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| 1 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 2 | Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer’s disease显示文摘Background:Alzheimer's disease(AD)is an incurable and irreversible neurodegen-erative disease,without a clear pathogenesis.Therefore,identification of candidates before amyloid-βplaque(Aβ)deposition proceeds is of major significance for earlier intervention in AD.Methods:To explore the potential noninvasive earlier biomarkers of AD in a 5XFAD mouse model,microRNAs(miRNAs)from urinary exosomes in 1-month-old pre-Aβaccumulation 5XFAD mice models and their littermate controls were profiled by mi-croarray analysis.The differentially expressed miRNAs were further analyzed via droplet digital PCR(ddPCR).Results:Microarray analysis demonstrated that 48 differentially expressed miRNAs(18 upregulated and 30 downregulated),of which six miRNAs-miR-196b-5p,miR-339-3p,miR-34a-5p,miR-376b-3p,miR-677-5p,and miR-721-were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR.Conclusions:Urinary exosomal miRNAs showing differences in expression prior to Aβ-plaque deposition were identified.These exosomal miRNAs represent potential noninvasive biomarkers that may be used to prevent AD in clinical applications. | Zhiqi Song Yajin Qu Yanfeng Xu Ling Zhang Li Zhou Yunlin Han Wenjie Zhao Pin Yu Yu Zhang Xianglei Li Chuan Qin | 2021 | Animal Models and Experimental Medicine2021，4，3： | 6 |
| 3 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 4 | A time-released osmotic pump fabricated by compression-coated method: Formulation screen, mechanism research and pharmacokinetic study显示文摘In this investigation,time-released monolithic osmotic pump(TMOP)tablets containing diltiazem hydrochloride(DIL)were prepared on the basis of osmotic pumping mechanism.The developed dosage forms were coated by Kollidon®SR-Polyethylene Glycol(PEG)mixtures via compression-coated technology instead of spray-coating method to form the outer membrane.For more efficient formulation screening,a three-factor five-level central composite design(CCD)was introduced to explore the optimal TMOP formulation during the experiments.The in vitro tests showed that the optimized formulation of DIL-loaded TMOP had a lag time of 4 h and a following 20-h drug release at an approximate zero-order rate.Moreover,the releasemechanismwas proven based on osmotic pressure and its profile could be well simulated by a dynamic equation.After oral administration by beagle dogs,the comparison of parameters with the TMOP tablets and reference preparations show no significant differences for C_(max)(111.56±20.42,128.38±29.46 ng/ml)and AUC_(0-48 h)(1654.97±283.77,1625.10±313.58 ng h/ml)but show significant differences for T_(max)(13.00±1.16,4.00±0.82 h).These pharmacokinetic parameters were consistent with the dissolution tests that the TMOP tablets had turned out to prolong the lag time of DIL release. | Tiegang Xin Yang Zhao Hengpan Jing Wenji Zhang Yunyun Gao Xinggang Yang Xukai Qu Weisan Pan | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，4： | 4 |
| 5 | Biomechanical research of joint III. An experimental biomechanical research on the Femur’s articular surface of knee of pongidae显示文摘 | Zhang Renxiang Lan Zuyun Qu Wenji | 1986 | Acta Mechanica Sinica1986，，2： | 1 |
| 6 | BIOMECHANICAL RESEARCH OF JOINT——Ⅲ. AN EXPERIMENTAL BIOMECHANICAL RESEARCH ON THE FEMUR’S ARTICULAR SURFACE OF KNEE OF PONGIDAE显示文摘 | Zhang Renxiang Lan Zuyun Qu Wenji Beijing University of Iron And Steel Technology | 1986 | Acta Mechanica Sinica1986，，02： | 1 |
| 7 | N^(6)-methyladenosine methyltransferase plays a role in hypoxic preconditioning partially through the interaction with lncRNA H19显示文摘N^(6)-methyladenosine(m6A),a m ethylation in the N6 position of adenosine especially in the mRNA,exerts diverse physiological and pathological functions.However,the precise role of m 6A methylation in hypoxic preconditioning(HPC)is still unknown.Here,we observed that HPC treatm ent protected H9c2 cells against H2O2-induced injury,upregulated the m 6A level in the total RNA and the expression of methyltransferase like 3(METTL3),methyltransferase like 14(METTL14),and long noncoding RNA(lncRNA)H19.Either knockdown of METTL3 or METTL14 notably reversed the HPC-induced enhancement of cell viability,anti-apoptosis ability,and H19 expression.M ethylated RNA im m unoprecipitation(IP)indicated that knockdown of METTL3 or METTL14 decreased m 6A level in the lncRNA H19.Gain-of-function assay dem onstrated that H19 overexpression could partially rescue the decreased protection mediated by METTL3 or METTL14 knockdown in HPCtreated H9c2 cells.RNA binding protein im m unoprecipitation(RIP)assay showed that METTL3 and METTL14 could directly bind w ith H19.Our study identified a novel pattern of posttranscriptional regulation in HPC treatm ent.Since METTL3,METTL14,and lncRNA H19 were involved in HPC protection,they could be considered as potential biomarkers and therapeutic targets in HPC-derived cardiac rehabilitation and therapeutic approaches. | Yamin Su Rongfeng X u Rui Zhang Yangyang Qu Wenjie Zuo Zhenjun Ji Haihua Geng Min Pan Genshan Ma | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 1 |
