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| 1 | Gut microbial balance and liver transplantation: alteration, management, and prediction显示文摘肝移植是为终端阶段肝疾病的常规治疗。然而,几复杂并发症仍然妨碍幸存率。肠的障碍破坏广泛地在收到肝的病人之中被观察移植并且因为在肠和肝之间的关系,受不了 ischemiareperfusion 或拒绝损害,两个在解剖和功能。重要地,内脏 microbiota 的产生改变在这个过程期间加重接枝机能障碍。这篇文章为内脏考察研究进步微生物引起的改变和肝移植。特别,这个工作也在内脏的管理上评估研究微生物引起的改变和在肝移植期间利用微生物引起的改变的可能的损害的预言。另外,我们为关于的研究建议可能的方向在肝移植期间毁坏微生物引起的改变并且在肝移植在微生物引起的改变的利用上提供一个假设。目的是不仅预言 perioperative 损害而且作为治疗的一个方法工作或甚至禁止肝移植的拒绝。 | Xinyao Tian Zhe Yang Fangzhou Luo Shusen Zheng | 2018 | Frontiers of Medicine2018，12，2： | 5 |
| 2 | COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation. | Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 4 |
| 3 | Decadal-to-interdecadal response and adjustment of the North Pacific to prescribed surface forcing in an oceanic general circulation model显示文摘The simulation of a higher-resolution oceanic GCM forced with COADS surface conditions during 1945~1993 was analyzed with insight into how the North Pacific responds to the surface forcing.The decadal-to-interdecadal variabilities in the thermal and dynamical fields especially those associated with the 1976/1977 regime shift in the North Pacific were investigated. The model successfully captures the dominant SST anomaly mode on the decadal-to-interdecadal time scales as well as the major feature of SST anomalies in the 1976/1977 regime shift. The model also successfully reproduces two typical subduction events that link the tropical and extratropical oceanic temperature anomalies during the 1970s and the 1980s. Most importantly, the model simulates the dynamical adjustment of the upper ocean under the surface wind forcing. The typical surface circulation anomaly is characterized by a pattern that is simultaneously related to the wind stress anomalies. The typical anomalous pattern for the entire upper-ocean is characterized by coherent anomalies of two oceanic gyres, i.e., the subtropical and subpolar gyres. The delayed response and slower adjustment of the gyres, especially of the subpolar gyre, give rise to a persistent SST anomaly in the central North Pacific. The upper-ocean heat budgets in three target regions, i.e., the central North Pacific, the Californian coastal region and the KOE region, are examined. The cooling in the central North Pacific around 1976/1977 is attributed to the heat flux and meridional advection anomalies. The associated warming in the Californian coastal region is only due to the heat flux anomaly. A cooling shift in the KOE region which lags that in the central basin by 3 to 4 a is largely due to the meridional advection anomaly and the heat flux acts only as a damping role. | FANG Jiabei RONG Xinyao YANG Xiuqun | 2006 | Acta Oceanologica Sinica2006，25，3： | 3 |
| 4 | Effects of tillage managements and maize straw returning on soil microbiome using 16S rDNA sequencing显示文摘Agricultural practices could affect bacterial diversity and community structure by altering soil physical and chemical properties. Straw returning and tillage practices are widely used in agriculture, however, the effects of these agricultural practices on microbiomes are still unclear. In the present study, we compared the 18 bacterial communities of soil with different straw returning and tillage treatment combinations. The V3-V4 regions of the 16S ribosomal RNA were amplified and analyzed by high-throughput sequencing technology. The results showed that the bacterial communities were consistently dominated by Acidobacteria, Proteobacteria, Actinobacteria, and Chloroflexi. Short-term straw returning and tillage practices significantly altered the diversity, relative abundance and functions of the soil microbiome. Soil subjected to rotary tillage and straw returning (RTS) combination possessed the highest bacterial diversity and lowest ratio of G+/G- bacteria, indicating that RTS could be an efficient integrated management system to improve microbiome in the short term. Double verifications based on relative abundance and network analysis, revealed close relationships of Mycobacterium and Methylibium with RTS, indicating they could serve as biomarkers for RTS. Investigating microbial changes under different agricultural practices will provide valuable foundations for land sustainable utilization and increase crop yields. | Xinyao Xia Piaopiao Zhang Linlin He Xingxing Gao Weijun Li Yuanyuan Zhou Zongxin Li Hui Li Long Yang | 2019 | Journal of Integrative Plant Biology2019，61，6： | 3 |
