|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Histone Deacetylase AtSRT1 Links Metabolic Flux and Stress Response in Arabidopsis显示文摘怎么种新陈代谢的流动,改变基因表示优化植物生长,对应力的反应仍然保持大部分不清楚。这里,我们报导 Arabidopsis thaliana NAD +-dependent histone deacetylase AtSRT1 否定地调整植物公差到应力和 glycolysis,但是刺激 mitochondrial 呼吸。我们发现 AtSRT1 与 Arabidopsis cMyc 有约束力的蛋白质 1 交往(AtMBP-1 ) ,一个 transcriptional 抑压者由 cytosolic glycolytic enolase 基因 LOS2/ENO2 的其他的翻译生产了。我们证明 AtSRT1 能与 AtMBP-1 目标 LOS2/ENO2 和 STZ/ZAT10 的染色质联系,哪个编码关键压力管理者,并且在这些基因减少 H3K9ac 层次镇压他们的抄写。AtSRT1 和 AtMBP-1 的 Overexpression 在 glycolytic 基因的表示上有 synergistic 效果, glycolytic 酶的活动,和 mitochondrial 呼吸。而且,我们发现 AtMBP-1 是 lysine-acetylated 并且对 proteasomal 蛋白质降级脆弱,当 AtSRT1 能移开它的离氨酸 acetylation 并且显著地提高它的稳定性在时 ? vivo。一起拿,这些结果显示 AtSRT1 在 Arabidopsis 由 epigenetic 规定和 AtMBP-1 transcriptional 活动的调整调整主要新陈代谢和压力反应。 | Xiaoyun Liu Wei Wei Wenjun Zhu Lufang Su Zeyang Xiong Man Zhou Yu Zheng and Dao-Xiu Zhou | 2017 | Molecular Plant2017，10，12： | 6 |
| 2 | Histone Deacetylase HDA9 and WRKY53 Transcription Factor Are Mutual Antagonists in Regulation of Plant Stress Response显示文摘Epigenetic regulation of gene expression is important for plant adaptation to environm ental changes.Previous results showed that Arabidopsis RPD3-like histone deacetylase HDA9 is known to function in repressing plant response to stress in Arabidopsis.However,how HDA9 targets to specific chromatin loci and controls gene expression netw orks involved in plant response to stress remains largely unclear.Here,we show that HDA9 represses stress tolerance response by interacting with and regulating the DNA binding and transcriptional activity of WRKY53,which functions as a high-hierarchy positive regulator of stress response.We found that WRKY53 is post-translationally modified by lysine acetylation at multiple sites,some of which are removed by HDA9,resulting in inhibition of WRKY53 transcription activity.Conversely,WRKY53 negatively regulates HDA9 histone deacetylase activity.Collectively,our results indicate that HDA9 and WRK53 are reciprocal negative regulators of each other's activities,illustrating how the functional interplay between a chromatin regulator and a transcription factor regulates stress tolerance in plants. | Yu Zheng Jingyu Ge Chun Bao Wenwen Chang Jingjing Liu Jingjie Shao Xiaoyun Liu Lufang Su Lei Pan Dao-Xiu Zhou | 2020 | Molecular Plant2020，13，4： | 6 |
| 3 | Machinability of damage-tolerant titanium alloy in orthogonal turn-milling显示文摘The damage-tolerant titanium alloy TC21 is used extensively in important parts of advanced aircraft because of its high strength and durability. However, cutting TC21 entails problems, such as high cutting temperature, high tool tip stress, rapid tool wear, and difficulty guaranteeing processing quality. Orthogonal turn-milling can be used to solve these problems. In this study, the machinability of TC21 in orthogonal turn-milling is investigated experimentally to optimize the cutting parameters of orthogonal turn-milling and improve the machining efficiency, tool life, and machining quality of TC21. The mechanism of the effect of turn-milling parameters on tool life is discussed, the relationship between each parameter and tool life is analyzed, and the failure process of a TiAlN-coated tool in turn-milling is explored. Experiments are conducted on the integrity of the machined surface (surface roughness, metallographic structure, and work hardening) by turn-milling, and how the parameters influence such integrity is analyzed. Then, reasonable cutting parameters for TC21 in orthogonal turn-milling are recommended. This study provides strong guidance for exploring the machinability of difficult-to-cut-materials in orthogonal turn-milling and improves the applicability of orthogonal turn-milling for such materials. | Tao SUN Lufang QIN Junming HOU Yucan FU | 2020 | Frontiers of Mechanical Engineering2020，15，3： | 1 |
