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| 1 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 2 | Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses显示文摘Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses.However,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed analysis.Administration of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of GVHD.Immunization with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO mice.Immunization with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO mice.Adoptive cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T cells.ACTs using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be evaluated.Therefore,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice. | Tomonori Yaguchi Asuka Kobayashi Takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio Takashi Iwata Yuyo Ka Ikumi Katano Ryoji Ito Mamoru Ito Yutaka Kawakami | 2018 | Cellular & Molecular Immunology2018，15，11： | 6 |
| 3 | Reevaluation of postoperative radiotherapy for thoracic esophageal carcinoma显示文摘 | Michinori Yamamoto Takashi Yamashita Toshiki Matsubara Tadashi Kitahara Kenji Sekiguchi Masahiko Furukawa Akiyoshi Uki Masao Kobayashi Emiko Tanaka Mamoru Ueda Toshifusa Nakajima | 1997 | International Journal of Radiation Oncology Biology Physics1997，，1： | 1 |
| 4 | Helicobacter pylori and Mucosal Atrophy in Patients with Gastric Cancer (A Special Study Regarding the Methods for Detecting Helicobacter pylori)显示文摘 | Hisahiko Tabata Tadahiko Fuchigami Hiroyuki Kobayashi Yuji Sakai Mamoru Nakanishi Kaoru Tomioka Shotaro Nakamura Masatoshi Fujishima | 1999 | Digestive Diseases and Sciences1999，，10： | 1 |
| 5 | IL-10 plays a crucial role for the protection of experimental cerebral malaria by co-infection with non-lethal malaria parasites显示文摘 | Mamoru Niikura Shigeru Kamiya Akio Nakane Kiyoshi Kita Fumie Kobayashi | 2009 | International Journal for Parasitology2009，，1： | 1 |
| 6 | Development and Manufacturing System of Alloy 690 for PWR Steam Generator Tubing显示文摘 | Nagano Hiroo Yamanaka Kazuo Kobayashi Kenichi Inoue Mamoru | 1988 | Sumitomo Metals1988，40，4： | 1 |
| 7 | Development of the environment friendly hybrid permeable concrete pavement显示文摘 | Mamoru Kagata Takayoshi Kodama | 2002 | Transactions of the Japan Concrete Institute2002，23，： | 1 |
| 8 | Development of the environment friendly hybrid permeable concrete pavement 显示文摘 | Tetsuo Kobayashi Mamoru Kagata Takayoshi Kodama | 2001 | Concrete Journal2001，39，3： | 1 |
| 9 | Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats显示文摘 | Ian Fukudome Michiya Kobayashi Ken Dabanaka Hiromichi Maeda Ken Okamoto Takehiro Okabayashi Ryoko Baba Nana Kumagai Koji Oba Mamoru Fujita Kazuhiro Hanazaki | 2014 | Medical Molecular Morphology2014，，2： | 1 |
| 10 | Framed Aloha for multiple RFID objects identification 显示文摘 | Bin Zhen Mamoru KOBAYASHI Masashi SHIMIZU | 2005 | IEICE Transactions on Com- munications2005，88，： | 1 |
| 11 | Scavenging Free Radicals by Low-Dose Carvedilol Prevents Redox-Dependent Ca 2+ Leak Via Stabilization of Ryanodine Receptor in Heart Failure显示文摘 | Mamoru Mochizuki Masafumi Yano Tetsuro Oda Hiroki Tateishi Shigeki Kobayashi Takeshi Yamamoto Yasuhiro Ikeda Tomoko Ohkusa Noriaki Ikemoto Masunori Matsuzaki | 2007 | Journal of the American College of Cardiology2007，，： | 1 |
| 12 | Influence of Soft Reduction With One-Piece Rolls on Cen-ter Segregation in Continuously Casting显示文摘 | Shigeaki Ogibayyashi Masayuki Kobayashi Mamoru Yamada | 1991 | ISIJ Internation-al1991，，12： | 1 |
| 13 | Reevaluation of postoperative radiotherapy for thoracic esophageal carcinoma显示文摘 | Michinori Yamamoto Takashi Yamashita Toshiki Matsubara Tadashi Kitahara Kenji Sekiguchi Masahiko Furukawa Akiyoshi Uki Masao Kobayashi Emiko Tanaka Mamoru Ueda Toshifusa Nakajima | 1997 | International Journal of Radiation Oncology, Biology, Physics1997，，1： | 1 |
| 14 | Genetic Control of Peltate Glandular Trichome Formation in Perilla frutescens显示文摘 | Atsushi Nishizawa Gisho Honda Yoko Kobayashi Mamoru Tabata | 1992 | Planta Med1992，，02： | 1 |
| 15 | Characterization of Side Cell Populations Obtained from Human Amnion Mesenchymal Cells显示文摘Human amnion mesenchymal cells (AMCs) contain multipotent cells. To enrich such multipotent stem cells, we applied to AMCs the new method for the isolation of side population (SP) cells used for the enrichment of multipotent stem cells from many tissues. We succeeded in obtaining SP cells from AMCs (AMC-SP cells). AMC-SP cells were found in 0.2% of AMCs, irrespective of the length of pregnant period, ranging from 37 to 40 weeks. Cell cycle analyses suggested that AMC-SP cells belonged to a cell population that proliferated very slowly and/or was in a quiescent state in the amniotic membrane. Upon culturing, they proliferated with 40 to 80 cell doublings. However, they did not form colonies in a soft agarose culture, whereas HepG2 cells, representative human hepatoma cells formed many large colonies. These results suggest that AMC-SP cells that have considerable value for the use of regenerative medicine can be managed safely in vitro. | LI Ning PIAO Zheng-fu Mamoru Kobayashi Koji Sasaki DING Shu-qin Aiko Kikuchi Isao Kamo Norio Sakuragawa | 2009 | Chinese Journal of Biomedical Engineering(English Edition)2009，18，1： | 1 |
| 16 | Reduced expression of the REIC / Dkk-3 gene by promoter-hypermethylation in human tumor cells显示文摘 | Kazuyasu Kobayashi Mamoru Ouchida Toshiya Tsuji Hiroko Hanafusa Masahiro Miyazaki Masayoshi Namba Nobuyoshi Shimizu Kenji Shimizu | 2002 | Gene2002，，1： | 1 |
| 17 | Sinus Fungus Ball in the Japanese Population: Clinical and Imaging Characteristics of 104 Cases显示文摘 | Kazuhiro Nomura Daiya Asaka Tsuguhisa Nakayama Tetsushi Okushi Yoshinori Matsuwaki Tsuyoshi Yoshimura Mamoru Yoshikawa Nobuyoshi Otori Toshimitsu Kobayashi Hiroshi Moriyama Jeffrey P. Pearson | 2013 | International Journal of Otolaryngology2013，，： | 1 |
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