|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Acupuncture preconditioning protects hippocampal neurons from transient ischemia/reperfusion injury显示文摘The present study established a model of brain ischemia in aged rats using four-vessel occlusion.We observed hippocampal CA1 neuronal apoptosis and apoptosis-mediated protease caspase-3 expression following preconditioning of electroacupuncture at Baihui(GV 20).Our results showed that the number of hippocampal CA1 normal neurons was decreased,and degenerated neurons were increased 12 hours to 3 days following cerebral ischemia/reperfusion.The number of hippocampal CA1 apoptotic neurons and caspase-3-positive neurons in rats with cerebral ischemia/reperfusion injury was significantly decreased following acupuncture preconditioning.Acupuncture preconditioning protects aged rats against ischemia/reperfusion injury by regulating caspase-3 protein expression. | Mingshan Wang Haipeng Zhou Fei Shi Shilong Ma Yanlin Bi Yuqiu Liu Hong Liu Haiou Li | 2011 | Neural Regeneration Research2011，6，15： | 12 |
| 2 | Identifying changes in the wheat kernel proteome under heat stress using iTRAQ显示文摘Wheat(Triticum aestivum L.) is one of the three major global food crops. Hightemperature stress can affect its yield and quality. Studies of the effect of hightemperature stress on wheat kernel development are important because they can reveal the stability of wheat quality and lead to the genetic improvement of wheat quality traits. In this study, the isobaric tags for relative and absolute quantitation(iTRAQ)method was adopted to analyze changes in the protein expression profile of wheat cultivars under high temperature stress. The protein content of wheat grain increased under heat stress, while the SDS-sedimentation value and starch content decreased.Grain filling was deficient under high temperature stress, which reduced thousandkernel weight but did not affect wheat kernel length. The 207 differentially expressed proteins identified in Gaocheng 8901 under heat stress were associated with energy metabolism, growth and development, and stress response. Gene Ontology enrichment analysis showed that the annotated proteins that were differentially expressed in Gaocheng 8901 under heat stress were involved mainly in stimulus response, abiotic stress response, stress response, and plasma membrane. A set of 78 differentially expressed proteins were assigned to 83 KEGG signaling/metabolic pathways. KEGG pathway enrichment analysis showed that this set of proteins was significantly enriched in members of 51 pathways, and the proteins participated mainly in protein synthesis in the endoplasmic reticulum, starch and sucrose metabolism, and reaction on ribosomes. Five differentially expressed proteins were involved in protein–protein interaction networks that may greatly influence the yield and quality of wheat grain. In wheat, high-temperature stress leads to a variety of effects on protein expression and may ultimately cause changes in yield and quality. | Yufeng Zhang Hongyao Lou Dandan Guo Ruiqi Zhang Meng Su Zhenghong Hou Haiying Zhou Rongqi Liang Chaojie Xie Mingshan You Baoyun Li | 2018 | The Crop Journal2018，6，6： | 5 |
| 3 | Effects of Huatan Tongluo decoction on vascular endothelial growth factor receptor 2 expression in synovial tissues of rats with collagen-induced arthritis显示文摘OBJECTIVE: To determine the therapeutic effect and potential mechanism of Huatan Tongluo decoction on rats with collagen-induced arthritis.METHODS: Forty specific pathogen-free Wistar rats were selected, and 10 were randomly selected as the control(group 1). The remaining rats were injected intradermally with emulsified type Ⅱ bovine collagen at the tail base and back, followed by a booster 7 d post first immunization. After establishing collagen-induced arthritis(CIA), rats were randomly divided into three groups(n = 10). The rats were treated orally for 30 d as follows: group 1, saline; group 2, model(saline); group 3, tripterygium polyglycoside(TP; 7.81 mg/kg, positive control);group 4, Huatan Tongluo decoction(HTTL; 7.5 g/kg). Body weight, ankle swelling and arthritis index were measured over the course of the study. The rats were sacrificed 30 d after treatment. Morphological changes in the synovium were observed by hematoxylin and eosin staining. Pannus formation and synovial thickness in the left ankle were observed by color Doppler ultrasoundVascular endothelial growth