| 5 | New approaches for rare earth-magnesium based hydrogen storage alloys显示文摘As the most possibility applied to the next generation negative electrode materials of Ni/ MH second battery,rare earth(RE)-magnesium(Mg) based alloys have been developed over the last few years. Recent advances about the RE-Mg based intermetallic compounds on the crystal structures, hydrogenation behaviors and electrochemical performances are reviewed in the paper. On the other hand, new results about the preparation and modification methods of the alloys are also covered in details. | Huaiwei Zhang Xinyao Zheng Xiao Tian Yang Liu Xingguo Li | 2017 | Progress in Natural Science:Materials International2017，27，1： | 2 |
| 6 | Post COVID-19 burden:focus on the short-term condition显示文摘The catastrophic pandemic of the coronavirus disease 2019(COVID-19)has caused serious harm to human life and global social economy.As of June 13,2022,there were more than 530 million confirmed cases of COVID-19 and over 6.3 million deaths[1].During the past 2 years,global studies on prevention and therapies for COVID-19 have achieved a series of promising findings,including antiviral drugs(Remdesivir,Molnupiravir,Paxlovid)and monoclonal antibodies(Bamlanivimab and Etesevimab,Sotrovimab,Casirivimab and Imdevimab)[2]. | Fengwen Yang Bo Pang Xinyao Jin Zhe Chen Wentai Pang Qingquan Liu Junhua Zhang Boli Zhang | 2022 | Acupuncture and Herbal Medicine2022，2，3： | 2 |
| 7 | Effects of iron plaque on phosphorus uptake by Pilea cadierei cultured in constructed wetland显示文摘 | Yang Lufang Li Yuanwei Yang Xinyao | 2011 | Procedia Environmental Sciences2011，，11： | 1 |
| 8 | Lonicera caerulea polyphenols inhibit fat absorption by regulating Nrf2-ARE pathway mediated epithelial barrier dysfunction and special microbiota显示文摘Scope:High-fat diet(HFD)induces imbalance in the small intestine environment,where fat digestion and absorption mainly take place.This study aimed to elucidate the mechanisms by which Lonicera caerulea polyphenols(LCP)might inhibit fat absorption,from the perspective of small intestine microbiota and epithelial barrier integrity.Methods and results:Male Sprague-Dawley rats were given HFD with or without co-administration of LCP for 8 weeks.The results showed that LCP supplementation significantly decreased the levels of serum triglycerides(TG),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C),and increased the contents of fecal sterols,in HFD rats.LCP also inhibited the dysfunction of the small intestine epithelial barrier,via alleviating the oxidative stress activated by Nrf2-ARE pathway,and by modulating the expressions of pro-inflammatory factors such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),cyclooxygenase-2(COX-2),nuclear factor kappa-B p65(NF-κB p65)and inducible nitric oxide synthase(iNOS)in the small intestine.Additionally,LCP administration restored the balance in small intestine microbiota and increased the abundance of the specific bacteria,such as Lactobacillus,involved in fat absorption.Conclusion:Our results demonstrated that LCP may be beneficial to inhibit fat absorption.The mechanism seems to be associated with the protection of the epithelial barrier integrity and the modulation of specific bacteria in the small intestine. | Yuehua Wang Ningxuan Gao Andrea Nieto-Veloza Lingxi Zhou Xiyun Sun Xu Si Jinlong Tian Yang Lin Xinyao Jiao Bin Li | 2023 | Food Science and Human Wellness2023，12，4： | 1 |
| 9 | An evolutionary approach to materialized views selection in a data warehouse environment显示文摘 | Chuan zhang Xinyao Jian Yang | 2004 | IEEE Transaction on System Man Andcybemetics2004，8，31： | 1 |
| 10 | Analysis on the Problems Existing in China's College Classes and Management Strategies显示文摘Class is a place where all kinds of teaching activities are carried out and is a space where the teachers and students gather to study and grow up together. The scientific and reasonable college class management methods not only can effectively maintain the teaching order in class, but also can improve the students' learning initiative and increase the teaching efficiency, thus improving the quality of higher education. However, the situation of college class management is not optimistic at present. This paper is aimed at analyzing the problems existing in China's college classes and exploring the relevant solutions based on them to provide the reference for the quality of China's higher education. | Qingzheng Wang Xiuxiu Shen Xinyao Zhang Jiaojiao Yang Xiang Ao Hui Li Shengping Gao | 2017 | Journal of Educational Theory and Management2017，1，1： | 0 |
