|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Surfactants oil displacement system in high salinity formations:research and application 显示文摘 | Wang Yefei Wang Lushan Li Jiyong | 2001 | SPE 700472001，，： | 1 |
| 3 | Organosilicon-group-derived silica-ionogel electrolyte for lithium ion batteries显示文摘In order to avoid leakage problem caused by liquid electrolyte, a new ionogel electrolyte was developed by in situ immobilizing organosilicon-functionalized ionic liquid within a nanoporous silica matrix. The ionic liquid evenly coats on the surface of porous silica and fills in the silica framework pores with no strong chemical interaction.The ionogel electrolyte has the dual advantages of a silica solid support and a wide electrochemical stability window of ionic liquid(4.87 V vs. Li^+/Li). The half-cells assembled with this electrolyte and LiFePO_4 electrode have excellent performance at room temperature and 60 ℃. The Li/SiO_2-IGE/LiFePO_4 cell displays a discharge capacity of 129.1 mAh·g^(-1) after 200 charge/discharge cycles at room temperature. | YueJiao Li Cui Guo LuShan Yue WenJie Qu Nan Chen YuJuan Dai RenJie Chen Feng Wu | 2018 | Rare Metals2018，37，6： | 1 |
| 4 | Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models显示文摘Chronic cerebral hypoperfusion leads to white matter injury(WMI),which subsequently causes neurodegeneration and even cognitive impairment.However,due to the lack of treatment specifically for WMI,novel recognized and effective therapeutic strategies are urgently needed.In this study,we found that honokiol and magnolol,two compounds derived from Magnolia officinalis,significantly facilitated the differentiation of primary oligodendrocyte precursor cells(OPCs)into mature oligodendrocytes,with a more prominent effect of the former compound.Moreover,our results demonstrated that honokiol treatment improved myelin injury,induced mature oligodendrocyte protein expression,attenuated cognitive decline,promoted oligodendrocyte regeneration,and inhibited astrocytic activation in the bilateral carotid artery stenosis model.Mechanistically,honokiol increased the phosphorylation of serine/threonine kinase(Akt)and mammalian target of rapamycin(mTOR)by activating cannabinoid receptor 1 during OPC differentiation.Collectively,our study indicates that honokiol might serve as a potential treatment for WMI in chronic cerebral ischemia. | Zhi Zhang Xin Shu Qian Cao Lushan Xu Zibu Wang Chenggang Li Shengnan Xia Pengfei Shao Xinyu Bao Liang Sun Yuhao Xu Yun Xu | 2023 | Neuroscience Bulletin2023，39，10： | 1 |
| 5 | G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction显示文摘GTPase-activating SH3 domain-binding protein 2(G3BP2)is a mediator that responds to environmental stresses through stress granule formation and is involved in the progression of chronic diseases.However,no studies have examined the contribution of G3BP2 in the oscillatory shear stress(OSS)-induced endothelial dysfunction.Here we assessed the effects of G3BP2 in endothelial cells(ECs)function and investigated the underlying mechanism.Using shear stress apparatus and partial ligation model,we identified that stress granulerelated genes in ECs could be induced by OSS with RNA-seq,and then confirmed that G3BP2 was highly and specifically expressed in athero-susceptible endothelia in the OSS regions.G3bp2e/eApoee/e mice had significantly decreased atherosclerotic lesions associated with deficiency of G3BP2 in protecting endothelial barrier function,decreasing monocyte adhesion to ECs and inhibiting the proinflammatory cytokine levels.Furthermore,loss of G3BP2 diminished OSS-induced inflammation in ECs by increasing YAP nucleocytoplasmic shuttling and phosphorylation.These data demonstrate that G3BP2 is a critical OSS regulated gene in regulating ECs function and that G3BP2 inhibition in ECs is a promising atheroprotective therapeutic strategy. | Tianhan Li Juhui Qiu Tingting Jia Yinming Liang Kun Zhang Wenhua Yan Zhengjun Hou Shiwei Yang Lushan Liu Wenhao Xiong Yaokai Chen Guixue Wang | 2022 | Genes & Diseases2022，9，6： | 1 |
| 6 | Three new shRNA expression vectors targeting the CYP3A4 coding sequence to inhibit its expression显示文摘RNA interference(RNAi)is useful for selective gene silencing.Cytochrome P4503A4(CYP3A4),which metabolizes approximately 50% of drugs in clinical use,plays an important role in drug metabolism.In this study,we aimed to develop a short hairpin RNA(shRNA)to modulate CYP3A4 expression.Three new shRNAs(S1,S2 and S3)were designed to target the coding sequence(CDS)of CYP3A4,cloned into a shRNA expression vector,and tested in different cells.The mixture of three shRNAs produced optimal reduction(55%)in CYP3A4 CDS-luciferase activity in both CHL and HEK293 cells.Endogenous CYP3A4 expression in HepG2 cells was decreased about 50%at both mRNA and protein level after transfection of the mixture of three shRNAs.In contrast,CYP3A5 gene expression was not altered by the shRNAs,supporting the selectivity of CYP3A4 shRNAs.In addition,HepG2 cells transfected with CYP3A4 shRNAs were less sensitive to Ginkgolic acids,whose toxic metabolites are produced by CYP3A4.These results demonstrate that vector-based shRNAs could modulate CYP3A4 expression in cells through their actions on CYP3A4 CDS,and CYP3A4 shRNAs may be utilized to define the role of CYP3A4 in drug metabolism and toxicity. | Siyun Xu Yongsheng Xiao Li Li Lushan Yu Huidi Jiang Aiming Yu Su Zeng | 2014 | Acta Pharmaceutica Sinica B2014，4，5： | 0 |
