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| 1 | An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants显示文摘Abscisic 酸(骆驼毛的织物) 是最重要的荷尔蒙让植物抵抗干旱和另外的不能生活的压力。骆驼毛的织物直接绑在骆驼毛的织物受体的 PYR/PYL 家庭,导致类型 2C 磷酸酶(PP2C ) 和下游的骆驼毛的织物发信号的激活的抑制。骆驼毛的织物由小分子发信号的干预能帮助植物克服象干旱,寒冷和土壤咸度那样的不能生活的压力,这被想象。然而,由植物酶的化学不稳定性和快速的分解代谢限制骆驼毛的织物本身的实际申请。这里,我们报导一件小分子骆驼毛的织物的鉴定模仿(AM1 ) 那充当骆驼毛的织物受体的家庭的多重成员的有势力使活跃之物。在 Arabidopsis, AM1 激活高度类似于由骆驼毛的织物导致了那的一个基因网络。有 AM1 的处理禁止种子萌芽,阻止叶水损失,并且支持干旱抵抗。我们与 PYL2 骆驼毛的织物受体和 HAB1 PP2C 在建筑群解决了 AM1 的水晶结构,它表明 AM1 调停交往的 gate-latch-lock 网络,在骆驼毛的织物界限 receptor/PP2C 建筑群被保存的一个结构的特征。一起,这些结果证明一件单个小分子骆驼毛的织物模仿能激活多重骆驼毛的织物受体并且保护植物免受水损失和干旱应力的伤害。而且, AM1 复杂水晶结构为设计 ABA-mimicking 小分子的下一代提供一个结构的基础。 | Minjie Cao Xue Liu Yan Zhang Xiaoqian Xue X EdwardZhou Karsten Melcher Pan Gao Fuxing Wang Liang Zeng Yang Zhao Pan Deng Dafang Zhong Jian-Kang Zhu H Eric Xu Yong Xu | 2013 | Cell Research2013，23，8： | 17 |
| 2 | An Overview of Big Data Industry in China显示文摘The year of 2011 is considered the first year of big data market in China.Compared with the global scale,China's big data growth will be faster than the global average growth rate,and China will usher in the rapid expansion of big data market in the next few years.This paper presents the overall big data development in China in terms of market scale and development stages,enterprise development in the industry chain,the technology standards,and industrial applications.The paper points out the issues and challenges facing big data development in China and proposes to make polices and create support approaches for big data transactions and personal privacy protection. | LIU Yue HE Jia GUO Minjie YANG Qing ZHANG Xinsheng | 2014 | China Communications2014，11，12： | 11 |
| 3 | A 600-year flood history in the Yangtze River drainage:Comparison between a subaqueous delta and historical records显示文摘Based on grain size analysis and high-resolution elemental scanning of core YD0901,taken from the subaqueous Yangtze River delta,a 600-year flood history was reconstructed for the Yangtze River drainage system.Zr/Rb ratios were chosen as a proxy for Yangtze River floods.Zr resides mainly in the coarse-grained minerals,and Rb is found in the fine-grained minerals.When floods occur,the discharge of the Yangtze River increases,which carries more coarse-grained minerals into the East China Sea.Therefore,deposition of coarse-grained minerals significantly increases relative to fine-grained minerals on the subaqueous delta,and subsequently the Zr/Rb ratios also increase.The higher the Zr/Rb peaks,the greater number of coarse particles deposited by saltation processes.Zr/Rb peaks correlate very well with historical records for Yangtze River floods.Especially at about AD 1870,the Zr/Rb ratio reached a maximum value over the last 600 years,which is consistent with 'the extreme flood event' in the upper and middle reaches of the Yangtze River in AD 1870,as indicated in the historical records.Results show that floods have occurred at a relatively high frequency over the last 600 years,which is consistent with historical records when,during the Ming-Qing Dynasty,floods occurred once every 4 years.In addition,spectral analysis of the Zr/Rb ratio showed that there is close link between the Yangtze River floods and ENSO intensity. | WANG MinJie ZHENG HongBo XIE Xin FAN DaiDu YANG ShouYe ZHAO QuanHong WANG Ke | 2011 | Chinese Science Bulletin2011，56，2： | 9 |
