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| 1 | The discovery of annually laminated sediments (varves) from shallow Sugan Lake in inland arid China and their paleoclimatic significance显示文摘Detailed examination of sedimentary cores retrieved from Sugan Lake in the northern Qaidam Basin of northwest China’s Tibetan Plateau reveal that fine laminated beddings form in the sediments where water depth exceeds 3 m. Seasonal surface sediments trapped at the bottom of the lake suggest that sediments deposited during summer and autumn are mainly light colored monohydrocalcites, while those deposited in winter are dark organic matter, indicating that varve layers form under modern limnological conditions. Continuous varve sediments comprising four types have accumulated in the upper 5.5 m of Core SG03I from the center of the lake. All types exhibit clear seasonality indicative of annual deposition. Varve counts correspondence with 210Pb dates on recent sediments in the upper core suggest the continuous varves of the upper 5.5 m of the core formed in the late Holocene (2670 a BP). The Sugan Lake varve sequence is the first demonstration of annually laminated sediments re-ported in arid western China. | ZHOU AiFeng CHEN FaHu QIANG MingRui YANG MeiLin ZHANG JiaWu | 2007 | Science China Earth Sciences2007，50，8： | 17 |
| 2 | Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells显示文摘人的表皮的生长因素受体 2 (HER2/neu,也作为 ErbB2 知道) overexpression 在癌症与差的预后和 chemoresistance 被相关。乳癌抵抗蛋白质(BCRP 和 ABCG2 ) 在许多癌症房间是为 multidrug 抵抗(MDR ) 负责的药流出泵。HER2 和 BCRP 在乳癌病人与差的治疗反应被联系,尽管在 HER2 和 BCRP 表示之间的关系不是清楚的。这里,我们证明进 MCF7 乳癌房间(MCF7/HER2 ) 的 HER2 的 transfection 经由 phosphatidylinositol 3-kinase (PI3K ) 导致了 BCRP 的一条起来规定 /Akt 和发信号的原子 factor-kappa B (NF-B ) 。有 PI3K 禁止者 LY294002, IB phosphorylation 禁止者 Bay11-7082,和 IB 的主导的否定异种的 MCF/HER2 房间的治疗禁止了导致 HER2 的 BCRP 倡导者活动。而且,我们发现 HER2 overexpression 导致了 MCF7 房间的一个增加的电阻到多重 antitumor 药象 paclitaxel (Taxol ) 那样, cisplatin (DDP ) , etoposide (VP-16 ) , adriamycin (ADM ) , mitoxantrone (MX ) ,和 5 氟尿嘧啶(5-FU ) 。而且, silencing BCRP 或有选择地的表示禁止 Akt 或 NF-B 的活动部分地至少敏化 MCF7/HER2 房间到这些化疗代理人。一起拿,通过表明小径的 PI3K/AKT/NF-B 的 BCRP 的起来规定在 MCF7 的调停 HER2 的 chemoresistance 起了一个重要作用房间,和 AKT, NF-B,和 BCRP 小径可能为治疗学的干预用作潜在的目标。 | Weijia Zhang Wei Ding Ye Chen Meilin Feng Yongmei Ouyang Yanhui Yu Zhimin He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 8 |
| 3 | Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy显示文摘Activating transcription factors, ATFs, are a group of bZIP transcription factors that act as homodimers or heterodimers with a range of other bZIP factors. In general, ATFs respond to extracellular signals, indicating their important roles in maintaining homeostasis. The ATF family includes ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7. Consistent with the diversity of cellular processes reported to be regulated by ATFs, the functions of ATFs are also diverse. ATFs play an important role in cell proliferation, apoptosis, differentiation and inflammation-related pathological processes. The expression and phosphorylation status of ATFs are also related to neurodegenerative diseases and polycystic kidney disease. Various miRNAs target ATFs to regulate cancer proliferation, apoptosis, autophagy, sensitivity and resistance to radiotherapy and chemotherapy. Moreover, ATFs are necessary to maintain cell redox homeostasis. Therefore, deepening our understanding of the regulation and function of ATFs will provide insights into the basic regulatory mechanisms that influence how cells integrate extracellular and intracellular signals into genomic responses through transcription factors. Under pathological conditions, especially in cancer biology and response to treatment, the characterization of ATF dysfunction is important for understanding how to therapeutically utilize ATF2 or other pathways controlled by transcription factors. In this review, we will demonstrate how ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7 function in promoting or suppressing cancer development and identify their roles in tumour immunotherapy. | Meilin Chen Yijun Liu Yuqin Yang Yanbing Qiu Zhicheng Wang Xiaoxu Li Wenling Zhang | 2022 | Genes & Diseases2022，9，4： | 3 |
