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| 1 | Synthesis of ordered mesoporous carbonaceous materials and their highly efficient capture of uranium from solutions显示文摘An extremely effortless method was applied for successful synthesis of mesoporous carbonaceous materials(MCMs) using well-ordered mesoporous silica as template. Various characterizations(scanning electron microscopy(SEM), transmission electron microscopy(TEM), X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FT-IR), Raman, X-ray photoelectron spectroscopy(XPS), Brunner-Emmet-Teller(BET) and Zeta potential) confirmed that MCMs had large surface area, uniform pore size distribution, and abundant oxygen-containing functional groups. The batch techniques were employed to study U(VI) adsorption on MCMs under a wide range of experiment conditions. The adsorption kinetics of U(VI) onto MCMs were well-fitted by pseudo-second-order kinetic model, indicating a chemisorption process. The excellent adsorption capacity of MCMs calculated from the Langmuir model was 293.95 mg g^(-1) at pH 4.0. The FT-IR and XPS analyses further evidenced that the binding of U(VI) onto MCMs was ascribed to the plentiful adsorption sites(–OH and –COOH groups) in the internal mesoporous structure, which could efficiently trap guest U(VI) ions. The results presented herein revealed that MCMs were ideal adsorbents in the efficient elimination of uranium or other lanthanides/actinides from aqueous solutions, which would play an important role in environmental pollution management application. | Chenlu Zhang Xing Li Zhongshan Chen Tao Wen Shuyi Huang Tasawar Hayat Ahmed Alsaedi Xiangke Wang | 2018 | Science China Chemistry2018，61，3： | 8 |
| 2 | Toward emerging gallium oxide semiconductors:A roadmap显示文摘Owing to the advantages of ultra-wide bandgap and rich material systems,gallium oxide(Ga_(2)O_(3))has emerged as a highly viable semiconductor material for new researches.This article mainly focuses on the growth processes,material characteristics,and applications of Ga_(2)O_(3).Compared with single crystals and the epitaxial growth of other wide-bandgap semiconductors,large-size and high-quality��-Ga_(2)O_(3) single crystals can be efficiently grown with a low cost,making them highly competitive.Thanks to the availability of high-quality single crystals,epi-taxial films,and rich material systems,high-performance semiconductor devices based on Ga_(2)O_(3) go through a booming development in recent years.The defects and interfaces of Ga_(2)O_(3) are comprehensively analyzed owing to their significant influence on practical applications.In this study,the two most common applications of Ga_(2)O_(3) materials are introduced.The high breakdown electric field,high working temperature,and excellent Baliga’s figure-of-merit of Ga_(2)O_(3) represent an inspiring prospect for power electronic devices.In addition,the excellent absorption in deep-ultraviolet band provides new ideas for optoelectronic detectors and ensures the dramatic progress.Finally,the summary,challenges,and prospects of the Ga_(2)O_(3) materials and devices are presented and discussed. | Yuan Yuan Weibing Hao Wenxiang Mu Zhengpeng Wang Xuanhu Chen Qi Liu Guangwei Xu Chenlu Wang Hong Zhou Yanni Zou Xiaolong Zhao Zhitai Jia Jiandong Ye Jincheng Zhang Shibing Long Xutang Tao Rong Zhang Yue Hao | 2021 | Fundamental Research2021，1，6： | 5 |
| 3 | Temperature-induced Lifshitz transition in topological insulator candidate HfTe_5显示文摘The ongoing discoveries and studies of novel topological quantum materials have become an emergent and important field of condensed matter physics.Recently,HfTe_5 ignited renewed interest as a candidate of a novel topological material.The single-layer HfTe_5 is predicted to be a two-dimensional large band gap topological insulator and can be stacked into a bulk that may host a temperature-driven topological phase transition.Historically,HfTe_5 attracted considerable interest for its anomalous transport properties characterized by a peculiar resistivity peak accompanied by a sign reversal carrier type.The origin of the transport anomaly remains under a hot debate.Here we report the first