| 4 | Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo显示文摘Fucoidan 是从棕色的海草孤立的主要 sulfated 多糖之一。在这研究,我们在弥漫的大 B 房间淋巴瘤(DLBCL ) 上决定了 fucoidan 的反癌症活动在 vitro 并且在 vivo 的房间。Fucoidan 在一个剂量依赖者和时间依赖者举止禁止了 DLBCL 细胞的生长,并且 fucoidan 治疗挑起了 G 0/G1 细胞周期拘捕,它被 p21 伴随起来规定和 cyclin D1, Cdk4,和 Cdk6 下面规定。Fucoidan 也在 DLBCL 房间线和主要 DLBCL 房间导致了 caspase 依赖的房间 apoptosis。另外, fucoidan 治疗从线粒体引起了 mitochondrial 膜潜力的损失和细胞色素 c 和导致 apoptosis 因素的版本进 cytosol。Fucoidan 也加强了在杀死 DLBCL 房间的 carfilzomib 的活动。fucoidan 的口头的管理有效地在异种皮移植老鼠模型禁止了肿瘤生长。我们的调查结果作为一个 anti-DLBCL 代理人揭示 fucoidan 的新奇功能,它能在 DLBCL 的临床的治疗被使用。 | Guang Yang Qianqiao Zhang Yuanyuan Kong Bingqian Xie Minjie Gao Yi Tao Hongwei Xu Fenghuang Zhan Bojie Dai Jumei Shi Xiaosong Wu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 9 |
| 5 | Genomic insights into the fast growth of paulownias and the formation of Paulownia witches' broom显示文摘Paulownias are among the fastest growing trees in the world,but they often suffer tremendous loss of wood production due to infection by Paulownia witches'broom(PaWB)phytoplasmas.In this study,we have sequenced and assembled a high-quality nuclear genome of Paulownia fortunei,a commonly cultivated paulownia species.The assembled genome of P.fortunei is 511.6 Mb in size,with 93.2%of its sequences anchored to 20 pseudo-chromosomes,and it contains 31985 protein-coding genes.Phylogenomic analyses show that the family Paulowniaceae is sister to a clade composed of Phrymaceae and Orobanchaceae.Higher photosynthetic efficiency is achieved by integrating C3 photosynthesis and the crassulacean acid metabolism pathway,which may contribute to the extremely fast growth habit of paulownia trees.Comparative transcriptome analyses reveal modules related to cambial growth and development,photosynthesis,and defense responses.Additional genome sequencing of PaWB phytoplasma,combined with functional analyses,indicates that the effector PaWB-SAP54 interacts directly with Paulownia PfSPLa,which in turn causes the degradation of PfSPLa by the ubiquitin-mediated pathway and leads to the formation of witches'broom.Taken together,these results provide significant insights into the biology of paulownias and the regulatory mechanism for the formation of PaWB. | Yabing Cao Guiling Sun Xiaoqiao Zhai Pingluo Xu Liming Ma Minjie Deng Zhenli Zhao Haibo Yang Yanpeng Dong Zhonghai Shang Yujie Lv Lijun Yan Haifang Liu Xibing Cao Bingbing Li Zhe Wang Xiaogai Zhao Haiyan Yu Fan Wang Wen Ma Jinling Huang Guoqiang Fan | 2021 | Molecular Plant2021，14，10： | 7 |
| 6 | Bronchial artery embolization for hemoptysis:A systematic review and meta-analysis显示文摘Objective:To assess the safety and efficacy of bronchial artery embolization(BAE)for hemoptysis.Methods and materials:Databases with articles published in English,including Pubmed,Embase,Web of science and Chochrane library,were comprehensively searched to get accurate,up-to-date and sufficient literature about BAE for hemoptysis until March 2020.The technical success rates,immediate control rates,recurrence rates,mortality rates,and total complication rates(minor and major complication rates)extracted from the articles were pooled to estimate and assess the efficacy and safety of BAE using random-effect and fixed-effect models.Results:21 articles published between 2008 and 2019,which include a total of 2511 patients,were studied to evaluate the safety and efficacy of BAE.The technical success and immediate control rates are 99.9%(95%CI:99%-100%)and 99.5%(95%CI:97.8%-99.2%),respectively.This study showed hemoptysis recurrence in 23.7%(95%CI:18.5%-28.9%)with a mortality rate of 2%(95%CI:0-3%).Additionally,the assessment of complications revealed a total complication rate of 13.4%(95%CI:7.6-19.2%),in which 0.2%(95%CI:0.2-0.4%)were major complications and 10%(95%CI:4.7-9.6%)were minor complications.Conclusion:BAE is an effective,safe,and feasible procedure with a low complication rate for hemoptysis patients.However,recurrence of hemoptysis is still at high risk after BAE due to different underlying diseases. | Zhiyuan Zheng Zhiquan Zhuang Minjie Yang Jianjun Luo Wen Zhang Zhiping Yan Xiaolin Wang | 2021 | Journal of Interventional Medicine2021，4，4： | 7 |
