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| 1 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 2 | Recent progress on nanoparticle-based drug delivery systems for cancer therapy显示文摘The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer nanotherapeutics have overcome several limitations of conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size and surface characteristics are the key components of nanotherapeutics, and are designed to passively or actively deliver anti-cancer drugs to tumor cells. We provide an overview of nanoparticle-based drug delivery methods and cancer therapies based on tumor-targeting delivery strategies that have been developed in recent years. | Yanru Xin Mingming Yin Liyuan Zhao Fanling Meng Liang Luo | 2017 | Cancer Biology & Medicine2017，14，3： | 10 |
| 3 | A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes显示文摘细胞毒素的 T 房间(CTL ) 在肝炎 B 的控制起一个关键作用病毒(HBV ) 感染和病毒的清理。然而,大多数识别 CTL epitopes 从遗传型 A 和 D 的 HBV 被导出,并且很少在在亚洲更流行的遗传型 B 和 C 的病毒被定义。因为 HBV 核心蛋白质(HBc ) 是最保守、产生免疫性的部件,在这研究,我们使用了盖住 HBc 屏蔽并且识别特定的 CTL epitopes 的一个重叠 9-mer 肽水池。异乎寻常的 HLA-A2-restricted epitope HBc141149 被结晶化分析发现,在结构上描绘了。immunogenicity 和 anti-HBV 活动进一步在 HBV 和 HLA-A2 被决定转基因的老鼠。最后,我们证明在 HBc141149 epitope 的变化与病毒的参数被联系,在 HBV 的疾病前进感染了病人。我们的数据因此提供卓见进这异乎寻常的 epitope 绑定的结构特征给 MHC-I 分子,以及 epitope 特定的 CTL 活动在 HBV 安排 T 房间反应和有免疫力的避免感染的病人。 | Lu Sun Yu Zhang Bao Zhao Mengmeng Deng Jun Liu Xin Li Junwei Hou Mingming Gui Shuijun Zhang Xiaodong Li George F. Gao Songdong Meng | 2014 | Protein & Cell2014，5，4： | 7 |
| 4 | Toward dendrite-free and anti-corrosion Zn anodes by regulating a bismuth-based energizer显示文摘Aqueous rechargeable zinc metal batteries display high theoretical capacity along with economical effectiveness,environmental benignity and high safety.However,dendritic growth and chemical corrosion at the Zn anodes limit their widespread applications.Here,we construct a Zn/Bi electrode via in-situ growth of a Bi-based energizer upon Zn metal surface using a replacement reaction.Experimental and theoretical calculations reveal that the Bi-based energizer composed of metallic Bi and ZnBi alloy contributes to Zn plating/stripping due to strong adsorption energy and fast ion transport rates.The resultant Zn/Bi electrode not only circumvents Zn dendrite growth but also improves Zn anode anti-corrosion performance.Specifically,the corrosion current of the Zn/Bi electrode is reduced by 90%compared to bare Zn.Impressively,an ultra-low overpotential of 12mV and stable cycling for 4000h are achieved in a Zn/Bi symmetric cell.A Zn–Cu/Bi asymmetric cell displays a cycle life of 1000 cycles,with an average Coulombic efficiency as high as 99.6%.In addition,an assembled Zn/Bi-activated carbon hybrid capacitor exhibits a stable life of more than 50,000 cycles,an energy density of 64Wh kg−1,and a power density of 7kWkg−1.The capacity retention rate of a Zn/Bi–MnO_(2)full cell is improved by over 150%compared to a Zn–MnO_(2)cell without the Bi-based energizer.Our findings open a new arena for the industrialization of Zn metal batteries for large-scale energy storage applications. | Mingming Wang Yahan Meng Ke Li Touqeer Ahmad Na Chen Yan Xu Jifei Sun Mingyan Chuai Xinhua Zheng Yuan Yuan Chunyue Shen Ziqi Zhang Wei Chen | 2022 | eScience2022，2，5： | 4 |
| 5 | Lymphangiogenesis contributes to exercise-induced physiological cardiac growth显示文摘Background:Promoting cardiac lymphangiogenesis exerts beneficial effects for the heart.Exercise can induce physiological cardiac growth with cardiomyocyte hypertrophy and increased proliferation markers in cardiomyocytes.However,it remains unclear whether and how lymphangiogenesis contributes to exercise-induced physiological cardiac growth.We aimed to investigate the role and mechanism of lymphangiogenesis in exercise-induced physiological cardiac growth.Methods:Adult C57 BL6/J mice were subjected to 3 weeks of swimming exercise