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| 1 | Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells显示文摘Surgery is essential for controlling the symptoms and complications of stage IV breast cancer.However,locoregional treatment of primary tumors often results in distant progression,including lung metastasis,the most common type of visceral metastasis.As a minimally invasive thermal therapy,microwave ablation(MWA)has been attempted in the treatment of breast cancer,but the innate immune response after MWA has not yet been reported.Using two murine models of stage IV breast cancer,we found that MWA of primary breast cancer inhibited the progression of lung metastasis and improved survival.NK cells were activated after MWA of the primary tumor and exhibited enhanced cytotoxic functions,and the cytotoxic pathways of NK cells were activated.Depletion experiments showed that NK cells but not CD4+or CD8+T cells played a pivotal role in prolonging survival.Then,we found that compared with surgery or control treatment,MWA of the primary tumor induced completely different NK-cell-related cytokine profiles.Macrophages were activated after MWA of the primary tumor and produced IL-15 that activated NK cells to inhibit the progression of metastasis.In addition,MWA of human breast cancer stimulated an autologous NK-cell response.These results demonstrate that MWA of the primary tumor in metastatic breast cancer inhibits metastatic progression via the macrophage/IL-15/NK-cell axis.MWA of the primary tumor may be a promising treatment strategy for de novo stage IV breast cancer,although further substantiation is essential for clinical testing. | Muxin Yu Hong Pan Nan Che Li Li Cong Wang Yue Wang Ge Ma Mengjia Qian Jiawei Liu Mingjie Zheng Hui Xie Lijun Ling Yi Zhao Xiaoxiang Guan Qiang Ding Wenbin Zhou Shui Wang | 2021 | Cellular & Molecular Immunology2021，18，9： | 5 |
| 2 | Spreading of Human Babesiosis in China:Current Epidemiological Status and Future Challenges显示文摘Human babesiosis is an infection caused by intraerythrocytic protozoa of the genus Babesia and is a worldwide emerging tick-borne disease(1).Babesia is mainly parasitized in erythrocytes of human or other vertebrates and transmitted by the bite of ticks,blood transfusion,or organ transplantation(1).Humans are generally susceptible to Babesia,especially those who are immunocompromised with conditions such as splenectomy or splenic dysfunction,as well as those of old age,with infirmity,or with other severe diseases. | Muxin Chen Qin Liu Jingbo Xue Shaohong Chen Dana Huang Yingfang Yu Yuchun Cai Yan Lu Peng Song Renli Zhang Lin Ai Jiaxu Chen | 2020 | China CDC weekly2020，2，33： | 3 |
| 3 | Chagas Disease — An Underestimated Global Public Health Challenge显示文摘American trypanosomiasis,commonly called Chagas disease(CD),was prevalent once in rural areas of Latin America where poverty is widespread and was considered a silent and poorly visible disease(1).It has become a global neglected tropical disease and a significant public health threat worldwide due to globalization over last century.More recently,it has attracted much more attention,and“April 14”has been designated as“World Chagas Disease Day”by the World Health Assembly of 2019 to raise awareness of the disease as a neglected tropical disease,to improve the rates of early treatment and recovery,and to achieve the ambitious goal to interrupt its transmission(2). | Qin Liu Muxin Chen Xiao-nong Zhou | 2020 | China CDC weekly2020，2，20： | 2 |
| 4 | A COVID-19 Outbreak Emerging in a Food Processing Company——Harbin City,Heilongjiang Province,China,January-February 2021显示文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)epidemic in China had been effectively controlled for several months,but as the ambient temperature dropped,large gathering-initiated epidemics occurred in northern China,including Hebei,Liaoning,and Jilin provinces. | Lei Hou Hao Zhou Nanxi Meng Xue Yu Xin Wang Tuo Wang Jianfeng Zhang Yan Wang Shie Li Shuzhen Guo Jianxing Yu Muxin Chen Wenhui Shi Ning Xiao Chao Yang Jianxiang Liu | 2021 | China CDC weekly2021，3，32： | 2 |
| 5 | Structure of cis-[Pt(NH_(3))(2-picoline)]^(2+)and DNA adduct and its bonding characteristics显示文摘Several methods including molecular mechanics, molecular dynamics, ONIOM that combines quantum chemistry with molecular mechanics and standard quantum chemistry are used to study the configuration and electron structures of an adduct of the DNA segment d(ATACATG*G*TACATA)·d(TATGTACCATGTAT) with cis-[Pt(NH3)(2-Picoline)]2+. The investigation shows that the configuration optimized by ONIOM is similar to that determined by NMR. Strong chemical bonds between Pt of the complex and two N7s of neighboring guanines in the DNA duplex and hydrogen bond between the NH3 of the complex and O6 of a nearby guanine have a large impact on the configuration of the adduct. Chemical bonds, the aforementioned hydrogen bond, and the interaction between a methyl of the complex and a methyl of the base in close proximity are critical for the complex to specifically recognize DNA. | JIA Muxin, LIU Kai, YANG Zuoyin & CHEN GuangjuDepartment of Chemistry, Beijing Normal University, Beijing 100875, China Beijing General Research Institute of Mining and Metullargy, Beijing 100044, China | 2004 | Science China Chemistry2004，47，1： | 2 |
| 6 | Selective recognition of sodium cyanide and potassium cyanide by diaza-erown ether-capped Zn-porphyrin receptors in polar solvents 显示文摘 | Liu Hui Shao Xuebin Jia Muxin | 2005 | Tetrahedron2005，61，34： | 1 |