| 7 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 8 | GATA family members as inducers for cellular reprogramming to pluripotency显示文摘GATA 蛋白质家庭的成员在系说明和 transdifferentiation 起重要作用。以前的报告证明 GATA 蛋白质家庭罐头的一些成员也由代替 Oct4 在体的房间导致 pluripotency,一个关键联系 pluripotency 的因素。然而,连接指定系的暗示的机制和 pluripotency 的激活留下逃犯。这里,我们报导所有 GATA 家庭成员能代替让 Oct4 导致 pluripotency。我们发现 GATA 家庭的所有成员能禁止 overrepresented ectodermal 系基因,它与以前的报告显示不同指定系的力量的平衡为 pluripotency 的恢复是重要的一致。一根保存锌手指在 C 终点的 DNA 有约束力的领域是批评的让 GATA 家庭导致 pluripotency。用 RNA-seq 和 ChIP-seq,我们决定 pluripotency 相关的基因 Sall4 在 reprogramming 期间是 GATA 家庭成员的一个直接目标并且用作连接指定系的 GATA 家庭到 pluripotency 电路的一座桥。因此, GATA 家庭是所有成员能作为 reprogramming 进程的 inducers 工作并且能代替 Oct4 的第一个蛋白质家庭。我们的结果建议在 reprogramming 的 GATA 家庭的角色被低估了并且 GATA 家庭可以担任房间命运变换的一个重要调停人。 | Jian Shu Ke Zhang Minjie Zhang Yao Sida Shao Fengxia Du Caiyun Yang Wenhan Chen Chen Wu Weifeng Yang Yingli Sun Hongkui Deng | 2015 | Cell Research2015，25，2： | 5 |
| 9 | Compositional dependence of microstructure and tribological properties of plasma sprayed Fe-based metallic glass coatings显示文摘Gas-atomized powders of three Fe-based glass-forming alloys were sprayed on mild steel substrates by atmospheric plasma spaying using the same spaying parameters. Microstructures, thermal stabilities and tribological properties of the sprayed coatings were analyzed. The coating performances showed a strong dependence on the intrinsic characters of the compositions, i.e., glass-forming ability (GFA) and supercooled liquid region (?Tx). The coatings tended to exhibit higher amorphous phase fraction for the composition with higher GFA and lower porosity for that with larger ?Tx. All the coatings exhibited superior wear resistance compared with the substrate. Higher wear resistance could be obtained in coatings with higher amorphous phase fraction, i.e. higher GFA of the composition. This study has important implications for composition selecting and optimizing in the fabrication of metallic glass coatings. | YANG Qin LI Ran LIU ZengQian SHI MinJie LUO XueKun ZHANG Tao | 2012 | Science China(Technological Sciences)2012，55，5： | 4 |
| 10 | Myeloma cells resistance to NK cell lysis mainly involves an HLA class I-dependent mechanism显示文摘房间具有升起的生来的杀手(NK ) 的反多重的骨髓瘤(公里) 潜力对最近的年的兴趣。然而,到骨髓瘤房间的 NK 房间 cytotoxicity 的分子的机制仍然保持不清楚。在现在的学习,我们调查了人的白血球的 theexpressions 在耐心的骨髓瘤房间的抗原(HLA ) 一级和 HLA-G,并且决定了他们的关联住院病人肿瘤房间危险性到 NK 房间 cytotoxicity。我们的结果给那个病人看了骨髓瘤房间(n = 12 ) 对 NK-92 房间细胞溶解相对抵抗,与骨髓瘤房间线相比(n = 7, P < 0.01 ) 。基因表示介绍和流动 cytometry 分析证明 HLA 一级的 mRNA 和蛋白质是在 12 个耐心的骨髓瘤房间的 highlyexpressed。有趣地,没有或低 HLA-G 表面表示被检测,尽管多重 HLA-Gtranscripts 在这些骨髓瘤房间被检测。NK 房间功能试金证明由酸治疗的下面调整的 HLA 一级 expressionon 病人房间显著地增加了公里房间的危险性到调停 NK 的细胞溶解。而且,我们发现在骨髓瘤上用抗体堵住膜界限 HLA 一级而非 HLA-G 显著地取样 increasedtheir 危险性到调停 NK 的杀死。这些结果证明到 NK 的耐心的公里房间的抵抗 lysismainly 包含一个 HLA 班我依赖的机制,建议那 HLA 一级可以涉及保护公里房间调停 fromNK 在 vivo 攻击并且贡献他们的有免疫力的逃跑。 | Minjie Gao Lu Gao Guang Yang Yi Tao Jun Hou Hongwei Xu Xiaojing Hu Ying Han Qianqiao Zhang Xiaosong Wu Jumei Shi | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 3 |
| 11 | Proteasome inhibitor carfilzomib interacts synergistically with histone deacetylase inhibitor vorinostat in Jurkat T-leukemia cells显示文摘在现在的学习,我们在 Jurkat T 白血病房间调查了在 proteasome 禁止者 carfilzomib (CFZ ) 和 histone deacetylaseinhibitor vorinostat 之间的相互作用。到 CFZ 与的最低限度地致命的集中的细胞的 Coexposure 很, vorinostat 的 lowconcentration 导致了 synergistic antiproliferative 效果并且在 Jurkat T-leukemiacells 提高了 apoptosis ,与严厉地增加的反应的氧种( ROS )伴随了,在 mitochondrial membranepotential ( MMP )的惹人注目的减少,细胞色素 c 的增加的版本, caspase-9 和-3,和 PARP.The 的劈开的提高的激活联合了 Jurkat 细胞的处理与 ROS 预先对待而且, NAC 也在 apoptotic 房间导致了显著减小,显示为由联合处理的 increasedROS 产生的一个关键角色。另外,联合了逮捕的处理在 G 2-M 的房间周期阶段。这些结果暗示 CFZ 在 Jurkat T 白血病房间与 vorinostat synergistically 交往了,哪个有 vorinostat 的 carfilzomib 的联合可以在对待 T 房间代表新奇策略的 raisedthe 可能性白血病。 | Minjie Gao Lu Gao Yi Tao Jun Hou Guang Yang Xiaosong Wu Hongwei Xu Van S. Tompkins Ying Han Huiqun Wu Fenghuang Zhan Jumei Shi | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 3 |