| 4 | Investigation on the Prime Factors Influencing the Formation of Entangled Metal-Organic Frameworks显示文摘 | YANG Guoping HOU Lei MA Lufang | 2013 | Cryst Eng Comrn2013，15，： | 1 |
| 5 | Study of direct electron transfer and enzyme activity of glucose oxidase on graphene surface显示文摘 | Liang Bo Shan Xi LuFang Guo | 2015 | Electrochemistry Communications2015，50，： | 1 |
| 6 | 显示文摘 | LUFang(路芳) LIUJing(刘菁) XUJie(徐杰) | 2003 | 化学进展2003，15，： | 1 |
| 7 | Effects of iron plaque on phosphorus uptake by Pilea cadierei cultured in constructed wetland显示文摘 | Yang Lufang Li Yuanwei Yang Xinyao | 2011 | Procedia Environmental Sciences2011，，11： | 1 |
| 8 | Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specificLass2-knockout mice coincident with upregulation of the TGF-β1-Smad4-PAI-1 axis显示文摘 | Lufang Chen Xiaodong Lu Tiantian Zeng Yuanyuan Chen Qian Chen Weijiang Wu Xun Yan Honghua Cai Zhijian Zhang Qixiang Shao Wenxin Qin | 2014 | Oncology Reports2014，，2： | 1 |
| 9 | Particle analysis based on light scattering of particles illuminated by a divergent Gaussian beam 显示文摘 | Lufang Guo Jianqi Shen Chen Wan | 2013 | Opt & Lasers in Eng2013，51，7： | 1 |
| 10 | Syntheses and crystal structures of rare earth (Nd, Gd) 1-D chain com-plexes with N-p-tolylsulfonyl-β-alanine显示文摘Two rare earth complexes of Ts-β-AlaH with the formula of [Ln2(H2O)4(Ts-β-AlaH)6]n·4nH2O (where Ln = Nd(1), Gd(2); Ts-β-AlaH = N-p-tolylsulfonyl-β-Alanine) have been synthesized and characterized by elemental analysis, IR, and X-ray diffraction. The results show that the two complexes are isostructural. They crystallize in a monoclinic system with P21/n space group. Crystal data for 1: a = 0.95149(19) nm, b = 1.9012(4) nm, c = 2.2863(5) nm, β = 100.37(3)°, Z = 4, Dc = 1.509 mg/cm3, F(000) = 1880, R1 = 0.0560, wR2 = 0.1564 [I > 2σ (I)]; for 2: a = 0.9495(2) nm, b = 1.9037(4) nm, c = 2.2987(5) nm, β = 99.87(3)°, Z = 4, Dc= 1.541 mg/cm3, F(000) = 1916, R1 = 0.0515, wR2 = 0.1566 [I>2σ (I)]. The two complexes are one-dimensional chains and the coordination number of the Nd3+ or Gd 3+ ion is nine. | MA Lufang LI Xiaodong WANG Liya LIANG Fupei ZHANG Manbo YU Kaibei | 2005 | Rare Metals2005，24，4： | 1 |
| 11 | Positive quasi-periodic solutions to Lotka-Volterra system显示文摘In this paper,we prove the existence of positive quasi-periodic solutions for a class of Lotka-Volterra system with quasi-periodic coefficients by KAM technique. | Cong HongZi Mi LuFang Yuan XiaoPing | 2010 | Science China Mathematics2010，53，5： | 1 |
| 12 | Round blade cutting experimentalstudy of TC21titanium alloy tool life显示文摘 | Sun Tao Qin Lufang | 2012 | Machine Tool AndHydraulics2012，43，5： | 1 |
| 13 | Nutritional status in chronically hospitalized stroke patients complicated with pulmonary infection显示文摘Complicated pulmonary infection following stroke has traditionally been considered an aspirated infection by many physicians,and little attention has been paid to concomitant protein-energy malnutrition.In the present study,we hypothesized that protein-energy malnutrition may be present in hospitalized chronic stroke patients complicated with pulmonary infection.The results revealed that body protein and fat stores were significantly depleted in stroke