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1High salt primes a specific activation state of macrophages, M(Na)显示文摘Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan 2015Cell Research2015,25,8:15
2Toward emerging gallium oxide semiconductors:A roadmap显示文摘Owing to the advantages of ultra-wide bandgap and rich material systems,gallium oxide(Ga_(2)O_(3))has emerged as a highly viable semiconductor material for new researches.This article mainly focuses on the growth processes,material characteristics,and applications of Ga_(2)O_(3).Compared with single crystals and the epitaxial growth of other wide-bandgap semiconductors,large-size and high-quality��-Ga_(2)O_(3) single crystals can be efficiently grown with a low cost,making them highly competitive.Thanks to the availability of high-quality single crystals,epi-taxial films,and rich material systems,high-performance semiconductor devices based on Ga_(2)O_(3) go through a booming development in recent years.The defects and interfaces of Ga_(2)O_(3) are comprehensively analyzed owing to their significant influence on practical applications.In this study,the two most common applications of Ga_(2)O_(3) materials are introduced.The high breakdown electric field,high working temperature,and excellent Baliga’s figure-of-merit of Ga_(2)O_(3) represent an inspiring prospect for power electronic devices.In addition,the excellent absorption in deep-ultraviolet band provides new ideas for optoelectronic detectors and ensures the dramatic progress.Finally,the summary,challenges,and prospects of the Ga_(2)O_(3) materials and devices are presented and discussed.Yuan Yuan Weibing Hao Wenxiang Mu Zhengpeng Wang Xuanhu Chen Qi Liu Guangwei Xu Chenlu Wang Hong Zhou Yanni Zou Xiaolong Zhao Zhitai Jia Jiandong Ye Jincheng Zhang Shibing Long Xutang Tao Rong Zhang Yue Hao 2021Fundamental Research2021,1,6:5
3Study on performance degradation and failure analysis of machine gun barrel显示文摘An increase in the use of the gun barrel will cause wear of the inner wall,which reduces the muzzle velocity and the spin rate of the projectile.The off-bore flight attitude and trajectory of the projectile also change,affecting the shooting power and the accuracy.Exterior ballistic data of a high-speed spinning projectile are required to study the performance change.Therefore,based on the barrel’s accelerated life test,the whole process of projectile shooting is reproduced using numerical simulation technology,and key information on the ballistic performance change at each shooting stage are acquired.Studies have shown that in the later stages of barrel shooting,the accuracy of shooting has not decreased significantly.However,it is found that the angle of attack of the projectile increases as the wear of the barrel increases.The maximum angle of attack reaches 0.106 rad when the number of shots reaches 4300.Meanwhile,elliptical bullet hole has appeared on the target at this shooting stage.Through combining external ballistic theory with simulation results,the primary reason of this phenomenon is found to be a significant decrease in the muzzle spin rate of the projectile.At the end of the barrel life,the projectile muzzle spin rate is 57.5%lower than that of a barrel without wear.Xiaolong Li Lei Mu Yong Zang Qin Qin 2020Defence Technology(防务技术)2020,16,2:4
4Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors.Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang 2022Cell Research2022,32,11:2
5Synthesis,Characterization of Rare-Earth Metal Chlorides Bearing Indolyl-Based NCN Pincer Ligand and Their Catalytic Activity toward 1,4-cis Polymerization of Isoprene显示文摘A novel indolyl-based NCN pincer ligand precursor HL(HL=(1-(2-(CH_(2))_(4)NCH_(2)CH_(2))-3-(2,6-ipr_(2)C_(6)H_(3)N=CH)C_(8)H_(5)N))was rationally and precisely designed,and successfully prepared in a high yield.Lithiation of HL with ^(n)BuLi in n-hexane,followed by treatment with RECl_(3) in THF led to the isolation of rare-earth metal chlorides in monomeric form(κ^(3)-L)RECI_(2)(THF)(RE=Sc(2),Yb(3)),and dimeric form[(κ^(3)-L)RECI(THF)(μ-Cl)]_(2)(RE=Er(4),Y(5))bearing the novel indolyl-based NCN pincer ligand in designed pincer ligation depending on different metal ionic radii;and the chloride bridged rare-earth metal and lithium mixed complexes in form(κ^(2)-L)_(2)RE(μ-Cl)_(2)Li(THF)_(2)(RE=Y(6),Dy(7)).All complexes were fully characterized and their structures were determined.The diamagnetic complexes 2,5 and 6 were furtherly characterized by the NMR spectroscopic method.The catalytic activity studies revealed that the central metal ions,borates,aluminum alkyls,and ligation of the central metal ions have influences on catalytic activity,and regio-and stereoselectivity for the polymerization of isoprene.With cooperation of the cocatalysts,the pincer-type yttrium chloride 5 initiated the isoprene polymerization with a high activity producing polymers with high regio-and stereoselectivity(1,4-cis polymers up to 99.6%),and the Mn as high as 8.76×10^(5).Zeming Huang Shaowu Wang Xiancui Zhu Yun Wei Qingbing Yuan Shuangliu Zhou Xiaolong Mu Hua Wang 2021Chinese Journal of Chemistry2021,39,12:2