| 12 | Factors Affecting Kyphotic Angle Reduction in Osteoporotic Vertebral Compression Fractures with Kyphoplasty显示文摘 | Shen Minjie Wang Heng Chen Guangdong Gan Minfeng Yuan Quan Wang Zhidong Liu Ling Yang Huilin | 2013 | Orthopedics (Online)2013，，4： | 2 |
| 13 | Morphological properties and proliferation analysis of olfactory ensheathing cells seeded onto three-dimensional collagen-heparan sulfate biological scaffolds显示文摘This study aimed to examine the differences in the morphological properties and proliferation of ol-factory ensheathing cells in three-dimensional culture on collagen-heparan sulfate biological scaf-folds and in two-dimensional culture on common flat culture plates.The proliferation rate of olfactory ensheathing cells in three-dimensional culture was higher than that in two-dimensional culture,as detected by an MTT assay.In addition,more than half of the olfactory ensheathing cells subcultured using the trypsinization method in three-dimensional culture displayed a spindly Schwann cell-like morphology with extremely long processes,while they showed a flat astrocyte-like morphology in two-dimensional culture.Moreover,spindle-shaped olfactory ensheathing cells tended to adopt an elongated bipolar morphology under both culture conditions.Experimental findings indicate that the morphological properties and proliferation of olfactory ensheathing cells in three-dimensional culture on collagen-heparan sulfate biological scaffolds are better than those in two-dimensional culture. | Na Liu Zhouping Tang Zhiyuan Yu Minjie Xie Yu Zhang Erfang Yang Shabei Xu | 2012 | Neural Regeneration Research2012，7，16： | 2 |
| 14 | A single-molecule multicolor electrochromic device generated through medium engineering显示文摘Multicolor organic electrochromic materials are important for the generation of full-color devices.However,achieving multiple colors using a single-molecule material has proved challenging.In this study,a multicolor electrochromic prototype device is generated by integrating medium engineering/in situ‘electro base’/laminated electrode technologies with the simple flying fish-shaped methyl ketone TM1.This multicolor electrochromic(green,blue and magenta)device is durable and has a high coloration efficiency(350 cm^(2) C^(-1)),a fast switching time(50 ms)and superior reversibility.This study is a successful attempt to integrate solvatochromism and basochromism in an electronic display.This integration not only introduces a new avenue for color tuning,in addition to the structural design of the colorant,but will also inspire further developments in the tuning of many other properties by this medium engineering approach,such as conductance and the redox property,and thereby accelerate versatile applications in data recording,ultrathin flexible displays,and optical communication and sensing. | Yu-Mo Zhang Xiaojun Wang Weiran Zhang Wen Li Xiaofeng Fang Bing Yang Minjie Li Sean Xiao-An Zhang | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 15 | Induced Pluripotent Stem Cells Are Sensitive to DNA Damage显示文摘Induced pluripotent stem cells(iPSCs)resemble embryonic stem cells(ESCs)in morphology,gene expression and in vitro differentiation,raising new hope for personalized clinical therapy.While many efforts have been made to improve reprogramming effciency,signifcant problems such as genomic instability of iPSCs need to be addressed before clinical therapy.In this