patients with pulmonary infection.Protein-energy malnutrition was present in 12 of 27 patients with pulmonary infection.In comparison,only eight of 42 stroke patients without pulmonary infection exhibited protein-energy malnutrition.A significantly higher prevalence of protein-energy malnutrition was found in the pulmonary infection group,suggesting that protein-energy malnutrition is more likely to be present in hospitalized chronic stroke patients with pulmonary infection. | Yue Chen Lufang Chen Yiqing Tao Maomao Han Chunlan Cui Shichao Liu | 2011 | Neural Regeneration Research2011，6，13： | 0 |
| 14 | 线粒体融合蛋白与心血管疾病显示文摘心血管疾病(CVD)发生是一种多因素综合症候群,在全球范围内,是威胁生命的头号杀手,并且发病率随年龄的增长呈稳定上升趋势。虽然诊断和治疗已经取得了进步,但是CVD的发病率和死亡率仍然很高,部分原因归究于对其病理机制理解不清。心脏的首要功能是为器官供血,这就需要持续而大量的ATP能量供应。因此线粒体在心肌细胞中广泛丰富分布。正常的线粒体功能的维持依赖于其完整性和相互作用,并且受到线粒体融合蛋白和分裂蛋白的调控。该文简要综述了线粒体融合蛋白及其改变,特别是线粒体融合蛋白2异常在CVD发生发展中的作用。了解CVD中线粒体融合蛋白的作用对于增进知识以及发展新的治疗策略具有重要的意义。 | KahYong Goh Lufang Zhou 练桂丽 | 2014 | 中华高血压杂志2014，22，10： | 0 |
| 15 | Salvage treatments for prostate-specific antigen relapse of cT3N0M0 prostatic adenocarcinoma after radical prostatectomy combined with neoadjuvant androgen deprivation显示文摘Objective The aim of the study was to evaluate the efficiency of salvage treatments for prostate specific antigen(PSA)relapse of cT3N0M0 prostatic adenocarcinoma(PCa)after radical prostatectomy(RP)combined with neoadjuvant androgen deprivation(ADT).Methods A total of 332 patients with cT3N0M0 PCa were enrolled in the prospective study and received RP and pelvic lymph node dissection with neoadjuvant ADT for 3 months.All patients with PSA relapse were treated with salvage external beam radiation therapy(RT)and ADT for 6 months.Results The 5-year postoperative PSA relapse rate was 40.96%(136/332).The patients have been divided into the PSA relapse and PSA relapse-free groups in order to compare patient characteristics.The ratio of patients with Gleason score≥8 and positive surgical margin in the PSA relapse group were significantly higher than those of in the PSA relapse-free group(P=0.01).The mean duration between the start of operative treatment and PSA relapse was 31 months.Salvage treatment to all 136 PSA relapse patients led to favorable outcomes.PSA relapse was not observed after salvage treatment by the end of follow-up.The 5-year overall survival rates of the PSA relapse and PSA relapse-free groups were 94.9%and 93.9%,respectively.Conclusion In pursuit of curative treatment,our study showed that RP combined with neoadjuvant ADT is an aggressive multimodality strategy associated with lower PSA relapse and better survival outcomes for stage cT3N0M0 PCa patients.Patients with PSA relapse after RP may benefit from early aggressive salvage RT combined with short-term ADT. | Lufang Zhang Dongliang Pan Ludong Liu Yunjiang Zang Ningchen Li | 2020 | Oncology and Translational Medicine2020，6，6： | 0 |
| 16 | High-level expression of recombinant IgG1 by CHO K1 platform显示文摘中国仓鼠卵巢(CHO K1 ) 房间被用来由在这研究优化生产房间线的构造的站台表示指向的反癌症 monoclonal 抗体。支持者 CHO K1 首先在化学定义媒介被使适应暂停文化。然后,夫酸安合成酶(GS ) 向量被使用构造单个 plasmid 到 overexpress monoclonal 抗体 IgG1。波斯特 transfection,房间水池的生产被没有夫酸安的选择和扩大用蛋氨酸 sulfoximine 的各种各样的集中优化。CHO K1/IgG1 的最好的房间水池被用来用克隆的限制冲淡屏蔽最高的单个克隆。最后, 780 mg/L 的高 IgG1 生产从一种批文化被获得。这研究证明高生产房间的构造排队,从基因到克隆,能在六个月以内被完成,基因扩大极大地改进了蛋白质生产。 | Ningning Xu Jianfa Ou Al-Karim (AI) Gilani Lufang Zhou Margaret Liu | 2015 | Frontiers of Chemical Science and Engineering2015，9，3： | 0 |