high-resolution laser-based angle-resolved photoemission measurements on the temperature-dependent electronic structure in HfTe_5.Our results indicated that a temperature-induced Lifshitz transition occurs in HfTe_5,which provides a natural understanding on the origin of the transport anomaly in HfTe_5.In addition,our observations suggest that HfTe_5 is a weak topological insulator that is located at the phase boundary between weak and strong topological insulators at very low temperature. | Yan Zhang Chenlu Wang Guodong Liu Aiji Liang Lingxiao Zhao Jianwei Huang Qiang Gao Bing Shen Jing Liu Cheng Hu Wenjuan Zhao Genfu Chen Xiaowen Jia Li Yu Lin Zhao Shaolong He Fengfeng Zhang Shenjin Zhang Feng Yang Zhimin Wang Qinjun Peng Zuyan Xu Chuangtian Chen Xingjiang Zhou | 2017 | Science Bulletin2017，62，13： | 4 |
| 4 | High CO_(2) absorption capacity of metal-based ionic liquids: A molecular dynamics study显示文摘The absorption of CO_(2)is of importance in carbon capture,utilization,and storage technology for greenhouse gas control.In the present work,we clarified the mechanism of how metal-based ionic liquids (MBILs),Bmim[XCl_(n)]_(m)(X is the metal atom),enhance the CO_(2)absorption capacity of ILs via performing molecular dynamics simulations.The sparse hydrogen bond interaction network constructed by CO_(2)and MBILs was identified through the radial distribution function and interaction energy of CO_(2)-ion pairs,which increase the absorption capacity of CO_(2)in MBILs.Then,the dynamical properties including residence time and self-diffusion coefficient confirmed that MBILs could also promote the diffusion process of CO_(2)in ILs.That's to say,the MBILs can enhance the CO_(2)absorption capacity and the diffusive ability simultaneously.Based on the analysis of structural,energetic and dynamical properties,the CO_(2)absorption capacity of MBILs increases in the order Cl^-→[ZnCl_(4)]^(2-)→[CuCl_(4)]^(2-)→[CrCl_(4)]^-→[FeCl_(4)]^-,revealing the fact that the short metal–Cl bond length and small anion volume could facilitate the performance of CO_(2)absorbing process.These findings show that the metal–Cl bond length and effective volume of the anion can be the effective factors to regulate the CO_(2)absorption process,which can also shed light on the rational molecular design of MBILs for CO_(2)capture and other key chemical engineering processes,such as IL-based gas sensors,nano-electrical devices and so on. | Biwen Li Chenlu Wang Yaqin Zhang Yanlei Wang | 2021 | Green Energy & Environment2021，6，2： | 3 |
| 5 | HSP70 alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial dysfunction-initiated NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes显示文摘Background:Sepsis-induced cardiomyopathy(SIC)is an identified serious complication of sepsis that is associated with adverse outcomes and high mortality.Heat shock proteins(HSPs)have been implicated in suppressing septic inflammation.The aim of this study was to investigate whether HSP70 can attenuate cellular mitochondrial dysfunction,exuberated inflammation and inflammasome-mediated pyroptosis for SIC intervention.Methods:Mice with cecal ligation plus perforation(CLP)and lipopolysaccharide(LPS)-treated H9C2 cardiomyocytes were used as models of SIC.The mouse survival rate,gross profile,cardiac function,pathological changes and mitochondrial function were observed by photography,echocardiography,hematoxylin-eosin staining and transmission electron microscopy.In addition,cell proliferation and the levels of cardiac troponin I(cTnI),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were determined by Cell Counting Kit-8,crystal violet staining and enzyme-linked immunosorbent assay.Moreover,mitochondrial membrane potential was assessed by immunofluorescence staining,and dynamin-related protein 1 and pyroptosis-related molecules[nucleotide-binding domain,leucine-rich-repeat containing family pyrin domain-containing 3(NLRP3),caspase-1,gasdermin-D(GSDMD),gasdermin-D N-terminal(GSDMD-N)]were measured by western blotting,immunoprecipitation and immunoblotting.Finally,hsp70.1 knockout mice with CLP were used to verify the effects of HSP70 on SIC and the underlying