| 4 | Serological characterization of Haemophilus parasuis isolates from China显示文摘 | Xuwang Cai Huanchun Chen P.J. Blackall Zhengyan Yin Lei Wang Zhengfei Liu Meilin Jin | 2005 | Veterinary Microbiology2005，，3： | 3 |
| 5 | Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer显示文摘 | Zhi Xu Haixia Zhu John M. Luk Dongmei Wu Dongying Gu Weida Gong Yongfei Tan Jianwei Zhou Jinhai Tang Zhengdong Zhang Meilin Wang Jinfei Chen | 2012 | Cancer2012，，22： | 2 |
| 6 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history显示文摘 | Fahu Chen Zicheng Yu Meilin Yang Emi Ito Sumin Wang David B. Madsen Xiaozhong Huang Yan Zhao Tomonori Sato H. John B. Birks Ian Boomer Jianhui Chen Chengbang An Bernd Wünnemann | 2007 | Quaternary Science Reviews2007，，3： | 2 |
| 7 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history显示文摘 | Fahu Chen Zicheng Yu Meilin Yang Emi Ito Sumin Wang David B. Madsen Xiaozhong Huang Yan Zhao Tomonori Sato H. John B. Birks Ian Boomer Jianhui Chen Chengbang An Bernd Wünnemann | 2007 | Quaternary Science Reviews2007，，3： | 2 |
| 8 | Early T-cell precursor leukemia:a subtype of high risk childhood acute lymphoblastic leukemia显示文摘Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia(T-ALL)and B-cell acute lymphoblastic leukemia(B-ALL).In children,T-ALL usually has a worse prognosis than B-ALL,although childhood T-ALL prognoses have improved remarkably.The varying outcomes among T-ALL cases suggest that an unrecognized biological heterogeneity may contribute to chemo-resistance.Deep exploration of T-lymphocyte development in recent years has found a subgroup of patients with a phenotype that resembles early T-cell precursor,which confers a much poorer prognosis than any other form of T-ALL.This novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia(ETP-ALL).Flow cytometry data from T-ALL patients enrolled in Shanghai Children’s Medical Center between July 2002 and October 2010 were assessed according to Dr.Campana’s protocol.Among total 89 T-ALL cases,74 cases had enough immunophenotype data available to differentiate between ETP(CD1a^(-),CD8^(-),CD5^(dim),at least one marker of stem cell or myeloid lineage)and non-ETP.From these 74 subjects,12 ETP-ALL cases(16.2%)were identified.The event-free survival(EFS)rate at 66.8 months was 11.1%±10.1% for ETP-ALL and 57.6%±5.6% for non-ETP-ALL(P=0.003).The overall survival rates were 13.3%±11.0% for ETP-ALL and 64.7%±6.3% for non-ETP-ALL(P=0.002).Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic leukemia with poor prognosis. | Meilin Ma Xiang Wang Jingyan Tang Huiliang Xue Jing Chen Ci Pan Hua Jiang Shuhong Shen | 2012 | Frontiers of Medicine2012，6，4： | 2 |
| 9 | Projection of Temperature-Related Excess Mortality by Integrating Population Adaptability Under Changing Climate—China,2050s and 2080s显示文摘What is already known about this topic?An increasing number of studies have projected temperature-related mortality,but few consider the change of population’s adaptability to future temperature and mortality burden from cold and heat effects.What is added by this report?This study offers a comprehensive characterization of human adaptability and excess mortality burden of temperature across various regions of China.What are the implications for public health practice?The temperature-related excess mortality was projected to increase in the 2050s and decrease in the 2080s.Heat adaptability was projected to increase in the future,but along with the rising temperatures,the heatrelated excess mortality continuously rose,except for the low-speed rising scenario.Although the excess mortality of cold was projected to decrease in the nearer future,it might not keep declining in the long run,due to the decreasing cold-adaptability,which deserves more attention. | Zhiying Sun Qing Wang Chen Chen Yang Yang Meilin Yan Hang Du Kai Chen John S.Ji Tiantian Li | 2021 | China CDC weekly2021，3，33： | 2 |