| 8 | Isoforsythiaside, an antioxidant and antibacterial phenylethanoid glycoside isolated from Forsythia suspensa显示文摘 | Huanhuan Qu Yongmin Zhang Xiaoyun Chai Wenji Sun | 2011 | Bioorganic Chemistry2011，，： | 1 |
| 9 | Simple Vanilla Derivatives for Long-Lived Room-Temperature Polymer Phosphorescence as Invisible Security Inks显示文摘Developing novel long-lived room-temperature polymer phosphorescence(RTPP)materials could significantly expand their application scope.Herein,a series of RTPP materials based on eight simple vanilla derivatives for security ink application are reported.Attributed to strong mutual hydrogen bonding with polyvinyl alcohol(PVA)matrix,vanilla-doped PVA films exhibit ultralong phosphorescence emission under ambient conditions observed by naked eyes,where methyl vanillate shows the longest emission time up to 7 s.Impressively,when vanilla-doped PVA materials are utilized as invisible security inks,and the inks not only present excellent luminescent emission stability under ambient conditions but also maintain perfect reversibility between room temperature and 65℃ for multiple cycles.Owing to the unique RTPP performance,an advanced anticounterfeiting data encoding/reading strategy based on handwriting technology and complex pattern steganography is developed. | Yongfeng Zhang Zhonghao Wang Yan Su Yan Zheng Wenji Tang Chaolong Yang Hailong Tang Lunjun Qu Youbing Li Yanli Zhao | 2021 | Research2021，，1： | 1 |
| 10 | Organosilicon-group-derived silica-ionogel electrolyte for lithium ion batteries显示文摘In order to avoid leakage problem caused by liquid electrolyte, a new ionogel electrolyte was developed by in situ immobilizing organosilicon-functionalized ionic liquid within a nanoporous silica matrix. The ionic liquid evenly coats on the surface of porous silica and fills in the silica framework pores with no strong chemical interaction.The ionogel electrolyte has the dual advantages of a silica solid support and a wide electrochemical stability window of ionic liquid(4.87 V vs. Li^+/Li). The half-cells assembled with this electrolyte and LiFePO_4 electrode have excellent performance at room temperature and 60 ℃. The Li/SiO_2-IGE/LiFePO_4 cell displays a discharge capacity of 129.1 mAh·g^(-1) after 200 charge/discharge cycles at room temperature. | YueJiao Li Cui Guo LuShan Yue WenJie Qu Nan Chen YuJuan Dai RenJie Chen Feng Wu | 2018 | Rare Metals2018，37，6： | 1 |
| 11 | Tissue distribution comparison between healthy and fatty liver rats after oral administration of hawthorn leaf extract 显示文摘 | YIN Jingjing QU Jianguo ZHANG Wenjie | 2014 | Biomedical Chromatography2014，28，5： | 1 |
| 12 | Tissue distribution comparison between healthy and fatty liver rats after oral administration of hawthorn leaf extract显示文摘 | Jingjing Yin Jianguo Qu Wenjie Zhang Dongrui Lu Yucong Gao Xixiang Ying Tingguo Kang | 2014 | Biomed. Chromatogr2014，，： | 1 |
| 13 | Effects of wind speed,underlying surface,and seed morphological traits on the secondary seed dispersal in the Tengger Desert,China显示文摘The maintenance of sand-fixing vegetation is important for the stability of artificial sand-fixing systems in which seed dispersal plays a key role.Based on field wind tunnel experiments using 11 common plant species on the southeastern edge of the Tengger Desert,China,we studied the secondary seed dispersal in the fixed and semi-fixed sand dunes as well as in the mobile dunes in order to understand the limitations of vegetation regeneration and the maintenance of its stability.Our results indicated that there were significant variations among the selected 11 plant species in the threshold of wind speed(TWS).The TWS of Caragana korshinskii was the highest among the 11 plant species,whereas that of Echinops gmelinii was the lowest.Seed morphological traits and underlying surface could generally explain the TWS.During the secondary seed dispersal processes,the proportions of seeds that did not disperse(no dispersal)and only dispersed over short distance(short-distance dispersal within the wind tunnel test section)were significantly higher than those of seeds that were buried(including lost seeds)and dispersed over long distance(long-distance dispersal beyond the wind tunnel test section).Compared with other habitats,the mobile dunes were the most difficult places for secondary seed dispersal.Buried seeds were the easiest to be found in the semi-fixed sand dunes,whereas fixed sand dunes were the best sites for seeds that dispersed over long distance.The results of linear mixed models showed that after controlling the dispersal distance,smaller and rounder seeds dispersed farther.Shape index and wind speed were the two significant influencing factors on the burial of seeds.The explanatory power of wind speed,underlying surface,and seed morphological traits on the seeds that did not disperse and dispersed over short distance was far greater than that on the seeds that were buried and dispersed over long distance,implying that the processes and mechanisms of burial and long-distance dispersal are more complex.In summary,most seeds in the study area either did not move,were buried,or dispersed over short distance,promoting local vegetation regeneration. | QU Wenjie ZHAO Wenzhi YANG Xinguo WANG Lei ZHANG Xue QU Jianjun | 2024 | Journal of Arid Land2024，16，4： | 0 |
