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| 1 | Mechanism of floral scent production in Osmanthus fragrans and the production and regulation of its key floral constituents,β-ionone and linalool显示文摘Sweet osmanthus(Osmanthus fragrans Lour.)is among the top ten most well-known flowers in China and is recognized as both an aromatic plant and ornamental flower.Here,manual sectioning,scanning electron microscopy,and transmission electron microscopy of sweet osmanthus petals revealed that large amounts of lipids are present inside the petal cells and on the cell surfaces.However,no secretory structures were observed.Instead,the petal cells protrude slightly outward,and the surfaces of the cells are adorned with highly regular brush-shaped hairs.The surfaces of the‘Yingui’petals possessed mostly curled and more numerous hairs,whereas the‘Dangui’petals possessed fewer brush-shaped and more sparsely arranged hairs.In addition,many granular substances were attached to the brush-shaped hairs,and the granules were denser on the hairs of the‘Yingui’petals compared to the hairs on the‘Dangui’petals.Furthermore,35 aromatic components in the‘Yingui’petals and 30 aromatic components in the‘Dangui’petals were detected via GC-MS.The main aromatic component of the‘Yingui’petals wasβ-ionone,whereas that of the‘Dangui’petals was linalool and its oxides.Transcriptome sequencing and qRT-PCR indicated that the highβ-ionone content in the‘Yingui’petals was due to the overexpression of CCD1 and CCD4 and that the high linalool content in the‘Dangui’petals was due to the overexpression of MECS,HDR,IDI1,and LIS1,which function upstream of the linalool synthetic pathway.In particular,the expression levels of CCD4 and LIS1 were upregulated by 5.5-and 5.1-fold in the‘Yingui’and‘Dangui’petals,respectively.One transcription factor(ERF61)was cloned and named,and the expression pattern of ERF61 in sweet osmanthus petals was found to be generally consistent with that of CCD4.Tobacco transformation experiments,yeast one-hybrid experiments,and electrophoretic mobility shift assays indicated that ERF61 binds to the CCD4 promoter and stimulates CCD4 expression,thereby regulating the synthesis ofβ-ionone in sweet osmanthus petals. | Yuanji Han Hongyun Wang Xiaodan Wang Ke Li Meifang Dong Yong Li Qian Zhu Fude Shang | 2019 | Horticulture Research2019，6，1： | 13 |
| 2 | Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase显示文摘Casticin,从 Fructus viticis 的 polymethoxyflavone 在中国传统的药用作一个反煽动性的代理人,被报导了有反癌症活动。这研究的目的是在人的颈的癌症房间和它的分子的机制上检验 casticin 的 apoptotic 活动。我们揭示了导致 casticin 的 apoptosis 由发生的新奇机制并且第一次证明 casticin 导致的 apoptosis 通过反应的氧种类(ROS ) 的产生被调停并且在 HeLa 细胞支撑了 c6 月 N 终端 kinase (JNK ) 的激活。Casticin 显著地增加了细胞内部的 ROS 的层次并且导致了 phosphorylated JNK 和 c6 月蛋白质的表示。有 N-acetylcysteine 和 SP600125 的预告的处理有效地在 HeLa 房间由 casticin 稀释了 apoptosis 的正式就职。而且, casticin 在另外的颈的癌症房间线导致了 ROS 生产和 apoptotic 房间死亡,例如 CasKi 和 SiHa。重要地, casticin 没在正常的人的外部血 mononuclear 房间和胚胎的肾上皮引起 ROS 的产生或 apoptosis 的正式就职 293 个房间。这些结果建议由 casticin 的 ROS 产生和持续 JNK 激活在导致 casticin 的 apoptosis 起一个作用并且提起有 casticin 的治疗可能作为对人的颈的癌症的新治疗有希望的可能性。 | Fanxiang Zeng Li Tian Fei Liu Jianguo Cao Meifang Quan Xifeng Sheng | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 9 |
| 3 | Flame retardancy of polyamide 6 hybrid fibers:Combined effects of α-zirconium phosphate and ammonium sulfamate显示文摘Synergistic effect between α-zirconium phosphate(α-ZrP) and ammonium sulfamate(AS) for enhanced flame retardant properties of Polyamide 6(PA6) was investigated by using oxygen index instrument,cone calorimeter,thermogravimetric analyzer(TGA),Instron universal test machine and scanning electron microscopy(SEM).PA6/AS/α-ZrP ternary hybrid materials with various contents of α-ZrP and AS were fabricated by melt-mixing method.The result from flammabihty indicated that the Limiting oxygen index(LOI) and Underwriters Laboratories-94(UL-94) rating of PA6/AS/α-ZrP were significantly accelerated under the coordinating function of α-ZrP and AS.Moreover,the thermal stability for PA6/AS/α-ZrP studied by TGA also demonstrated this synergistic effect between α-ZrP and AS on the heat resistance.The effects of the usage amount of α-ZrP and AS on mechanical properties were analyzed by using uniaxial tensile test.It was found that the addition of AS provided negative effects on the tensile strength of PA6/AS/α-ZrP,however,the adverse trends that mentioned above could be overcome by using the well dispersed α-ZrP. | Hengxue Xiang Lili Li Wei Chen Senlong Yu Bin Sun Meifang Zhu | 2017 | Progress in Natural Science:Materials International2017，27，3： | 7 |