mechanism.Results:Models of SIC were successfully established,as reduced consciousness and activity with liparotrichia in CLP mice were observed,and the survival rate and cardiac ejection fraction(EF)were decreased;conversely,the levels of cTnI,TNF-αand IL-1βand myocardial tissue damage were increased in CLP mice.In addition,LPS stimulation resulted in a reduction in cell viability,mitochondrial destabilization and activation of NLRP3-mediated pyroptosis molecules in vitro.HSP70 treatment improved myocardial tissue damage,survival rate and cardiac dysfunction caused by CLP.Additionally,HSP70 intervention reversed LPS-induced mitochondrial destabiliza-tion,inhibited activation of the NLRP3 inflammasome,caspase-1,GSDMD and GSDMD-N,and decreased pyroptosis.Finally,knockout of hsp70.1 mice with CLP aggravated cardiac dysfunction and upregulated NLRP3 inflammasome activity,and exogenous HSP70 significantly rescued these changes.It was further confirmed that HSP70 plays a protective role in SIC by attenuating mitochondrial dysfunction and inactivating pyroptotic molecules.Conclusions:Our study demonstrated that mitochondrial destabilization and NLRP3 inflammasome activation-mediated pyroptosis are attributed to SIC.Interestingly,HSP70 ameliorates sepsis-induced myocardial dysfunction by improving mitochondrial dysfunction and inhibiting the acti-vation of NLRP3 inflammasome-mediated pyroptosis,and such a result may provide approaches for novel therapies for SIC. | Chenlu Song Yiqiu Zhang Qing Pei Li Zheng Meiyu Wang Youzhen Shi Shan Wu Wei Ni Xiujun Fu Yinbo Peng Wen Zhang Min Yao | 2022 | Burns & Trauma2022，10，1： | 2 |
| 6 | Coupled Tamm plasmon polaritons induced narrow bandpass filter with ultra-wide stopband显示文摘Narrow bandpass filters(NBPFs)play important roles in optics,such as quantum communication,spectrometer,and wavelength division multiplexing.However,the stopband and restraint ability of traditional NBPFs is limited.In this article,a coupled Tamm plasmon polaritons(TPPs)induced transmission theory has been proposed to design high-efficiency NBPFs with ultra-wide deep stopbands.An NBPF at 1.55 μm has been experimentally demonstrated with full width at half maximum(FWHM)of 10 nm and stopband ranging from 0.2 to 25 μm which is 62 times wider than that of traditional ones.Furthermore,the restraint depth of the stopband reaches 0.03%,which is only 1/20 of a traditional filter with the same FWHM.Its advantage in restraining ambient light over traditional ones has also been demonstrated with an InGaAs infrared detector.It provides a very powerful way to capture specific narrowband optical signals from ultra-wide strong ambient light,especially useful for daytime quantum communications. | Qingquan Liu Xinchao Zhao Chenlu Li Xinglei Zhou Yu Chen Shaowei Wang Wei Lu | 2022 | Nano Research2022，15，5： | 2 |
| 7 | Toripalimab in advanced biliary tract cancer显示文摘Gemcitabine combined with platinum/fluorouracil drugs is the standard firstline treatment for advanced biliary tract cancers(BTCs).We explored the safety and efficacy of toripalimab plus gemcitabine and S-1(GS)as the first-line treatment for advanced BTCs.At a one-sided significance level of 0.025,a total of 50 patients could provide 80%power to show the efficacy at targeted progression-free survival(PFS)rate at 6 months of 70%versus 40%for the combined treatment.This single-arm,phase II study enrolled 50 patients with advanced BTCs who previously received no systemic treatment.The regimen was as follows:toripalimab(240 mg,i.v.,d1),gemcitabine(1,000 mg/m2,i.v.,d1 and d8),and S-1(40–60 mg bid p.o.,d1–14,Q21d).The primary endpoint was progression-free survival.The secondary endpoints included overall survival(OS),objective response rate(ORR),duration of response(DOR),and safety.The associations between response with PDL1 expression,tumor mutational burden(TMB),and genetic variations were explored.Patients were enrolled from January 2019 to August 2020,with a median follow-up time of 24.0 months(IQR:4.3–31.0 months). | Wei Li Yueqi Wang Yiyi Yu Qian Li Yan Wang Chenlu Zhang Xiaojing Xu Xi Guo Yu Dong Yuehong Cui Qing Hao Lujia Huang Houbao Liu Tianshu Liu | 2022 | The Innovation2022，3，4： | 1 |
