|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury显示文摘We report the generation of human ESC-derived,expandable hepatic organoids(hEHOs)using our newly established method with wholly defined(serum-free,feeder free)media.The hEHOs stably maintain phenotypic features of bipotential liver stem/progenitor cells that can differentiate into functional hepatocytes or cholangiocytes.The hEHOs can expand for 20 passages enabling large scale expansion to cell numbers requisite for industry or clinical programs.The cells from hEHOs display remarkable repopulation capacity in injured livers of FRG mice following transplantation,and they differentiate in vivo into mature hepatocytes.If implanted into the epididymal fat pads of immune-deficient mice,they do not generate non-hepatic lineages and have no tendency to form teratomas.We further develop a derivative model by incorporating human fetal liver mesenchymal cells(hFLMCs)into the hEHOs,referred to as hFLMC/hEHO,which can model alcoholic liver disease-associated pathophysiologic changes,including oxidative stress generation,steatosis,inflammatory mediators release and fibrosis,under ethanol treatment.Our work demonstrates that the hEHOs have considerable potential to be a novel,ex vivo pathophysiological model for studying alcoholic liver disease as well as a promising cellular source for treating human liver diseases. | Shuyong Wang Xuan Wang Zuolong Tan Yuxin Su Juan Liu Mingyang Chang Fang Yan Jie Chen Tao Chen Chuanjiang Li Jie Hu Yunfang Wang | 2019 | Cell Research2019，29，12： | 20 |
| 2 | Terahertz metasurface zone plates with arbitrary polarizations to a fixed polarization conversion显示文摘Metasurfaces that can realize the polarization manipulation of electromagnetic waves on the sub-wavelength scale have become an emerging research field.Here,a novel strategy of combining the metasurface and Fresnel zone plate to form a metasurface zone plate is proposed to realize the conversion from nearly arbitrary polarizations to a fixed polarization.Specifically,when one polarized wave is incident on adjacent ring zones constructed by different types of meta-atoms,the transmitted waves generated by odd-numbered and even-numbered ring zones converge at the same focus and superimpose to generate a fixed polarized wave.As function demonstrations,we have designed two types of metasurface zone plates:one is a focused linear polarizer,and the other can convert nearly arbitrary polarized waves into focused circularly polarized waves.The simulated and measured results are consistent with theoretical expectations,suggesting that the proposed concept is flexible and feasible.Our work provides an alternative platform for polarization manipulation and may vigorously promote the development of polarization photonic devices. | Zhen Yue Jitao Li Jie Li Chenglong Zheng Jingyu Liu Guocui Wang Hang Xu Mingyang Chen Yating Zhang Yan Zhang Jianquan Yao | 2022 | Opto-Electronic Science2022，1，3： | 9 |
| 3 | Improved electromagnetic dissipation of Fe doping LaCoO_(3)toward broadband microwave absorption显示文摘Perovskite LaCoO_(3)is of great potential in electromagnetic wave absorption considering its outstanding dielectric loss as well as the existing magnetic response with the magnetic doping.However,the dissipation mechanism of the magnetic doping on the microwave absorption is lack of sufficient investigated.In this paper,LaCo_(1-x)Fe_(x)O_(3)(x=0,0.05,0.1,0.15,0.2,0.25,0.3,LCFOs)perovskites with different Fe doping amounts were prepared successfully by the sol-gel method and subsequent heat treatment in the air atmosphere.The structure characterization carried out by the frst-principles calculations shows the effect of Fe doping on the dielectric and magnetic properties of LCFOs and the strong hybridization of Co/Fe-3d with O-2p in the LCFOs system was successfully demonstrated.Particularly,when x=0.1 and the thickness is only 1.95 mm,the LaCo_(0.9)Fe_(0.1)O_(3)exhibits the best microwave absorption performance with the minimum reflection loss(RL)value of about-41 dB.The typical samples achieve a broad effective absorption bandwidth(EAB)of 5.16 GHz(7.92-13.08 GHz),which covers the total X band(8-12 GHz).Considering that,the especial Fe doping perovskite is promising to be a candidate as efficient microwave absorbers. | Fan Wang Weihua Gu Jiabin Chen Qianqian Huang Mingyang Han Gehuan Wang Guangbin Ji | 2022 | Journal of Materials Science & Technology2022，，10： | 6 |
