CDRX convert rapidly with the increase of HAGBs fraction.But the size of CDRX grains is deduced to be minimum 3.3 μm by theoretical analysis,and it is obtained from experimental result that the maximal size of CDRX is 5.3 μm. | ZHU Danyang,ZHEN Liang,HU Wenhao,CHEN Junzhou,CUI Yuexian,and SHAO Wenzhu School of Materials Science and Engineering,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 3 |
| 6 | Remanufacturing Scheme Design for Used Parts Based on Incomplete Information Reconstruction显示文摘The different conditions of use of a component result in a variety of damage levels.Therefore,excluding differences in shape and size,used parts show a high degree of uncertainty regarding failure characteristics,quality conditions,and remaining life,which seriously affects the efficiency of a remanufacturing scheme design.Aiming to address this problem,a remanufacturing scheme design method based on the reconstruction of incomplete information of used parts is proposed.First,the remaining life of the reconstructed model is predicted by finite element analysis,and the demand for the next life cycle is determined.Second,the scanned 3D damage point cloud data are registered with the original point cloud data using the integral iterative method to construct a missing point cloud model to achieve the restoration of geometric information.Then,according to reverse engineering and laser cladding remanufacturing,the tool remanufacturing process path can be generated by the tool contact point path section line method.Finally,the proposed method is adopted for turbine blades to evaluate the effectiveness and feasibility of the proposed scheme.This study proposes a remanufacturing scheme design method based on the incomplete reconstruction of used part information to solve the uncertain and highly personalized problems in remanufacturing. | Wenhao Huang Zhigang Jiang Teng Wang Yan Wang Xiaoli Hu | 2020 | Chinese Journal of Mechanical Engineering2020，33，3： | 3 |
| 7 | Upcycling biomass waste into Fe single atom catalysts for pollutant control显示文摘Contaminants of heavy metals and antibiotics, which are frequently detected in water, soil and food chains with increasing prevalence in our current society, can cause potential harm to human health and disrupt human ecosystem irreversibly. Herein, we have successfully utilized biomass waste ferns contaminated by iron mines, to fabricate a first-of-its-kind high-performance class of Fe single-atom catalysts(FeSAC) by a facile pyrolysis. The optimal FeSAC-800 shows an excellent efficiency in the fastphotocatalytic degradation of six types of quinolone antibiotics(e.g., norfloxacin, levofloxacin, ciprofloxacin, enrofloxacin, lomefloxacin, flumequine) in 1 h under the simulated natural light irradiation. Based on advanced characterization, a well-defined structure of FeN_(4), confined in the porous carbon is elaborated for the FeSAC-800. Mechanism of the photodegradation is via a Fenton-like oxidation process whereas the reactive oxygen species play a key role. These findings open a new avenue for efficient, sustainable utilization of biomass waste in pollutant control. | Xin Li Kang Hu Yizhe Huang Qingqing Gu Yuwen Chen Bing Yang Rongliang Qiu Wenhao Luo Bert M.Weckhuysen Kai Yan | 2022 | Journal of Energy Chemistry2022，31，6： | 3 |
| 8 | High-risk phenotypes of genetic disease in a Neonatal Intensive Care Unit population显示文摘To the Editor: Genetic diseases contribute to 35% of deaths during the first year of life and are a significant cause of intensive care.[1] A previous study based on the China Neonatal Genomes Project investigated the genetic causes of early infant deaths and found that >25% of deceased neonates with genetic diagnoses can be cured if diagnosed in time.[2] Therefore, it is crucial to target and diagnose neonates with genetic diseases as early as possible. According to our experience, the typical phenotypes, such as special facial features or multiple congenital anomalies (MCAs), indicate a high risk of genetic disease and lead physicians to perform genetic testing in neonates as early as possible. However, in practice, infants without typical phenotypes typically undergo a long and costly diagnostic process before genetic diagnoses are confirmed. Moreover, a recent survey by the American College of Medical Genetics and Genomics (ACMG) and other national professional organizations indicated that there are insufficient numbers of qualified geneticists to fulfil genetic service needs.