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24篇 您的检索式:作者名="Mingxia Guo"
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1SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy.Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun 2019Acta Pharmaceutica Sinica B2019,9,2:18
2Determination of metastable zone and induction time of analgin for cooling crystallization显示文摘The solubility, metastable zone width, and induction time of analgin for unseeded batch cooling crystallization in ethanol–aqueous system were experimentally determined. The solubility data could be well described by the van't Hoff equation model. The metastable zone width at various cooling rates was measured, and some parameters of nucleation kinetic were calculated using the Ny'vlt theory. Furthermore, the induction period of various temperatures and supersaturation ratios was also measured. According to classical nucleation theory, some nucleation parameters and interfacial energy was calculated through the induction time(t_(ind)) data. Homogeneous nucleation tended to occur when the supersaturation is high, whereas heterogeneous nucleation was more likely to occur when the supersaturation is low.Ling Zhou Zhao Wang Meijing Zhang Mingxia Guo Shijie Xu Qiuxiang Yin 2017Chinese Journal of Chemical Engineering2017,25,3:7
3Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected patients显示文摘Dear Editor,In late December 2019,an outbreak of severe pneumonia caused by an unknown etiological agent was initially reported in Wuhan,China,and then quickly spread throughout China and even abroad(Zhu et al.,2020).Swift control measures and etiological investigations were conducted by the Chinese government,physicians and researchers,and by using high throughput sequencing and virological testing,the mysterious pneumonia pathogen was shown to be a novel coronavirus(SARS-CoV-2)capable of person-to-person transmission(Zhu et al.,2020).Coronaviruses are a group of non-segmented,enveloped and positive-sense RNA viruses that belong to the subfamily of Coronavirinae in the family of Coronavirdiae and order of Nidovirales.Dachuan Lin Lei Liu Mingxia Zhang Yunlong Hu Qianting Yang Jiubiao Guo Yongchao Guo Youchao Dai Yuzhong Xu Yi Cai Xinchun Chen Zheng Zhang Kaisong Huang 2020Science China(Life Sciences)2020,63,4:6
4Catalytic activity of porous manganese oxides for benzene oxidation improved via citric acid solution combustion synthesis显示文摘Various manganese oxides(MnOx) prepared via citric acid solution combustion synthesis were applied for catalytic oxidation of benzene. The results showed the ratios of citric acid/manganese nitrate in synthesizing process positively affected the physicochemical properties of MnOx, e.g., BET(Brunauer-Emmett-Teller) surface area, porous structure, reducibility and so on, which were in close relationship with their catalytic performance. Of all the catalysts, the sample prepared at a citric acid/manganese nitrate ratio of 2:1(C2M1) displayed the best catalytic activity with T(90)(the temperature when 90% of benzene was catalytically oxidized) of 212 ℃. Further investigation showed that C2M1 was Mn2O3 with abundant nano-pores, the largest surface area and the proper ratio of surface Mn^4+/Mn^3+, resulting in preferable low-temperature reducibility and abundant surface active adsorbed oxygen species. The analysis results of the in-situ Fourier transform infrared spectroscopy(in-situ FTIR) revealed that the benzene was successively oxidized to phenolate, o-benzoquinone, small molecules(such as maleates, acetates, and vinyl), and finally transformed to CO2 and H2O.Hao Guo Zhixiang Zhang Zhi Jiang Mingxia Chen Hisahiro Einaga Wenfeng Shangguan 2020Journal of Environmental Sciences2020,32,12:5
5Rejection of insulin therapy among patients with type 2 diabetes in China: reasons and recommendations显示文摘Xiong Zhenzhen Yuan Li Guo Xiaohui Lou Qingqing Zhao Fang Shen Li Zhang Mingxia Sun Zilin 2014Chinese Medical Journal2014,,20:4
6Thermodynamic properties of metamizol monohydrate in pure and binary solvents at temperatures from(283.15 to 313.15) K显示文摘The thermodynamic properties of metamizol monohydrate in pure solvents(methanol,ethanol,n-propanol and isopropanol) and two binary mixed solvent systems including(methanol+ethanol) and(methanol+isopropanol) were measured from 283.15 K to 313.15 K by gravimetric method under atmospheric pressure thought as 0.1 MPa.The modi fied Apelblat equation,the CNIBS/R-K equation,the Hybrid model and the NRTL model were used to correlate the solubility of metamizol monohydrate,respectively.The results show that the solubility of metamizol monohydrate in all the tested solvents increases with the rising temperature which means that it has temperature dependence.What's more,the effects of solvent components of the binary solvent mixtures on solubility were discussed,it illustrates that the increasing of the molar fraction of methanol gives the system a greater dissolving power.Furthermore,according to the NRTL model,the enthalpy,the Gibbs energy and the entropy of the mixing process were also obtained and discussed.Mingxia Guo Qiuxiang Yin Chang Wang Yaohui Huang Yang Li Zaixiang Zhang Xia Zhang Zhao Wang Meijing Zhang Ling Zhou 2017Chinese Journal of Chemical Engineering2017,25,10:3