| 4 | PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision显示文摘Invariant natural killer T1(iNKT1)cells are characterized by the preferential expression of T-box transcription factor T-bet(encoded by Tbx21)and the production of cytokine IFN-γ,but the relationship between the developmental process and iNKT1 lineage diversification in the thymus remains elusive.We report in the present study a crucial role of programmed cell death 5(PDCD5)in iNKT cell terminal maturation and iNKT1 fate determination.Mice with T cell-specific deletion of PDCD5 had decreased numbers of thymic and peripheral iNKT cells with a predominantly immature phenotype and defects in response toα-galactosylceramide.Loss of PDCD5 also selectively abolished the iNKT1 lineage by reducing T-bet expression in iNKT cells at an early thymic developmental stage(before CD44 upregulation).We further demonstrated that TOX2,one of the high mobility group proteins that was highly expressed in iNKT cells at stage 1 and could be stabilized by PDCD5,promoted the permissive histone H3K4me3 modification in the promoter region of Tbx21.These data indicate a pivotal and unique role of PDCD5/TOX2 in iNKT1 lineage determination.They also suggest that the fate of iNKT1 may be programmed at the developmental stage of iNKT cells in the thymus. | Ke Wang Xinwei Zhang Yifan Wang Gaowen Jin Mingyang Li Shusong Zhang Jie Hao Rong Jin Xiaojun Huang Hounan Wu Jun Zhang Yingyu Chen Qing Ge | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 5 | Amorphous and humidity caking: A review显示文摘Caking of products is a common and undesired phenomenon in food, chemical, pharmaceutical, and fertilizer industries which leads to extra cost and irregular quality. In general, caking processes could be identified as amorphous caking or humidity caking. In this review, history of studying caking, formation, methods, and prospects of these two caking processes are summarized and discussed. The relevant studies from the 1920 s to today are mentioned briefly. According to the different properties(i.e. hygrocapacity, hygrosensitivity, mechanical properties, and diffusion behavior) of amorphous powders and crystals, the conditions and mechanisms of amorphous and humidity caking are discussed. It is summarized that glass transition, moisture sorption, quantitative methods characterizing caking, accelerated caking tests, and simulation of caking behaviors are the main aspects that should be studied for a caking process. The methods for these five aspects are reviewed. Potential research points are proposed including caking of mixed particles, caking with phase transition or polymorph transition,non-homogenous caking, and simulation of caking. | Mingyang Chen Dejiang Zhang Weibing Dong Zhilong Luo Chao Kang Haichao Li Gang Wang Junbo Gong | 2019 | Chinese Journal of Chemical Engineering2019，27，6： | 3 |
| 6 | Virtual Speed Sensorless Desired Control Strategy of Maglev Single-sided Linear Induction Motors显示文摘单边短初级长次级直线感应电机己普遍应用于低速磁悬浮的驱动系统。由于在动态纵向边端效应影响下等效电路不对称,单边直线感应电机(single-sided linear inductionmotor,SLIM)的一些参数非线性变化。传统的应用于旋转电机的无速度传感器方法不再适用。首先分析了SLIM的M/T轴等效电路,选择次级磁链作为速度观测器状态变量。根据李雅普诺夫系统稳定性判据,推导出适用于SLIM的无速度传感器辨识;然后,采用反馈广义积分观测器控制稳态辨识速度的双幅脉振幅值;引入虚拟期望变量(virtualdesiredvariable,VDV)法,利用估算速度参与SLIM的恒滑差频率矢量控制。仿真与实验对所提控制算法的有效性和实用性进行了验证,所得结论可为磁悬浮的无速度传感器控制提供参考。 | DENG Jiangming CHEN Tefang TANG Jianxiang ZHANG Guixin YU Mingyang | 2012 | 中国电机工程学报2012，32，27： | 3 |