to induce physiological cardiac growth.Oral treatment with vascular endothelial growth factor receptor 3(VEGFR3) inhibitor SAR1 3 1 675 was used to investigate whether cardiac lymphangiogenesis was required for exercise-induced physiological cardiac growth by VEGFR3 activation.Furthermore,human dermal lymphatic endothelial cell(LEC)-conditioned medium was collected to culture isolated neonatal rat cardiomyocytes to determine whether and how LECs could influence cardiomyocyte proliferation and hypertrophy.Results:Swimming exercise induced physiological cardiac growth accompanied by a remarkable increase of cardiac lymphangiogenesis as evidenced by increased density of lymphatic vessel endothelial hyaluronic acid receptor 1-positive lymphatic vessels in the heart and upregulated LYVE-1 and Podoplanin expressions levels.VEGFR3 was upregulated in the exercised heart,while VEGFR3 inhibitor SAR131675 attenuated exercise-induced physiological cardiac growth as evidenced by blunted myocardial hypertrophy and reduced proliferation marker Ki67 in cardiomyocytes,which was correlated with reduced lymphatic vessel density and downregulated LYVE-1 and Podoplanin in the heart upon exercise.Furthermore,LEC-conditioned medium promoted both hypertrophy and proliferation of cardiomyocytes and contained higher levels of insulinlike growth factor-1 and the extracellular protein Reelin,while LEC-conditioned medium from LECs treated with SAR131675 blocked these effects.Functional rescue assays further demonstrated that protein kinase B(AKT) activation,as well as reduced CCAAT enhancer-binding protein beta(C/EBPβ) and increased CBP/p300-interacting transactivators with E(glutamic acid)/D(aspartic acid)-rich-carboxylterminal domain 4(CITED4),contributed to the promotive effect of LEC-conditioned medium on cardiomyocyte hypertrophy and proliferation.Conclusion:Our findings reveal that cardiac lymphangiogenesis is required for exercise-induced physiological cardiac growth by VEGFR3 activation,and they indicate that LEC-conditioned medium promotes both physiological hypertrophy and proliferation of cardiomyocytes through AKT activation and the C/EBPβ-CITED4 axis.These results highlight the essential roles of cardiac lymphangiogenesis in exercise-induced physiological cardiac growth. | Yihua Bei Zhenzhen Huang Xing Feng Lin Li Meng Wei Yujiao Zhu Shuqin Liu Chen Chen Mingming Yin Huimin Jiang Junjie Xiao | 2022 | Journal of Sport and Health Science2022，11，4： | 2 |
| 6 | Assembly-promoted photocatalysis:Three-dimensional assembly of CdS_(x)Se_(1-x)(x=0-1) quantum dots into nanospheres with enhanced photocatalytic performance显示文摘In this paper,through an emulsion-based bottom-up self-assembly method,monodisperse CdS_(x)Se_(1-x)(x=0-1)quantum dots(QDs)with tailoring compositions have been three-dimensionally assembled into spherical architectures in sub-micrometer sizes.UVeVis absorption measurements revealed the enhanced light harvesting abilities of the assembled CdS_(x)Se_(1-x) spheres relative to their constituting QDs.HRTEM characterizations over the CdS_(x)Se_(1-x) assemblies suggested the existence of localized oriented adjoining of the CdS_(x)Se_(1-x) QDs and the resulting nano-twin structures that are favorable for photogenerated electron-hole separation.The quenching of photoluminescence and the improvement in IPCE after the assembly of CdS_(x)Se_(1-x) QDs provided a clue to the likely suppressed electron-hole recombination brought about by the unique architectures and interfaces derived from self-assembly.The above findings were coincided with the remarkably improved H2 evolution activities observed for the wellassembled CdS_(x)Se_(1-x) nanospheres in photocatalytic water splitting,underpinning the importance of the alternative strategy to design advanced semiconductor photocatalysts based on architectural engineering. | Lina Wang Qiumei Di Mingming Sun Jia Liu Chuanbao Cao Jiajia Liu Meng Xu Jiatao Zhang | 2017 | Journal of Materiomics2017，3，1： | 2 |