| 8 | Ufl1 deficiency causes kidney atrophy associated with disruption of endoplasmic reticulum homeostasis显示文摘The UFMylation modification is a novel ubiquitin-like conjugation system,consisting of UBA5(E1),UFC1(E2),UFL1(E3),and the conjugating molecule UFM1.Deficiency in this modification leads to embryonic lethality in mice and diseases in humans.However,the function of UFL1 is poorly characterized.Studies on Ufl1 conditional knockout mice have demonstrated that the deletion of Ufl1 in cardiomyocytes and in intestinal epithelial cells causes heart failure and increases susceptibility to experimentally induced colitis,respectively,suggesting an essential role of UFL1 in the maintenance of the homeostasis in these organs.Yet,its physiological function in other tissues and organs remains completely unknown.In this study,we generate the nephron tubules specific Ufl1 knockout mice and find that the absence of Ufl1 in renal tubular results in kidney atrophy and interstitial fibrosis.In addition,Ufl1 deficiency causes the activation of unfolded protein response and cell apoptosis,which may be responsible for the kidney atrophy and interstitial fibrosis.Collectively,our results have demonstrated the crucial role of UFL1 in regulating kidney function and maintenance of endoplasmic reticulum homeostasis,providing another layer of understanding kidney atrophy. | You Zhou Xifu Ye Chenlu Zhang Jiabao Wang Zeyuan Guan Juzhen Yan Lu Xu Ke Wang Di Guan Qian Liang Jian Mao Junzhi Zhou Qian Zhang Xiaoying Wu Miao Wang Yu-Sheng Cong Jiang Liu | 2021 | Journal of Genetics and Genomics2021，48，5： | 1 |
| 9 | Spin-coating derived LSM-SDC films with uniform pore structure显示文摘 | Fei Ye Zhicheng Wang Wenjian Weng Kui Cheng Chenlu Song Piyi Du Ge Shen Gaorong Han | 2007 | Thin Solid Films2007，，16： | 1 |
| 10 | 3-D RIGID PLASTIC FEM SIMULATION OF EXTRUDING-BULGING PROCESS OF TEE TUBES显示文摘1INTRODUCTIONTeetubesarewidelyappliedasimportantpipejunctionsinpipageinalkindsofindustrydepartments.Withthedevelopmentofindus... | Wang, Chenlu Shan, Debin Lu, Yan | 1999 | 中国有色金属学会会刊:英文版1999，9，2： | 1 |
| 11 | Synthetic Analogues of Betulinic Acid as Potent Inhibitors of PS1/BACE1 Interaction to Reduce Aβ Generation显示文摘lupane 类型 triterpenoids 被赋予以大量生物活动例如抗病毒,反煽动性并且 anticancer 活动。我们这里在 Alzheimers 描述它的潜在的申请疾病(广告) 治疗作为 PS1/BACE1 的一个禁止者相互作用。3-α-Akebonoic 酸,从高产量发出了屏蔽,被发现防碍 PS1/BACE1 相互作用和还原剂淀粉的 β-protein (Aβ) 生产。鉴于有限来源,当为铅优化和它的衍生物的一个集中的图书馆的开始的材料被构造获得 PS1/BACE1 相互作用的 triterpenoid 类型禁止者的结构活动关系(SAR ) 的更好的理解,我们相反使用了自然地富有的 betulinic 酸(化合物 2 ) 。化合物 22 最后被选择为大多数有势力 PS1/BACE1 相互作用禁止者,它有效地减少了 Aβ 产生。 | Chenlu Zhang Xiaoyin Wang Jin Cui Xiaohang Li Yangming Zhang Xin Wang Haifeng Gu Wei Li Xin Xie Jian Zhao Gang Pei Fajun Nan | 2017 | Chinese Journal of Chemistry2017，35，1： | 0 |
| 12 | Multilevel Characteristic Basis Function Method with ACA for Accelerated Solution of Electrically Large Scattering Problems显示文摘The multilevel characteristic basis function method(MLCBFM)with the adaptive cross approximation(ACA)algorithm for accelerated solution of electrically large scattering problems is studied in this paper.In the conventional MLCBFM based on Foldy-Lax multiple scattering equations,the improvement is only made in the generation of characteristic basis functions(CBFs).However,it does not provide a change in impedance matrix filling and reducing matrix calculation procedure,which is time-consuming.In reality,all the impedance and reduced matrix of each level of the MLCBFM have low-rank property and can be calculated efficiently.Therefore,ACA is used for the efficient generation of two-level CBFs and the fast calculation of reduced matrix in this study.Numerical results are given to demonstrate the accuracy and efficiency of the method. | Li Chenlu Sun Yufa Wang Zhonggen Wang Guohua | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，3： | 0 |
