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| 1 | Arabidopsis F-box gene FOA1 involved in ABA signaling显示文摘The expression of FOA1(F-box overexpressed/oppressed ABA signaling) in different organs of Arabidopsis,and in response to ABA and NaCl,was analyzed.The expression level of FOA1 is higher in the root and is lower in the stem,and is induced rapidly by ABA and NaCl.The phenotypes of T-DNA insertion mutant foa1 and FOA1 overexpression lines FOA1ox1 and FOA1ox2 were analyzed.The foa1 mutant exhibited a lower germination rate,shorter root length,more stomatal opening,increased proline accumulation and hypersensitivity to ABA compared with the wild type.In contrast,the overexpression lines showed lower sensitivity to ABA than the wild type.The expression levels of several ABA and stress-responsive transcription factors and genes were altered in the foa1 mutant in response to ABA.Compared with the wild type,the expression levels of ABA-responsive transcription factors were higher,but ABA and stress-responsive genes were lower in foa1 mutant.This study demonstrates that FOA1 is an ABA signaling-related gene,and may play a negative role in ABA signaling. | PENG Juan YU DaShi WANG LiQun XIE MinMin YUAN CongYing WANG Yu TANG DongYing ZHAO XiaoYing LIU XuanMing | 2012 | Science China(Life Sciences)2012，55，6： | 12 |
| 2 | Efficacy and safety of the Chinese herbal medicine shuganjieyu with and without adjunctive repetitive transcranial magnetic stimulation (rTMS) for geriatric depression: a randomized controlled trial显示文摘 | Minmin XIE Wenhai JIANG Haibo YANG | 2015 | 上海精神医学2015，27，2： | 6 |
| 3 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 4 | Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses显示文摘Ferritin,an iron-storage protein,regulates cellular iron metabolism and oxidative stress.The ferritin structure is characterized as a spherical cage,inside which large amounts of iron are deposited in a safe,compact and bioavailable form.All ferritins readily catalyze Fe(II)oxidation by peroxides at the ferroxidase center to prevent free Fe(II)from participating in oxygen free radical formation via Fenton chemistry.Thus,ferritin is generally recognized as a cytoprotective stratagem against intracellular oxidative damage.The expression of cytosolic ferritins is usually regulated by iron status and oxidative stress at both the transcriptional and post-transcriptional levels.The mechanism of ferritin-mediated iron recycling is far from clarified,though nuclear receptor co-activator 4(NCOA4)was recently identified as a cargo receptor for ferritin-based lysosomal degradation.Cytosolic ferritins are heteropolymers assembled by H-and L-chains in different proportions.The mitochondrial ferritins are homopolymers and distributed in restricted tissues.They play protective roles in mitochondria where heme-and Fe/S-enzymes are synthesized and high levels of ROS are produced.Genetic ferritin disorders are mainly related to the L-chain mutations,which generally cause severe movement diseases.This review is focused on the biochemistry and function of mammalian intracellular ferritin as the major iron-storage and anti-oxidation protein. | Jianlin Zhang Xuehui Chen Juanji Hong Aifa Tang Yang Liu Ni Xie Guohui Nie Xiyun Yan Minmin Liang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 5 | Effect of Mn content on the microstructure and mechanical properties of Mg–6Li–4Zn-xMn alloys显示文摘The as-cast Mg–6Li–4Zn-x Mn alloys were prepared and extruded at 280℃with an extrusion ratio of 25:1.The effects of Mn content on the microstructure and mechanical properties of Mg–6Li–4Zn-x Mn alloys were investigated in this study.The XRD results show that Mg–6Li–4Zn–x Mn alloys consisted ofα-Mg(hcp)+β-Li(bcc)duplex structured matrix,Mg Li_(2)Zn and Mn phases.The grains of the extruded Mg–6Li–4Zn–x Mn alloys were refined by dynamic recrystallization during the extrusion process.The EBSD results show that the extruded alloys had basal textures.The grain size of the extruded alloys decreased while the basal texture was strengthened with the increasing Mn addition.The TEM results show that a large amount of nanoscale Mn precipitates existed in the extruded Mg–6Li–4Zn–1.2 Mn alloy,which can effectively inhibit the dynamic recrystallized(DRXed)grains growth during the hot extrusion and is beneficial to the improvement of mechanical properties.Mg–6Li–4Zn–1.2 Mn alloy in this research possesses the best mechanical properties with the ultimate tensile strength and yield strength of 321 MPa,250 MPa,respectively. | Hongju Deng Yan Yang Minmin Li Xiaoming Xiong Guobing Wei Weidong Xie Bin Jiang Xiaodong Peng Fusheng Pan | 2021 | Progress in Natural Science:Materials International2021，31，4： | 3 |