| 11 | The Jidong Eye Cohort Study:objectives,design,and baseline characteristics显示文摘Background:To describe the objective,design and baseline characteristics of the Jidong Eye Cohort Study(JECS),a community-based cohort in China based on etiology,imaging and biomarkers.The JECS will clarify the pathogenesis of visual impairment and status of ocular indicators in the occurrence and progression of cardiocerebrovascular and neurological diseases.Methods:Between August 2019 and January 2020,the JECS recruited consecutive participants aged 18 years and older from the Jidong communities in China.The demographic and clinical characteristics were collected by trained site personnel via face-to-face interviews.The relevant biological samples were also collected.The participants underwent comprehensive ophthalmic examination,such as retinal photography and optical coherence tomography(OCT)angiography.The following outcomes were measured annually:ocular vascular abnormality,optic nerve degeneration,cardiovascular diseases(CVD)and neurological diseases.The study will be performed until 2024.Results:Among 3377 participants,the average age was 45.0±12.5 years and 1809(53.6%)were women.Hypertension occurred in 825 individuals(25.0%),diabetes in 258(7.7%),hyperglycemia in 474(14.2%),and a CVD history in 100(3.0%).The mean best-corrected visual acuity was 0.1 logMAR in the recruited subjects.The average OCT signal index was 8.2±1.2.Additionally,the mean vessel densities for the entire measured area were 46.4%and 50.8%for the superficial and deep vascular complex,respectively.Mean area and perimeter of foveal avascular zone was 0.3 mm2 and 2.3 mm.Conclusions:The JECS is a large community-based prospective cohort in North China.Rich data collected from this study will provide the opportunity to identify risk factors,imaging,and biomarkers of visual impairment(either ocular vascular anomalies or optic nerve degeneration)and to evaluate their associations with CVD and neurological diseases. | Kai Yang Lele Cui Guoyun Zhang Xianwei Wang Xiaoxuan Zhu Yunfan Xiao Binbin Su Daiyu Song Xinyao Zhang Yang Zheng Fan Lu Jia Qu Ming Li | 2020 | Eye and Vision2020，7，1： | 0 |
| 12 | Construction of cobalt-copper bimetallic oxide heterogeneous nanotubes for high-efficient and low-overpotential electrochemical CO_(2) reduction显示文摘Currently,global warming and energy problems become more and more serious with the development of economy and the continuous consumption of fossil fuel,which are due to the release of greenhouse gas in the process of fossil fuel combustion and industrial manufacturing. | Zhong Cheng Xiaodeng Wang Hengpan Yang Xinyao Yu Qing Lin Qi Hu Chuanxin He | 2021 | Journal of Energy Chemistry2021，30，3： | 0 |
| 13 | Simulation of the Northern and Southern Hemisphere Annular Modes by CAMS-CSM显示文摘As leading modes of the planetary-scale atmospheric circulation in the extratropics, the Northern Hemisphere(NH)annular mode(NAM) and Southern Hemisphere(SH) annular mode(SAM) are important components of global circulation, and their variabilities substantially impact the climate in mid-high latitudes. A 35-yr(1979-2013) simulation by the climate system model developed at the Chinese Academy of Meteorological Sciences(CAMS-CSM) was carried out based on observed sea surface temperature and sea ice data. The ability of CAMS-CSM in simulating horizontal and vertical structures of the NAM and SAM, relation of the NAM to the East Asian climate, and temporal variability of the SAM is examined and validated against the observational data. The results show that CAMS-CSM captures the zonally symmetric and out-of-phase variations of sea level pressure anomaly between the midlatitudes and polar zones in the extratropics of the NH and SH. The model has also captured the equivalent barotropic structure in tropospheric geopotential height and the meridional shifts of the NH and SH jet systems associated with the NAM and SAM anomalies. Furthermore, the model is able to reflect the variability of northern and southern Ferrel cells corresponding to the NAM and SAM anomalies. The model reproduces the observed relationship of the boreal winter NAM with the East Asian trough and air temperature over East Asia. It also captures the upward trend of the austral summer SAM index during recent decades. However, compared with the observation, the model shows biases in both the intensity and center locations of the NAM's and SAM's horizontal and vertical structures. Specifically, it overestimates their intensities. | Sulan NAN Junli YANG Yan BAO Jian LI Xinyao RONG | 2019 | Journal of Meteorological Research2019，33，5： | 0 |