| 13 | Rbm8a regulates neurogenesis and reduces Alzheimer's disease-associated pathology in the dentate gyrus of 5×FAD mice显示文摘Alzheimer’s disease is a prevalent and debilitating neurodegenerative condition that profoundly affects a patient’s daily functioning with progressive cognitive decline,which can be partly attributed to impaired hippocampal neurogenesis.Neurogenesis in the hippocampal dentate gyrus is likely to persist throughout life but declines with aging,especially in Alzheimer’s disease.Recent evidence indicated that RNA-binding protein 8A(Rbm8a)promotes the proliferation of neural progenitor cells,with lower expression levels observed in Alzheimer’s disease patients compared with healthy people.This study investigated the hypothesis that Rbm8a overexpression may enhance neurogenesis by promoting the proliferation of neural progenitor cells to improve memory impairment in Alzheimer’s disease.Therefore,Rbm8a overexpression was induced in the dentate gyrus of 5×FAD mice to validate this hypothesis.Elevated Rbm8a levels in the dentate gyrus triggered neurogenesis and abated pathological phenotypes(such as plaque formation,gliosis reaction,and dystrophic neurites),leading to ameliorated memory performance in 5×FAD mice.RNA sequencing data further substantiated these findings,showing the enrichment of differentially expressed genes involved in biological processes including neurogenesis,cell proliferation,and amyloid protein formation.In conclusion,overexpressing Rbm8a in the dentate gyrus of 5×FAD mouse brains improved cognitive function by ameliorating amyloid-beta-associated pathological phenotypes and enhancing neurogenesis. | Chenlu Zhu Xiao Ren Chen Liu Yawei Liu Yonggang Wang | 2024 | Neural Regeneration Research2024，19，4： | 0 |
| 14 | GPIBase:A comprehensive resource for geminivirus-plant-insect research显示文摘Dear Editor,As one of the most widespread and destructive families of plant viruses,Geminiviridae,named for the twinned icosahedral particles of virus members in the family,poses a serious threat to agricultural production worldwide.Transmitted by various homopterans insects such as whiteflies,leafhoppers,aphids,and treehoppers,geminiviruses infect,in addition to wild plants,vegetable,root,and fiber crops,thus causing important losses around the globe(Hanley-Bowdoin et al.,2013;Li et al.,2022). | Yaqin Wang Yang Mei Chenlu Su Zuoqi Wang Fangfang Li Tao Hu Zhanqi Wang Shusheng Liu Fei Li Xueping Zhou | 2023 | Molecular Plant2023，16，4： | 0 |
| 15 | High photocatalytic activity over starfish-like La-doped ZnO/SiO_(2) photocatalyst for malachite green degradation under visible light显示文摘In this work,the unique starlike La-doped ZnO-SiO_(2) photocatalysts were constructed by an evaporation and calcination method and characterized in detail.UV-vis reflectance and DFT calculation confirm that the doping with La allows to obtain a decrease of band gap of ZnO/SiO_(2),which enhances visible light absorbance and oxidizing ability.The photoluminescence intensity reduces greatly,indicating more effective separation of the photo generated carriers of La-doped ZnO-SiO_(2).Photocatalytic activities of Ladoped ZnO-SiO_(2) with different doping ratios under simulated visible light irradiation were evaluated with malachite green(MG) as a model pollutant.Under optimized conditions including solution pH of 8,15 mg/L of MG solution and 15 mg of catalyst dosage,0.2% La-ZnO-SiO_(2) exhibits the best catalytic activity in photodegradations of MG in water.The removal and mineralization efficiency of MG can reach 96.1%and 70.9% in 140 min,respectively.The as-prepared catalysts present superior stability and recyclability after four times reuse.Moreover,selective quenching experiments indicate that hydroxyl radical(·OH),hole(h^(+)) and superoxide radical(·O_(2)^(-)) are the main reactive species responsible for MG degradation.Possible mechanism for photocatalytic elimination of MG over La-doped ZnO/SiO_(2) photocatalyst is finally proposed. | Shuo Wang Zhenke Chen Ying Zhao Chenlu Sun Jianye Li | 2021 | Journal of Rare Earths2021，39，7： | 0 |