7Influence of Shot Peening Treatment on the Fatigue and Corrosion Resisting Properties of 2Cr13 Stainless Steel显示文摘In the present paper,shot peening treatments were used to strengthen the steel surface,and the influence on the fatigue and corrosion resisting properties of 2Cr13 stainless steel was examined.The residual stress and the surface roughness were investigated by XRD and AFM.The characteristics of fatigue and corrosion resistance have also been analyzed by bending fatigue and salt spray tests.The result reveals that the fatigue limit of the samples is improved dramatically with the increasing of the peening strength by 7.5%.Meanwhile,the peenging angle has no evident influence on the fatigue properties.Compared with the untreated samples,the acid corrosion weight loss of the samples after the shot peening treatment is decreased almost by 90%.From the above experimental results proper shot peening would improve not only the fatigue property but also the corrosion resistance of 2Cr13-typed stainless steel.Liu Mingxia Zhang Haicun Liu Daoxin Han Zengfu Zhi Jinhua Guo Wenyong Zhou Yafeng 2012稀有金属材料与工程2012,41,S1:2
8Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis显示文摘Impairment of glucose(Glu)uptake and storage by skeletal muscle is a prime risk factor for the development of metabolic diseases.Heterogeneous nuclear ribonucleoprotein A1(hnRNP Al)is a highly abundant RNA-binding protein that has been implicated in diverse cellular functions.The aim of this study was to investigate the function of hnRNP A1 on muscle tissue insulin sensitivity and systemic Glu homeostasis.Our results showed that conditional deletion of hnRNP Al in the muscle gave rise to a severe insulin resistance phenotype in mice fed a high-fat diet(HFD).Conditional knockout mice fed a HFD showed exacerbated obesity,insulin resistance,and hepatic steatosis.In vitro interference of hnRNP Al in C2C12 myotubes impaired insulin signal transduction and inhibited Glu uptake,whereas hnRNP Al overexpression in C2C12 myotubes protected against insulin resistance induced by supraphysiological concentrations of insulin.The expression and stability of glycogen synthase(gysl)mRNA were also decreased in the absence of hnRNP A l.Mechanistically,hnRNP Al interacted with gys l and stabilized its mRNA,thereby promoting glycogen synthesis and maintaining the insulin sensitivity in muscle tissue.Taken together,our findings are the first to show that reduced expression of hnRNP Al in skeletal muscle affects the metabolic properties and systemic insulin sensitivity by inhibiting glycogen synthesis.Mingxia Zhao Lihong Shen Zijun Ouyang Manru Li Guoliang Deng Chenxi Yang Wei Zheng Lingdong Kong Xuefeng Wu Xudong Wu Wenjie Guo Ye Yin Qiang Xu Yang Sun 2020Journal of Molecular Cell Biology2020,12,4:2
9Breaking the linear correlations for enhanced electrochemical nitrogen reduction by carbon-encapsulated mixed-valence Fe_(7)(PO_(4))_(6)显示文摘Electrochemical nitrogen reduction(NRR)is deemed as a consummate answer for the traditional Haber–Bosch technology.Breaking the linear correlations between adsorption and transition-state energies of intermediates is vital to improve the kinetics of ammonia synthesis and obtain a less energy-intensive process.Herein,carbon-encapsulated mixed-valence Fe_(7)(PO_(4))_(6) was prepared and applied as an electrocatalyst for high-efficiency NRR.A dramatic faradaic efficiency(FE)of 36.93%and an NH_(3) production rate of 13.1μg h^(-1) mg_(cat)^(-1) were obtained at-0.3 V versus RHE,superior to nearly all Fe-based catalysts.Experiments and DFT calculations revealed that the superior performance was ascribed to the synergistic effect of mixed-valence iron pair,which braked the linear correlations to improve the kinetics of ammonia from collaborative hydrogenation and*NH_(3) separation.This work proves the feasibility of mixedvalence catalysts for nitrogen reduction and thus opening a new avenue towards artificial nitrogenfixation catalysts.Lehui Ma Fanfan Xu Linlin Zhang Zhongfen Nie Kai Xia Mingxia Guo Mingzhu Li Xin Ding 2022Journal of Energy Chemistry2022,31,8:1