factor(VEGF) and VEGFR2 protein levels were measured by immunohistochemistry.VEGF/VEGFR2 mRNA levels were measured by real-time quantitative polymerase chain reaction.RESULTS: Compared with the model group, a significantly lower arthritis index was observed in the positive control group(P < 0.05) and HTTL group(P < 0.01), after treatment. Both positive control and HTTL reduced intra-articular pannus formation and synovial thickening. Furthermore, VEGF mRNA,and VEGFR2 protein and mRNA levels were significantly downregulated(P < 0.05) in the treatment groups.CONCLUSION: Inhibition of the expression of VEGF and VEGFR2 in synovial tissues and the formation of pannus and synovial hyperplasia may be part of the mechanism of HTTL for relieving the symptoms of rheumatoid arthritis in CIA rats. | Chen Jinchun Qiu Mingshan Li Yihan Zhang Qian Zhang Yiyan Lin Shuangjie Zhang Shaohong Qian Lixia Gao Hai Li Liang-cheng | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 4 |
| 4 | Direct gas-phase epoxidation of propylene to propylene oxide using air as oxidant on supported gold catalyst显示文摘在 2-SiO2, 和 ZrO 2-SiO2 支持的 SiO 2, TiO 2, TiO 上支持的金催化剂被与 tetrachloroauric 酸的基本溶液使每支持妊娠准备。X 光检查衍射(XRD ) ,传播电子显微镜学(TEM ) ,和 X 光检查光电子光谱学(XPS ) 技术被用来描绘他们的结构和表面作文。结果显示金粒子的尺寸能被控制到在由准备的这个方法的 10 nm 下面。有水的洗的金催化剂能显著地在表面上提高金属性的金粒子的分散,但是它不能完全移开氯化物离子留在表面上。在这些催化剂上把空气用作氧化剂的丙烯的直接蒸汽阶段 epoxidation 的催化表演在气压被评估。到丙烯氧化物(PO ) 的选择被发现在溪流上与反应时间变化。以空气压力的反应条件,温度 325 ° C,喂煤气的比率 V (C 3 H 6)/V (O 2)=½
,和 GHSV = 6000 h −1, 有 0.9% 丙烯的 17.9% PO 选择变换被获得在起始为 Au/SiO 2 的 10 min 催化剂。在反应以后 60 min 8.9% 仅仅 PO 选择被检测,但是丙烯变换升起到 1.4% 并且主要产品被转移到丙烯醛(72% 选择) 。因为更小的金粒子被获得,有镁柠檬酸盐答案的洗的 Au/TiO 2-SiO2 和 Au/ZrO 2-SiO2 样品能显著地提高这项活动和 PO 选择。 | Zhanghuai Suo Mingshan Jin Jiqing Lu Zhaobin Wei Can Li | 2008 | Journal of Natural Gas Chemistry2008，17，2： | 4 |
| 5 | Two-dimensional TiO_(2)(001)nanosheets as an effective photo-assisted recyclable sensor for the electrochemical detection of bisphenol A显示文摘Electrochemical detection is an efficient method for the detection of Bisphenol A(BPA).Herein,a sensitive photo-electrochemical sensor based on two-dimensional(2 D)TiO_(2)(001)nanosheets was fabricated and then used for BPA electrochemical detection.Upon light irradiation,the 2 D TiO_(2)(001)nanosheets electrode provided a lower detection limit of BPA detection compared with an ambient electrochemical determination.The low detection limit is^5.37 nmol/L(S/N=3).Furthermore,profiting from the photoelectric characteristics,the 2 D TiO_(2)(001)nanosheets electrode exhibits a nice regeneration prope rty.After 45 min of light irradiation,the electrochemical signal was regenerated from14.7%to 82.9%of the original signal at the 6th cycle.This is attributed to the non-selective·OH mediation produced by the 2 D TiO_(2)(001)nanosheets mineralizing anodic polymeric products and resuming surface reactive sites.This investigation indicates that photo-assistance is an efficient method to improve the electrochemical sensor for detecting BPA in water environments. | Sujuan Hu Yingjian Yu Yu Guan Yanhuan Li Baoling Wang Mingshan Zhu | 2020 | Chinese Chemical Letters2020，31，10： | 3 |
| 6 | Palladium-Catalyzed Tandem Carbonylative Aza-Wacker-Type Cyclization of Nucleophile Tethered Alkene to Access Fused N-Heterocycles显示文摘Although tandem reactions offer rapid access to structurally complex molecules in one-pot reaction,the selectivity issue needs to be addressed particularly when incompatible step reactions are involved.Herein,we report the selective synthesis of fused N-heterocycles from nucleophile-tethered alkenylamide and carbon monoxide via palladium(Pd)-catalyzed tandem carbonylative aza-Wacker-type cyclization.The electron-deficient nature of amide N—H and the intramolecular coordination of Pd with alkene accelerate the aminopalladation and effectively prevent the side oxidative carbonylation of diamine moiety to form urea.It is also found that the reported acyl Pd chloride intermediate may not be involved in this tandem cyclization.This work not only provides an efficient synthetic route to fused 1,4-diazepanones and 1,4-diazepanes but also inspires further development of tandem reactions for the diverse synthesis of heterocycles. | Lijun Shi Mingshan Wen Fuwei Li | 2021 | Chinese Journal of Chemistry2021，39，2： | 2 |
| 7 | Protective effects of protocatechuic acid on acute lung injury induced by lipopolysaccharide in mice via p38MAPK and NF-κB signal pathways显示文摘 | Xiuli Zhang Chunli Li Jun Li Yingzhen Xu Shui Guan Mingshan Zhao | 2015 | International Immunopharmacology2015，，1： | 1 |