| 14 | Potential risk of colonization of Bulinus globosus in the mainland of China under climate change显示文摘Background: Bulinus globosus,the main intermediate snail host of Schistosoma haematobium.The increased contacts between Africa and China could even lead to large-scale dissemination of B.globosus in China.Temperature is the key factor affecting fresh-water snail transmission.This study predicted potential risk of colonization of B.globosus in the mainland of China under climate change.Methods: We investigated minimum and maximum temperatures for B.globosus eggs,juveniles and adult snails kept under laboratory conditions to find the most suitable range by pinpointing the median effective temperatures(ET50).We also assessed the influence of temperature on spawning and estimated the accumulated temperature(AT).The average air temperatures between 1955 and 2019 in January and July,the coldest and hottest months in China,respectively,were collected from national meteorological monitoring stations and investigated in a geographic information system(GIS)using empirical Bayesian Kriging to evaluate the theoretical possibility for distribution of B.globosus in southern China based on temperature.Results: The effective minimum temperature(ET50min)for eggs,juveniles,adult snails and spawning were 8.5,7.0,7.0,14.9℃,respectively,with the corresponding maximum values(ET50max)of 36.6,40.5,40.2 and 38.1℃.The AT was calculated at 712.1±64.9℃·d.In 1955,the potential B.globosus distribution would have had a northern boundary stretching from the coastal areas of Guangdong Province and Guangxi Autonomous Region to southern Yunnan Province.Since then,this line has gradually moved northward.Conclusions: Annual regeneration of B.globosus can be supported by the current climate conditions in the mainland of China,and a gradual expansion trend from south to north is shown in the study from 2015 to 2019.Thus,there is a potential risk of colonization of B.globosus in the mainland of China under climate change. | Xinyao Wang Saleh Juma Wei Li Mchanga Suleman Mtumweni Ali Muhsin Jian He Mingzhen He Dacheng Xu Jianfeng Zhang Robert Bergquist Kun Yang | 2022 | Infectious Diseases of Poverty2022，11，3： | 0 |
| 15 | Sex-specific effects of organophosphate ester exposure on child growth trajectories in the first two years显示文摘The connections between urinary organophosphate ester(OPE)metabolites and child growth have been identified in prior research,but there is currently a dearth of epidemiological evidence regarding the sex-specific impact of OPEs on child growth trajectories.This study enrolled 804 maternal-child pairs,and five OPE congeners were quantified in maternal serum during pregnancy.In this study,the impact of prenatal OPE exposure on child growth trajectories was assessed using linear mixed-effect models and a group-based trajectory model(GBTM),with consideration given to sex-specific effects.Fetuses were frequently exposed to OPEs in utero,and tris(2-butoxyethel)phosphate(TBEP)exhibited the highest concentration levels in maternal serum.Among male children,an increase of 2.72 ng/g lipid in TBEP concentration was associated with a 0.11-unit increase in head circumference-for-age z-score(HCAZ),and the effect was mainly concentrated at 1 and 2 months of age.Among female children,an increase of 2.72 ng/g lipid in tris(2-chloro-1-(chloromethyl)ethyl)phosphate(TDCPP)concentration was associated with a 0.15-unit increase in length-for-age z-score(LAZ)and a 0.14-unit increase in weight-for-age z-score(WAZ),and the effects were mainly concentrated at 9 months of age.For HCAZ trajectories,higher prenatal TBEP exposure was associated with higher odds for the fast growth group in male children.For the LAZ and WAZ trajectories,higher prenatal TDCPP exposure was associated with higher odds for the fast growth group in female children.The trajectory analysis approach provided insight into the complex associations between OPE exposure and child growth. | Hang Wang Liyi Zhang Jie Wu Pengpeng Wang Qiang Li Xinyao Sui Yaqi Xu Yue Zhao Yang Liu Yunhui Zhang | 2023 | Eco-Environment & Health2023，2，3： | 0 |