10Study on the Corrosion Properties of Several Kinds of High-temperature Solid Self-lubricating Material显示文摘In some adjusting mechanism,solid self-lubricating material that has hot-resistant and corrosion-resistant is need for adapting the work condition.In the present article,by the comparison study of mass loss and surface topography after corrosion in acid solution and vapour of the four kinds of material,graphite,polymer,BN composite and cermet,it was found that,graphite has good corrosion-resistant to acid solution and vapour under 200℃,but the corrosion-resistant will become worse dramatically under 400℃,polymer has worse corrosion-resistant behavior above 200℃.By comparison,BN self-lubricating composite has better hot-resistant and corrosion-resistant,which can meet the demand of the work condition.Guo Wenyong Zhang Haicun Han Zhihai Liu Mingxia Zhi Jinhua 2012稀有金属材料与工程2012,41,S1:1
11Gelation Phenomenon During Crystallization of Cefpiramide Sodium显示文摘Unlike the adverse eff ect caused by the gelation during crystallization process, gelation of cefpiramide sodium was found to provide ideal product properties, such as a larger and more regular crystal shape. The causes of the gelation phenomenon and the mechanism of gel-crystal transition during the crystallization of cefpiramide sodium were both investigated in this work. The gel was formed due to the strapping of the solvents by the networks of cefpiramide sodium molecules. The whole gel-crystal transition process was divided into the following three stages:(1) when the temperature decreased, the system reached a metastable-state gelation;(2) the initial microcrystal in the gel grew slowly because of the low supersaturation;and (3) the gel fi nally disappeared, and a larger and more regular crystal was formed. The Hansen solubility parameters were used to analyze the eff ects of the solvents on this gelation;the analysis results can serve as guidance for solvent screening in the actual production process.Yu Wei Qiuxiang Yin Mingxia Guo Ling Zhou Ying Bao Yongfan Yang 2019Transactions of Tianjin University2019,25,4:1
12A new species of ice crawlers from Burmese amber(Insecta:Grylloblattodea)显示文摘Modern grylloblattids are one of the least diverse insect orders.The single extant family is contrasted with 46 families described from the fossil records,which extend to the Late Carboniferous.The most ancient grylloblattid nymphs are known from the Lower Permian.Till now,there is no report on grylloblattid from Burmese amber,which is a very old amber locality.Herein,we describe Sylvalitoralis cheni Zhang,Bai & Yang,sp.nov.from Grylloblattina based on a nymph specimen from the mid-Cretaceous Myanmar(Burmese) amber.Weiwei Zhang Mingxia Guo Xingke Yang Ming Bai 2016Zoological Systematics2016,41,3:1
13Mechanism of Simultaneous Nitrogen Removal and Electricity Generation by Microbial Fuel Cell显示文摘The working mechanism of MFC used for simultaneous nitrogen removal and electricity generation was studied.The results show that the electrode biofilms and suspension had different modes of electron transfer.The microorganisms growing on the electrodes and bioflocs could transfer electrons by direct contact and intermediaries respectively.The electrode biofilms and bioflocs were dominant in different functional spaces,and played a synergistic role in the process of contaminant removal,but showed a certain competitive relationship in the process of electricity generation.This study can provide a theoretical basis for the development of a new low-consumption wastewater treatment technology and promote technological innovation in wastewater treatment.Tong Xue Wang Mingxia Shao Huijun Zhang Jiqiang Guo Haiying Cai Jing 2019Meteorological and Environmental Research2019,10,5:0
14The Distribution of Tribe Blaptini( Coleoptera,Tenebrionidae) in China显示文摘In this paper,the distribution status of genera and species of the tribe Balptini discovered in China was summarized.According to related data,19 genera and 169 species of the tribe Balptini are distributed in various provinces and regions of China.Different genera and species of the tribe Balptini are distributed in different regions.This study laid the theoretical foundation for further investigation of the evolutionary process of tribe Blaptini in China.Zhonghua WEI Mingxia GUO Zhaoshan HU Juan XU Yuanying FAN Aimin SHI 2015Agricultural Biotechnology2015,4,2:0