| 8 | TaMADS29 interacts with TaNF-YB1 to synergistically regulate early grain development in bread wheat显示文摘Grain development is a crucial determinant of yield and quality in bread wheat(Triticum aestivum L.).However,the regulatory mechanisms underlying wheat grain development remain elusive.Here we report how Ta MADS29 interacts with Ta NF-YB1 to synergistically regulate early grain development in bread wheat.The tamads29 mutants generated by CRISPR/Cas9 exhibited severe grain filling deficiency,coupled with excessive accumulation of reactive oxygen species(ROS)and abnormal programmed cell death that occurred in early developing grains,while overexpression of Ta MADS29 increased grain width and1,000-kernel weight.Further analysis revealed that Ta MADS29 interacted directly with Ta NF-YB1;null mutation in Ta NF-YB1caused grain developmental deficiency similar to tamads29 mutants.The regulatory complex composed of Ta MADS29 and Ta NF-YB1 exercises its possible function that inhibits the excessive accumulation of ROS by regulating the genes involved in chloroplast development and photosynthesis in early developing wheat grains and prevents nucellar projection degradation and endosperm cell death,facilitating transportation of nutrients into the endosperm and wholly filling of developing grains.Collectively,our work not only discloses the molecular mechanism of MADS-box and NF-Y TFs in facilitating bread wheat grain development,but also indicates that caryopsis chloroplast might be a central regulator of grain development rather than merely a photosynthesis organelle.More importantly,our work offers an innovative way to breed high-yield wheat cultivars by controlling the ROS level in developing grains. | Guoyu Liu Runqi Zhang Sen Li Rehmat Ullah Fengping Yang Zihao Wang Weilong Guo Mingshan You Baoyun Li Chaojie Xie Liangsheng Wang Jie Liu Zhongfu Ni Qixin Sun Rongqi Liang | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 9 | Transcriptome analysis of wheat grain using RNA-Seq显示文摘With the increase in consumer demand,wheat grain quality improvement has become a focus in China and worldwide.Transcriptome analysis is a powerful approach to research grain traits and elucidate their genetic regulation.In this study,two cDNA libraries from the developing grain and leaf-stem components of bread wheat cultivar,Nongda211,were sequenced using Roche/454 technology.There were 1061274 and 1516564 clean reads generated from grain and leaf-stem,respectively.A total of 61393 high-quality unigenes were obtained with an average length of 1456 bp after de novo assembly.The analysis of the 61393 unigenes involved in the biological processes of the grain showed that there were 7355 differentially expressed genes upregulated in the grain library.Gene ontology enrichment and the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that many transcription products and transcription factors associated with carbohydrate and protein metabolism were abundantly expressed in the grain.These results contribute to excavate genes associated with wheat quality and further study how they interact. | Liu WEI Zhihui WU Yufeng ZHANG Dandan GUO Yuzhou XU Weixia CHEN Haiying ZHOU Mingshan YOU Baoyun LI | 2014 | Frontiers of Agricultural Science and Engineering2014，1，3： | 1 |
| 10 | Phase noise floor suppression of the output carrier from double sideband-carrier suppressed modulation system显示文摘A theoretical model of all the influencing factors on the phase noise floor of the output carrier from the double sideband-carrier suppressed (DSB-CS) modulation system is presented. Based on the established DSB-CS modulation system with different cases, the phase noise of the input carrier and the output doubled frequency carrier is measured and calculated using the theoretical model, respectively. The calculation results basically agree with the measurement results. It is shown that the phase noise floor of the output carrier is primarily influenced by the signal-spontaneous beat noise and the relative intensity noise (RIN) of the laser. So the phase noise floor of the output carrier can be minimized by choosing the laser with low RIN and the EDFA with low noise factor. | LUO Xin HAN XiuYou GU YiYing LI ShanFeng & ZHAO MingShan | 2011 | Science China(Information Sciences)2011，54，6： | 1 |