6Research Advancements in Key Technologies for Space-Based Situational Awareness显示文摘The space environment has become highly congested due to the increasing space debris,seriously threatening the safety of orbiting spacecraft.Space-based situational awareness,as a comprehensive capability of threat knowledge,analysis,and decision-making,is of significant importance to ensure space security and maintain normal order.Various space situational awareness systems have been designed and launched.Data acquisition,target recognition,and monitoring constituting key technologies make major contributions,and various advanced algorithms are explored as technical supports.However,comprehensive reviews of these technologies and specific algorithms rarely emerge.It disadvantages the future development of space situational awareness.Therefore,this paper further reviews and analyzes research advancements in key technologies for space situational awareness,emphasizing target recognition and monitoring.Many mature and emerging methods are presented for these technologies while discussing application advantages and limitations.Specially,the research prospects of multiagent and synergetic constellation technologies are expected for future situational awareness.This paper indicates the future directions of the key technologies,aiming to provide references for space-based situational awareness to realize space sustainability.Beichao Wang Shuang Li Jinzhen Mu Xiaolong Hao Wenshan Zhu Jiaqian Hu 2022Space(Science & Technology)2022,,1:1
7Molecular grafting towards high-fraction active nanodots implanted in N-doped carbon for sodium dual-ion batteries显示文摘Sodium-based dual-ion batteries(Na-DIBs) show a promising potential for large-scale energy storage applications due to the merits of environmental friendliness and low cost.However,Na-DIBs are generally subject to poor rate capability and cycling stability for the lack of suitable anodes to accommodate large Na+ ions.Herein,we propose a molecular grafting strategy to in situ synthesize tin pyrophosphate nanodots implanted in N-doped carbon matrix(SnP_(2)O_(7)@N-C),which exhibits a high fraction of active SnP_(2)O_(7) up to 95.6 wt% and a low content of N-doped carbon(4.4 wt%) as the conductive framework.As a result,this anode delivers a high specific capacity400 mAh g^(-1) at 0.1 A g^(-1),excellent rate capability up to 5.0 A g^(-1) and excellent cycling stability with a capacity retention of 92% after 1200 cycles under a current density of1.5 A g^(-1).Further,pairing this anode with an environmentally friendly KS6 graphite cathode yields a SnP_(2)O_(7)@N-C||KS6 Na-DIB,exhibiting an excellent rate capability up to 30 C,good fast-charge/slow-discharge performance and long-term cycling life with a capacity retention of96% after 1000 cycles at 20 C.This study provides a feasible strategy to develop high-performance anodes with high-fraction active materials for Na-based energy storage applications.Sainan Mu Qirong Liu Pinit Kidkhunthod Xiaolong Zhou Wenlou Wang Yongbing Tang 2021National Science Review2021,8,7:1
8Stereolithography 3D printing of ceramic cores for hollow aeroengine turbine blades显示文摘Hollow superalloy or single-crystal superalloy turbine blades are the most important component of advanced aeroengines for fifth-and higher-generation fighter aircrafts [1,2,3]. The thrust-toweight ratio is largely influenced by the turbine inlet temperature,which places strict requirements on the performance of the turbine blades at high operating temperatures [4]. To reduce the operating temperature of the blades, complex internal cooling structures are required. However, the fabrication of complex cooling channels inside the blades is an unquestionably challenging task [5].Xiaolong An Yahang Mu Jingjing Liang Jinguo Li Yizhou Zhou Xiaofeng Sun 2022Journal of Materials Science & Technology2022,,32:1
9A novel reconfiguration strategy for active distribution network considering maximum power supply capability 显示文摘LIANG Wei JIN Xiaolong MU Yunfei 2014Applied Mechanics and Materials2014,448,:1
10A novel recon- figuration strategy for active distribution network consid- ering maximum power supply capability显示文摘Liang Wei Jin Xiaolong Mu Yunfei 2014Applied Me- chanics and Materials2014,,:1
