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| 1 | Optical properties and applications for MoS_2-Sb_2Te_3-MoS_2 heterostructure materials显示文摘Two-dimensional(2D) materials with potential applications in photonic and optoelectronic devices have attracted increasing attention due to their unique structures and captivating properties. However, generation of stable high-energy ultrashort pulses requires further boosting of these materials' optical properties, such as higher damage threshold and larger modulation depth. Here we investigate a new type of heterostructure material with uniformity by employing the magnetron sputtering technique. Heterostructure materials are synthesized with van der Waals heterostructures consisting of MoS_2 and Sb_2Te_3. The bandgap, carrier mobility, and carrier concentration of the MoS_2-Sb_2Te_3-MoS_2 heterostructure materials are calculated theoretically. By using these materials as saturable absorbers(SAs), applications in fiber lasers with Q-switching and mode-locking states are demonstrated experimentally. The modulation depth and damage threshold of SAs are measured to be 64.17%and 14.13 J∕cm^2, respectively. Both theoretical and experimental results indicate that MoS_2-Sb_2Te_3-MoS_2 heterostructure materials have large modulation depth, and can resist high power during the generation of ultrashort pulses. The MoS_2-Sb_2Te_3-MoS_2 heterostructure materials have the advantages of low cost, high reliability, and suitability for mass production, and provide a promising solution for the development of 2D-material-based devices with desirable electronic and optoelectronic properties. | WENJUN LIU YA-NAN ZHU MENGLI LIU BO WEN SHAOBO FANG HAO TENG MING LEI LI-MIN LIU ZHIYI WEI | 2018 | Photonics Research2018，6，3： | 3 |
| 2 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 3 | MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1显示文摘Unhealable diabetic wounds need to be addressed with the help of newer,more efficacious strategies.Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound treatment.Here,the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch(SFP)were demonstrated to promote diabetic wound healing.Silk fibroin binding peptide(SFBP)was screened through phage display,and SFBP-Gluc-MS2(SGM)and pac-miR146a-pac fusion protein were constructed.The designed exosomes(SGM-Exos,miR146a-Exos,and SGM-miR146a-Exos)were isolated from the engineered placental mesenchymal stem cells(PMSCs)transduced with SGM or/and pac-miR146a-pac protein.Gluc signals indicated SGM-Exo@SFP markedly increased the binding rate and the stability of SGM-Exo.Moreover,the loading efficiency of miR146a in SGM-miR146a-Exos was ten-fold higher than that in miR146a-Exos.Superior to untreated,SGM-miR146a-Exo-only treated,and SFP-only treated groups,SGM-miR146a-Exo@SFP drived wound healing associated with less inflammation,collagen deposition,and neovascularization.The transcriptomics analysis suggested anti-inflammatory and regenerative effects with SGM-miR146a-Exo@SFP treatment.Here,we show efficient exosome@biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering. | Qiankun Li Wenzhi Hu Qilin Huang Jie Yang Bingmin Li Kui Ma Qian Wei Yaxi Wang Jianlong Su Mengli Sun Shengnan Cui Rungong Yang Haihong Li Xiaobing Fu Cuiping Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 4 | Localization in Supermarket Based on RFID Technology显示文摘 | Song Wei LI Mengli | 2012 | Procedia Engineering2012，29，： | 1 |
| 5 | Nonlinear optical properties of WSe_2 and MoSe_2 films and their applications in passively Q-switched erbium doped fiber lasers显示文摘Transition metal dichalcogenides(TMDs) are successfully applied in fiber lasers for their photoelectric properties.However, in previous work, how to improve the modulation depth of TMD-based saturable absorbers(SAs) has been a challenging issue. In this paper, WSe_2 and MoSe_2 SAs are fabricated with the chemical vapor deposition method. Compared with previous experiments, the modulation depths of WSe_2 and MoSe_2 SAs with sandwiched structures are effectively increased to 31.25% and 25.69%, respectively. The all-fiber passively Q-switched erbium doped fiber lasers based on WSe_2 and MoSe_2 SAs are demonstrated. The signal-to-noise ratios of those lasers are measured to be 72 and 57 dB, respectively. Results indicate that the proposed WSe_2 and MoSe_2 SAs are efficient photonic devices to realize stable fiber lasers. | WENJUN LIU MENGLI LIU HAINIAN HAN SHAOBO FANG HAO TENG MING LEI ZHIYI WEI | 2018 | Photonics Research2018，6，10： | 1 |
