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| 1 | Dyslipidemia management in primary prevention of cardiovascular disease:Current guidelines and strategies显示文摘Cardiovascular disease is the leading cause of death in the United States. In 2010, the Centers for Disease Control and Prevention estimated that $444 billion was spent on cardiovascular diseases alone, about $1 of every $6 spent on health care. As life expectancy continues to increase, this annual cost will also increase, making costeffective primary prevention of cardiovascular disease highly desirable. Because of its role in development of atherosclerosis and clinical events, dyslipidemia management is a high priority in cardiovascular prevention. Multiple major dyslipidemia guidelines have been published around the world recently, four of them by independent organizations in the United States alone. They share the goal of providing clinical guidance on optimal dyslipidemia management, but guidelines differ in their emphasis on pharmacotherapy, stratification of groups, emphasis on lifestyle modification, and use of a fixed target or percentage reduction in low density lipoprotein cholesterol. This review summarizes eight major guidelines for dyslipidemia management and considers the basis for their recommendations. Our primary aim is to enhance understanding of dyslipidemia management guidelines in patient care for primary prevention of future cardiovascular risk. | Aditya D Hendrani Tolulope Adesiyun Renato Quispe Steven R Jones Neil J Stone Roger S Blumenthal Seth S Martin | 2016 | World Journal of Cardiology2016，8，2： | 5 |
| 2 | Health-related quality of life in high-grade glioma patients显示文摘Gliomas are malignant primary brain tumors and yet incurable. Palliation and the maintenance or improvement of the patient's quality of life is therefore of main importance. For that reason, health-related quality of life(HRQoL) has become an important outcome measure in clinical trials, next to traditional outcome measures such as overall and progression-free survivals, and radiological response to treatment. HRQoL is a multidimensional concept covering physical, psychological, and social domains, as well as symptoms induced by the disease and its treatment. HRQoL is assessed by using self-reported, validated questionnaires. Various generic HRQoL questionnaires, which can be supplemented with a brain tumor- specific module, are available. Both the tumor and its treatment can have a negative effect on HRQoL. However, treatment with surgery, radiotherapy, chemotherapy, and supportive treatment may also improve patients' HRQoL, in addition to extending survival. It is expected that the impact of HRQoL measurements in both clinical trials and clinical practice will increase. Hence, it is important that HRQoL data are collected, analyzed, and interpreted correctly. Methodological issues such as selection bias and missing data may hamper the interpretation of HRQoL data and should therefore be accounted. In clinical trials, HRQoL can be used to assess the benefits of a new treatment strategy, which should be weighed carefully against the adverse effects of that treatment. In daily clinical practice, HRQoL assessments of an individual patient can be used to inform physicians about the impact of a specific treatment strategy, and it may facilitate the communication between the physicians and the patients. | Linda Dirven Neil K.Aaronson Jan J.Heimans Martin J.B.Taphoorn | 2014 | Chinese Journal of Cancer2014，33，1： | 4 |
| 3 | Image-guided endoscopic evacuation of spontaneous intracerebral hemorrhage显示文摘 | Chad M. Miller Paul Vespa Jeffrey L. Saver Chelsea S. Kidwell Stanley T. Carmichael Jeffry Alger John Frazee Sid Starkman David Liebeskind Valeriy Nenov Robert Elashoff Neil Martin | 2008 | Surgical Neurology2008，，5： | 2 |
| 4 | On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease显示文摘 | Fumito Saijo Alexandra B. Milsom Nathan S. Bryan Selena M. Bauer Thorsten Vowinkel Marina Ivanovic Chris Andry D. Neil Granger Juan Rodriguez Martin Feelisch | 2009 | Nitric Oxide2009，，2： | 2 |
| 5 | Legal idioms: a framework for evidential reasoning显示文摘 | DavidA. Lagnado Norman Fenton Martin Neil | 2013 | Argument & Computation2013，，1： | 1 |
| 6 | N-acyl homoserine lactone binding to the CarR receptor determines quorumsensing specificity in Erwinia 显示文摘 | Martin W Daniel E T Neil A | 2000 | EMBO J2000，1999，4： | 1 |
| 7 | Masks for Hadamard transform optics,and weighing designs显示文摘 | SLOANE Neil J A HARWIT Martin | 1976 | Applied Optics1976，15，1： | 1 |
| 8 | Active Surveillance of Small Renal Masses: Progression Patterns of Early Stage Kidney Cancer 显示文摘 | Michael A.S. Jewett Kamal Mattar Joan Basiuk Christopher G. Morash Stephen E. Pautler D. Robert Siemens Simon Tanguay Ricardo A. Rendon Martin E. Gleave Darrel E. Drachenberg Raymond Chow Hannah Chung Joseph L. Chin Neil E. Fleshner Andrew J. Evans Brenda | 2011 | European Urology2011，，： | 1 |
| 9 | Clinician-Patient Risk Discussion for Atherosclerotic Cardiovascular Disease Prevention显示文摘 | Seth S. Martin Laurence S. Sperling Michael J. Blaha Peter W.F. Wilson Ty J. Gluckman Roger S. Blumenthal Neil J. Stone | 2015 | Journal of the American College of Cardiology2015，，： | 1 |
| 10 | Inorganic crystal engineering using self-assembly of tailored building-blocks 显示文摘 | Alexander J B Neil R C Martin S | 1999 | Coord Chem Rev1999，183，1： | 1 |
| 11 | Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era?显示文摘 | Nazneem N Wahab Elizabeth A Cowden Neil J Pearce Martin J Gardner Heather Merry Jafna L Cox | 2002 | Journal of the American College of Cardiology2002，，10： | 1 |
| 12 | Availability modelling of repairable systems using Bayesian networks 显示文摘 | Neil Martin Marquez David | 2012 | Engineering Applications and Atificial Intelligence2012，25，4： | 1 |
| 13 | RNA-mediated interference as a tool for identifying drug targets显示文摘 | Martin RL Tomlinson ML | 2001 | Am J Pharmacogenomics2001，1，1： | 1 |
| 14 | Using Bayesian Networks toModel Expected and Unexpected Operational Losses,Risk Analysis显示文摘 | Martin Neil Norman Fenton Manesh Tailor | 2005 | 25(4):963-9722005，25，4： | 1 |
| 15 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
| 16 | RNA-mediated interference as a tool for identifying drug targets显示文摘 | O' Neil N J Martin R L Tomlinson M L | 2001 | Am J Pharmacogenomics2001，，1： | 1 |
| 17 | Making connections: global production networks, standards, and embeddedness in the mobile-telecommunications industry 显示文摘 | Martin H Neil M | 2006 | Environment and Planning A2006，38，7： | 1 |
| 18 | Endoscopic Raman spectroscopy enables objective diagnosis of dysplasia in Barrett’s esophagus显示文摘 | L. Max Almond Jo Hutchings Gavin Lloyd Hugh Barr Neil Shepherd John Day Oliver Stevens Scott Sanders Martin Wadley Nick Stone Catherine Kendall | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 19 | Volume-rendered Helical Computerized Tomograpgy in the Detection and Characterization of Intracranial Aneurysms显示文摘 | Villablance JP Martin Neil Jahan R | 2000 | J Neursurg2000，93，2： | 1 |
| 20 | Rural Community and Rural Resilience: What is important to farmers in keeping their country towns alive?显示文摘 | Phil McManus Jim Walmsley Neil Argent Scott Baum Lisa Bourke John Martin Bill Pritchard Tony Sorensen | 2011 | Journal of Rural Studies2011，，1： | 1 |
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