11Synthesis, structure, and catalytic activity of rare-earth metal amides with a neutral pyrrolyl-functionalized indolyl ligand显示文摘The reactions of neutral pyrrolyl-functionalized indole with rare-earth metal amides [(Me3Si)2N]3RE(μ-Cl)Li(THF)3 produced the rare-earth metal complexes [(Me3Si)2N]2RE([η1:μ-η2-3-(2-(N–CH3)C4H3NCH=N–CH2CH2)C8H5N])(μ-Cl)Li(THF)(RE = Er, Y) having indolyl ligand η1 bonded to rare-earth metal ion and η2 bonded to lithium ion. The catalytic activities of these lanthanide amido complexes for addition of terminal alkynes to aromatic nitriles were explored. Results reveal that these complexes displayed a good catalytic activity for the addition reaction under mild conditions.YANG Song ZHU XianCui ZHOU ShuangLiu WANG ShaoWu FENG ZhiJun WEI Yun MIAO Hui GUO LiPing WANG FenHua ZHANG GuangChao GU XiaoXia MU XiaoLong 2014Science China Chemistry2014,57,8:1
12In-situ construction of amorphous/crystalline contact Bi_(2)S_(3)/Bi_(4)O_(7) heterostructures for enhanced visible-light photocatalysis显示文摘Constructing a heterojunction photocatalyst is a significant method to enhance photocatalytic activity because it can promote the separation of photogene rated carriers.Herein,amorphous/crystalline contact Bi_(2)S_(3)/Bi_(4)0_(7) heterostructure was successfully synthesized by in-situ sulfidation of Bi407.The amorphous Bi_(2)S_(3) is diffused on the surface of Bi_(4)0_(7) rod,enhancing the visible light response and improving the transport of photogene rated carriers.Various characterizations confirm that the rapid separation of photogene rated carriers leads to increased photocatalytic performance.The optimized Bi_(2)S_(3)/Bi_(4)O_(7) heterostructure photocatalyst(BiS-0.15) exhibits the highest Cr(Ⅵ) reduction(0.01350 min^(-1)) and RhB oxidation(0.08011 min^(-1)) activity,which is much higher than that of pure Bi_(4)0_(7) and mixture under visible light irradiation.This work provides new insights into the construction of efficient novel photocatalysts.Feihu Mu Benlin Dai Wei Zhao Xiaofan Yang Xiaolong Zhao Xujing Guo 2021Chinese Chemical Letters2021,32,8:0
13Pure Detail Feature Extraction Network for Visible-Infrared Re-Identification显示文摘Cross-modality pedestrian re-identification has important appli-cations in the field of surveillance.Due to variations in posture,camera per-spective,and camera modality,some salient pedestrian features are difficult to provide effective retrieval cues.Therefore,it becomes a challenge to design an effective strategy to extract more discriminative pedestrian detail.Although many effective methods for detailed feature extraction are proposed,there are still some shortcomings in filtering background and modality noise.To further purify the features,a pure detail feature extraction network(PDFENet)is proposed for VI-ReID.PDFENet includes three modules,adaptive detail mask generation module(ADMG),inter-detail interaction module(IDI)and cross-modality cross-entropy(CMCE).ADMG and IDI use human joints and their semantic associations to suppress background noise in features.CMCE guides the model to ignore modality noise by generating modality-shared feature labels.Specifically,ADMG generates masks for pedestrian details based on pose estimation.Masks are used to suppress background information and enhance pedestrian detail information.Besides,IDI mines the semantic relations among details to further refine the features.Finally,CMCE cross-combines classifiers and features to generate modality-shared feature labels to guide model training.Extensive ablation experiments as well as visualization results have demonstrated the effectiveness of PDFENet in eliminating background and modality noise.In addition,comparison experi-ments in two publicly available datasets also show the competitiveness of our approach.Jiaao Cui Sixian Chan Pan Mu Tinglong Tang Xiaolong Zhou 2023Intelligent Automation & Soft Computing2023,37,8:0
14Establishment of a CouplingModel for the Prediction of Heat Dissipation of the Internal Combustion Engine Based on Finite Element显示文摘The aerodynamics and heat transfer performance in the rear-mounted automobile cabin have an important influence on the engine’s safety and the operational stability of the automobile.The article uses STARCCM and GT-COOL software to establish the 3D wind tunnel model and engine cooling system model of the internal combustion engine.At the same time,we established a 3D artificial coupling model through parameter transfer.The research results show that the heat transfer coefficient decreases with the increase of the comprehensive drag coefficient of the nacelle.This shows that the cabin flow field has an important influence on the heat transfer coefficient.Themainstream temperature rise of the engine room increases with the increase of the engine load.It is proved that vehicle speed affects the amount of heat dissipation of the engine room internal combustion engine under certain load conditions.The article provides a more effective and fast calculation method for the research on the heat dissipation of the internal combustion engine and the optimization of the cooling system equipment.Hongyu Mu Yinyan Wang Hong Teng Xingtian Zhao Xiaolong Zhang Yan Jin Shiyang Hao Jingfeng Zhao 2022Energy Engineering2022,119,3:0