| 7 | Stoichiometric effect on electrical and near-infrared photodetection properties of full-composition-range GaAs1−xSbx nanowires显示文摘As one of the most important narrow bandgap ternary semiconductors, GaAs1−xSbx nanowires (NWs) have attracted extensive attention recently, due to the superior hole mobility and the tunable bandgap, which covers the whole near-infrared (NIR) region, for technological applications in next-generation high-performance electronics and NIR photodetection. However, it is still a challenge to the synthesis of high-quality GaAs1−xSbx NWs across the entire range of composition, resulting in the lack of correlation investigation among stoichiometry, microstructure, electronics, and NIR photodetection. Here, we demonstrate the success growth of high-quality GaAs1−xSbx NWs with full composition range by adopting a simple and low-cost surfactant-assisted solid source chemical vapor deposition method. All of the as-prepared NWs are uniform, smooth, and straight, without any phase segregation in all stoichiometric compositions. The lattice constants of each NW composition have been well correlated with the chemical stoichiometry and confirmed by high-resolution transmission electron microscopy, X-ray diffraction, and Raman spectrum. Moreover, with the increase of Sb concentration, the hole mobility of the as-fabricated field-effect-transistors and the responsivity and detectivity of the as-fabricated NIR photodetectors increase accordingly. All the results suggest a careful stoichiometric design is required for achieving optimal NW device performances. | Jiamin Sun Mingming Han Meng Peng Lei Zhang Dong Liu Chengcheng Miao Jiafu Ye Zhiyong Pang Longbing He Hailu Wang Qing Li Peng Wang Lin Wang Xiaoshuang Chen Chongxin Shan Litao Sun Weida Hu Zai-xing Yang | 2021 | Nano Research2021，14，11： | 1 |
| 8 | Meridian effect of fatty strip structure in governing acupuncture analgesia in rats 显示文摘 | Meng FanXun Zhou MingMing Huang JinRu | 2006 | Abstract of WFAS 2006 Malaysia International Symposium of Acupuncture2006，8788，： | 1 |
| 9 | Meridian effect of fatty strip structure in governing acupuncture analgesia in rats显示文摘 | Meng FanXun Zhou MingMing Huang JinRu | 2006 | Abstract of WFAS 2006 Malaysia International Symposium of Acupuncture2006，8789，： | 1 |
| 10 | Preparation, characterization, and in vitro/vivo evaluation of polymer-assisting formulation of atorvastatin calcium based on solid dispersion technique显示文摘Due to low solubility and bioavailability, atorvastatin calcium is confronted with challenge in conceiving appropriate formulation. Solid dispersion of atorvastatin calcium was prepared through the solvent evaporation method, with Poloxamer 188 as hydrophilic carriers. This formulation was then characterized by scanning electron microscopy, differential scanning calorimetry, powder X-ray diffraction and fourier transform infrared spectroscopy. Moreover, all these studies suggested the conversion of crystalline atorvastatin calcium. In addition, the drug solubility studies as well as dissolution rates compared with bulk drug and market tablets Lipitor were also examined. Furthermore, the study investigated the pharmacokinetics after oral administration of Lipitor and solid dispersion. And the AUC 0–8 h and C max increased after taking ATC-P188 solid dispersion orally compared with that of Lipitor. All these could be demonstrated that ATC-P188 solid dispersions would be prospective means for enhancing higher oral bioavailability of ATC. | Wenxiang Dong Xitong Su Meng Xu Mingming Hu Yinghua Sun Peng Zhang | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 1 |