| 16 | Dynamic Analysis of Launch Vehicle Piping Systems显示文摘Due to complex assembly boundaries and working environment of the piping system in a launch vehicle,it is difficult to simulate realistic flight conditions on the ground.The lack of analysis on the complex environment and boundary conditions in the design process may lead to flight failures,even cause the fuel to combust and destroy the launch vehicle.This paper studies the technology and methods for dynamic simulation analysis of piping systems in launch vehicles,and established a dynamic simulation model of representative pipelines,which is expected to provide a basis for simulation analysis of piping system states in realistic flight. | WANG Shuai LI Chao ZHOU Yuguo ZHANG Xinyao YANG Dongsheng ZHONG Sheng | 2023 | Aerospace China2023，24，3： | 0 |
| 17 | 肝胆肿瘤中肿瘤特异性CircRNA衍生抗原肽的鉴定显示文摘基于肿瘤抗原的免疫治疗的应用受到验证免疫原性肽稀缺性的阻碍。本研究旨在研究环状RNA(circRNA)在肝胆肿瘤类器官中作为肿瘤抗原肽新来源的潜力。使用RNA测序(RNA-seq)和基于算法的评分工具,预测3950个翻译的肿瘤特异性环状RNA在27个类器官中产生18971个抗原肽。从抗原格局来看,11个氨基酸长度(mer)肽和人白细胞抗原(HLA)-A结合肽具有最高的免疫原性相关评分。在分析的3/5类器官中,有13个预测抗原肽通过质谱(MS)免疫肽组学被直接确认为HLA-A、HLA-B和HLA-C(HLA-ABC)结合肽。在流式细胞术和酶联免疫吸附试验(ELISA)中,由HLA-ABC分子呈递的circRNA衍生的肿瘤特异性肽刺激CD8(CD8)T细胞,显示CD107a干扰素γ(IFNγ)共表达和IFNγ分泌增加。免疫原性环状RNA衍生肽诱导的靶向类器官的细胞毒性T细胞活性在杀伤实验中得到验证。值得注意的是,来自circTBC1D15的抗原肽YGFNEILKK不仅被认为是类器官的HLA-ABC呈递肽,而且还显著降低了肿瘤类器官的存活率。本研究的发现强调了产生肿瘤抗原的一个关键亚群,这对靶向肿瘤特异性circRNA具有重要意义。 | Wenwen Wang Lili Ma Zheng Xing Tinggan Yuan Jinxia Bao Yanjing Zhu Xiaofang Zhao Yan Zhao Yali Zong Yani Zhang Siyun Shen Xinyao Qiu Shuai Yang 王红阳 高栋 王鹏 陈磊 | 2023 | Engineering2023，，3： | 0 |
| 18 | On-chip multiphoton Greenberger-Horne Zeilinger state based on integrated frequency combs显示文摘One of the most important multipartite entangled states,Greenberger-Horne-Zeilinger state(GHZ),serves as a fundamental resource for quantum foundat ion test,quantum communication and quantum computation.To increase the number of entangled particles,significant experimental efforts should been invested due to the complexity of optical setup and the difficulty in maintaining the coherence condition for high-fidelity GHZ state.Here,we propose an ultra-integrated scalable on-chip GHZ state generation scheme based on frequency combs.By designing several microrings pumped by different lasers,multiple partially overlapped quantum frequency combs are generated to supply as the basis for on-chip polarization-encoded GHZ state with each qubit occupying a certain spectral mode.Both even and odd numbers of GHZ states can be engineered with constant small number of integrated components and easily scaled up on the same chip by only adjusting one of the pumnp wavelengths.In addition,we give the on-chip design of projection measurement for characterizing GHZ states and show the reconfigurability of the state.Our proposal is rather simple and feasible within the existing fabrication technologies and we believe it will boost the development of multiphoton technologies. | Pingyu Zhu Qilin Zheng Shichuan Xue Chao Wu Xinyao Yu Yang Wang Yingwen Liu Xiaogang Qiang Junjie Wu Ping Xu | 2020 | Frontiers of physics2020，15，6： | 0 |
| 19 | Incidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma显示文摘Glaucoma is one of the most common optic neuropathies,featuring progressive retinal ganglion cell damage and visual field loss(Tham et al.,2014;Xu et al.,2020).Currently,the only effective treatment for this condition is the reduction of intraocular pressure(IOP)(Palmberg,2001;Heijl et al.,2002).Canaloplasty is a proven bleb-independent surgery with good efficacy and safety profiles in primary open-angle glaucoma(POAG)(Gołaszewska et al.,2021).However,early transient postoperative IOP elevation has been reported in up to 30%of cases(Riva et al.,2019),similar to that commonly observed in other internal drainage glaucoma surgeries such as implantation using iStent(0%–21.0%),CyPass(10.8%),and Hydrus(4.8%–6.5%)(Lavia et al.,2017). | Lijuan XU Xinyao ZHANG Yang CAO Yin ZHAO Juan GU Wenqing YE Xiaojie WANG Jinxin LI Ruiyi REN Yuanbo LIANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，4： | 0 |
| 20 | Chemical constituents and pharmacological effects of Croton crassifolius显示文摘Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research. | Luyan Yang Yibo Wang Xinyao Wang Xiaoxia Xu Yunpeng Yang Meng Zhang Yu Chen | 2024 | Asian Journal of Traditional Medicines2024，19，2： | 0 |
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