15Application of the Same-Stuff and Equal-Strength Laser Cladding Technology on the Repaired Semishrouded Impeller显示文摘0Cr17Ni4Cu4Nb powder was used to investigate the same-stuff laser repair(LR)technology on the semishrounded impeller.To improve the repaired effect,heat treatment was used after LR forming process.By means of optical microscopy,scan electron microscopy(SEM),micro-hardness tester and tensile tests,the microstructure of the coating was investigated and mechanical properties were measured.The experimental results show that cladding layer is well bonded to the substrate,the microstructure of the laser repaired zone(LRZ)is coarse martensite which will be refined after heat-treatment.The mechanical property experiments indicate that the micro-hardness and toughness would be increased after heat-treatment,the strength of LRZ after heat-treatment is 1050~1200 MPa,while the strength of normal laser repaired sample is 1000~1050 MPa.The refinement effect due to the heat treatment plays an important role in the improvement of the mechanical properties of samples.Overspeed examination and the real operation of the impeller after repairing also confirmed the reliability of this same-stuff and equal-strength laser cladding technology.Zhang Haicun Liu Mingxia Liu Daoxin Guo Wenyong Zhi Jinhua Zhou Yafeng 2012稀有金属材料与工程2012,41,S1:0
16Research on the Feeding Habits and Food Range of Periplaneta fuligiosa显示文摘[Objective] This study aimed to investigate the feeding habits and food range of Periplaneta fuligiosa. [Method]Common insects,foods,daily necessities,plants and fruits were used to feed P. fuligiosa; one food or item was put into the culture bottle each time in a small amount,to observe the feeding habits of P. fuligiosa. Foods or items uneaten after three days were excluded from its food range. Subsequently,P. fuligiosa was fed with random combinations of two or more foods according to the food range,to observe and record the feeding order. [Result]P. fuligiosa has a relatively wide food range,which dislikes dead bodies of hard-shelled insects such as Cyrtotrachelus longimanus and Popillia quadriguttata. P. fuligiosa is an omnivorous insect but tends to be carnivorous. [Conclusion] This study provided the basis for the cultivation,prevention and control of P. fuligiosa.Zhonghua WEI Mingxia GUO Juan XU Aimin SHI 2015Agricultural Biotechnology2015,4,4:0
17Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis显示文摘The clinical utilization of doxorubicin(Dox)in various malignancies is restrained by its major adverse effect:irreversible cardiomyopathy.Extensive studies have been done to explore the prevention of Dox cardiomyopathy.Currently,ferroptosis has been shown to participate in the incidence and development of Dox cardiomyopathy.Sorting Nexin 3(SNX3),the retromer-associated cargo binding protein with important physiological functions,was identified as a potent therapeutic target for cardiac hypertrophy in our previous study.However,few study has shown whether SNX3 plays a critical role in Dox-induced cardiomyopathy.In this study,a decreased level of SNX3 in Dox-induced cardiomyopathy was observed.Cardiac-specific Snx3 knockout(Snx3-cKO)significantly alleviated cardiomyopathy by downregulating Dox-induced ferroptosis significantly.SNX3 was further demonstrated to exacerbate Dox-induced cardiomyopathy via induction of ferroptosis in vivo and in vitro,and cardiac-specific Snx3 transgenic(Snx3-cTg)mice were more susceptible to Dox-induced feroptosis and cardiomyopathy.Mechanistically,SNX3 facilitated the recycling of transferrin 1 receptor(TFRC)via direct interaction,disrupting iron homeostasis,increasing the accumulation of iron,triggering ferroptosis,and eventually exacerbating Dox-induced cardiomyopathy.Overall,these findings established a direct SNX3-TFRC-ferroptosis positive regulatory axis in Dox-induced cardiomyopathy and suggested that targeting SNX3 provided a new effective therapeutic strategy for Dox-induced cardiomyopathy through TFRCdependentferroptosis.Wenjing Yu Yuehuai Hu Zhiping Liu Kaiteng Guo Dinghu Ma Mingxia Peng Yuemei Wang Jing Zhang Xiaolei Zhang Panxia Wang Jiguo Zhang Peiqing Liu Jing Lu 2023Acta Pharmaceutica Sinica B2023,13,12:0
18Two-dimensional silica enhanced solid polymer electrolyte for lithium metal batteries显示文摘Solid polymer electrolytes(SPEs)are promising substitutes for current flammable liquid electrolytes to achieve high-safety and high-energy-density lithium metal batteries.Polyethylene oxide(PEO)based solid polymer electrolytes have attracted increasing attention because of their excellent flexibility,manufacturability,light weight,and low-cost processing,while they often suffer from low ionic con-ductivity at room temperature,low lithium transference number and unsatisfactory interfacial resis-tance,which largely restrain their practical application.Herein,two-dimensional holey silica nanosheets(2D-HSN)as the fillers,together with LiNO_(3) as the electrolyte additive,are introduced in a PEO/poly(-vinylidene