| 4 | Magnetic resonance study of the structure and function of the hippocampus and amygdala in patients with depression显示文摘 | Li Yuefeng Yan Jinchuan Wang Dongqing Sun Meifang Zhu Yan Zhu Xiaolan Jiang Ping Yin Ruigen Zhao Liang | 2014 | Chinese Medical Journal2014，，20： | 6 |
| 5 | Effect of TiO_2@SiO_2 nanoparticles on the mechanical and UV-resistance properties of polyphenylene sulfide fibers显示文摘In order to avoid the inherent photo-catalysis and aggregation of TiO2 in PPS, TiO2 nanoparticles were coated with SiO2 layers, which were chosen as the UV absorbent to improve the UV stability of polyphenylene sul fi de(PPS) fi ber. The PPS–TiO2@SiO2 nanocomposites fi bers were prepared via melt spinning, and the nanocomposites fi bers displayed different crystallization behaviors on variation of the diameters of TiO2@SiO2 nanoparticles, as con fi rmed by Differential Scanning Calorimetry(DSC). The spinnability, breaking strength and UV-resistance properties of PPS nanocomposites fi bers, as measured by homemade melt spinning machine, Xenon-lamp Weather Resistance Test Chamber and Yarn Tensile Tester, manifested the dependence on the diameters. The addition of nanoparticles with the diameter of 25 nm improved the spinnability and the mechanical performance of PPS most, which is attributed to the heterogeneous nucleation effect of nanoparticles. The UVresistance properties of the PPS nanocomposites were improved by the addition of TiO2@SiO2 nanoparticles. After aging for 180 h, PPS nanocomposites fi ber still maintained a high strength. | Zexu Hu Lili Li Bin Sun Si Meng Long Chen Meifang Zhu | 2015 | Progress in Natural Science:Materials International2015，25，4： | 5 |
| 6 | Adsorption of 17β-estradiol from aqueous solution by raw and direct/pre/post-KOH treated lotus seedpod biochar显示文摘Five biochars derived from lotus seedpod(LSP)were applied to examine and compare the adsorption capacity of 17β-estradiol(E2)from aqueous solution.The effect of KOH activation and the order of activation steps on material properties were discussed.The effect of contact time,initial concentration,p H,ionic strength and humic acid on E2 adsorption were investigated in a batch adsorption process.Experimental results demonstrated that the pseudo second-order model fitted the experimental data best and that adsorption equilibrium was reached within 20 hr.The efficiency of E2 removal increased with increasing E2 concentration and decreased with the increase of ionic strength.E2 adsorption on LSP-derived biochar(BCs)was influenced little by humic acid,and slightly affected by the solution p H when its value ranged from 4.0 to 9.0,but considerably affected at p H 10.0.Low environmental temperature is favorable for E2 adsorption.Chemisorption,π–πinteractions,monolayer adsorption and electrostatic interaction are the possible adsorption mechanisms.Comparative studies indicated that KOH activation and the order of activation steps had significant impacts on the material.Post-treated biochar exhibited better adsorption capacity for E2 than direct treated,pretreated,and raw LSP biochar.Pyrolyzed biochar at higher temperature improved E2 removal.The excellent performance of BCs in removing E2 suggested that BCs have potential in E2 treatment and that the biochar directly treated by KOH would be a good choice for the treatment of E2 in aqueous solution,with its advantages of good efficiency and simple technology. | Ni Liu Yunguo Liu Guangming Zeng Jilai Gong Xiaofei Tan Jun Wen Shaobo Liu Luhua Jiang Meifang Li Zhihong Yin | 2020 | Journal of Environmental Sciences2020，32，1： | 4 |