| 17 | A 3D/0D cobalt-embedded nitrogen-doped porous carbon/supramolecular porphyrin magnetic-separation photocatalyst with highly efficient pollutant degradation and water oxidation performance显示文摘A 3D/0D cobalt-embedded nitrogen-doped porous carbon nanocubes(Co-N-C)/supramolecular tetra(4-carboxylphenyl)porphyrin nanocrystals(SA-TCPP)photocatalyst was successfully self-assembled viaπ–πinteraction,hydrogen bonding,and chemical bonding.Co-N-C/SA-TCPP heterostructure exhibited satisfactory visible photocatalytic oxidation performance on pollutant degradation and water evolution.The degradation rates of Co-N-C/ST(30%)composite towards 2,4-dichlorophenol,ofloxacin,and ethylene were10.9,7.2,and 2.1 times faster than SA-TCPP,respectively.The oxygen evolution efficiency was 1.9 times higher than SA-TCPP.The remarkably improved oxidation activities of Co-N-C/SA-TCPP were mainly ascribed to the following reasons:(1)Co-N-C could enhance the light absorption ability of SA-TCPP to produce more photoinduced carriers.(2)The well-developed porosity of Co-N-C could optimize the dispersibility of SA-TCPP to provide more reactive sites and charge separation channels.(3)Theπ–πinteraction between SA-TCPP and Co-N-C was beneficial to interlayer charge mobility,while the embedded cobalt nanoparticles(Co NPs)and N-doped carbon matrix could serve as electron traps to accelerate interfacial electron transfer.Additionally,the ferromagnetic Co NPs endowed Co-N-C/SA-TCPP with magnetic-separation function to promote recyclability in practical application. | Lufang Ning Jing Xu Yang Lou Chengsi Pan Zhouping Wang Yongfa Zhu | 2022 | Journal of Materials Science & Technology2022，，29： | 0 |
| 18 | Research on the influence of outdoor trees on natural ventilation performance of an academic building显示文摘Planting trees around buildings has always been used as one of the most common viable landscaping strategies in schools.However,the impact of trees on natural ventilation inside the building has been neglected without investigation.The emphasis of this study related to the impact of outdoor trees around the academic building on indoor ventilation.Numerical simulations of the indoor wind environment of the academic building affected by trees were performed utilizing the k-εmodel with additional source terms.The numerical model was also validated by measured data.Two kinds of trees were selected,they are camphor and metasequoia.Camphor is a kind of broad-leaved tree and metasequoia is a kind of coniferous tree.26 simulation cases with six different tree canopy spacings were conducted.These results showed that the outdoor trees had great influences on the natural ventilation performance of the academic building.Compared with the case without the trees,the highest decrement in ventilation flow rate could be up to 31.97%in this study.For the cases of classrooms with horizontal distribution,the ages of air of the classrooms became fresher with the increase of the canopy spacing.While for the cases of classrooms with vertical distribution,the canopy spacing had fewer effects on the natural ventilation performances.It was also found that the blocking effects of camphor on indoor ventilation were higher than that of metasequoia.The average ventilation flow rate in cases with metasequoia was increased by 14.89%compared to the cases with camphor.This study could provide guidance for the layout design of trees around the building. | Shengnan Niu Xiaodong Liu Annan Wang Lufang Chen Xin Zhou Xing Shi Liu Yang Xing Jin | 2023 | Building Simulation2023，16，6： | 0 |