| 10 | The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway显示文摘Polyphyllin I(PPI)and polyphyllin II(PII)are the main active substances in the Paris polyphylla.However,liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated.In this work,we found that PPI and PII exposure could induce significant hepatotoxicity in human liver cell line L-02 and zebrafish in a dose-dependent manner.The results of the proteomic analysis in L-02 cells and transcriptome in zebrafish indicated that the hepatotoxicity of PPI and PII was associated with the cholesterol biosynthetic pathway disorders,which were alleviated by the cholesterol biosynthesis inhibitor lovastatin.Additionally,3-hydroxy-3-methy-lglutaryl CoA reductase(HMGCR)and squalene epoxidase(SQLE),the two rate-limiting enzymes in the cholesterol synthesis,selected as the potential targets,were confirmed by the molecular docking,the overexpression,and knockdown of HMGCR or SQLE with siRNA.Finally,the pull-down and surface plasmon resonance technology revealed that PPI could directly bind with SQLE but not with HMGCR.Collectively,these data demonstrated that PPI-induced hepatotoxicity resulted from the direct binding with SQLE protein and impaired the sterol-regulatory element binding protein 2/HMGCR/SQLE/lanosterol synthase pathways,thus disturbing the cholesterol biosynthesis pathway.The findings of this research can contribute to a better understanding of the key role of SQLE as a potential target in drug-induced hepatotoxicity and provide a therapeutic strategy for the prevention of drug toxic effects with similar structures in the future. | Zhiqi Li Qiqi Fan Meilin Chen Ying Dong Farong Li Mingshuang Wang Yulin Gu Simin Guo Xianwen Ye Jiarui Wu Shengyun Dai Ruichao Lin Chongjun Zhao | 2023 | Journal of Pharmaceutical Analysis2023，13，1： | 2 |
| 11 | Nalmefene attenuates malignant potential in colorectal cancer cell via inhibition of opioid receptor显示文摘吗啡被要求在在外科手术前的时期期间支持肿瘤生长和转移的一个风险因素,和肿瘤房间的高 glycolysis 被证明加速肿瘤前进。在这研究,我们调查了是否 nalmefene,一个 opioid 受体禁止者,能通过影响细胞 glycolysis 禁止 CT26 结肠癌细胞生长。CCK8 和 transwell 迁居试金证明 nalmefene 以一种集中依赖者方式禁止了 CT26 房间生存能力和移植。细胞外的使发酸率和氧消费率证明 nalmefene 禁止了 CT26 房间的 glycolysis。而且,西方的污点分析和量的即时 PCR 表明 nalmefene 减少了与 glycolysis 有关的酶的表情。流动 cytometry 结果揭示了那细胞内部的钙(Ca 2+) 水平被 nalmefene 改变,西方的污点分析证明 nalmefene 减少了 calmodulin 表示和 calcium/calmodulin 依赖者蛋白质 kinases II (CaMK II ) phosphorylation,因此禁止 serine/threonine kinase (AKT ) 肝糖 synthase kinase-3 (GSK-3 ) 小径。而且, KN93 的效果, CaMK II 的一个禁止者,类似于 nalmefene,和 nalmefene 的反肿瘤效果的效果能被吗啡抵抗。在结论, nalmefene 的反肿瘤效果可以被禁止 opioid 受体和下面调整的 calmodulin 表示和 CaMK II phosphorylation 完成,因此禁止 AKT-GSK-3 小径和 CT26 房间的 glycolysis。 | Qichao Wu Xiangyuan Chen Jiaqiang Wang Pengfei Sun Meilin Weng Wankun Chen Zhirong Sun Minmin Zhu Changhong Miao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 2 |
| 12 | Influence of freeze tube deviation on the development of frozen wall during long cross-passage construction显示文摘This paper investigates the influence of the deviation in freeze pipe installation on the development of the frozen wall in long cross passages by numerical simulation with ANSYS software.The study case is from the artificial ground freezing project along the Fuzhou Metro Line 2 between Ziyang Station and Wuliting Station.Two freezepipe configurations,i.e.,one with perfectly aligned pipes without any deviation from design and another with randomly distributed deviation,are included for comparison.The effect of the random deviation in the freeze pipes on frozen wall interconnection time,the thickness of the frozen wall and the development of the temperature field is explored.For the characteristic section of the numerical model at a depth of 25 m,it is found that the frozen wall interconnection time under the random deviation case and no deviation case is 24 days and 18 days,respectively.The difference in the thickness of the thinnest frozen wall segment between the random deviation and no deviation cases is the largest in the early freezing stage(up to 0.75 m),which decreases with time to 0.31 m in the late freezing stage.The effects of random deviation are more significant in the early freezing stage and diminish as the freezing time increases. | JunHao Chen JianLin Wang LeXiao Wang Han Li MeiLin Chen | 2022 | Research in Cold and Arid Regions2022，14，4： | 2 |