| 7 | The relationships among aerosol optical depth, ice, phytoplankton and dimethylsulfide and the implication for future climate in the Greenland Sea显示文摘The sea-to-air flux of dimethylsulphide(DMS) is one of the major sources of marine biogenic aerosol, and can have an important radiative impact on climate, especially in the Arctic Ocean. Satellite-derived aerosol optical depth(AOD) is used as a proxy for aerosol burden which is dominated by biogenic aerosol during summer and autumn. The spring sea ice melt period is a strong source of aerosol precursors in the Arctic. However, high aerosol levels in early spring are likely related to advection of continental pollution from the south(Arctic haze).Higher AOD was generally registered in the southern part of the study region. Sea ice concentration(SIC) and AOD were positively correlated, while cloud cover(CLD) and AOD were negative correlation. The seasonal peaks of SIC and CLD were both one month ahead of the peak in AOD. There is a strong positive correlation between AOD and SIC. Melting ice is positively correlated with chlorophyll a(CHL) almost through March to September,but negatively correlated with AOD in spring and early summer. Elevated spring and early summer AOD most likely were influenced by combination of melting ice and higher spring wind in the region. The peak of DMS flux occurred in spring due to the elevated spring wind and more melting ice. DMS concentration and AOD were positively correlated with melting ice from March to May. Elevated AOD in early autumn was likely related to the emission of biogenic aerosols associated with phytoplankton synthesis of DMS. The DMS flux would increase more than triple by 2100 in the Greenland Sea. The significant increase of biogenic aerosols could offset the warming in the Greenland Sea. | QU Bo GABRIC Albert J. ZHAO Li SUN Wenjing LI Hehe GU Peijuan JIANG Limei ZENG Meifang | 2018 | Acta Oceanologica Sinica2018，37，5： | 4 |
| 8 | High thermal stability Cu_(2)O@OZrP micro-nano hybrids for melt-spun excellent antibacterial activity polyester fibers显示文摘Public safety incidents caused by bacterial infections have attracted widespread attention towards antibacterial textiles(fibers,fabrics,etc.).Nevertheless,it is still challenging to efficiently load inorganic nano-antibacterial materials in polymer fibers.In this work,zirconium phosphate(ZrP,layered micro-nano materials)was utilized as a micro-nano carrier.The octadecyl triphenyl phosphonium bromide(OTP)was intercalated between the ZrP sheets by the ion exchange method to improve the carrier-polymer compatibility and the antibacterial performance.Through in-situ chemical reduction,the ultra-small nano-sized cuprous oxide(Cu_(2)O<5 nm)was loaded on the outer surface of ZrP to realize the uniform and stable dispersion of the Cu_(2)O on the carrier and improve the antibacterial performance.The ZrP nanosheets loaded with Cu_(2)O and OTP(Cu_(2)O@OZrP)had excellent antibacterial properties,and the antibacterial rate against E.coli,S.aureus and C.albicans was more than 99%.The intercalation amount of OTP in Cu_(2)O@OZrP can reach 16%,and the thermal stability was excellent and a significant increase in the Zeta potential.Indeed,the decomposition temperature was greater than 350℃,which was suitable for high-temperature melt processing of polymers.Consequently,we prepared PET/Cu_(2)O@OZrP fibers using polyethylene glycol terephthalate(PET),which accounts for 70%of the total chemical fibers,as the fiber matrix.PET/Cu_(2)O@OZrP fibers exhibited excellent mechanical property and antibacterial performance when the content of Cu_(2)O@OZrP was only 0.2%.The antibacterial rate against five types of bacteria including super bacteria(MRSA,VRE)was more than 99%. | Jialiang Zhou Yaping Wang Weinan Pan Hengxue Xiang Peng Li Zhe Zhou Meifang Zhu | 2021 | Journal of Materials Science & Technology2021，，22： | 4 |