| 16 | Quantitative analysis of coherent structures affecting instantaneous fluctuation of point-source plumes based on PIV-POD method显示文摘For an enclosed space like an industrial plant where devices and equipment generate a large amount of heat,the fluctuation characteristics of thermal plume become more crucial.This paper aims to study the unique air distribution of the point-source plume by shutting down all valves in a thermostatic chamber.250 consecutive instantaneous flow fields(in each zone)were measured by a two-dimensional particle image velocimetry(PIV)system at a sampling frequency of 3 Hz to quantify the air distribution of the plume.Based on the experimental data,the indoor instantaneous velocity and vorticity fields were analyzed,and the transient velocity fluctuation characteristics of typical points were discussed.The fluctuation periods of the plume at different heights were ini-tially estimated.Through the proper orthogonal decomposition(POD)analysis,the dominant coherent structures in complex instantaneous flow fields were excavated,and the turbulent kinetic energy of coherent structures was calculated.In addition,POD analysis provided a new method for validating and improving transient numerical simulation models. | Yukun Xu Xin Wang Fei Wang Bingyan Song Yujie Zhang Chenlu Shi | 2020 | Energy and Built Environment2020，1，2： | 0 |
| 17 | Integrated analysis of gut microbiome and host immune responses in COVID-19显示文摘Emerging evidence indicates that the gut microbiome contributes to the host immune response to infectious diseases.Here,to explore the role of the gut microbiome in the host immune responses in COVID-19,we conducted shotgun metagenomic sequencing and immune profiling of 14 severe/critical and 24 mild/moderate COVID-19 cases as well as 31 healthy control samples.We found that the diversity of the gut microbiome was reduced in severe/critical COVID-19 cases compared to mild/moderate ones.We identified the abundance of some gut microbes altered post-SARS-CoV-2 infection and related to disease severity,such as Enterococcus faecium,Coprococcus comes,Roseburia intestinalis,Akkermansia ntuciniphila,Bacteroides cellulosilyticus and Blautia obeum.We further analyzed the correlation between the abundance of gut microbes and host responses,and obtained a correlation map between clinical features of COVID-19 and 16 severity-related gut microbe,including Coprococcus comes that was positively correlated with CD3^(+)/CD4^(+)/CD8^(+)lymphocyte counts.In addition,an integrative analysis of gut microbiome and the transcriptome of peripheral blood mononuclear cells(PBMCs)showed that genes related to viral transcription and apoptosis were up-regulated in Coprococcus comes low samples.Moreover,a number of metabolic pathways in gut microbes were also found to be differentially enriched in severe/critical or mild/moderate COVID-19 cases,including the superpathways of polyamine biosynthesis II and sulfur oxidation that were suppressed in severe/critical COVID-19.Together,our study highlighted a potential regulatory role of severity related gut microbes in the immune response of host. | Xiaoguang Xu Wei Zhang Mingquan Guo Chenlu Xiao Ziyu Fu Shuting Yu Lu Jiang Shengyue Wang Yun Ling Feng Liu Yun Tan Saijuan Chen | 2022 | Frontiers of Medicine2022，16，2： | 0 |
| 18 | Lamellar water induced quantized interlayer spacing of nanochannels walls显示文摘The nanoscale confinement is of great important for the industrial applications of molecular sieve,desalination,and also essential in bio-logical transport systems.Massive efforts have been devoted to the influence of restricted spaces on the properties of confined fluids.However,the situation of channel-wall is crucial but attracts less attention and remains unknown.To fundamentally understand the mechanism of channel-walls in nanoconfinement,we investigated the interaction between the counter-force of the liquid and interlamellar spacing of nanochannel walls by considering the effect of both spatial confinement and surface wettability.The results reveal that the nanochannel stables at only a few discrete spacing states when its confinement is within 1.4 nm.The quantized interlayer spacing is attributed to water molecules becoming laminated structures,and the stable states are corresponding to the monolayer,bilayer and trilayer water configurations,respectively.The results can potentially help to understand the characterized interlayers spacing of graphene oxide membrane in water.Our findings are hold great promise in design of ion filtration membrane and artificial water/ion channels. | Yue Zhang Chenlu Wang Chunlei Wang Yingyan Zhang Junhua Zhao Ning Wei | 2024 | Green Energy & Environment2024，9，2： | 0 |