| 7 | Distribution characteristics and its controlling factor of lacustrine high-quality source rocks in the Bozhong sag,Bohai Bay Basin显示文摘Distribution of Paleogene lacustrine high-quality source rocks in the Bozhong sag in Bohai Bay Basin is analyzed through data of geochemistry,geology and well logging,and its differences under the control of climate and tectonics is also well discussed.Distribution characteristics of the high-quality source rocks developed in the saline environment controlled by the climate are quite different from that developed in the rapid subsidence environment controlled by tectonics.The high-quality source rocks in Member 1 of Shahejie Formation developed in the saline environment account for 81.9%of total subsag area,and are distributed widely and extensively.The high-quality source rocks in Member 3 of Shahejie Formation and Member 3 of Dongying Formation is developed in the tectonic subsidence environment,and horizontally,the subsag subsidence rates has a positive correlation with the area proportion of the high-quality source rocks in the sag;vertically,the reduction-oxidation interface of the lake controls the enrichment of highquality source rocks.Controlled by the saline environment and rapid subsidence environment,the highquality source rocks in the Bozhong sag and adjacent areas have three types of development condition:the saline water,the tectonic subsidence,and joint control of the saline water and the tectonic subsidence.The humid climate and low subsidence rate are not favorable for development of high-quality source rocks. | Hefeng Sun Lifang Liu Xue Jiang Shengbing Huang Mingyang Geng Shaoping Chen Nan Li Pu Shen | 2019 | Petroleum Research2019，4，3： | 3 |
| 8 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 9 | Detrital Zircon U-Pb Geochronology and Provenance of the Hebukesaier Formation in the Shaerbuerti Mountains,Northern West Junggar:Implication for Devonian Subduction of the Junggar–Balkhash Ocean显示文摘Limited Devonian magmatic record in northern West Junggar leads to contrasting models on its tectonic evolution.In this study,we conducted LA-ICP-MS U-Pb dating on detrital zircons of two sandstones from the Hebukesaier Formation in the Shaerbuerti Mountains.Detrital zircons with oscillatory zoning are characterized by high Th/U(>0.3)and low La/Yb(<0.15),indicating their magmatic origin.The youngest zircon ages of two samples are 402±2 Ma and 406±2 Ma,respectively,suggesting that the Hebukesaier Formation was deposited at the Early Devonian.Detrital zircon age patterns show single peaks(at ca.424 Ma,n=157),which indicates that these clastics were likely proximal accumulation after short distance transportation.Provenance of the Hebukesaier Formation was the Xiemisitai and Shaerbuerti Mountains.Detrital zircon ages range from 481 Ma to 395 Ma,which indicates that there was relatively continuous Early Paleozoic magmatism in the Xiemisitai and Shaerbuerti Mountains since the Early Ordovician.Age spectrums of sampled detrital zircons are distinct from those of Lower Devonian strata either in southern West Junggar or in East Junggar,which implies for individual tectonic evolution of northern West Junggar.We favor that Lower Devonian Hebukesaier Formation was developed in a fore–arc setting due to the northward subduction of the Junggar–Balkhash Ocean. | LIANG Hao CHEN Jiafu MA Xu YANG Hongzhang XIN Mingyang | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 2 |
| 10 | 对比经肛全直肠系膜切除术与腹腔镜全直肠系膜切除术:一项多中心III期随机临床试验(TaLaR试验)方案显示文摘背景:全直肠系膜切除术是直肠癌治疗的标准手术方法。经肛全直肠系膜切除术(taTME)是治疗低位直肠癌的新术式。既往研究表明,与腹腔镜全直肠系膜切除术(lapTME)相比,taTME应用于低位直肠癌患者可提供更高质量的手术标本,但其长期肿瘤学结果仍需进一步观察。因此,我们设计了这个非劣效性临床试验(TaLaR试验),比较taTME与lapTME治疗直肠癌的短期和长期结果。方法/设计:TaLaR试验是一项多中心III期随机对照试验。研究对象为经磁共振成像、直肠指检或结肠镜检查被诊断为位于腹膜反折以下的直肠癌,若肿瘤分期≤cT3N2直接手术,若>cT3N2则先行新辅助治疗。通过计算,本研究需纳入1,114例患者(每组557例)。纳入病例随机分配到taTME或lapTME组。本研究的主要终点是3年无病生存率(DFS)和5年总生存率(OS)。次要终点包括手术标本质量、围手术期结果、骨盆和肛门功能以及生活质量。讨论:我们认为,TaLaR试验将阐明taTME是否可以达到与lapTME相似的肿瘤学结果,以及是否可改善直肠癌患者的手术标本质量及恢复情况。 | Liang Kang Ziwei Zeng Shuangling Luo Hong Zhang Quan Wang Mingyang Ren Miao Wu Weidong Tong Qing Xu Yi Xiao Aiwen Wu Yuan-Guang Chen Bo Feng Zhanlong Shen Liang Huang Xingwei Zhang Minhua Zheng Jian-Ping Wang | 2021 | Gastroenterology Report2021，9，1： | 2 |