| 9 | Effects of Nutritional Factors on the Growth and Heterotrophic Eicosapentaenoic Acid Production of Diatom Nitzschia laevis显示文摘The effects of several nutritional factors on the growth and eicosapentaenoic acid(EPA) production of diatom Nitzschia laevis were studied. 4 LDM(quadrupled concentration of the nutrient salt) was the optimal concentration of nutrient salt for the growth and EPA production of N. laevis. The growth of N. laevis was inhibited when the glucose concentration was either lower than 10 gL-1 or higher than 15 gL-1. Both sodium nitrate and urea were good nitrogen sources for the growth and EPA production,while ammonium chloride seriously decreased the dry cell weight(DW) and the EPA content. Silicate seriously influenced the growth of N. laevis. The maximum DW of 2.34 gL-1 was obtained in the presence of 150 mgL-1 Na2SiO3· 9H2O. The EPA content remained almost the same when the silicate concentration was lower than 150 mgL-1;however,higher silicate concentrations resulted in a steady de-crease of EPA content. Low medium salinity(≤29) did not seem to influence the DW of N. laevis,and high salinity resulted in a decrease of DW. The highest EPA content(4.08%) and yield(110 mgL-1) were observed at the salinity of 36 and 29,respectively. | CAO Xiaohong LI Songyao WANG Chunling LU Meifang | 2008 | Journal of Ocean University of China2008，7，3： | 3 |
| 10 | Perovskite Solar Fibers:Current Status,Issues and Challenges显示文摘Perovskite-based solar cells with high power conversion efficiencies(PCEs)are currently being demonstrated in solid-state device designs.Their elevated performances can possibly be attained with different non-standard geometries,for example,the fiber-shaped perovskite solar cells,in the light of careful design and engineering.Fiber-shaped solar cells are promising in smart textiles energy harvesting towards next-generation electronic applications and devices.They can be made with facile process and at low cost.Recently,fiber-shaped perovskite solar devices have been reported,particularly with the focus on the proof-of-concept in such non-traditional architectures.In this line,there are so many technical aspects which need to be addressed,if these photovoltaic(PV)cells are to be industrialized and produced massively.Herein,a well-organized and comprehensive discussion about the reported devices in this arena is presented.The challenges that need to be addressed,the possible solutions and the probable applications of these PV cells are also discussed.More still,the perovskite fiber-shaped PV cells with other fiber PV devices reported in literature in terms of their scope,characteristic designs,performances,and other technical considerations have been summarised. | Andrew Balilonda Qian Li Mike Tebyetekerwa Rogers Tusiime Hui Zhang Rajan Jose Fatemeh Zabihi Shengyuan Yang Seeram Ramakrishna Meifang Zhu | 2019 | Advanced Fiber Materials2019，1，2： | 3 |
| 11 | Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders in mice显示文摘Both immunosuppressants and antibiotics (ABX) are indispensable for transplant patients. However, the former increases the risk of new-onset diabetes, whereas the latter impacts intestinal microbiota (IM). It is still unclear whether and how the interaction between immunosuppressants and ABX alters the IM and thus leads to glucose metabolism disorders. This study examined the alterations of glucose and lipid metabolism and IM in mice exposed to tacrolimus (TAC) with or without ABX. We found that ABX further aggravated TAC-induced glucose tolerance and increased insulin secretion. Combined treatment resulted in exacerbated lipid accumulation in the liver. TAC-altered microbial community was further amplified by ABX administration, as characterized by reductions in phylum Firmicutes, family Lachnospiraceae, and genus Copyococcus. Analyses based on the metagenomic profiles revealed that ABX augmented the effect of TAC on microbial metabolic function mostly related to lipid metabolism. The altered components of gut microbiome and predicted microbial functional profiles showed significant correlation with hepatic lipid accumulation and glucose disorders. In conclusion, ABX aggravated the effect of TAC on the microbiome and its metabolic capacities, which might contribute to hepatic lipid accumulation and glucose disorders. These findings suggest that the ABX-altered microbiome can amplify the diabetogenic effect of TAC and could be a novel therapeutic target for patients. | Yuqiu Han Xiangyang Jiang Qi Ling Li Wu Pin Wu Ruiqi Tang Xiaowei Xu Meifang Yang Lijiang Zhang Weiwei Zhu Baohong Wang Lanjuan Li | 2019 | Frontiers of Medicine2019，13，4： | 3 |
| 12 | In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures显示文摘 | Chao Ni Yuhui Chen Musheng Zeng Rongjuan Pei Yong Du Linquan Tang Mengyi Wang Yazhuo Hu Hanyu Zhu Meifang He Xiawei Wei Shan Wang Xiangkai Ning Manna Wang Jufang Wang Li Ma Xinwen Chen Qiang Sun Hong Tang Ying Wang Xiaoning Wang | 2015 | Cell Research2015，25，7： | 3 |