[3] The ACMG published the general clinical features for genetic testing indications. For example, patients with phenotypes or family history data that strongly implicate a genetic cause may undergo genetic testing.[1] However, the study indicated that many genetic conditions arise de novo or are inherited with no family history.[1] A previous study attempted to apply the non-phenotype-driven panel approach in neonates admitted to the neonate intensive care unit (NICU).[4] However, at present, the diagnostic yield is only 3.45% (1/29).[4] In addition, the economic and ethical issues associated with genomic screening remain challenging. Therefore, the available indications for genetic testing may improve the management of genetic diseases. | Tiantian Xiao Qi Ni Huiyao Chen Huijun Wang Lin Yang Bingbing Wu Yun Cao Guoqiang Cheng Laishuan Wang Liyuan Hu Hongfang Mei Yulan Lu Mengchun Gong Xinran Dong Wenhao Zhou | 2022 | Chinese Medical Journal2022，，5： | 2 |
| 9 | The opportunities and challenges of ionic liquids in perovskite solar cells显示文摘Metal halide perovskite solar cells(PSCs)have shown great potential to become the next generation of photovoltaic devices due to their simple fabrication techniques,low cost,and soaring power conversion efficiency(PCE).However,mismatched with the quickly updated PCEs,the improvement of device stability is challenging and still remains a critical hurdle in the path to commercialization.Recently,ionic liquids(ILs)have been found to play multiple roles in obtaining efficient and stable PSCs.These ILs usually consist of large organic cations and organic or inorganic anions,which have weak electrostatic attraction and are generally liquid at around 100℃.ILs are almost non-volatile,non-flammable,with high ionic conductivity and excellent thermal and electrochemical stability.The roles of ILs in PSCs vary with their composition,that is,the types of anions and cations.In this review,we summarize the roles of anions and cations in terms of precursor solutions,additives,perovskite/charge transport layer interface engineering,and charge transport layers.This article aims to set up a structure–property-stability-performance correlations conferred by the IL in PSC and provide assistance for the anion and cation selection for improving the quality of perovskite film,optimizing interface contact,reducing defect states,and improving charge extraction and transport characteristics.Finally,the application of IL in PSCs is discussed and prospected. | Jian Yang Jianfei Hu Wenhao Zhang Hongwei Han Yonghua Chen Yue Hu | 2023 | Journal of Energy Chemistry2023，，2： | 2 |
| 10 | Design, Synthesis and Biological Evaluation of Isothiazole Based 1,2,4-Trizaole Derivatives显示文摘 | Lai Chen Qifan Wu Zhijin Fan Hongpeng Li Jiwei Li Wenhao Hu Xiumei Liu Nataliya P Belskaya Tatiana Glukhareva Bin Zhao | 2018 | Chinese Journal of Chemistry2018，36，8： | 2 |
| 11 | Synthesis of unsymmetric triphenylene discotic liquid crystals with a semi-fluorinated chain and the influence of fluorophobic effect on mesogenic behavior显示文摘The fluorophobic effect of the semi-fluorinated chain of discotic molecules efficiently improves the stability of columnar mesophase.Low symmetric discogens exhibit decreased melting points and wide mesophase ranges.A series of triphenylene derivatives 1,C18H6(OCnH2n+1)4(OMe)(O2CC2H4C6F13),and their hydrocarbon analogues 2,C18H6(OCnH2n+1)4(OMe)(O2CC8H17),n = 4―8,were synthesized for the investigation of the influence of semi-fluorinated peripheral chain and molecular symmetry on mesomorphism.The structures were characterized with 1H NMR and MS.The mesomorphism was studied with differential scanning calorimetry(DSC) and polarizing optical microscopy(POM).The results showed that all triphenylene derivatives exhibited enantiotropic columnar mesophase.The semifluorinated triphenylenes 1a―1e displayed higher melting points and clearing points than their hydrocarbon analogies 2a―2e.Most of them were in columnar mesophase at room temperature. | YANG GaoFan ZHAO KeQing YU WenHao HU Ping WANG BiQin | 2009 | Science China Chemistry2009，52，8： | 2 |