| 11 | Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal显示文摘Female-to-male sex reversals(pseudomales)are common in lower vertebrates and have been found in natural populations,which is a concern under rapid changes in environmental conditions.Pseudomales can exhibit altered spermatogenesis.However,the regulatory mechanisms underlying pseudomale spermatogenesis remain unclear.Here,we characterized spermatogenesis in Chinese tongue sole(Cynoglossus semilaevis),a species with genetic and environmental sex determination,based on a highresolution single-cell RNA-seq atlas of cells derived from the testes of genotypic males and pseudomales.We identified five germ cell types and six somatic cell types and obtained a single-cell atlas of dynamic changes in gene expression during spermatogenesis in Chinese tongue sole,including alterations in pseudomales.We detected decreased levels of Ca^(2+)signaling pathway-related genes in spermatogonia,insufficient meiotic initiation in spermatocytes,and a malfunction of somatic niche cells in pseudomales.However,a cluster of CaSR genes and MAPK signaling factors were upregulated in undifferentiated spermatogonia of pseudomales.Additionally,we revealed that Z chromosome-specific genes,such as piwil2,dhx37,and ehmt1,were important for spermatogenesis.These results improve our understanding of reproduction after female-to-male sex-reversal and provide new insights into the adaptability of reproductive strategies in lower vertebrates. | Hong-Yan Wang Xiang Liu Jian-Yang Chen Yingyi Huang Yifang Lu Fujian Tan Qun Liu Mingming Yang Shuo Li Xianghui Zhang Yating Qin Wenxiu Ma Yingming Yang Liang Meng Kaiqiang Liu Qian Wang Guangyi Fan Rafael H.Nóbrega Shanshan Liu Francesc Piferrer Changwei Shao | 2023 | Science China(Life Sciences)2023，66，5： | 1 |
| 12 | Tailoring activation sites of metastable distorted 1T′-phase MoS_(2) by Ni doping for enhanced hydrogen evolution显示文摘Heteroatom doping is a promising approach to enhance catalytic activity by modulating physical properties,electronic structure,and reaction pathway.Herein,we demonstrate that appropriate Ni-doping could trigger a preferential transition of the basal plane from 2H(trigonal prismatic)to 1T′(clustered Mo)by inducing lattice distortion and S vacancy(SV)and thus dramatically facilitate its catalytic hydrogen evolution activity.It is noteworthy that the unique catalysts did possess superior catalytic performance of hydrogen evolution reaction(HER).The rate of photocatalytic hydrogen evolution could reach 20.45 mmol·g^(−1)·h^(−1) and reduced only slightly in the long period of the photocatalytic process.First-principles calculations reveal that the distorted Ni-1T′-MoS_(2) with SV could generate favorable water adsorption energy(Ead(H_(2)O))and Gibbs free energy of hydrogen adsorption(∆GH).This work exhibits a facile and promising pathway for synergistically regulating physical properties,electronic structure,or wettability based on the doping strategy for designing HER electrocatalysts. | Mingming Liu Hengxu Li Shijie Liu Longlu Wang Lingbin Xie Zechao Zhuang Chun Sun Jin Wang Meng Tang Shujiang Sun Shujuan Liu Qiang Zhao | 2022 | Nano Research2022，15，7： | 1 |
| 13 | Vanadium-based polyanionic compounds as cathode materials for sodium-ion batteries:Toward high-energy and high-power applications显示文摘Sodium ion batteries(SIBs)have been regarded as one of the alternatives to lithium ion batteries owing to their wide availability and significantly low cost of sodium sources.However,they face serious challenges of low energy&power density and short cycling lifespan owing to the heavy mass and large radius of Na^(+).Vanadium-based polyanionic compounds have advantageous characteristic of high operating voltage,high ionic conductivity and robust structural framework,which is conducive to their high energy&power density and long lifespan for SIBs.In this review,we will overview the latest V-based polyanionic compounds,along with the respective characteristic from the intrinsic crystal structure to performance presentation and improvement for SIBs.One of