| 13 | Synthesis of dental resins using diatomite and nano-sized SiO_2 and TiO_2 | Xiaoli Miao a,Meifang Zhu a,Yaogang Li b,Qinghong Zhang b,Hongzhi Wang a a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University,Shanghai 201620,China b Engineering Research Center of Advanced Glasses Manufacturing Technology,MOE,Donghua University,Shanghai 201620,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 3 |
| 14 | Acute toxicity study of Aspidopterys obcordata aqueous extract in Sprague-Dawley rats显示文摘OBJECTIVE: To examine the acute toxicity of an aqueous extract of Aspidopterys obcordata(A. obcordata) in Sprague Dawley rats.METHODS: The rats were orally administered a dose of 5000 mg/kg body weight and observed continuously for 6 h and then daily for 14 days. Control rats were administered distilled water. The effect of the extract on general behavior, body weight, and food and water intake were measured.After 14 days, the rats were sacrificed and their organs(liver, heart, spleen, lungs, kidney, adrenal glands, ovaries, and testes) were removed for macroscopic examination. The body and organ weights in addition to hematology(e.g., hemoglobin and white blood cell counts) and clinical blood biochemistry(e.g., albumin and bilirubin) were also examined.RESULTS: There were no deaths recorded, and the rats treated with A. obcordata showed no signs of toxicity. All measured parameters in rats treated with A. obcordata were unaffected when compared with those in control rats. The acute toxicity(LD_(50))was estimated to be > 5000 mg/kg body weight.CONCLUSION: Our results demonstrate the safety of an acute oral administration of an aqueous extract of A. obcordata in rats and indicate that future subacute and long-term toxicity testing of A. obcordata is warranted. | Li Yihang Li Guang Song Meifang Li Xuelan Zhan Xia Lu Juan Chen Xi | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 3 |
| 15 | Influence of acetone on nanostructure and electrochemical properties of interfacial synthesized polyaniline nanofibers显示文摘The growth of polyaniline(PANI) nano fi bers through interfacial polymerization can be well controlled by adding a small amount of acetone in the water/chloroform system. It was found that the polymerization rate became slower in the presence of acetone, yielding PANI nano fi bers with larger aspect ratios. The in fl uences of the acetone addition on the morphology, microstructure and properties of as-prepared PANI nano fi bers were studied by scanning electron microscope(FE-SEM), ultraviolet–visible spectra(UV–vis), Fourier transform infrared(FT-IR) and Raman spectroscopy, X-ray diffraction(XRD), thermogravity analysis(TGA), and electrical and electrochemical measurements. The experimental results showed that PANI nano fi bers prepared by using ammonium persulfate(APS) as an oxidant with acetone exhibited slower growth, the larger ratio of length to diameter, and higher crystallinity(2θ=6℃, 19℃, 26℃) than that without acetone, meanwhile remained larger yield of 11.23% and higher conductivity 1.8*10-2S/cm compared with that obtained by replacing APS with Fe Cl3. More importantly, these PANI nano fi bers exhibited better electrochemical behaviors, which bene fi tted from their high crystallinity and good conductivity. | Jianyun Zhao Zongyi Qin Tao Li Zhuozhan Li Zhe Zhou Meifang Zhu | 2015 | Progress in Natural Science:Materials International2015，25，4： | 2 |
| 16 | Investigation of spherical and concentric mechanism of compound droplets显示文摘Polymer shells with high sphericity and uniform wall thickness are always needed in the inertial confined fusion(ICF)experiments.Driven by the need to control the shape of water-in-oil(W1/O)compound droplets,the effects of the density matching level,the interfacial tension and the rotation speed of the continuing fluid field on the sphericity and wall thickness uniformity of the resulting polymer shells were investigated and the spherical and concentric mechanisms were also discussed.The centering of W1/O compound droplets,the location and movement of W1/O compound