| 6 | Asymmetric non-Gaussian effects in a tumor growth model with immunization显示文摘 | Mengli Hao Jinqiao Duan Renming Song Wei Xu | 2014 | Applied Mathematical Modelling2014，，： | 1 |
| 7 | An implantable antibacterial drug-carrier:Mesoporous silica coatings with size-tunable vertical mesochannels显示文摘Implant-associated bacterial infection remains one of the most common and serious complications.Therefore,a surface boasting long-term antibacterial ability for implants is highly desirable.Herein,mesoporous silica coatings(MSCs)with vertical and size-tunable mesochannels are fabricated on a variety of metal substrates via a nano-interfacial oriented assembly approach.Such facile and versatile approach relies on the vertically oriented fusion of composite micelles on the nanoscale flatness surface of substrates.Such orientation assembly process endows the MSCs with vertical mesochannels,tunable mesopore size(ca.5.5-13.5 nm),and switchable substrates even with complex and diversified surfaces.Importantly,the MSCs on titanium substrates(Ti@MSCs)exhibit excellent performances for drug adsorption and sustained release.The saturation adsorption capacity can reach 0.544 μg·cm^(-2) towards minocycline hydrochloride(MC-HCl)antibiotic molecules,which is 6.5 times as the bare titanium(Ti)substrate.In addition,the drug release time can be controlled from 84 to 216 h by simply adjusting the mesopore size.As a proof of concept,the Ti@MSCs can realize a higher antibacterial rate(95.9%),compared with the bare Ti(70.3%).The results highlight the high potential of MSCs as implant coating for long-term preventing and eliminating peri-implantitis. | Mengli Liu Fang Huang Chin-Te Hung Liwei Wang Wei Bi Yupu Liu Wei Li | 2022 | Nano Research2022，15，5： | 1 |
| 8 | Characterization of a Tn MAVS protein from Tetraodon nigroviridis显示文摘 | Zhiming Xiang Lin Qi Weijian Chen Chuanfu Dong Zhaoyu Liu Dong Liu Mengli Huang Wei Li Gan Yang Shaoping Weng Jianguo He | 2011 | Developmental and Comparative Immunology2011，，11： | 1 |
| 9 | Efficient Catalytic Conversion of Polysulfides by Biomimetic Design of “Branch‑Leaf” Electrode for High‑Energy Sodium–Sulfur Batteries显示文摘Rechargeable room temperature sodium–sulfur(RT Na–S)batteries are seriously limited by low sulfur utilization and sluggish electrochemical reaction activity of polysulfide intermediates.Herein,a 3D“branch-leaf”biomimetic design proposed for high performance Na–S batteries,where the leaves constructed from Co nanoparticles on carbon nanofibers(CNF)are fully to expose the active sites of Co.The CNF network acts as conductive“branches”to ensure adequate electron and electrolyte supply for the Co leaves.As an effective electrocatalytic battery system,the 3D“branch-leaf”conductive network with abundant active sites and voids can effectively trap polysulfides and provide plentiful electron/ions pathways for electrochemical reaction.DFT calculation reveals that the Co nanoparticles can induce the formation of a unique Co–S–Na molecular layer on the Co surface,which can enable a fast reduction reaction of the polysulfides.Therefore,the prepared“branch-leaf”CNF-L@Co/S electrode exhibits a high initial specific capacity of 1201 mAh g^−1 at 0.1 C and superior rate performance. | Wenyan Du Kangqi Shen Yuruo Qi Wei Gao Mengli Tao Guangyuan Du Shu‑juan Bao Mingyang Chen Yuming Chen Maowen Xu | 2021 | Nano-Micro Letters2021，13，3： | 1 |