| 13 | Flavonoids of Rosa rugosa Thunb.inhibit tumor proliferation and metastasis in human hepatocellular carcinoma HepG2 cells显示文摘Rosa rugosa Thunb.is recognized as both medicine and edible in China.The article investigated the antitumor activity of rose flavonoids.Water-extracted rose flavonoids(RFW)and ethanol-extracted rose flavonoids(RFE)were achieved by extracting with distilled water and 70%ethanol,respectively.The effects of the two extracts on proliferation inhibition,apoptosis inducement and metastasis prevention of human HepG2 hepatocellular carcinoma cell lines were tested,via optical/fluorescence microscopy,MTT detection,Transwell assay,flow cytometry and Western blot,etc.The results indicated that rose flavonoids at low concentration(10-40μg/mL)had a better inhibitory effect on migration and invasion of HepG2 cells in a dose-dependent manner,while rose flavonoids at high concentration(80-160μg/mL)could induce apoptosis of HepG2 cells by up-regulating the expression of pro-apoptotic proteins p53 and Bax,and down-regulating the expression of anti-apoptotic proteins Bcl-2,leading to the functioning of caspase-3 and caspase-9.The effect of RFE at the same concentration was significantly better than that of RFW.Conclusion,this study found that rose flavonoids had a certain inhibitory effect on proliferation and metastasis of human liver cancer cells HepG2,indicating the application of rose flavonoids in preventing and treating of liver cancer. | Zhiguo Zhang Meilin Wang Shu Xing Chen Zhang | 2022 | Food Science and Human Wellness2022，11，2： | 2 |
| 14 | Characterization of Streptococcus suis isolates from the diseased pigs in China between 2003 and 2007显示文摘 | Zigong Wei Ran Li Anding Zhang Hongkui He Yafeng Hua Jing Xia Xuehui Cai Huanchun Chen Meilin Jin | 2008 | Veterinary Microbiology2008，，1： | 1 |
| 15 | Genome-wide analysis of long noncoding RNA signature in human colorectal cancer显示文摘 | Yao Xue Gaoxiang Ma Dongying Gu Lingjun Zhu Qiuhan Hua Mulong Du Haiyan Chu Na Tong Jinfei Chen Zhengdong Zhang Meilin Wang | 2014 | Gene2014，，： | 1 |
| 16 | Wavelet analysis of rotor-tip dis- turbances in an axial-flow compressor 显示文摘 | LIN Feng CHEN Jingyi LI Meilin | 2004 | Journal of Propulsion and Power2004，20，2： | 1 |
| 17 | Wavelet analysis of rotor-tip disturbances in an axial-flow compressor显示文摘 | LIN Feng CHEN Jingyi LI Meilin | | 0，，02： | 1 |
| 18 | Wavelet Analysis of Rotor Tip Disturbances in an Axial Flow Compressor 显示文摘 | LIN Feng CHEN Jingyi LI Meilin | 2004 | Journal of Propulsion and Power2004，20，2： | 1 |
| 19 | Characterization of Streptococcus suis isolates from the diseased pigs in China between 2003 and 2007显示文摘 | Zigong Wei Ran Li Anding Zhang Hongkui He Yafeng Hua Jing Xia Xuehui Cai Huanchun Chen Meilin Jin | 2008 | Veterinary Microbiology2008，，1： | 1 |
| 20 | SARS-CoV-2 promote autophagy to suppress type I interferon response显示文摘Dear Editor,The outbreak of SARS-CoV-2 leads global epidemic with high morbidity and mortality.However,the pathophysiology of this deadly virus is complex and largely unknown.Autophagy is a highly conserved homeostatic process that allows cells to recycle their components.Several studies provided evidence that human coronavirus infections are closely related to various cellular aspects associated with autophagy.1 Autophagy may play a crucial role in the SARS-CoV-2 viral lifecycle. | Xianfeng Hui Linliang Zhang Lei Cao Kun Huang Ya Zhao Yufei Zhang Xi Chen Xian Lin Mingzhou Chen Meilin Jin | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 1 |
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