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| 1 | Comparative kinetics of coal and oil shale pyrolysis in a micro fluidized bed reaction analyzer显示文摘The characteristics and kinetics of coal and oil shale pyrolysis were comparatively studied by using a micro fluidized bed reaction analyzer(MFBRA).The isothermal differential model was first applied to calculate the kinetic parameters of activation energy and frequency factor according to the major gas components during pyrolysis.The results showed that the major gas components released from coal and oil shale under the isothermal condition had different initiating and ending time points,and the difference was more significant under the programmed heating conditions.The shrinking core model allowed better fitting relevance for the coal pyrolysis,while the three-dimension model was more suitable for oil shale pyrolysis,indicating that the gases from the pyrolysis process of coal and oil shale might go through different reaction paths.The activation energy of oil shale pyrolysis was 36.96 kJ·mol^(−1),larger than the value of pyrolysis of the two coals,which was 21.16 and 32.17 kJ·mol^(−1),respectively.The above results justified that the oil shale pyrolysis with high ash contents was somehow more difficult to take place in terms of higher activation energy and the MFBRA could be a useful tool to give some insight into the intrinsic kinetics and reaction mechanisms of coal and oil shale pyrolysis. | Yuming Zhang Mengxuan Zhao Rongxuan Linghu Chengxiu Wang Shu Zhang | 2019 | Carbon Resources Conversion2019，2，3： | 7 |
| 2 | Isolation and culture of hepatic stellate cells from mouse liver显示文摘肝的星形的房间(HSC ) 是在肝以内的主要细胞外的生产矩阵的房间并且有众多的 vitalfunctions。为 HSC 的隔离和文化的一个柔韧的协议是重要的因为房间 functionsand 的进一步的调查在肝疾病联系了机制。鼠标肝的卷比老鼠肝的小得多,哪个对更困难的 makesit 比老鼠 HSC 孤立鼠标 HSC (mHSCs ) 。目前,孤立 mHSCs 仍然是挑战 becausethere 不是有效、柔韧的方法孤立并且文化这些房间。在现在的学习, C57BL/6J 老鼠是有包含 liposome 的 dichloromethylene diphosphate (CL2MDP ) 的 intravenouslyinjected 有选择地从 theliver 消除 Kupffer 房间。老鼠肝然后在 situ 被酒,并且 mHSCs 与一种优化密度坡度 centrifugation 技术被孤立。在磷酸盐缓冲区答案(PBS )-liposome 组, mHSCs 的收益是(1. | Wenj u Chang Mengxuan Yang Lujun Song Kuntang Shen Hongshan Wang Xiaodong Gao Min Li Weixin Niu Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 6 |
| 3 | Experimental study on removing NO from flue gas using microwave irradiation over activated carbon carried catalyst显示文摘Nitrogen oxides(NOx) from flue gas can be removed efficiently by activated carbon continuously irradiated by microwave,which,however,needs high temperature and consumes excessive carbon. If catalyst is added into activated carbon,then reaction temperature can be reduced and selectivity of reaction enhanced. The effects on flue gas denitrification by adding different catalysts to microwave reactor were studied in this paper. It was found that the addition of catalyst could reduce the microwave power required by the same removal efficiency obviously;the difference of removal efficiency was different due to different catalysts,and the Cu-based catalyst has more catalytic action efficiency. Reaction temperature decreased by about 200℃ and removal efficiency increased by 25% after adding Cu-based catalyst. In addition,characteristic analysis for activated carbon conducted by X-ray diffraction confirmed that active component of catalyst existed on the surface of activated carbon. | MA ShuangChen JIN Xin WANG MengXuan JIN YiJing YAO JuanJuan LIU Wei | 2011 | Science China(Technological Sciences)2011，54，12： | 5 |
| 4 | Single-cell RNA sequencing reveals a high-resolution cell atlas of xylem in Populus显示文摘High-throughputsingle-cellRNAsequencing(sc RNA-seq) has advantages over traditional RNA-seq to explore spatiotemporal information on gene dynamic expressions in heterogenous tissues. We performed Drop-seq, a method for the dropwise sequestration of single cells for sequencing, on protoplasts from the differentiating xylem of Populus alba × Populus glandulosa. The sc RNA-seq profiled9,798 cells, which were grouped into 12 clusters.Through characterization of differentially expressed genes in each cluster and RNA in situ hybridizations,we identified vessel cells, fiber cells, ray parenchyma cells and xylem precursor cells. Diffusion pseudotime analyses revealed the differentiating trajectory of vessels, fiber cells and ray parenchyma cells and indicated a different differentiation process between vessels and fiber cells, and a similar differentiation process between fiber cells and ray parenchyma cells. We identified marker genes for each cell type(cluster) and key candidate regulators during developmental stages of xylem cell differentiation. Our study generates a high-resolution expression atlas of wood formation at the single cell level and provides valuable information on wood formation. | Hui Li Xinren Dai Xiong Huang Mengxuan Xu Qiao Wang Xiaojing Yan Ronald R.Sederoff Quanzi Li | 2021 | Journal of Integrative Plant Biology2021，63，11： | 4 |
