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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Predictors of Mitral Regurgitation Recurrence in Patients With Heart Failure Undergoing Mitral Valve Annuloplasty显示文摘 | Agnieszka Ciarka Jerry Braun Victoria Delgado Michel Versteegh Eric Boersma Robert Klautz Robert Dion Jeroen J. Bax Nico Van de Veire | 2010 | The American Journal of Cardiology2010，，： | 1 |
| 3 | Impact of parental emotional support and coercive control on adolescents’ self-esteem and psychological distress: Results of a four-year longitudinal study显示文摘 | Anne-Marie Boudreault-Bouchard Jacinthe Dion Jennifer Hains Jill Vandermeerschen Luc Laberge Michel Perron | 2013 | Journal of Adolescence2013，，4： | 1 |
| 4 | TG1050,an immunotherapeutic to treat chronic hepatitis B,induces robust T cells and exerts an antiviral effect in HBVpersistent mice显示文摘 | Martin P Dubois C Jacquier E Dion S ManciniBourgine M Godon O Kratzer R Lelu-Santolaria K Evlachev A Meritet J F Schlesinger Y Villeval D Strub J M Van Dorsselaer A Marchand J B Geist M Brandely R Findeli A Boukhebza H Menguy T Silvestre N Michel M L InchauspéG | 2015 | Gut2015，64，12： | 1 |
| 5 | HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase显示文摘 | Lise Rivière Laetitia Gerossier Aurélie Ducroux Sarah Dion Qiang Deng Marie-Louise Michel Marie-Annick Buendia Olivier Hantz Christine Neuveut | 2015 | Journal of Hepatology2015，，5： | 1 |
| 6 | Tricuspid annuloplasty prevents right ventricular dilatation and progression of tricuspid regurgitation in patients with tricuspid annular dilatation undergoing mitral valve repair显示文摘 | Nico R. Van de Veire Jerry Braun Victoria Delgado Michel I.M. Versteegh Robert A. Dion Robert J.M. Klautz Jeroen J. Bax | 2011 | The Journal of Thoracic and Cardiovascular Surgery2011，，6： | 1 |
| 7 | Prevalence and Antimicrobial Resistance of Salmonella Isolated from Broiler Farms, Chicken Carcasses, and Street-Vended Restaurants in Casamance, Senegal显示文摘 | Dione Michel M Ieven Margareta Garin Beno?t Marcotty Tanguy Geerts Stanny | 2009 | Journal of Food Protection2009，，11： | 1 |
| 8 | Preoperative left ventricular dimensions predict reverse remodeling following restrictive mitral annuloplasty in ischemic mitral regurgitation ☆显示文摘 | Jerry Braun Jeroen J. Bax Michel I.M. Versteegh Pieter G. Voigt Eduard R. Holman Robert J.M. Klautz Eric Boersma Robert A.E. Dion | 2005 | European Journal of Cardio-Thoracic Surgery2005，，： | 1 |
| 9 | What is corruption corrupting? A philo- sophical viewpoint显示文摘 | MICHEL DION | 2010 | Journal of Money Laundering Con- trol2010，13，1： | 1 |
| 10 | Expanding access to hepatitis C virus treatment—Extension for Community Healthcare Outcomes (ECHO) project: Disruptive innovation in specialty care显示文摘 | Sanjeev Arora Summers Kalishman Karla Thornton Denise Dion Glen Murata Paulina Deming Brooke Parish John Brown Miriam Komaromy Kathleen Colleran Arthur Bankhurst Joanna Katzman Michelle Harkins Luis Curet Ellen Cosgrove Wesley Pak | 2010 | Hepatology2010，，3： | 1 |
| 11 | MRI to Evaluate Left Atrial and Ventricular Reverse Remodeling After Restrictive Mitral Annuloplasty in Dilated Cardiomyopathy显示文摘 | Jos J.M. Westenberg Rob J. van der Geest Hildo J. Lamb Michel I.M. Versteegh Jerry Braun Joost Doornbos Albert de Roos Ernst E. van der Wall Robert A.E. Dion Johan H.C. Reiber Jeroen J. Bax | 2005 | 2005 (9 Su)2005，，9： | 1 |
| 12 | Ochratoxin A induces abnormal tryptophan metabolism in the intestine and liver to activate AMPK signaling pathway显示文摘Background Ochratoxin A(OTA)is a mycotoxin widely present in raw food and feed materials and is mainly pro-duced by Aspergillus ochraceus and Penicillium verrucosum.Our previous study showed that OTA principally induces liver inflammation by causing intestinal flora disorder,especially Bacteroides plebeius(B.plebeius)overgrowth.However,whether OTA or B.plebeius alteration leads to abnormal tryptophan-related metabolism in the intestine and liver is largely unknown.This study aimed to elucidate the metabolic changes in the intestine and liver induced by OTA and the tryptophan-related metabolic pathway in the liver.Materials and methods A total of 30 healthy 1-day-old male Cherry Valley ducks were randomly divided into 2 groups.The control group was given 0.1 mol/L NaHCO3 solution,and the OTA group was given 235μg/kg body weight OTA for 14 consecutive days.Tryptophan metabolites were determined by intestinal chyme metabolomics and liver tryptophan-targeted metabolomics.AMPK-related signaling pathway factors were analyzed by Western blot-ting and mRNA expression.Results Metabolomic analysis of the intestinal chyme showed that OTA treatment resulted in a decrease in intesti-nal nicotinuric acid levels,the downstream product of tryptophan metabolism,which were significantly negatively correlated with B.plebeius abundance.In contrast,OTA induced a significant increase in indole-3-acetamide levels,which were positively correlated with B.plebeius abundance.Simultaneously,OTA decreased the levels of ATP,NAD+and dipeptidase in the liver.Liver tryptophan metabolomics analysis showed that OTA inhibited the kynurenine metabolic pathway and reduced the levels of kynurenine,anthranilic acid and nicotinic acid.Moreover,OTA increased the phosphorylation of AMPK protein and decreased the phosphorylation of mTOR protein.Conclusion OTA decreased the level of nicotinuric acid in the intestinal tract,which was negatively correlated with B.plebeius abundance.The abnormal metabolism of tryptophan led to a deficiency of NAD+and ATP in the liver,which in turn activated the AMPK signaling pathway.Our results provide new insights into the toxic mechanism of OTA,and tryptophan metabolism might be a target for prevention and treatment. | Weiqing Ma Yang Fu Shanshan Zhu Daiyang Xia Shuangshuang Zhai Deqin Xiao Yongwen Zhu Michel Dione Lukuyu Ben Lin Yang Wence Wang | 2023 | Journal of Animal Science and Biotechnology2023，14，6： | 0 |
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