| 6 | Aberrant activation of Sonic hedgehog signaling in chronic cholecystitis and gallbladder carcinoma显示文摘 | Fang Xie Xiaoping Xu Angao Xu Cuiping Liu Fenfen Liang Minmin Xue Lan Bai | 2013 | Human Pathology2013，，： | 1 |
| 7 | Photoprotective Effects of D1 Protein Turnover and the Lutein Cycle on Three Ephemeral Plants under Heat Stress显示文摘To clarify the characteristics of photoinhibition and the primary defense mechanisms of ephemeral plant leaves against photodestruction under high temperature stress,inhibitors and the technology to determine chlorophyll fluorescence were used to explore the protective effects of D1 protein turnover and the lutein cycle in the high temperature stress of the leaves of three ephemeral plants.The results showed that the maximum light conversion efficiency(Fv/Fm)of the ephemeral plant leaves decreased,and the initial fluorescence(Fo)increased under 35℃±1℃ heat stress for 1-4 h or on sunny days in the summer.Both Fv/Fm and Fo could be recovered after 8 h of darkness or afternoon weakening of the external temperature.Streptomycin sulfate(SM)or dithiothreitol(DTT)accelerated the decrease of Fv/Fm and the photochemical quenching coefficient(qP)in the leaves of three ephemeral plants at high temperature,and the decrease was greater in the SM than in the DTT treatment.When the high temperature stress was prolonged,the Y(II)values of light energy distribution parameters of PSII decreased,and the Y(NPQ)and Y(NO)values increased gradually in all the treatment groups of the three ephemeral plants.The results showed that the leaves of the three ephemeral plants had their own highly advanced mechanisms to protect against photodamage,which inhibited the turnover of D1 protein and xanthophyll cycle.This can damage the PSII reaction center in the leaves of the three ephemeral plants under high temperature.The protective effect of D1 protein turnover on heat stress in Erodium oxyrrhynchum and Senecio subdentatus was greater than that of the lutein cycle,while the protective effect of lutein cycle was greater than that of D1 protein turnover in Heliotropium acutiflorum subjected to heat damage. | Minmin Xiao Moxiang Cheng Shuangquan Xie Xiushuang Wang Xingming Hao Li Zhuang | 2023 | Phyton-International Journal of Experimental Botany2023，92，6： | 0 |
| 8 | A natural nanozyme in life is found:the iron core within ferritin shows superoxide dismutase catalytic activity显示文摘Nanozymes are nanomaterials exhibiting intrinsic enzymatic properties,which suggests that inorganic nanoparticles could be bioactive.It’s in 2007,when we introduced the biological methodologies for natural enzymes to systematically study the enzymatic properties of iron oxide nanoparticles,we discovered nanozymes.We found that nanozymes,just as natural enzymes,are able to catalyze biochemical reactions under the physiological conditions,following the similar enzymatic kinetics and catalytic mechanisms(Gao et al.,2007).Since then,the developments of nanozymes bloomed,and lots of nanomaterials were found exhibiting various enzymatic activities(Huang et ah,2019). | Jianlin Zhang Shimin Li Ni Xie Guohui Nie Aifa Tang Xian-En Zhang Minmin Liang Xiyun Yan | 2021 | Science China(Life Sciences)2021，64，8： | 0 |
| 9 | Generative Mechanisms of Classroom Silence and the Path of Avoidance显示文摘Classroom silence is complex and discrete problem.It affects the overall teaching and learning quality as well as the high-quality development of both teachers and students.Avoiding classroom silence is a highly dynamic and valuable learning process.This study explores the ecological logic of classroom silence of both teachers and students based on the connotation of classroom silence and deconstructs the endogenous and exogenous mechanisms of classroom silence from the perspectives of escape culture and the continuity theory.Following that,we construct a new model of interaction for elementary school classroom,which includes optimizing the teaching evaluation tools,creating a multidimensional physical technology environment,and fostering an interactive culture of returning to the classroom,so as to promote the overall classroom effectiveness. | Minmin Xie Huanhuan Luo Wenhao Yao | 2022 | Journal of Contemporary Educational Research2022，6，12： | 0 |