| 11 | Stress corrosion cracking behaviors of RE-containing ME21 magnesium alloy processed by equal-channel angular pressing显示文摘A commercial as-cast ME21 magnesium alloy containing rare-earth (RE) element was processed by equalchannel angular pressing to obtain fine-grained micro structure. Stress corrosion cracking (SCC) behaviors of the fine-grained samples were studied by slow-strain-rate testing in air, distilled water and Hanks’solution at the strain rate of 1×10^(-6) s^(-1). All samples show a relatively low SCC sensitivity in distilled water but a great SCC tendency in Hanks’ solution. The microscopic observations of the fracture surfaces and the side surfaces reveal obvious active anodic dissolution and hydrogen embrittlement cracks, which indicate the higher SCC susceptibility in Hanks'solution. The fine-grained microstructure with more crystal defects promotes the passivation process of the oxide film and restrains the hydrogen induced cracking of the ME21 magnesium alloy, leading to the higher general corrosion resistance as well as SCC resistance. | Jinghua Jiang Qiuyuan Xie Mingshan Qiang Aibin Ma Evans-Kwesi Taylor Yuhua Li Dan Song Jianqing Chen | 2019 | Journal of Rare Earths2019，37，1： | 1 |
| 12 | Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease(Tg2576)显示文摘Cajal-Retzius cells are reelin-secreting neurons in the marginal zone of the neocortex and hippocampus.The aim of this study was to investigate Cajal-Retzius cells in Alzheimer's disease pathology.Results revealed that the number of Cajal-Retzius cells markedly reduced with age in both wild type and in mice over-expressing the Swedish double mutant form of amyloid precursor protein 695(transgenic(Tg) 2576 mice).Numerous reelin-positive neurons were positive for activated caspase 3 in Tg2576 mice,suggesting that Cajal-Retzius neuronal loss occurred via apoptosis in this Alzheimer's disease model.Compared with wild type,the number of Cajal-Retzius cells was significantly lower in Tg2576 mice.Western blot analysis confirmed that reelin levels were markedly lower in Tg2576 mice than in wild-type mice.The decline in Cajal-Retzius cells in Tg2576 mice was found to occur concomitantly with the onset of Alzheimer's disease amyloid pathology and related behavioral deficits.Overall,these data indicated that Cajal-Retzius cell loss occurred with the onset and development of Alzheimer's disease. | Dongming Yu Wenjuan Fan Ping Wu Jiexin Deng Jing Liu Yanli Niu Mingshan Li Jinbo Deng | 2014 | Neural Regeneration Research2014，9，4： | 1 |
| 13 | Serial Sectioning Method in the Construction of 3-D Microstructures for Particle-reinforced MMCs显示文摘 | Li Mingshan Somnath Ghosh Thomas Rouns N | 1998 | Materials Characterization1998，41，： | 1 |
| 14 | Sessile droplet freezing and ice adhesion on aluminum with different surface wettability and surface temperature显示文摘This paper focused on the sessile droplet freezing and ice adhesion on aluminum with different wettability(hydrophilic, common hydrophobic, and superhydrophobic surfaces, coded as HIS, CHS, SHS, respectively) over a surface temperature range of ?9°C to ?19°C. It was found that SHS could retard the sessile droplet freezing and lower the ice adhesion probably due to the interfacial air pockets(IAPs) on water/SHS interface. However, as surface temperature decreasing, some IAPs were squeezed out and such freezing retarding and adhesion lowering effect for SHS was reduced greatly. For a surface temperature of ?19°C, ice adhesion on SHS was even greater than that on CHS. To discover the reason for the squeezing out of IAPs, forces applied to the suspended water on IAPs were analyzed and it was found that the stability of IAPs was associated with surface micro-structures and surface temperature. These findings might be helpful to designing of SHS with good anti-icing properties. | OU JunFei SHI QingWen WANG ZhiLe WANG FaJun XUE MingShan LI Wen YAN GuiLong | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，7： | 1 |
| 15 | Serial sectioning method in the construction of 3-D microstructures for particle-reinforced MMCs显示文摘 | MINGSHAN LI SOMNATH GHOSH THOMAS N | 1998 | Materials Characterization1998，41，： | 1 |
| 16 | Synthesis and characterization of partly fluorinated poly(phthalazinone ether)s crosslinked by allyl group for passive optical waveguides显示文摘 | Guanghui Li Jinyan Wang Guipeng Yu Xigao Jian Linghua Wang Mingshan Zhao | 2010 | Polymer2010，，6： | 1 |