the most important aspect is to discover the essential problems existed in the present V-based polyanionic compounds for high-energy&power applications,and point out most suitable solutions from the crystal structure modulation,interface tailoring and electrode configuration design.Moreover,some scientific issues of V-based polyanionic compounds shall be also proposed and related future direction shall be provided.We believe that this review can serve as a motivation for further development of novel V-based polyanionic compounds and drive them toward high energy&power applications in the near future. | Zhiqiang Lv Moxiang Ling Meng Yue Xianfeng Li Mingming Song Qjong Zheng Huamin Zhang | 2021 | Journal of Energy Chemistry2021，30，4： | 1 |
| 14 | Evaluation of micelles incorporated into thermosensitive hydrogels for intratumoral delivery and controlled release of docetaxel:A dual approach for in situ treatment of tumors显示文摘The in situ gelling hybrid hydrogel system has been reported to effectively concentratechemotherapeutic drugs at the tumor site and sustain their release for a long period. DTX-micelles(docetaxel-loaded mixed micelles) are able to increase the solubility of DTX inwater, and then a high drug loading rate of hydrogels can be achieved by encapsulatingthe docetaxel-loaded mixed micelles into the hydrogels. The thermosensitive nature ofDTX-MM-hydrogels(thermosensitive hydrogels incorporated with docetaxel-loaded mixedmicelles) can accelerate the formation of a depot of this drug-loaded system at the siteof administration. Therefore, the hydrogels provide a much slower release compared withDTX-micelles and DTX-injection. An in vivo retention study has demonstrated that the DTX-MM-hydrogels can prolong the drug retention time and in viv o trials have shown that theDTX-MM-hydrogels have a higher antitumor efficacy and systemic safety. In conclusion, theDTX-MM-hydrogels prepared in this study have considerable potential as a drug deliverysystem, with higher tumor inhibition effects and are less toxic to normal tissues. | Meng Xu Yanhua Mou Mingming Hu Wenxiang Dong Xitong Su Rongxiaa Wu Peng Zhang | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，4： | 1 |
| 15 | Meridian effect of fattry strip structure in governing acupuncture analgesia in rats 显示文摘 | Meng FanXun Zhou MingMing Huang JinRu | 2006 | Abstract of WFAS 2006 Malaysia International Symposium of Acupuncture2006，8788，： | 1 |
| 16 | Set point optimization of controlled Organic Rankine Cycle systems显示文摘In this paper, an approach to optimize set points is proposed for controlled Organic Rankine Cycle(ORC)systems. Owing to both disturbances and variations of operating point existing in ORC systems, it is necessary to optimize the set points for controlled ORC systems so as to improve the energy conversion efficiency. At first, the optimal set points of controlled ORC systems are investigated by revisiting performance analysis and optimization of ORC systems. The expected set points of the evaporating pressure and the temperature at evaporator outlet are then determined by combining genetic algorithm with least squares support vector machine(GA-LSSVM). Simulation results show that the predicted results by GA-LSSVM can be regarded as the optimal set points of controlled ORC systems with varying operating conditions. | Jianhua Zhang Mingming Lin Fei Shi Jia Meng Jinliang Xu | 2014 | Chinese Science Bulletin2014，59，33： | 0 |