| 5 | Research on desorption and regeneration of simulated decarbonization solution in the process of CO_2 capture using ammonia method显示文摘Study on desorption and regeneration of simulated decarbonization solution using ammonia method for CO2 capture was carried out in order to understand the feature of regeneration of decarbonization solution. The mechanisms about solution desorption after decarbonization were introduced briefly. Under the atmospheric pressure and in the presence of nitrogen carrier gas, several effects related to desorption of simulated decarbonization solution were analyzed, such as temperature, solution concentration, pH, loading capacity, etc. The results showed that the CO2 desorption percentage increased with the increases of temperature, solution concentration and loading capacity, but CO2 desorption percentage increased with the increasing of pH and then decreased. | MA ShuangChen WANG MengXuan HAN TingTing CHEN WeiZhong LU DongLi CHEN GongDa | 2012 | Science China(Technological Sciences)2012，55，12： | 3 |
| 6 | Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach显示文摘Dear Editor,Hepatoid adenocarcinoma(HAC)is a rare pathological subtype of extrahepatic tumor,featured by hepatoid differentiation andα-fetoprotein(AFP)-production[1,2].Hepatoid adenocarcinoma of the stomach(HAS),accounting for 0.3%to 1.0%of all gastric cancers(GCs),has attracted increasing attention due to its high degree of malignancy[3].Compared with classic GC,HAS showed a higher rate of vascular invasion,lymph node metastasis,and liver metastasis,with only 9.0%survival rate at 5 years[4].Currently,there is no effective treatment for HAS,and little is known about its pathogenesis.Herein,we investigated the molecular features of HAS and identified potential therapeutic targets for HAS. | Mengxuan Zhu Erbao Chen Shan Yu Chen Xu Yiyi Yu Xin Cao Wei Li Pengfei Zhang Yan Wang Baofeng Lian Shuirong Zhang Yueting Qu Lujia Huang Weiwei Shi Yuehong Cui Li Qian Tianshu Liu | 2022 | Cancer Communications2022，42，10： | 3 |
| 7 | The Functional Characterization of Bat and Human P[3] Rotavirus VP8*s显示文摘P[3]rotavirus(RV)has been identified in many species,including human,simian,dog,and bat.Several glycans,including sialic acid,histo-blood group antigens(HBGAs)are reported as RV attachment factors.The glycan binding specificity of different P[3]RV VP8*s were investigated in this study.Human HCR3 A and dog P[3]RV VP8*s recognized glycans with terminal sialic acid and hemagglutinated the red blood cells,while bat P[3]VP8*showed neither binding to glycans nor hemagglutination.However,the bat P[3]VP8*mutant of C189 Y obtained the ability to hemagglutinate the red blood cells,while human P[3]HCR3 A/M2-102 mutants of Y189 C lost the ability.Sequence alignment and structural analysis indicated that residue 189 played an important role in the ligand recognition and may contribute to the cross-species transmission.Structural superimposition exhibited that bat P[3]VP8*model was quite different from the simian P[3]Rhesus rotavirus(RRV)P[3]VP8*,indicating that bat P[3]RV was relatively distinct and partially contributed to the no binding to tested glycans.These results promote our understanding of P[3]VP8*/glycans interactions and the potential transmission of bat/human P[3]RVs,offering more insight into the RV infection and prevalence. | Dandi Li Mengxuan Wang Tongyao Mao Mingwen Wang Qing Zhang Hong Wang Lili Pang Xiaoman Sun Zhaojun Duan | 2021 | Virologica Sinica2021，36，5： | 3 |