15Marine target detection based on Marine-Faster R-CNN for navigation radar plane position indicator images显示文摘As a classic deep learning target detection algorithm,Faster R-CNN(region convolutional neural network)has been widely used in high-resolution synthetic aperture radar(SAR)and inverse SAR(ISAR)image detection.However,for most common low-resolution radar plane position indicator(PPI)images,it is difficult to achieve good performance.In this paper,taking navigation radar PPI images as an example,a marine target detection method based on the Marine-Faster R-CNN algorithm is proposed in the case of complex background(e.g.,sea clutter)and target characteristics.The method performs feature extraction and target recognition on PPI images generated by radar echoes with the convolutional neural network(CNN).First,to improve the accuracy of detecting marine targets and reduce the false alarm rate,Faster R-CNN was optimized as the Marine-Faster R-CNN in five respects:new backbone network,anchor size,dense target detection,data sample balance,and scale normalization.Then,JRC(Japan Radio Co.,Ltd.)navigation radar was used to collect echo data under different conditions to build a marine target dataset.Finally,comparisons with the classic Faster R-CNN method and the constant false alarm rate(CFAR)algorithm proved that the proposed method is more accurate and robust,has stronger generalization ability,and can be applied to the detection of marine targets for navigation radar.Its performance was tested with datasets from different observation conditions(sea states,radar parameters,and different targets).Xiaolong CHEN Xiaoqian MU Jian GUAN Ningbo LIU Wei ZHOU 2022Frontiers of Information Technology & Electronic Engineering2022,23,4:0
16Simulation Analysis of New Energy Vehicle Engine Cooling System Based on K-E Turbulent Flow Mathematical Model显示文摘New energy vehicles have better clean and environmental protection characteristics than traditional fuel vehicles.The new energy engine cooling technology is critical in the design of new energy vehicles.This paper used oneand three-way joint simulation methods to simulate the refrigeration system of new energy vehicles.Firstly,a k-εturbulent flow model for the cooling pump flow field is established based on the principle of computational fluid dynamics.Then,the CFD commercial fluid analysis software FLUENT is used to simulate the flow field of the cooling pump under different inlet flow conditions.This paper proposes an optimization scheme for new energy vehicle engines’“boiling”phenomenon under high temperatures and long-time climbing conditions.The simulation results show that changing the radiator’s structure and adjusting the thermostat’s parameters can solve the problem of a“boiling pot.”The optimized new energy vehicle engine can maintain a better operating temperature range.The algorithm model can reference each cryogenic system component hardware selection and control strategy in the new energy vehicle’s engine.Hongyu Mu Yinyan Wang Chuanlei Yang Hong Teng Xingtian Zhao Hongquan Lu Dechun Wang Shiyang Hao Xiaolong Zhang Yan Jin 2023Energy Engineering2023,120,10:0
17Catalytically active atomically thin cuprate with periodic Cu single sites显示文摘Rational design and synthesis of catalytically active two-dimensional(2D)materials with an abundance of atomically precise active sites in their basal planes remains a great challenge.Here,we report a ligand exchange strategy to exfoliate bulk[Cu_(4)(OH)_(6)][O_(3)S(CH_(2))_4SO_(3)]cuprate crystals into atomically thin 2D cuprate layers([Cu_(2)(OH)_(3)]^(+)).The basal plane of 2D cuprate layers contains periodic arrays of accessible unsaturated Cu(Ⅱ)single sites(2D-CuSSs),which are found to promote efficient oxidative Chan-Lam coupling.Our me chanistic studies reveal that the reactions proceed via coordinatively unsaturated CuO_4(Ⅰ)single sites with the formation of Cu(Ⅰ)species in the rate-limiting step,as corroborated by both operando experimental and theoretical studies.The robust stability of 2D-CuSSs in both batch and continuous flow reactions,coupled with their recyclability and good performance in complex molecule derivatization,render 2D-CuSSs attractive catalyst candidates for broad utility in fine chemical synthesis.Huimin Yang Shibo Xi Na Guo Mu Wang Lingmei Liu Pin Lyu Xiaolong Yu Jing Li Haomin Xu Xiao Hai Zejun Li Xinzhe Li Tao Sun Xiaoxu Zhao Yu Han Wei Yu Jie Wu Chun Zhang Honghan Fei Ming Joo Koh Jiong Lu 2023National Science Review2023,10,1:0