| 14 | Spatiotemporal characteristics of seed rain and soil seed bank of artificial Caragana korshinskii Kom. forest in the Tengger Desert, China显示文摘Vegetation restoration and reconstruction are effective approaches to desertification control and achieving social and economic sustainability in desert areas.However,the self-succession ability of native plants during the later periods of vegetation restoration remains unclear.Therefore,this study was conducted to bridge the knowledge gap by investigating the regeneration dynamics of artificial forest under natural conditions.The information of seed rain and soil seed bank was collected and quantified from an artificial Caragana korshinskii Kom.forest in the Tengger Desert,China.The germination tests were conducted in a laboratory setting.The analysis of species quantity and diversity in seed rain and soil seed bank was conducted to assess the impact of different durations of sand fixation(60,40,and 20 a)on the progress of vegetation restoration and ecological conditions in artificial C.korshinskii forest.The results showed that the top three dominant plant species in seed rain were Echinops gmelinii Turcz.,Eragrostis minor Host.,and Agropyron mongolicum Keng.,and the top three dominant plant species in soil seed bank were E.minor,Chloris virgata Sw.,and E.gmelinii.As restoration period increased,the density of seed rain and soil seed bank increased first and then decreased.While for species richness,as restoration period increased,it gradually increased in seed rain but decreased in soil seed bank.There was a positive correlation between seed rain density and soil seed bank density among all the three restoration periods.The species similarity between seed rain or soil seed bank and aboveground vegetation decreased with the extension of restoration period.The shape of the seeds,specifically those with external appendages such as spines and crown hair,clearly had an effect on their dispersal,then resulting in lower seed density in soil seed bank.In addition,precipitation was a crucial factor in promoting rapid germination,also resulting in lower seed density in soil seed bank.Our findings provide valuable insights for guiding future interventions during the later periods of artificial C.korshinskii forest,such as sowing and restoration efforts using unmanned aerial vehicles. | SHEN Jianxiang WANG Xin WANG Lei WANG Jiahui QU Wenjie ZHANG Xue CHANG Xuanxuan YANG Xinguo CHEN Lin QIN Weichun ZHANG Bo NIU Jinshuai | 2024 | Journal of Arid Land2024，16，4： | 0 |
| 15 | Biocrust-induced partitioning of soil water between grass and shrub in a desert steppe of Northwest China显示文摘Maintaining the stability of exotic sand-binding shrub has become a large challenge in arid and semi-arid grassland ecosystems in northern China.We investigated two kinds of shrublands with different BSCs(biological soil crusts)cover in desert steppe in Northwest China to characterize the water sources of shrub(Caragana intermedia Kuang et H.C.Fu)and grass(Artemisia scoparia Waldst.et Kit.)by stable 18O isotopic.Our results showed that both shrublands were subject to persistent soil water deficiency from 2012 to 2017,the minimum soil depth with CV(coefficient of variation)<15% and SWC(soil water content)<6% was 1.4 m in shrubland with open areas lacking obvious BSC cover,and 0.8 m in shrubland covered by mature BSCs.For C.intermedia,a considerable proportion of water sources pointed to the surface soil.Water from BSCs contributed to averages 22.9%and 17.6%of the total for C.intermedia and A.scoparia,respectively.C.intermedia might use more water from BSCs in rainy season than dry season,in contrast to A.scoparia.The relationship between shrub(or grass)and soil water by δ^(18)O shown significant differences in months,which partly verified the potential trends and relations covered by the high variability of the water source at seasonal scale.More fine roots at 0-5 cm soil layer could be found in the surface soil layer covered by BSCs(8000 cm/m^(3))than without BSCs(3200 cm/m^(3)),which ensured the possibility of using the surface soil water by C.intermedia.The result implies that even under serious soil water deficiency,C.intermedia can use the surface soil water,leading to the coexistence between C.intermedia and A.scoparia.Different with the result from BSCs in desert areas,the natural withdrawal of artificial C.intermedia from desert steppe will be a long-term process,and the highly competitive relationship between shrubs and grasses also determines that its habitat will be maintained in serious drought state for a long time. | YANG Xinguo WANG Entian QU Wenjie WANG Lei | 2023 | Journal of Arid Land2023，15，1： | 0 |