| 11 | Selectivity switch in transformation of CO2 from ethanol to methanol on Cu embedded in the defect carbon显示文摘The copper-based catalysts have been generally regarded as high-performance catalysts for CO_2 hydrogenation toward methanol,while the production of ethanol via C–C coupling on the copper-based catalysts is still challenging.Herein,we report a new catalyst where Cu nanoparticles are embedded in the carbon support with abundant defect sites,achieving a high selectivity for ethanol in the CO_2 hydrogenation.The experiments coupled with the theoretical studies show a clear map where carbon defects serve as anchor sites that can stabilize interfacial copper species,and interfacial Cu sites with low coordination numbers can adsorb two C_1 species and later convert them to a C_2 species via a hydrogenation-induced coupling reaction.Further adjacent Cu atoms of interfacial Cu sites can facilitate OH reduction reactions via the Cu–Cu bridge adsorption to assist the formation of ethanol.Especially,those specific active sites easily disappear in the reducing conditions and during the reaction,the major product can transform from ethanol to methanol. | Shuohao Li Govindarajan Saranya Mingyang Chen Yan Zhu | 2020 | Science China Chemistry2020，63，5： | 2 |
| 12 | Hybrid Channel Access Mechanism Based on Coexistence Scenario of NR-Unlicensed显示文摘With the rapid development of 5G NR(New Radio),the explosive increment of traffic amount is calling the utilization of unlicensed band.3GPP has proposed LAA(Licensed Assisted Access)to use LTE in unlicensed band and pointed out that NR-U(NR-Unlicensed)can reuse most designs of it.However,the existing channel access mechanism of LAA is conservative under the coexistence scenario of NR-U,which leads to the waste of time resource.To address the problem this paper proposes a hybrid channel access mechanism to take advantage of the LBT(Listen-Before-Talk)mechanism of LAA when channel is quite busy and transmit directly with reduced power when it is relatively idle.The channel busy degree is judged by a series of periodically updated adaptive thresholds.System-level simulation verifies that under the coexistence scenario of NR-U the proposed mechanism can achieve higher UPT(User Perceived Throughput)and lower delay than other channel access mechanisms. | Zhening Zhang Jingyi Chen Mingyang Dong Yuehong Gao Jingjing Wang | 2020 | China Communications2020，17，1： | 2 |
| 13 | Risk factors associated with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation显示文摘Hemorrhagic cystitis(HC)is a common complication of allogeneic hematopoietic stem cell transplantation(HSCT).The incidence is about 7%to 68%,and some patients have to suffer a long period of frequent,urgent,and painful urination,which brings great pain.This study aimed to analyze risk factors of HC and its effect on patient survival.We collected the medical records of 859 patients who underwent HSCT at our hospital between August 2016 and August 2020.Patients with and without HC were matched using propensity score matching at a 1:1 ratio based on sex,age,and diagnosis,and logistic regression analyses were used to identify factors associated with HC.We used Kaplan–Meier curves to analyze the survival rates of patients in the HC and non-HC groups.We also analyzed the relationship between BK viral load and the occurrence of HC using receiver operating characteristic curve(ROC)analysis.After propensity score matching,there were 131 patients each in the HC and non-HC groups.In the HC group,89 patients(67.9%)had mild HC(stage II°)and 43(32.1%)had severe HC(stage III–IV).The median interval between stem cell transplantation and HC development was 31(3–244)days.Univariate analysis indicated that donor age,hematopoietic stem cell source,HLA,acute graft-versus-host disease,busulfan,anti-thymocyte globulin(ATG),total body irradiation,cytomegalovirus(CMV)(urine),and BK polyomavirus(BKV)(urine)were significantly associated with