study,we try to fgure out the real genomic state of iPSCs and their DNA damage response to ionizing radiation(IR).We found that iPSC line 3FB4-1 had lower DNA damage repair ability than mouse embryonic fbroblast(MEF)cells,from which 3FB4-1line was derived.After the introduction of DNA damage by IR,the number of c-H2AX foci in 3FB4-1 increased modestly compared to a large increase seen in MEF,albeit both signifcantly(P<0.01).In addition,whole-genome sequencing analysis showed that after IR,3FB4-1 possessed more point mutations than MEF and the point mutations spread all over chromosomes.These observations provide evidence that iPSCs are more sensitive to ionizing radiation and their relatively low DNA damage repair capacity may account for their high radiosensitivity.The compromised DNA damage repair capacity of iPSCs should be considered when used in clinical therapy. | Minjie Zhang Caiyun Yang Huixian Liu Yingli Sun | 2013 | Genomics, Proteomics & Bioinformatics2013，11，5： | 2 |
| 16 | Microwave based detector for continuous assessment of intracerebral hemorrhage显示文摘Continuous detecting of the rate and size of hematoma expansion is crucial for intracerebral hemorrhage management and treatment. To continuously assess intracerebral hemorrhage in human head, a novel nondestructive microwave head detecting system is presented in this study. An open-ended cylindrical waveguide is employed as sensing antenna, which is operated associated with a coaxial cable for signal transmission and data acquisition. Measurement of amplitude data over the frequency range of 100–400 MHz is processed to evaluate the changes in intracerebral hemorrhage, based on the system's operating principle that the sensor functions as a resonant cavity. Furthermore, 3D printed anatomically and dielectrically realistic human head phantoms with different lesions are fabricated to verify the efficacy of this proposed hemorrhagic stroke assessment system.It is worth noting that the quantitative results show that the system operating in TE_(111) mode is able to detect intracerebral hemorrhage size change as small as 1 cm^3, demonstrating the possibility of this proposed head evaluating system in future preclinical trials. | JIANG Yu Hao ZHAO MinJi WANG Lu YANG Li JU Yang | 2019 | Science China(Technological Sciences)2019，62，3： | 2 |
| 17 | Preparation, character- ization, and supercritical carbon dioxide foaming of poly- styrene/graphene oxide composites 显示文摘 | Yang Jintao Mu Minjie | 2011 | The Journal of Supercritical Fluids2011，56，2： | 1 |
| 18 | Responses of CO2 efflux from an alpine meadow soil on the Qinghai Tibetan Plateau to multi-form and low-level N addition显示文摘 | Huajun Fang Shulan Cheng Guirui Yu Jiaojiao Zheng Peilei Zhang Minjie Xu Yingnian Li Xueming Yang | 2012 | Plant and Soil (-)2012，，1： | 1 |
| 19 | Antitumor effect of dobutamine on multiple myeloma via mitogen-activated protein kinase pathway in vitro显示文摘多重骨髓瘤(公里) 是最恶意的癌症之一并且被房间, monoclonal 免疫球蛋白的分泌物和 osteolytic 损害,和它的发生在中年、老的病人正在增加的血浆被骨头髓的渗入描绘[1 ] 。作为公里房间异构并且药抵抗、起始的公里通常进行到 relapsed/refractory 阶段。尽管象镇静药, bortezomib,和 lenalidomide 那样的存在治疗能延长公里病人的幸存,公里是是仍然考虑了医不好。因此,建立新有效治疗对待 relapsed/refractory 公里是必要的。 | Bingqian Xie Zhijian Xu Guang Yang Gege Chen Bo Li Liangning Hu Wenqin Xiao Xi Sun Minjie Gao Lu Gao Xiaosong Wu Yi Tao Weiliang Zhu Jumei Shi | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 1 |
| 20 | Changes in Lipid-Sensitive Two-Pore Domain Potassium Channel TREK-1 Expression and Its Involvement in Astrogliosis Following Cerebral Ischemia in Rats显示文摘 | Minghuan Wang Jingjiao Song Wu Xiao Liu Yang Jianqing Yuan Wei Wang Zhiyuan Yu Minjie Xie | 2012 | Journal of Molecular Neuroscience2012，，2： | 1 |
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