| 19 | Programmed polymersomes with spatio-temporal delivery of antigen and dual-adjuvants for efficient dendritic cells-based cancer immunotherapy显示文摘Since antigen and adjuvant are rapid clearance in vivo,insufficient delivery to induce dendritic cells(DCs)maturation and cross-presentation,as well as limited migration efficiency of DCs to secondary lymph organs,greatly hinders the development of DCs-based immunotherapy.Herein,PCL-PEG-PCL polymersomes(PCEP-PS)as antigen and adjuvants delivery nanoplatforms(IMO-PS)were well-designed,which can electrostatically adsorb OVA antigen on the surface via DOTAP lipid and effectively encapsulate OVA antigen into the inner hydrophilic cavity to achieve both initial antigen exposure as well as slow and sustained antigen release,incorporate MPLA within the lipid layer to ligate with extracellular TLR4 of DCs as well as encapsulate IMQ in the hydrophobic membrane to ligate with intracellular TLR7/8 of DCs for activating synergistic immune responses via different signaling pathways.The IMO-PS significantly improved antigen uptake,promoted DCs maturation and cytokines production.DCs treated with IMO-PS could enhance migration into draining lymphoid nodes,and eventually induced antigen-specific CD8+and CD4+T cell responses and OVA-specific cytotoxic T lymphocyte(CTL)responses.Prophylactic vaccination of EG7-OVA tumor-bearing mice by IMO-PS+DCs significantly extended tumor-free time,effectively suppressed tumor growth,and greatly extended median survival time.The strategy may provide an effective nanoplatform for co-delivery antigen and dual-adjuvants in a spatio-temporally programmed manner for DC-based cancer immunotherapy. | Hanyong Wang Xinyu Yang Chunyan Hu Chenlu Huang Hai Wang Dunwan Zhu Linhua Zhang | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 20 | The complete and fully-phased diploid genome of a male Han Chinese显示文摘Since the release of the complete human genome,the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity.Here,we present a fully phased and well-annotated diploid human genome from a Han Chinese male individual(CN1),in which the assemblies of both haploids achieve the telomere-to-telomere(T2T)level.Comparison of this diploid genome with the CHM13 haploid T2T genome revealed significant variations in the centromere.Outside the centromere,we discovered 11,413 structural variations,including numerous novel ones.We also detected thousands of CN1 alleles that have accumulated high substitution rates and a few that have been under positive selection in the East Asian population.Further,we found that CN1 outperforms CHM13 as a reference genome in mapping and variant calling for the East Asian population owing to the distinct structural variants of the two references.Comparison of SNP calling for a large cohort of 8869 Chinese genomes using CN1 and CHM13 as reference respectively showed that the reference bias profoundly impacts rare SNP calling,with nearly 2 million rare SNPs miss-called with different reference genomes.Finally,applying the CN1 as a reference,we discovered 5.80 Mb and 4.21 Mb putative introgression sequences from Neanderthal and Denisovan,respectively,including many East Asian specific ones undetected using CHM13 as the reference.Our analyses reveal the advances of using CN1 as a reference for population genomic studies and paleo-genomic studies.This complete genome will serve as an alternative reference for future genomic studies on the East Asian population. | Chentao Yang Yang Zhou Yanni Song Dongya Wu Yan Zeng Lei Nie Panhong Liu Shilong Zhang Guangji Chen Jinjin Xu Hongling Zhou Long Zhou Xiaobo Qian Chenlu Liu Shangjin Tan Chengran Zhou Wei Dai Mengyang Xu Yanwei Qi Xiaobo Wang Lidong Guo Guangyi Fan Aijun Wang Yuan Deng Yong Zhang Jiazheng Jin Yunqiu He Chunxue Guo Guoji Guo Qing Zhou Xun Xu Huanming Yang Jian Wang Shuhua Xu Yafei Mao Xin Jin Jue Ruan Guojie Zhang | 2023 | Cell Research2023，33，10： | 0 |
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