18A Time-Domain Comparator Based Skipping-Window SAR ADC显示文摘This paper presents an energy efficient successive-approximation register(SAR)analog-to-digital converter(ADC)for low-power applications.To improve the overall energy-efficiency,a skipping-window technique is used to bypass corresponding conversion steps when the input falls in a window indicated by a time-domain comparator,which can provide not only the polarity of the input,but also the amount information of the input.The timedomain comparator,which is based on the edge pursing principle,consists of delay cells,two NAND gates,two D-flip-flop register-based phase detectors and a counter.The digital characteristic of the comparator makes the design more flexible,and the comparator can achieve noise and power optimization automatically by simply adjusting the delay cell number.An energy efficient digital-to-analog converter(DAC)control scheme suitable for the skipping window technique is also developed to reduce the switching energy during SAR conversion.Together with the skipping-window technique,the linearity and the power consumption of the SAR ADC are improved.The impact of different window sizes on comparison cycles,DAC switching energy and the overall energy efficiency is analyzed.Simulation results show that the proposed skipping-window technique can improve the overall energy-efficiency of the SAR ADC,as well as the linearity,and the optimized window size for the overall energy efficiency will vary with the DAC switching energy.Liangbo Xie Yan Ren Mu Zhou Xiaolong Yang Zhengwen Huang 2021Computers, Materials & Continua2021,,11:0
19Method for Calculating the Ultimate Strength of Pitting Corrosion Ship Structural Plates Under Combined Loads显示文摘In order to solve the problem of calculating the ultimate strength of marine plate under pitting corrosion,the plate taking from marine with pitting corrosion was studied. Based on the data of pitting corrosion recorded,the concept of pitting corrosion characteristic element matrix was proposed to describe the distribution and the forms of pitting. Moreover,the model of sensitivity calculation was established to analyse the sensitivity of pitting corrosion characteristic elements for the ultimate bearing capacity of ship structural plate. A new approach was proposed to calculate the ultimate strength of pitting damaged ship structural plate under combined loads based on the factor of rigidity reduction. Simultaneously this new approach was proven to be validated by finite element simulation. Finally,formula of ultimate strength of pitting damaged ship hull plate was established by series of numerical calculations based on the approach,and the reliability of the formula was validated as well.Lin Hua Fan Wh Jinlei Mu Xiaolong Ma 2018Journal of Harbin Institute of Technology(New Series)2018,25,5:0
20Sleep Apnea Monitoring System Based on Commodity WiFi Devices显示文摘To address the limitations of traditional sleep monitoring methods that highly rely on sleeping posture without considering sleep apnea,an intelligent apnea monitoring system is designed based on commodity WiFi in this paper.By utilizing linear fitting and wavelet transform,the phase error of channel state information(CSI)of the receiving antenna is eliminated,and the noise of the signal amplitude is removed.Moreover,the short-time Fourier transform(STFT)and sliding window method are combined to segment received wireless signals.Finally,several important statistical characteristics are extracted,and a back propagation(BP)neural network model is built to identify apnea state.Thus,interferences caused by changes of sleeping posture are eliminated.Extensive experimental results demonstrate that the proposed system can identify apnea state with an accuracy of over 95.6%.Furthermore,the accuracy can still reach more than 94.8%when the test environment layout is changed.Therefore,the proposed system can be used as a daily apnea monitoring system at home and provide users with health information.Xiaolong Yang Xin Yu Liangbo Xie Hao Xue Mu Zhou Qing Jiang 2021Computers, Materials & Continua2021,,11:0
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