HC.ATG,CMV(urine),and BKV(urine)were independent risk factors for HC based on the multivariate analysis.The Kaplan–Meier survival analysis showed no significant difference between the HC and non-HC groups(P=0.14).The 1-and 2-year survival rates in the HC group were 78.4%and 69.6%,respectively,and the corresponding rates in the non-HC group were 84.4%and 80.7%,respectively.ROC analysis indicated that a urine BKV load of 1×10^(7) copies/mL was able to stratify the risk of HC.In conclusion,when the BKV load is>1×10^(7),we needtobe aware of the potential for the development of HC. | Biao Shen Yueshen Ma Haixiao Zhang Mingyang Wang Jia Liu Jiaxin Cao Wenwen Guo Dan Feng Donglin Yang Rongli Zhang Xin Chen Qiaoling Ma Weihua Zhai Sizhou Feng Mingzhe Han Aiming Pang Erlie Jiang 无 | 2022 | Blood Science2022，4，2： | 2 |
| 14 | Research on correlation between weld concavity and weld process parameters in tailored blank laser welding 显示文摘 | ZHAN Mingyang ZOU Yuanyuan and CHEN Dang | 2011 | Advanced Materials Research Shenzhen China2011，2011，154： | 1 |
| 15 | Purification and identification of antioxidant peptides from egg white protein hydrolysate显示文摘 | CHEN Chen CHI Yujie ZHAO Mingyang | 2012 | Amino Acids2012，43，1： | 1 |
| 16 | Effect of Cr ( Ⅵ ) on the microbial activity of aerobic granular sludge 显示文摘 | Zheng Xiaoying Wang Mingyang Chen Wei | 2016 | Desalina- tion and Water Treatment2016，57，15： | 1 |
| 17 | A new cost effective sensor- less commutation method for brushless DC motors without phase shift circuit and neutral voltage 显示文摘 | CHEN Chenghu CHENG Mingyang | 2007 | IEEE Transactions on Power Electronics2007，22，2： | 1 |
| 18 | Catalytic Thiourea Promoted Electrophilic Thiocyanation of Indoles and Aromatic Amines with NCS/NH4SCN显示文摘为有 thiourea/NCS/NH 4 SCN 系统被开发了。现在的过程的主要特征是便宜、容易地可得到的 organocatalyst 的温和条件,好收益,短反应时间,和使用。而且, N-chlorosuccinimide (NCS ) 被发现到不可缺少,并且 thiourea 能极大地支持反应。 | Cancan Wang Zhonghao Wang Liang Wang Qun Chen Mingyang He | 2016 | Chinese Journal of Chemistry2016，34，11： | 1 |
| 19 | Nickel-catalysed C-O bond reduction of 2,4,6-triaryloxy-1,3,5-triazines in 2-methyltetrahydrofuran显示文摘A nickel-catalysed reduction of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine (TCT) in ecofriendly 2-methyltetrahydrofuran (2-MeTHF) is described. The phenol-TCT derivatives were readily prepared using grinding method in short time without further purification. This catalytic system allowed the facile C-O cleavage of phenol-TCT derivatives under mild reaction conditions with high efficiency and good functional group tolerance. Gram-scale reaction was also achieved. Particularly, sequential functionalization of phenol-TCT derivatives followed by C-O bond reduction could also be realized,affording the high value-added products in moderate to good yields. | Yaoyao Wang Jun Shen Qun Chen Liang Wang Mingyang He | 2019 | Chinese Chemical Letters2019，30，2： | 1 |
| 20 | Towards Friction Stir Remanufacturing of High‑Strength Aluminum Components显示文摘Volumetric defects in high-strength aluminum alloy components were repaired via friction stir remanufacturing(FSR).Various consumable pins made of AA7075-T6 were designed.Top diameters of the consumable pins afected material fow,which ensured that the materials at the repairing interface were forged to metallurgical bonding.Conical angles determined load transfer besides material fow,which afected the fracture of the pins before the dwelling stage.Sound repaired components were achieved when the conical angle of the consumable pin was 1°larger than that of the volumetric defect.The ultimate tensile strength and elongation of the repaired components reached 445.9 MPa and 9.6%,respectively.The design criteria of the consumable pin in the FSR was established,which provided valuable references to repair volumetric defects in high-strength aluminum components. | Xiangchen Meng Yuming Xie Xiaotian Ma Mingyang Liang Xiaoyang Peng Shiwei Han Lei Kan Xin Wang Sihao Chen Yongxian Huang | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员