| 8 | Location and size regulation of manganese oxides within mesoporous silica for enhanced antibiotic degradation显示文摘Refractory antibiotics in domestic wastewater are hard to be completely eliminated by conventional methods,and then lead to severe environmental contamination and adverse effects on public health.In present work,advanced oxidation processes(AOPs)are adopted to remove the antibiotic of sul-fachloropyridazine(SCP).Nanosized Mn_(2)O_(3) was fabricated on the SBA-15 material to catalytically acti-vate potassium peroxydisulfate(PDS)to generate reactive oxygen radicals of.OH and SO_(4).for SCP degradation.The effects of location and size of Mn_(2)O_(3) were explored through choosing either the as-made or template free SBA-15 as the precursor of substrate.Great influences from the site and size of Mn_(2)O_(3) on the oxidation activity were discovered.It was found that Mn_(2)O_(3) with a large size at the exterior of SBA-15(Mn-tfSBA)was slightly easier to degrade SCP at a low manganese loading of 1.0-2.0 mmol.g;however,complete SCP removal could only be achieved on the catalyst of Mn_(2)O_(3) with a refined size at the interior of SBA-15(Mn-asSBA).Moreover,the SO_(4).species were revealed to be the decisive radicals in the SCP degradation processes.Exploring the as-made mesoporous silica as a support provides a new idea for the further development of environmentally friendly catalysts. | Min Lu Mengxuan Liu Chunli Xu Yu Yin Lei Shi Hong Wu Aihua Yuan Xiao-Ming Ren Shaobin Wang Hongqi Sun | 2022 | Chinese Journal of Chemical Engineering2022，35，8： | 3 |
| 9 | Deep insight into the voltage amplification effect from ferroelectric negative capacitance显示文摘Dear editor, Power dissipation has become one of the most serious problems for nano-electronics. For conventional transistors, the operation voltage cannot be continuously reduced due to the fundamental limitation of sub threshold swing (SS)(60 mV / decade at room temperature)[1,2]. The voltage amplification (VA) induced by the negative capacitance (NC) effect of ferroelectrie (FE) material provides a possible approach for FE-based transistors to achieve sub-60 SS charactetistics [3]. However, the physical origin of NC effect in FE-FET are still unclear and controversial. | Huimin WANG Qianqian HUANG Mengxuan YANG Xing ZHANG Ru HUANG | 2019 | Science China(Information Sciences)2019，62，8： | 2 |
| 10 | Vortex Smith-Purcell radiation generation with holographic grating显示文摘Smith–Purcell radiation(SPR)is the electromagnetic wave generated by free electrons passing above a diffraction grating,and it has played an important role in free-electron light sources and particle accelerators.Orbital angular momentum(OAM)is a new degree of freedom that can significantly promote the capacity of information carried by an electro-magnetic beam.In this paper,we propose an integrable method for generating vortex Smith–Purcell radiation(VSPR),namely,SPR carrying OAM,by having free-electron bunches pass on planar holographic gratings.VSPRs generated by different electron energies,with different topological charges of the OAM,radiation angles,and frequencies are demonstrated numerically.It is also found that,for high-order radiation,the topological charge of the OAM wave will be multiplied by the radiation order.This work introduces a new way to generate SPR with OAM and provides a method to achieve an integratable and tunable free-electron OAM wave source at different frequency regions. | MENGXUAN WANG FANG LIU YUECHAI LIN KAIYU CUI XUE FENG WEI ZHANG YIDONG HUANG | 2020 | Photonics Research2020，8，8： | 2 |
| 11 | Surface hydrophobic modification enhanced catalytic performance of electrochemical nitrogen reduction reaction显示文摘Electrocatalytic nitrogen reduction reaction(NRR)is a sustainable approach for NH_(3)production with low energy consumption.However,competing hydrogen reduction reaction(HER)in aqueous solution results in low NH_(3)production and Faraday efficiency(FE).Here,MoS_(2)nanostructures with a hydrophobic surface are synthesized by alkyl thiols modification.Aerophilic and hydrophobic surface facilitates an efficient three-phase contact of N_(2),H_(2)O,and catalyst.Thus,localized concentrated N_(2)molecules can overcome the mass transfer limitation of N2 and depress the HER due to lowering the proton contacts.Although the active-sites decrease with the increase of the alkyl chain since the thiol may cover the active site,the optimized electrocatalyst achieves NH_(3)yield of 12.86×10^(-11)mol·cm^(-2)·s^(-1)at-0.25 V and 22.23%FE,which are 4.3 and 24 times higher than those of MoS2-CP electrocatalyst,respectively.The increased catalytic performance is attributed to the high N_(2)adsorption and depressed HER. | Lijuan Niu Ziwen Liu Guohua Liu Mengxuan Li Xupeng Zong Dandan Wang Li An Dan Qu Xiaoming Sun Xiayan Wang Zaicheng Sun | 2022 | Nano Research2022，15，5： | 2 |