| 10 | Bone metastasis is a late-onset and unfavorable event in survivors of gastric cancer after radical gastrectomy:Results from a clinical observational cohort显示文摘Background The timing and incidence of recurrent bone metastasis(BM)after radical gastrectomy in patients with gastric cancer(GC)as well as the survival of these patients were not fully understood.The aim of this study was to analyze the data of an observational GC cohort and identify patients who underwent curative gastrectomy and had recurrent BM to describe and clarify the pattern and profile of BM evolution after surgery.Methods Data were retrieved from a hospital-based GC cohort,and patients who underwent upfront radical gastrectomy were selected.The time points of specific organ metastatic events were recorded,and the person-year incidence rate of metastatic events was calculated.The latency period of BM events after gastrectomy was measured and compared with that of the other two most common metastatic events,liver metastasis(LM)and distant lymph node metastasis(LNM),using analysis of variance.Propensity score matching and subgroup analysis were used for sensitivity analysis.Results A total of 1324 GC cases underwent radical gastrectomy between January 2011 and December 2021.Of these,67 BM,218 LM,and 248 LNM occurred before the last follow-up.The incidence of BM events was 1.7/100 person-years,which was approximately 3-fold lower than that of LM and distant LNM events(5.5 and 6.3 per 100 person-years,respectively).BM events had a significantly longer latency(median time,16.5 months)than LM and LNM events(11.1 and 12.0 months,respectively).Recurrent BM led to a worse prognosis(median survival,4.5 months)than those of LM and LNM events(median survival,7.7 and 7.1 months,respectively).However,no difference in overall survival after gastrectomy was observed among the groups.Conclusions Compared with other common metastatic events,BM in GC after gastrectomy is a late-onset event indicating poor survival. | Cheng Zhang Xiaopeng Zhang Chong Feng Yahui Yang Minmin Xie Ying Feng Zhijun Wu Hui Xu Changhao Wu Tai Ma | 2024 | Cancer Pathogenesis and Therapy2024，2，1： | 0 |
| 11 | An Integration Testing Framework and Evaluation Metric for Vulnerability Mining Methods显示文摘Software vulnerability mining is an important way to detect whether there are some loopholes existing in the software, and also is an important way to ensure the security of information systems. With the rapid development of information technology and software industry, most of the software has not been rigorously tested before being put in use, so that the hidden vulnerabilities in software will be exploited by the attackers. Therefore, it is of great significance for us to actively detect the software vulnerabilities in the security maintenance of information systems. In this paper, we firstly studied some of the commonly used vulnerability detection methods and detection tools, and analyzed the advantages and disadvantages of each method in different scenarios. Secondly, we designed a set of evaluation criteria for different mining methods in the loopholes evaluation. Thirdly, we also proposed and designed an integration testing framework, on which we can test the typical static analysis methods and dynamic mining methods as well as make the comparison, so that we can obtain an intuitive comparative analysis for the experimental results. Finally, we reported the experimental analysis to verify the feasibility and effectiveness of the proposed evaluation method and the testingframework, with the results showing that the final test results will serve as a form of guidance to aid the selection of the most appropriate and effective method or tools in vulnerability detection activity. | Jin Li Jinfu Chen Minhuan Huang Minmin Zhou Wanggen Xie Zhifeng Zeng Shujie Chen Zufa Zhang | 2018 | China Communications2018，15，2： | 0 |
| 12 | A Vulnerability Model Construction Method Based on Chemical Abstract Machine显示文摘形式化危险的原因是困难的,并且没有有效模型揭示危险的原因和特征。在这份报纸,一个危险模型构造方法被建议认识到对危险属性的描述和一个危险模型的构造。一个危险模型基于化学抽象机器(可汗) 被构造认识到对危险模型的可汗描述,和危险的框架当模特儿也被讨论。案例研究被执行验证建议模型的可行性和有效性。另外,一个原型系统也基于建议危险模型被设计并且实现。试验性的结果证明建议模型是比在软件危险的察觉的另外的方法更有效的。 | LI Xiang CHEN Jinfu LIN Zhechao ZHANG Lin WANG Zibin ZHOU Minmin XIE Wanggen | 2018 | Wuhan University Journal of Natural Sciences2018，23，2： | 0 |
| 13 | Iron-catalyzed hydroaminocarbonylation of alkynes:Selective and efficient synthesis of primaryα,β-unsaturated amides显示文摘α,β-Unsaturated primary amides are important intermediates and building blocks in organic synthesis.Herein,we report a ligand-free iron-catalyzed hydroaminocarbonylation of alkynes using NH_(4)HCO_(3)as the ammonia source,enabling the highly efficient and regioselective synthesis of linearα,β-unsaturated primary amides.Various aromatic and aliphatic alkynes are transformed into the desired linearα,β-unsaturated primary amides in good to excellent yields.Further studies show that using NH_(4)HCO_(3)as the ammonia source is key to obtain good yields and selectivity.The utility of this route is demonstrated with the synthesis of linearα,β-unsaturated amides including vanilloid receptor-1 antagonist TRPV-1. | Zijun Huang Jia Tang Xiongwei Jiang Tianle Xie Minmin Zhang Donghui Lan Shaofeng Pi Zhengde Tan Bing Yi Yuehui Li | 2022 | Chinese Chemical Letters2022，33，11： | 0 |
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