| 10 | LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection显示文摘The activation of NLRC4 is a major host response against intracellular bacteria infection.However,NLRC4 activation after a host senses diverse stimuli is difficult to understand.Here,we found that the IncRNA LNCGM1082 plays a critical role in the activation of NLRC4.LNCGM1082 in macrophages affects the maturation of interleukin(IL)-1βand pyroptotic cell death only after exposure to an NLRC4 ligand.Similar to NLRC4-/-mice,LNCGM1082-/-mice were highly sensitive to Salmonella Typhimurium(S.T)infection.LNCGM1082 deficiency in mouse or human macrophages inhibited IL-1βmaturation and pyroptosis.Mechanistically,LNCGM1082 induced the binding of PKCS with NLRC4 in both mice and humans.In contrast,NLRC4 did not bind PKCo in LNCGM1082-/-macrophages.The activity of the IncRNA LNCGM1082 induced by S.T may be mediated through TLR5 in the macrophages of both mice and humans.In summary,our data indicate that TLR5-mediated LNCGM1082 activity can promote the binding of PKC with NLRC4 to activate NLRC4 and induce resistance to bacterial infection. | Yunhuan Gao Yazheng Yang Jianmei Wei Jianmei Yue Ya Wang Qianjing Zhang Mengli Jin Rong Wang Xiaorong Yang Junqi Zhang Xinqi Liu Lin Liu Yuan Zhang Rongcun Yang | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
| 11 | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys显示文摘Neurological manifestations are frequently reported in the COVID-19 patients.Neuromechanism of SARS-CoV-2 remains to be elucidated.In this study,we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19.In rhesus monkey,SARS-CoV-2 invades the CNS primarily via the olfactory bulb.Thereafter,viruses rapidly spread to functional areas of the central nervous system,such as hippocampus,thalamus,and medulla oblongata.The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons,microglia,and astrocytes in the CNS.Consistently,SARS-CoV-2 infects neuro-derived SK-N-SH,glial-derived U251,and brain microvascular endothelial cells in vitro.To our knowledge,this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model,which provides important insights into the CNS-related pathogenesis of SARS-CoV-2. | Li Jiao Yun Yang Wenhai Yu Yuan Zhao Haiting Long Jiahong Gao Kaiyun Ding Chunxia Ma Jingmei Li Siwen Zhao Haixuan Wang Haiyan Li Mengli Yang Jingwen Xu Junbin Wang Jing Yang Dexuan Kuang Fangyu Luo Xingli Qian Longjiang Xu Bin Yin Wei Liu Hongqi Liu Shuaiyao Lu Xiaozhong Peng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 12 | Optical properties and applications of SnS_(2) SAs with different thickness显示文摘Q-switched lasers have occupied important roles in industrial applications such as laser marking,engraving,welding,and cutting due to their advantages in high pulse energy.Here,SnS_(2)-based Q-switched lasers are implemented.Consid-ering that SnS_(2) inherits the thickness sensitive optical characteristics of TMD,three kinds of SnS2 with different thick-ness are characterized in terms of nonlinearity and used to realize the Q-switched pulses under consistent implementa-tion conditions for comparison tests.According to the results,the influence of thickness variation on the nonlinear per-formance of saturable absorber,such as modulation depth and absorption intensity,and the influence on the correspond-ing laser are analyzed.In addition,compared with other traditional saturable absorbers,the advantage of SnS_(2) in realiz-ing ultrashort pulses is also noticed.Our work explores the thickness-dependent nonlinear optical properties of SnS_(2),and the rules found is of great reference value for the establishment of target lasers. | Mengli Liu Hongbo Wu Ximei Liu Yaorong Wang Ming Lei Wenjun Liu Wei Guo Zhiyi Wei | 2021 | Opto-Electronic Advances2021，4，10： | 0 |
| 13 | Distributed optimization based on improved push-sum framework for optimization problem with multiple local constraints and its application in smart grid显示文摘In this paper,the optimization problem subject to N nonidentical closed convex set constraints is studied.The aim is to design a corresponding distributed optimization algorithm over the fixed unbalanced graph to solve the considered problem.To this end,with the push-sum framework improved,the distributed optimization algorithm is newly designed,and its strict convergence analysis is given under the assumption that the involved graph is strongly connected.Finally,simulation results support the good performance of the proposed algorithm. | Qian XU Chutian YU Xiang YUAN Mengli WEI Hongzhe LIU | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，9： | 0 |
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