| 12 | Combined Adaptive Multiple Subtraction Based on Optimized Event Tracing and Extended Wiener Filtering显示文摘The surface-related multiple elimination(SRME) method is based on feedback formulation and has become one of the most preferred multiple suppression methods used. However, some differences are apparent between the predicted multiples and those in the source seismic records, which may result in conventional adaptive multiple subtraction methods being barely able to effectively suppress multiples in actual production. This paper introduces a combined adaptive multiple attenuation method based on the optimized event tracing technique and extended Wiener filtering. The method firstly uses multiple records predicted by SRME to generate a multiple velocity spectrum, then separates the original record to an approximate primary record and an approximate multiple record by applying the optimized event tracing method and short-time window FK filtering method. After applying the extended Wiener filtering method, residual multiples in the approximate primary record can then be eliminated and the damaged primary can be restored from the approximate multiple record. This method combines the advantages of multiple elimination based on the optimized event tracing method and the extended Wiener filtering technique. It is an ideal method for suppressing typical hyperbolic and other types of multiples, with the advantage of minimizing damage of the primary. Synthetic and field data tests show that this method produces better multiple elimination results than the traditional multi-channel Wiener filter method and is more suitable for multiple elimination in complicated geological areas. | TAN Jun SONG Peng LI Jinshan WANG Lei ZHONG Mengxuan ZHANG Xiaobo | 2017 | Journal of Ocean University of China2017，16，3： | 2 |
| 13 | H_(2)O_(2)mediates transcriptome reprogramming during Soybean mosaic virus-induced callose deposition in soybean显示文摘The main defense response to Soybean mosaic virus(SMV)infection in soybean[Glycine max(L.)Merr.]is thought to be blockage of intercellular virus transport by callose deposition on plasmodesmata.But the specific regulatory mechanism remains largely unknown.In this study,we found that hydrogen peroxide(H_(2)O_(2))signal downstream of NO was associated with the regulation of callose accumulation.Abundant H_(2)O_(2)was produced on the cell membrane and cell wall in the incompatible combination of soybean cultivar Jidou 7 and SMV strain N3,whereas no obvious H_(2)O_(2)was observed in the compatible combination of Jidou 7 and strain SC-8.When H_(2)O_(2)production was inhibited,callose accumulation induced by SMV infection decreased to a level insufficient to restrict virus transport in the incompatible combination.The H_(2)O_(2)-associated transcriptome dynamics of soybean during SMV infection was investigated.Transcriptome and functional analysis using virus-induced gene silencing showed that Gm SEOB and Gm PAP27,two genes regulated by H_(2)O_(2),functioned in resistance by positively regulating the accumulation of callose in response to SMV infection.These results lay a foundation for further research on the signal transduction and molecular regulation of callose deposition during soybean resistance to SMV infection. | Tianjie Sun Xizhe Sun Fukuan Li Nan Ma Mengxuan Wang Yan Chen Na Liu Yuan Jin Jie Zhang Chunyan Hou Chunyan Yang Dongmei Wang | 2022 | The Crop Journal2022，10，1： | 1 |
| 14 | Structural Basis of Glycan Recognition in Globally Predominant Human P[8]Rotavirus显示文摘Rotavirus(RV)causes acute gastroenteritis in infants and children worldwide.Recent studies showed that glycans such as histo-blood group antigens(HBGAs)function as cell attachment factors affecting RV host susceptibility and prevalence.P[8]is the predominant RV genotype in humans,but the structural basis of how P[8]RVs interact with glycan ligands remains elusive.In this study,we characterized the interactions between P[8]VP8~*s and glycans which showed that VP8~*,the RV glycan binding domain,recognized both mucin core 2 and H type 1 antigens according to the ELISA-based oligosaccharide binding assays.Importantly,we determined the structural basis of P[8]RV-glycans interaction from the crystal structures of a Rotateq P[8]VP8~*in complex with core 2 and H type 1 glycans at 1.82.3?,respectively,revealing a common binding pocket and similar binding mode.Structural and sequence analysis demonstrated that the glycan binding site is conserved among RVs in the P[Ⅱ]genogroup,while genotype-specific amino acid variations determined different glycan binding preference.Our data elucidated the detailed structural basis of the interactions between human P[8]RVs and different host glycan factors,shedding light on RV infection,epidemiology,and development of anti-viral agents. | Xiaoman Sun Lei Dang Dandi Li Jianxun Qi Mengxuan Wang Wengang Chai Qing Zhang Hong Wang Ruixia Bai Ming Tan Zhaojun Duan | 2020 | Virologica Sinica2020，35，2： | 1 |