| 19 | Post-stroke seizures in consecutive elderly stroke patients显示文摘This prospective study sought to investigate the clinical,radiological and electroencephalographic(EEG) characteristics of seizures in elderly stroke patients,and their outcomes.Over a 2-year study period,158 consecutive elderly patients with stroke were examined and followed up.Of these patients,32(20%) developed seizures,primarily related to stroke,within a follow up period between 5 months and 2 years.Of these 32 cases,20 experienced infarctions,and 12 experienced hemorrhages.Involvement of cortical regions was detected in most of the patients exhibiting seizures.In these patients,44% of the lesions involved cortical areas exclusively or in addition to subcortical areas observed on computed tomography(CT) images.Twenty-five patients(78%) developed early seizures(within 2 weeks after stroke),and half exhibited immediate post-stroke seizures.None of the patients exhibiting early onset seizures developed recurrent seizures or epilepsy,while 57% of late onset seizures(four cases) developed epilepsy.No specific EEG patterns were apparent in those who later developed epilepsy.Overall,early onset seizures after stroke were found to be relatively common,and did not affect outcome.Late onset seizures were less common,but were associated with chronic epilepsy. | Yue Chen Lufang Chen Yiqing Tao Maomao Han Chunlan Cui Shichao Liu | 2011 | Neural Regeneration Research2011，6，9： | 0 |
| 20 | Pollutant exposure and health outcomes:protocol for a comprehensive umbrella review of meta-analyses and evidence mapping显示文摘Background:Many systematic reviews and meta-analyses(MAs)regarding the association between pollutant(e.g.,air pollution,noise pollution,and heavy metal pollution)exposure and health outcomes have been published recently,but there is still a lack of comprehensive research based on these MAs,and the evidence quality of these MAs are unknown.Therefore,we designed an umbrella review to address these gaps in knowledge.Methods:MAs that evaluated the association between pollutant exposure and health outcomes will be systematically searched through the PubMed and Embase databases in May 2021.Pairs of reviewers will conduct the study screening and data extraction independently,and cross-check the results.PRISMA and AMSTAR 2 will be used to evaluate the reporting and methodological quality of MAs included,respectively,and an evidence mapping method will be used to present the results.The corrected cover area(CCA)method will be used to assess the degree of overlap for included primary studies among MAs.The outcomes will be reanalyzed based on the random-effects model using the appropriate effect size,and the corresponding 95%confidence intervals will be reported.Meanwhile,sensitivity analysis and subgroup analysis will be used to explore heterogeneity.The GRADE method will be used to evaluate the evidence quality of outcome indicators.Stata 16.0 and Excel 2019 will be used for data analysis,and P<0.05 will be considered to indicate statistical significance.Results:The results of this umbrella review will be submitted to a peer-reviewed English journal for publication.Conclusion:We designed the first umbrella review to summarize evidence from MAs on the association between common pollutant exposure and health conditions.The results of this study will provide evidence for health policy makers to formulate appropriate health policies and researchers to conduct new studies. | Jing Qi Lufang Feng Jiemei Hu Haitong Zhao Jieyun Li Lixin Ke Xue Shang Kehu Yang Cuncun Lu | 2021 | Asian Toxicology Tesearch2021，3，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员