fiuoride-co-hexafluoropropylene)(PVDF-HFP)blended polymer matrix to obtain a SPE.The incorporation of HSN filler creates supplementary channels for lithium ion migration and lowers the crystallinity of the polymer,thereby facilitating the movement of lithium ions.The HSN-based SPE demonstrates higher ionic conductivity up to 3.7 x 10-4 S cm-1 at 30℃,larger Li+transference number close to 0.34,and more stable lithium plating/stripping than that without the fillers,and HSN can promote the formation of more stable solid electrolyte interphase(SEI)layer.The as-assembled LiFePO4||Li batteries deliver a high specific capacity of 159 mA h g-1 with the capacity retention of 95.5%after 200 cycles at 30℃,as well as superior rate performance and cycling stability compared to that using the blank SPE.Zhihong Luo Weiyong Li Chong Guo Ya Song Mingxia Zhou Yan Shi Jing Xu Long Li Bin Shi Quansheng Ouyang Jiao-jing Shao Guangmin Zhou 2024Particuology2024,85,2:0
19Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate显示文摘Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals,controlling metabolic states beyond energy metabolism.However,whether glycolytic metabolites also play a role in controlling cell fate remains unexplored.Here,we find that low levels of glycolytic metabolite 3-phosphoglycerate(3-PGA)can switch phosphoglycerate dehydrogenase(PHGDH)from cataplerosis serine synthesis to pro-apoptotic activation of p53.PHGDH is a p53-binding protein,and when unoccupied by 3-PGA interacts with the scaffold protein AXIN in complex with the kinase HIPK2,both of which are also p53-binding proteins.This leads to the formation of a multivalent p53-binding complex that allows HIPK2 to specifically phosphorylate p53-Ser46 and thereby promote apoptosis.Furthermore,we show that PHGDH mutants(R135W and V261M)that are constitutively bound to 3-PGA abolish p53 activation even under low glucose conditions,while the mutants(T57A and T78A)unable to bind 3-PGA cause constitutive p53 activation and apoptosis in hepatocellular carcinoma(HCC)cells,even in the presence of high glucose.In vivo,PHGDH-T57A induces apoptosis and inhibits the growth of diethylnitrosamine-induced mouse HCC,whereas PHGDH-R135W prevents apoptosis and promotes HCC growth,and knockout of Trp53 abolishes these effects above.Importantly,caloric restriction that lowers whole-body glucose levels can impede HCC growth dependent on PHGDH.Together,these results unveil a mechanism by which glucose availability autonomously controls p53 activity,providing a new paradigm of cell fate control by metabolic substrate availability.Yu-Qing Wu Chen-Song Zhang Jinye Xiong Dong-Qi Cai Chen-Zhe Wang Yu Wang Yan-Hui Liu Yu Wang Yiming Li Jian Wu Jianfeng Wu Bin Lan Xuefeng Wang Siwei Chen Xianglei Cao Xiaoyan Wei Hui-Hui Hu Huiling Guo Yaxin Yu Abdul Ghafoor Changchuan Xie Yaying Wu Zheni Xu Cixiong Zhang Mingxia Zhu Xi Huang Xiufeng Sun Shu-Yong Lin Hai-Long Piao Jianyin Zhou Sheng-Cai Lin 2023Cell Research2023,33,11:0
20Engineering human spinal microphysiological systems to model opioid-induced tolerance显示文摘pioids are commonly used for treating chronic pain.However,with continued use,they may induce tolerance and/or hyperalgesia,which limits therapeutic efficacy.The human mechanisms of opioid-induced tolerance and hyperalgesia are significantly understudied,in part,because current models cannot fully recapitulate human pathology.Here,we engineered novel human spinal microphysiological systems(MPSs)integrated with plug-and-play neural activity sensing for modeling human nociception and opioid-induced tolerance.Each spinal MPS consists of a flattened human spinal cord organoid derived from human stem cells and a 3D printed organoid holder device for plug-and-play neural activity measurement.We found that the flattened organoid design of MPSs not only reduces hypoxia and necrosis in the organoids,but also promotes their neuron maturation,neural activity,and functional development.We further demonstrated that prolonged opioid exposure resulted in neurochemical correlates of opioid tolerance and hyperalgesia,as measured by altered neural activity,and downregulation ofμ-opioid receptor expression of human spinal MPSs.The MPSs are scalable,cost-effective,easy-to-use,and compatible with commonly-used well-plates,thus allowing plug-and-play measurements of neural activity.We believe the MPSs hold a promising translational potential for studying human pain etiology,screening new treatments,and validating novel therapeutics for human pain medicine.Hongwei Cai Zheng Ao Chunhui Tian Zhuhao Wu Connor Kaurich Zi Chen Mingxia Gu Andrea G.Hohmann Ken Mackie Feng Guo 2023Bioactive Materials2023,,4:0
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