| 15 | Kinetic experimental study on desorption of decarbonization solution using ammonia method显示文摘 | Ma Shuangchen Wang Mengxuan Han Tingting Song Huihui Zang Bin Lu Dongli Chen Weizhong | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 16 | Injectable nanofiber-reinforced bone cement with controlled biodegradability for minimally-invasive bone regeneration显示文摘Injectable materials show their special merits in regeneration of damaged/degenerated bones in minimally-invasive approach.Injectable calcium phosphate bone cement(CPC)has attracted broad attention for its bioactivity,as compared to non-degradable polymethyl methacrylate cement.However,its brittleness,poor anti-washout property and uncontrollable biodegradability are the main challenges to limit its further clinical application mainly because of its stone-like dense structure and fragile inorganic-salt weakness.Herein,we developed a kind of injectable CPC bone cement with porous structure and improved robustness by incorporating poly(lactide-co-glycolic acid)(PLGA)nanofiber into CPC,with carboxymethyl cellulose(CMC)to offer good injectability as well as anti-wash-out capacity.Furthermore,the introduction of PLGA and CMC also enabled a formation of initial porous structure in the cements,where PLGA nanofiber endowed the cement with a dynamically controllable biodegradability which provided room for cell movement and bone ingrowth.Inter-estingly,the reinforced biodegradable cement afforded a sustainable provision of Ca^(2+)bioactive components,together with its porous structure,to improve synergistically new bone formation and osteo-integration in vivo by using a rat model of femur condyle defect.Further study on regenerative mechanisms indicated that the good minimally-invasive bone regeneration may come from the synergistic enhanced osteogenic effect of calcium ion enrichment and the improved revascularization capacity contributed from the porosity as well as the lactic acid released from PLGA nanofiber.These results indicate the injectable bone cement with high strength,anti-washout property and controllable biodegradability is a promising candidate for bone regeneration in a minimally-invasive approach. | Peihao Cai Shunyi Lu Jieqin Yu Lan Xiao Jiayi Wang Haifeng Liang Lei Huang Guanjie Han Mengxuan Bian Shihao Zhang Jian Zhang Changsheng Liu Libo Jiang Yulin Li | 2023 | Bioactive Materials2023，，3： | 1 |
| 17 | Comparative Experimental Analysis on Coal Spontaneous Combustion显示文摘The goal of this study was to investigate coal quality features and their relationship to coal spontaneous combustion characteristics in multi-seam coal mines to better predict when coal spontaneous combustion is likely to occur.To that end,coal samples of various particle sizes were obtained from five coal seams(Nos.6,8,9,12 and 20)in the Shuangyashan City Xin’an Coal Mine.The samples were then respectively heated using a temperature programming system to observe and compare similarities and differences in the sponta-neous combustion process of different particle sizes in response to rising temperature.The experimental results show,that in all five coal seams,the concentration of CO,C_(2)H_(4),and C_(2)H_(6) increased with a certain degree of regularity as a function of rising temperature.However,of these three gasses,only CO and C_(2)H_(4) can be used as indicators to predict coal mine spontaneous combustion.The critical temperature for samples from all five coal seams ranged from 50–85℃,while the dry cracking temperature of coal seams 8 and 12(80–100℃)were lower than those of 6,9,and 20(100–120℃).Furthermore,the production rate of CO,C_(2)H_(4),and C_(2)H_(6) is related to both coal particle size and temperature.The smaller the particle size,the faster the production rate;and the higher the temperature,the more gas that gets produced.All five coal seems are mainly com-posed of long flame coal.However,they differ in that the No.12 coal seam contains weak cohesive coal;the No.8 coal seam contains lean and gas coal;and the Nos.6,9,and 20 coal seams contain a certain amount of anthracite.During the programmed coal heating,the CO,C_(2)H_(4),and C_(2)H_(6) release trend for the coal seams was No.12>No.8>Nos.6,9,and 20.These results demonstrate that the presence of weak cohesive coal and anthracite highly influence the concentration of CO,C_(2)H_(4),and C_(2)H_(6) released during coal spontaneous combustion. | Haitao Wang Yongli Liu Bin Shen Mengxuan Ren Qiyuan Shan | 2022 | Energy Engineering2022，119，5： | 0 |