| 12 | SAFE:a Scalable Filter-Based Packet Filtering Scheme显示文摘Recently, Denial-of-Service(Do S) attacks have become the mainstream threat to the Internet service availability. The filter-based packet filtering is a key technology to defend against such attacks. Relying on the filtering location, the proposed schemes can be grouped into Victim-end Filtering and Source-end Filtering. The fi rst scheme uses a single fi ltering router to block the attack flows near the victim, but does not take the factor that the filters are scarce resource into account, which causes the huge loss of legitimate flows; considering each router could contribute a few filters, the other extreme scheme pushes the fi ltering location back into each attack source so as to obtain ample filters, but this may incur the severe network transmission delay due to the abused filtering routers. Therefore, in this paper, we propose a scalable filter-based packet filtering scheme to balance the number of filtering routers and the available filters. Through emulating Do S scenarios based on the synthetic and real-world Internet topologies and further implementing the various filter-based packet filtering schemes on them, the results show that our scheme just uses fewer filtering routers to cut off all attack flows while minimizing the loss of legitimate fl ows. | LU Ning HU Wenhao | 2016 | China Communications2016，13，2： | 1 |
| 13 | Diagnostic value of S100P for pancreatic cancer: a meta-analysis显示文摘 | Haolin Hu Qi Zhang Chenfei Huang Yi Shen Xundi Chen Xin Shi Wenhao Tang | 2014 | Tumor Biology2014，，10： | 1 |
| 14 | Establishment and Application of Quasi-2D Control Field 显示文摘 | Li Xin Feng Wenhao Hu Zhentian | 2005 | SPIE2005，6043，： | 1 |
| 15 | MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment显示文摘尽管 temozolomide (TMZ ) 是为 glioblastoma 的首要的化学疗法的代理人,它经常由于药抵抗是非药品。克服 glioblastoma 房间的抵抗到 TMZ,为结果预言识别预示的标记并且开发敏化 chemo 代理人是必要的。这里, TMZ 抵抗、 TMZ 敏感的样品的基因表示侧面被 microarray 分析,和激活 mitogen 的蛋白质 kinase kinase 比较(MEK2 ) 2 在抵抗 glioma 房间然而并非在敏感肿瘤房间或非肿瘤纸巾明确地是 upregulated。而且,耐心的数据的全面分析表明 MEK2 表示的增加的水平响应 TMZ 治疗与 glioma 等级和更坏的预后的前进相关很好。而且,在 U251 glioma 房间线或 xenografted glioma 减少 MEK2 的水平通过调停 shRNA 的基因为击倒的禁止的房间增长建模并且向 TMZ 治疗提高了房间的敏感。从由即时 PCR 的 glioma 病人的肿瘤样品的进一步的分析显示增加的 MEK2 表示水平仔细与许多药抵抗基因的激活被联系。最后,在 MEK2 是在 vitro 的 silenced 以后,这些抵抗基因是 downregulated,建议导致 MEK2 的 chemo 抵抗的机制能被这些抵抗基因的 transcriptional 激活调停。一起,我们的数据显示 MEK2 的表示水平能为 glioma 化疗用作一个预示的标记并且 MEK2 对手能被用作 chemo-sensitizers 提高 TMZ 的治疗功效。 | Hua He Maojin Yao Wenhao Zhang Bangbao Tao Feili Liu Shu Li Yan Dong Chenran Zhang Yicheng Meng Yuxin Li Guohan Hu Chun Luo Hui Zong Yicheng Lu | 2016 | Cellular & Molecular Immunology2016，13，5： | 1 |
| 16 | Rapid visual detection of Vibrio parahaemolyticus by combining LAMP-CRISPR/Cas12b with heat-labile uracil-DNA glycosylase to eliminate carry-over contamination显示文摘Vibrio parahaemolyticus is a major pathogen frequently found in seafood.Rapid and accurate detection of this pathogen is important for the control of bacterial foodborne diseases and to ensure food safety.In this study,we established a one-pot system that combines uracil-DNA glycosylase(UDG),loopmediated isothermal amplification(LAMP),and clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 12b(Cas12b)for detecting V.parahaemolyticus in seafood.This detection system can effectively perform identification using a single tube and avoid the risk of carryover contamination. | Fang WU Chen LU Wenhao HU Xin GUO Jiayue CHEN Zhidan LUO | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，8： | 1 |
| 17 | Asymmetric synthesis XXII: Asymmetric catalytic trimethylsilylcyanation of benzaldehyde by novel Ti(IV)-chiral schiff base complexes显示文摘 | Jiang Yaozhong Zhou Xiangge Hu Wenhao Wu Lanjun Mi Aiqiao | 1995 | Tetrahedron: Asymmetry1995，，2： | 1 |
| 18 | Synthesis of disk-rod-disk liquid crystal trimers by using click chemistry显示文摘A series of disk-rod-disk liquid crystal trimers were synthesized.CuI-NEt3 catalyzed alkyne azide cycloaddition in toluene at room temperature connected two triphenylene discogens to a biphenyl rod-shaped mesogen.The trimers were characterized by using 1H NMR,IR,and high resolution mass spectrometry.The mesomorphic properties were investigated using polarized optical microscopy(POM) ,differential scanning calorimetry(DSC) ,and wide-angle X-ray diffraction.The results showed that the trimers exhibited rectangular columnar mesophase(Colr) .The length of the flexible spacer connecting the three segments has prominent influence on the phase transition temperatures of the trimers. | Yu, WenHao Nie, ShiChang Bai, YueFeng Jing, Yang Wang, BiQin Hu, Ping Zhao, KeQing | 2010 | Science China Chemistry2010，53，5： | 1 |
| 19 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 20 | Recent advances in metal carbenoid mediated nitrogen-containing zwitterionic intermediate trapping process显示文摘 | Xing Dong Hu Wenhao | 2014 | Tetrahedron Lett2014，55，4： | 1 |
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