| 7 | Preparation of highly preferred orientation TiB_2 coatings显示文摘This paper focuses on the preparation of titanium diboride (TiB2) coatings on the graphite substrate by continuous current plating (CCP) and pulse current plating (PIC) electrochemical techniques in fluoride electrolytes (LiF-NaF-KF) containing K2TiF6 and KBF4 as the electrochemically-active components at 700°C. Thick leveled and uniform coatings were obtained and were composed of relatively pure TiB2. The effect of the experimental parameters on the microstructure of the coatings was studied. The results showed the electrodeposition with PIC produced coatings with better quality, when compared with those obtained by CCP, under the conditions of the current density i = 0.6 A/cm2, frequency = 100 Hz, and ton/toff = 4/1. XRD analysis indicated that the preferred orientation of coatings is (110) plane, which is in accordance with the prediction of the two-dimensional crystal nuclei theory. The effect of a ratio of ton/toff and frequency on the crystal size, tex- ture coefficient and microstress was also investigated. | LI Jun LI Bing JIANG Lushan DONG Zheng 'e YE Yifu | 2006 | Rare Metals2006，25，2： | 0 |
| 8 | Data-driven strategies for the computational design of enzyme thermal stability:trends,perspectives,and prospects显示文摘Thermal stability is one of the most important properties of enzymes,which sustains life and determines the potential for the industrial application of biocatalysts.Although traditional methods such as directed evolution and classical rational design contribute greatly to this field,the enormous sequence space of proteins implies costly and arduous experiments.The development of enzyme engineering focuses on automated and efficient strategies because of the breakthrough of high-throughput DNA sequencing and machine learning models.In this review,we propose a data-driven architecture for enzyme thermostability engineering and summarize some widely adopted datasets,as well as machine learning-driven approaches for designing the thermal stability of enzymes.In addition,we present a series of existing challenges while applying machine learning in enzyme thermostability design,such as the data dilemma,model training,and use of the proposed models.Additionally,a few promising directions for enhancing the performance of the models are discussed.We anticipate that the efficient incorporation of machine learning can provide more insights and solutions for the design of enzyme thermostability in the coming years. | Zhixin Dou Yuqing Sun Xukai Jiang Xiuyun Wu Yingjie Li Bin Gong Lushan Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 9 | Enhancement of extracellular Cr(Ⅵ) reduction for anammox recovery using hydrazine: performance, pathways, and mechanism显示文摘The hexavalent chromium(Cr(Ⅵ))would frequently impose inhibition to anaerobic ammonium oxidation(anammox)process,hindering the efficiency of nitrogen removal in wastewater treatment.Hydrazine(N2H4),which is an intermediate product of anammox,participates in intracellular metabolism and extracellular Cr(Ⅵ)reduction.However,the roles of N_(2)H_(4)-induced intracellular metabolism and extracellular reduction in nitrogen removal under Cr(Ⅵ)stress remain unclear.The addition of 3.67 mg/L of N2H4 increased the anammox activity by 17%.As an intermediate,N2H4 enhanced anammox metabolism by increasing the heme c content and electron transfer system activity.As a reductant,N_(2)H_(4) accelerated the reduction of c-Cyts-mediated extracellular Cr(Ⅵ)to the less toxic Cr(Ⅲ).Extracellular Cr(Ⅲ)accounts for 74%of the total Cr in a Cr(Ⅵ)-stressed anammox consortia.These findings highlight that N_(2)H_(4)-induced extracellular Cr(Ⅵ)reduction is the dominant mechanism for the survival of anammox consortia.We also found that N_(2)H_(4) increased the production of extracellular polymeric substances to sequester excessive Cr(Ⅵ)and produced Cr(Ⅲ).Taken together,the study findings suggest a potential strategy for enhancing nitrogen removal from ammonium-rich wastewater contaminated with Cr(Ⅵ). | Caiyan Qu Lushan Li Fan Feng Kainian Jiang Xing Wu Muchuan Qin Jia Tang Xi Tang Ruiyang Xiao Di Wu Chongjian Tang | 2023 | Frontiers of Environmental Science & Engineering2023，17，9： | 0 |
| 10 | Experimental characterization and mechanism of hydraulic pulsation waves driving microscopic residual oil显示文摘To clarify microscopic mechanisms of residual oil displacement by hydraulic pulsation wave,microscopic visualization experiments of hydraulic pulsation wave driving residual oil were carried out by using the microscopic visualization device of pulsating water drive.For the four types of residual oil left in the reservoir after water flooding,i.e.membrane,column,cluster,and blind end residual oils,hydraulic pulsation waves broke the micro-equilibrium of the interface by disturbing the oil-water interface,so that the injected water invaded into and contacted with the remaining oil in small pores and blind holes,and the remaining oil was pushed or stripped to the mainstream channel by deformation superposition effect and then carried out by the injected water.In the displacement,the pulsation frequency mainly affected the cluster and blind end remaining oil,and the hydraulic pulsation wave with a frequency of about 1 Hz had the best effect in improving the recovery.The pulsation amplitude value mainly affected the membrane and column residual oil,and the larger the amplitude value,the more remaining oil the hydraulic pulsation wave would displace.The presence of low intensity continuous flow pressure and holding pressure end pressure promoted the concentration of pulsating energy and greatly improve the recovery of cluster residual oil.The rise in temperature made the hydraulic pulsation wave work better in displacing remaining oil,improving the efficiency of oil flooding. | WU Feipeng LI Na YANG Wei CHEN Jiahao DING Bujie XIA Lei LIU Jing WANG Cong WANG Lushan | 2022 | Petroleum Exploration and Development2022，49，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员