droplets in the external phase(W2)were significantly affected by the density matching level of the key stage and the rotation speed of the continuing fluid field.Therefore,by optimizing the density matching level and rotation speed,the batch yield of polystyrene(PS)shells with high sphericity and uniform wall thickness increased.Moreover,the sphericity also increased by raising the oil/water(O/W2)interfacial tension,which drove a droplet to be spherical.The experimental results show that the spherical driving force is from the interfacial tension affected by the two relative phases,while the concentric driving force,as a resultant force,is not only affected by the three phases,but also by the continuing fluid field.The understanding of spherical and concentric mechanism can provide some guidance for preparing polymer shells with high sphericity and uniform wall thickness. | Meifang Liu Lin Su Jie Li Sufen Chen Yiyang Liu Jing Li Bo Li Yongping Chen Zhanwen Zhang | 2016 | Matter and Radiation at Extremes2016，1，4： | 2 |
| 17 | Functionalization-Directed Stabilization of Hydrogen-Bonded Polymer Complex Fibers:Elasticity and Conductivity显示文摘Elastic,repairable and conductive fibers are desirable in the newly emerging field of soft electronic and wearable devices.Here,we design a multifunctional fiber by incorporation of different components to optimize its performance.The combination of the poly(acrylic acid)(PAA)and poly(ethylene oxide)(PEO)through hydrogen bonding endows the fiber with high elasticity and repairability.Polydopamine(PDA)significantly increases the stability of the fiber,thus the fiber will not dissolve in alkaline solutions and still keep the repairable ability.The fiber shows a reversible swelling-shrinking property as pH values go up and down.Further,the conductive component,carbon nanotube,is adsorbed at the swelling state and then is fastened with fiber shrinking. | Jiefu Li Jiaxing Sun Di Wu Wentao Huang Meifang Zhu Elsa Reichmanis Shuguang Yang | 2019 | Advanced Fiber Materials2019，1，1： | 2 |
| 18 | An Efficient Multi-Keyword Query Processing Strategy on P2P Based Web Search显示文摘The paper presents a novel benefit based query proc- essing strategy for efficient query routing. Based on DHT as the overlay network, it first applies Nash equilibrium to construct the optimal peer group based on the correlations of keywords and coverage and overlap of the peers to decrease the time cost, and then presents a two-layered architecture for query processing that utilizes Bloom filter as compact representation to reduce the bandwidth consumption. Extensive experiments conducted on a real world dataset have demonstrated that our approach obviously decreases the processing time, while improves the precision and recall as well. | SHEN Derong LI Meifang ZHU Hongkai YU Ge | 2007 | Wuhan University Journal of Natural Sciences2007，12，5： | 2 |
| 19 | Identification and validation of heterotypic cell-in-cell structure as an adverse prognostic predictor for young patients of resectable pancreatic ductal adenocarcinoma显示文摘Dear Editor,Pancreatic ductal adenocarcinoma(PDAC)has a poor prognosis,with an overall 5-year survival rate of less than 10%.Between 20 and 30%of PDAC cases are resectable at diagnosis;however,patients’post-operative survival periods vary widely,irrespective of active therapeutic interventions.1 Therefore,extensive efforts have been made to identify biomarkers that may identify patients with an improved prognosis.Although profound local immune suppression had been implicated in PDAC progression and poor patient survival,a prognostic marker that can directly and functionally read immune evasion in situ is not yet available. | Hongyan Huang Meifang He Yanbin Zhang Bo Zhang Zubiao Niu You Zheng Wen Li Peilin Cui Xiaoning Wang Qiang Sun | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 20 | The trend in newly diagnosed Crohn’s disease and extraintestinal manifestations of Crohn’s disease in central China: a retrospective study of a single center显示文摘 | Fengming Yi Min Chen Meifang Huang Jin Li Junzhang Zhao Lixia Li Bing Xia | 2012 | European Journal of Gastroenterology & Hepatology2012，，12： | 1 |
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