| 17 | AIl-fiber ultrafast thulium-doped fiber ring laser with dissipative soliton and noise-like output in normal dispersion by single-wall carbon nanotubes显示文摘 | Qingqing Wang Tong Chen Mingshan Li | 2013 | Appl Phys Lett2013，103，01： | 1 |
| 18 | A fast and adaptive method for complex-valued SAR image denoising based on l_k norm regularization显示文摘This paper developed a fast and adaptive method for SAR complex image denoising based on lk norm regularization, as viewed from parameters estimation. We firstly establish the relationship between denoising model and ill-posed inverse problem via convex half-quadratic regularization, and compare the difference between the estimator variance obtained from the iterative formula and biased Cramer-Rao bound, which proves the theoretic flaw of the existent methods of parameter selection. Then, the analytic expression of the model solution as the function with respect to the regularization parameter is obtained. On this basis, we study the method for selecting the regularization parameter through minimizing mean-square error of estimators and obtain the final analytic expression, which resulted in the direct calculation, high processing speed, and adaptability. Finally, the effect of regularization parameter selection on the resolution of point targets is analyzed. The experiment results of simulation and real complex-valued SAR images illustrate the validity of the proposed method. | WANG WeiWei WANG ZhengMing YUAN ZhenYu LI MingShan | 2009 | Science in China(Series F)2009，52，1： | 1 |
| 19 | Effects of Boscalid on the Antioxidant Enzyme System of Adult Zebrafish (Danio rerio)显示文摘[Objective] This study was conducted to evaluate the ecotoxicity of boscalid to adult zebrafish(Danio rerio). [Method]The activities of antioxidant enzymes superoxide dismutase(SOD), catalase(CAT), peroxidase(POD), glutathione peroxidase(GPx), as well as a non-enzymatic antioxidant malondialdehyde(MDA), in the liver were measured 3, 7, 14 and 21 d post exposure(dpe) to 0.02(1/100 of acute toxicity), 0.036(monitored concentration), 0.08(1/20 of acute toxicity), 0.16(1/10 of acute toxicity) and 0.32 mg/L(1/5 of acute toxicity) boscalid using a semi-static method. [Result] SOD, CAT, POD, GPx and MDA activity in the liver of zebrafish varied with boscalid concentration and exposure time. Boscalid significantly enhanced MDA content at 21 dpe. A significant upregulation of the activity of SOD, CAT, POD and GPx at 7 dpe was observed, suggesting that boscalid resulted in oxidative stress and lipid peroxidation. [Conclusion] These results show that these biomarkers are all appropriate for monitoring oxidative stress and the lipid peroxidation status of fish after exposure to boscalid. | Xiaoxia ZANG Mingshan JI Kai WANG Xiuwei LI Yang ZHANG Xinghai LI Hongzhe TIAN He ZHU Fang DU | 2017 | Agricultural Science & Technology2017，18，2： | 0 |
| 20 | Development of the cerebellar cortex in the mouse显示文摘The cerebellum is a highly conserved structure in the central nervous system of vertebrates,and is involved in the coordination of voluntary motor behavior.Supporting this function,the cerebellar cortex presents a layered structure which requires precise spatial and temporal coordination of proliferation,migration,differentiation,and apoptosis events.The formation of the layered structure in the developing cerebellum remains unclear.The present study investigated the development of the cerebellar cortex.The results demonstrate that the primordium of the cerebellum comprises the ependymal,mantle,and marginal layers at embryonic day 12(E12).Subsequently,the laminated cerebellar cortex undergoes cell proliferation,differentiation,and migration,and at about postnatal day 0(P0),the cerebellar cortex presents an external granular layer,a molecular layer,a Purkinje layer,and an internal granular layer.The external granular layer is thickest at P6/7 and disappears at P20.From P0 to P30,the internal granular cells and the Purkinje cells gradually differentiate and develop until maturity.Apoptotic neurons are evident in the layered structure in the developing cerebellar cortex.The external granular layer disappears gradually because of cell migration and apoptosis.The cells of the other layers primarily undergo differentiation,development,and apoptosis. | Xiangshu Cheng Jin Du Dongming Yu Qiying Jiang Yanqiu Hu Lei Wang Mingshan Li Jinbo Deng | 2011 | Neural Regeneration Research2011，6，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员