| 18 | Development of surface displaying system for heterologous protein expression in Candida tropicalis显示文摘The purpose of this study was to assess the potential application of cell surface display in Candida tropicalis.Surface display gene cassettes were constructed using five anchoring proteins from Saccharomyces cerevisiae,three of which[(suppression of exponential defect protein,SED1),(cell wall protein 2,CWP2)and(delayed anaerobic protein 4,DAN4)]were reported to show higher activity of heterologous proteins thanα-agglutinin(AGα1).The performance of yeast-enhanced green fluorescent protein(yeGFP)was evaluated using laser scanning confocal microscopy and flow cytometry.The results showed that the three anchoring regions(SED1,CWP2 and AGα1)successfully displayed yeGFP on the cell wall.To investigate the effect of the three anchoring proteins on the surface display of Rhizopus oryzaeα-amylase(ROA1)and Aspergillus aculeatusβ-glucosidase(BGL1)in C.tropicalis,we constructed surface display gene cassettes for ROA1 and BGL1,respectively.The strains containing the anchoring proteins SED1 and CWP2 showed higher activity of ROA1 and BGL1 than the strains containing the anchoring protein AGα1.The highest ROA1 and BGL1 activities of strains with SED1 were 6.37 U/g CDW and 7.93 U/g CDW,respectively,which were sixfold and eightfold higher than those of strain with AGα1.In addition,we also optimized signal peptides.The results indicated that signal peptides have an impact on enzyme activity. | Tingting Wang Haibing Zhang Mengxuan Li Jiaxi Zheng Yuanyuan Xia Haiquan Yang Wei Shen Xianzhong Chen | 2023 | Systems Microbiology and Biomanufacturing2023，3，2： | 0 |
| 19 | Ultrasmall pH-responsive silicon phthalocyanine micelle for selective photodynamic therapy against tumo显示文摘Targeted photodynamic therapy(TPDT)based on the photosensitizers responsive for tumor micr oenvironment is promising because of the better anti-tumor effect and less phototoxicity against normal tissue than the traditional PDT.Nanoparticle based stimuli responsive photo-sensitizers have been widely explored for TPDT.Based on the acidic microenvironments in solid tumors,an ultrasmall pH-responsive silicon phthalocyanine nanomicelle(PSN)(smaller than 10 nm)was designed for selective PDT of tumor.PSN had high drug loading efficacy(more than 28%)and exhibited morphological transitions,enhanced fuorescence and improved singlet∞x-ygen yield under acidic environments.PSN was renal dlearable and could rapidly accumulate and be retained at tumor sites,achieving a tumor-inhibiting ffect better than phthalocyanine micelle without pH response.Tumors of mice treated with PSN for PDT were completely ablated without recurrence.Thus,we have developed a phthalocyanine-based pH responsive micelle with excellent tumor targeting ability,which is expected to realize the selective PDT of tumor. | Yiming Zhou Wenlong Zeng Mengxuan Wang Rui Li Xiuli Yue Zhifei Dai | 2022 | Journal of Innovative Optical Health Sciences2022，15，6： | 0 |
| 20 | The monkey microbial biobank brings previously uncultivated bioresources for nonhuman primate and human gut microbiomes显示文摘Impact statement Nonhuman primates(NHPs)such as monkeys are the closest living relatives to humans and are the best available models for causative studies of human health and diseases.Gut microbiomes are intensively involved in host health.In this study,by large-scale cultivation of microbes from fecal samples of monkeys,we obtained previously uncultured bacterial species and constructed a Macaca fascicularis Gut Microbial Biobank(MfGMB).The MfGMB consisted of 250 strains that represent 97 species of 63 genera,25 families,and 4 phyla.The information of the 250 strains and the genomes of 97 cultured species are publicly accessible.The MfGMB represented nearly 50% of core gut microbial compositions at the genus level and covered over 80% of the KO-based known gut microbiome functions of M.fascicularis.Data mining showed that the bacterial species in the MfGMB were prevalent not only in NHPs gut microbiomes but also in human gut microbiomes.This study will help the understanding and future investigations on how gut microbiomes interact with their mammalian hosts. | Danhua Li Chang Liu Rexiding Abuduaini Mengxuan Du Yujing Wang Haizhen Zhu Honghe Chen Nan Zhou Yuhua Xin Linhuan Wu Juncai Ma Yuguang Zhou Yong Lu Chengying Jiang Qiang Sun Shuang-Jiang Liu | 2022 | mLife2022，1，2： | 0 |
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