| 17 | Chrysophanol inhibits the progression of gastric cancer by activating nod-like receptor protein-3显示文摘Aim:Gastric cancer(GC)is one of the most common malignant tumors.Chrysophanol has been reported to possess antitumor effects on a variety of cancers;however,its role in GC remains unclear.This study aimed to investigate the effects of chrysophanol on the proliferation,pyroptosis,migration,and invasion of GC cells.Methods:Human GC cell lines MKN 28 and AGS cells were treated with different concentrations of chrysophanol,then cell proliferation,migration,invasion and pyroptosis were determined by CCK-8,colony-forming assay,wound healing assay,Transwell assay,and flow cytometry.Cell migration and invasion were reassessed in these transfected cells following the transfection of nod-like receptor protein-3(NLRP3)siRNA in MKN 28 and AGS cells.To examine the downstream signaling pathway of the NLRP3 signaling pathway,NLRP3,caspase-1,gasdermin-D,interleukin(IL)-1β,and IL-18 were detected by quantitative real-time-polymerase chain reaction or western blotting.Results:Chrysophanol inhibited the proliferation of GC cells,caused pyroptosis,inhibited cell migration and invasion,and increased the expression of NLRP3 inflammasomes in GC cells.Knockdown of NLRP3 inhibited the effects of chrysophanol on proliferation,pyroptosis,migration,and invasion of GC cells.Chrysophanol plays an anticancer role by enhancing NLRP3.Conclusions:Chrysophanol exerts anti-neoplastic effects in vitro in GC cells by modulating NLRP3,thus highlighting its therapeutic potential in GC. | BINFEN HOU LI ZHAO TIANHAO ZHAO MINGMING YANG WANWAN ZHU XIAODONG CHEN XIQUAN KE ZHENZENG MA LIN GU MENG WANG MIN DENG | 2023 | BIOCELL2023，47，1： | 0 |
| 18 | Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids显示文摘 | MENG Ying ZHANG Hongwei LIU Zehua ZENG Shanchao SUN Chiyu ZHANG Lijuan ZHAO Mingming WANG Guan JIANG Mengying SHI Wei SONG Hongrui | 2014 | Chemical Research in Chinese Universities2014，30，4： | 0 |
| 19 | Halloysite‒gold core‒shell nanosystem synergistically enhances thermal conductivity and mechanical properties to optimize the wear-resistance of a pheonlic-PBO/PTFE textile composite liner显示文摘Polymer-textile liner composites have potential applications in aerospace applications for reducing the abrasion damage of moving parts during operation owing to their self-lubrication,light weight,and high loading capacity.Herein,Au nanoparticles(AuNPs)are successfully loaded into the lumen of halloysite nanotubes(HNTs)to construct an HNTs‒Au peasecod core‒shell nanosystem to optimize the wear resistance of phenolic resin-based poly(p-phenylene benzobisoxazole)(PBO)/polytetrafluoroethylene(PTFE)textile composites.Transmission electron microscope(TEM)characterization reveals that the AuNPs are well-dispersed inside the HNTs,with an average diameter of 6‒9 nm.The anti-wear performance of the HNTs and Au-reinforced PBO/PTFE composites is evaluated using a pin-on-disk friction tester at 100 MPa.Evidently,the addition of HNTs‒Au induces a 27.9%decrease in the wear rate of the composites.Possible anti-wear mechanisms are proposed based on the analyzed results of the worn surface morphology and the cross-section of the tribofilm obtained by focused ion beam transmission electron microscopy. | Yanling WANG Zhaozhu ZHANG Meng LIU Yaohui HE Peilong LI Junya YUAN Mingming YANG Weimin LIU | 2023 | Friction2023，11，12： | 0 |
| 20 | A disease-relevant mutation of SPOP highlights functional significance of ATM-mediated DNA damage response显示文摘Dear Editor,Accumulating evidence supports that,as a critical genome guardian mechanism,the DNA damage response(DDR)is a barrier to early tumorigenesis.As a crucial DDR pathway,Ataxia Telangiectasia Mutated(ATM)-mediated phosphorylation of downstream targets is essential for activation of cell cycle checkpoints,DNA repair,and programed cell death in the presence of DNA damage.Despite extensive biochemical and cellular studies on ATM phosphorylation,these phosphorylation sites are rarely mutated in cancers,challenging the pathophysio-logical relevance of ATM-mediated phosphorylation in the disease setting. | Mingming Xiao Joshua S.Fried Jinlu Ma Yang Su Rebecca J.Boohaker Qinghua Zeng Yaqi Mo Fanbiao Meng Rong Xiang Bo Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 0 |
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