| 16 | Quadruple-band metamaterial absorber based on the cuboid dielectric particles显示文摘In this work,a quadruple-band dielectric metamaterial absorber(MMA)was proposed and studied,which is composed of eight cuboid dielectric particles and a metallic ground plate.When electromagnetic wave is incident on the dielectric particles,dielectric particles act as resonators and produce abundant resonant modes,which can result in perfect absorption.In simulation,four absorption peaks are observed at 9.13,9.62,10.0 and 10.46 GHz with 88%,89%,100%and 96%,respectively.By adjusting geometry parameters of the dielectric particles,dielectric MMAs with different bands can be obtained.Further investigation shows that the absorption peaks can be changed by increasing the permittivity of the dielectric.Based on the designing technique of using simple cuboid dielectric particles directly acting as resonator,this work provides a simple method to construct multiband alldielectric MMA. | Wenjie Wang Mingde Feng Jun Wang Zhiqiang Li Jiafu Wang Hua Ma Shaobo Qu | 2018 | Journal of Advanced Dielectrics2018，8，4： | 0 |
| 17 | A survey of public needs for government information service in libraries显示文摘Purpose:This paper describes a comprehensive user survey carried out in China to investigate public needs for government information service in libraries.It is expected to provide insights into the ways to help public libraries meet the user needs.Design/methodology/approach:The paper is founded on a survey among library users,librarians and non-library users.Paper questionnaires were distributed in the National Library of China and 32 provincial public libraries in China and electronic questionnaires were sent to non-library users.A total of 909 valid questionnaires were collected.Findings:A lot of attention is paid to policies,laws and regulations relating to common people's work and lives such as science,technology,education,culture,finance,market supervision,health care,sports,urban construction and environment protection.A wide variety of government information resources is needed and information delivered to users shall be accurate and timely.Internet has become the main means of accessing government information and mobile phones the preferred Web access channel,while printed materials are considered important information sources.Users need assistance and training in the use of library information resources and services.Research limitations:The sample was limited to respondents from provincial-level public libraries,but city and county-level library users were not included.Practical implications:The survey results are beneficial for the Chinese public libraries to design service programs and improve their services.Originality/value:The paper is one of the comprehensive surveys on public needs for government information service in the Chinese libraries and some of die findings will be of wider interest for other libraries. | Yunpeng QU Huiwei LIANG Lei SA Yumei XU Wenjie DUN Rongrong ZHAO Qiuhui CHEN | 2014 | Chinese Journal of Library and Information Science2014，，1： | 0 |
| 18 | Switchable chiral mirror based on PIN diodes显示文摘Chiral mirrors can produce spin selective absorption for left-handed circularly polarized(LCP) or right-handed circularly polarized(RCP) waves. However, the previously proposed chiral mirror only absorbs the designated circularly polarized(CP) wave in the microwave frequency band, lacking versatility in practical applications.Here, we propose a switchable chiral mirror based on a pair of PIN diodes. The switchable chiral mirror has four working states, switching from the handedness-preserving mirror to the LCP mirror, RCP mirror, and perfect absorber. The basis of these advances is to change the chirality of two-dimensional(2D) chiral metamaterials and the circular conversion dichroism related to it, which is the first report in the microwave frequency band.Surface current distributions shed light on how switchable chiral mirrors work by handedness-selective excitation of reflective and absorbing electric dipole modes. Energy loss distributions verify the working mechanism. The thickness of the switchable chiral mirror is one-tenth of the working wavelength, which is suitable for integrated manufacturing. The measurement results are in good agreement with the simulation results. | ZHIBIAO ZHU ZHE QIN HE WANG LIXIN JIANG YONGFENG LI WENJIE WANG HONGYA CHEN JIAFU WANG YONGQIANG PANG SHAOBO QU | 2023 | Photonics Research2023，11，7： | 0 |
| 19 | Studies on Pollen Viability in Sweet Sorghum induced by Carbon Ion Beam Irradiation显示文摘 | Liu Ruiyuan Dong Xicun Li Wenjian Jin Wenjie He Jinyu Qu Ying | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 20 | Effect on Meiosis of Pollen Mother Cells in Sweet Sorghum induced by Carbon Ion Beam Irradiation显示文摘 | Liu Ruiyuan Dong Xicun Li Wenjian Jin Wenjie He Jinyu Qu Ying | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
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