| 7 | The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis显示文摘Understanding mechanisms underlying the heterogeneity of multipotent stem cells offers invaluable insights into biogenesis and tissue development. Extracellular matrix (ECM) stiffness has been acknowledged as a crucial factor regulating stem cell fate. However, how cells sense stiffness cues and adapt their metabolism activity is still unknown. Here we report the novel role of mitochondrial phosphoenolpyruvate carboxykinase (PCK2) in enhancing osteogenesis in 3D ECM via glycolysis. We experimentally mimicked the physical characteristics of 3D trabeculae network of normal and osteoporotic bone with different microstructure and stiffness, observing that PCK2 promotes osteogenesis in 3D ECM with tunable stiffness in vitro and in vivo. Mechanistically, PCK2 enhances the rate-limiting metabolic enzyme pallet isoform phosphofructokinase (PFKP) in 3D ECM, and further activates AKT/extracellular signal-regulated kinase 1/2 (ERK1/2) cascades, which directly regulates osteogenic differentiation of MSCs. Collectively, our findings implicate an intricate crosstalk between cell mechanics and metabolism, and provide new perspectives for strategies of osteoporosis. | Zheng Li Muxin Yue Xuenan Liu Yunsong Liu Longwei Lv Ping Zhang Yongsheng Zhou | 2022 | Bioactive Materials2022，7，12： | 1 |
| 8 | Study on the liquefaction of shengli lignite with NaOH/methanol 显示文摘 | Zhiping Lei Muxin Liu Hengfu Shui | 2010 | Fuel Processing Technology2010，91，7： | 1 |
| 9 | Kinetic Modeling of Coal Swelling in Solvent显示文摘 | Li Chen Yang Jianli Liu Muxin | 2010 | Industrial and Engineering Chemistry Re- search2010，50，5： | 1 |
| 10 | Effects and its possible mechanism of Radix Saposhnikoviae on rat colonic smooth muscle in vitro显示文摘Objective:To determine the effect of different concentrations of Radix Saposhnikoviae(RS) on the contraction of smooth muscle strips and the Ca2+ mobilization of cultured smooth muscle cells of rat colon and its possible mechanism of action.Methods:Strips of rat colon longitudinal muscle were prepared and smooth muscle cells from rat colon were isolated and cultured.In the experiments,in vitro muscle strips were suspended in an organ bath and the contraction of the strips was recorded.In the cell-experiments,intracellular Ca2+ was assessed using fluorescent intensity(FI) of smooth muscle cells loaded with Fluo-4/AM,measured with a laser scanning confocal microscope and related software.Results:In the in vitro experiment,RS(0.02,0.2,2,20 g/L) inhibited contraction of muscle strips in a concentration-dependent manner,and this inhibition was significant for the three higher RS concentrations(P < 0.01) for both Peak(the maximal contraction amplitude) and Area(the area under curves).Similarly,RS inhibited Ach-induced contraction.In these experiments the inhibition of the Peak values in the RS 2 and 20 g/L groups was significant(P < 0.01),as was the inhibition of the Area values in all RS groups(P < 0.05).Naloxone and propranolol did not significantly affect the inhibitory effect of RS on smooth muscle contractility,while phentolamine significantly reduced the inhibitory effect(P < 0.01).In experiments using primary smooth muscle cell cultures in Ca2+-containing buffer,the post-treatment fluorescence of cells in the RS 0.2,2 and 20 g/L groups differed significantly from pre-treatment values(P < 0.05),and the percent inhibition of fluorescence in the RS 2 g/L and 20 g/L groups was significant(P < 0.01).However,in Ca2+-free buffer,FS had no significant effect on cell fluorescence.Conclusion:RS inhibited both the spontaneous and Ach-stimulated contraction of rat colonic smooth muscle strips.This RS effect appeared to involve α-adrenoceptors,but not β-adrenoceptors or opioid receptors.In cultured primary smooth muscle cells,RS reduced the mobilization of Ca2+ from extracellular sources,but may had no effect on the release of Ca2+ from sarcoplasmic reticulum and endoplasmic reticulum. | Zhenqing Liu Tao Lü Ping Hu Muxin Wei | 2009 | Journal of Nanjing Medical University2009，23，5： | 0 |
| 11 | Deformation mechanisms for a new medium-Mn steel with 1.1 GPa yield strength and 50% uniform elongation显示文摘A new medium-Mn steel was designed to achieve unprecedented tensile properties,with a yield strength beyond 1.1 GPa and a uniform elongation over 50%.The tensile behavior shows a heterogeneous deforma-tion feature,which displays a yield drop followed by a large Lüders band strain and several Portevin-Le Châtelier bands.Multiple strain hardening mechanisms for excellent tensile properties were revealed.Firstly,non-uniform martensite transformation occurs only within a localized deformation band,and ini-tiation and propagation of every localized deformation band need only a small amount of martensite transformation,which can provide a persistent and complete transformation-induced-plasticity effect dur-ing a large strain range.Secondly,geometrically necessary dislocations induced from macroscopic strain gradient at the front of localized deformation band and microscopic strain gradient among various phases provide strong heter-deformation-induced hardening.Lastly,martensite formed by displacive shear trans-formation can inherently generate a high density of mobile screw dislocations,and interstitial C atoms segregated at phase boundaries and enriched in austenite play a vital role in the dislocation multipli-cation due to the dynamic strain aging effect,and these two effects provide a high density of mobile dislocations for strong strain hardening. | Wei Wang Yanke Liu Zihan Zhang Muxin Yang Lingling Zhou Jing Wang Ping Jiang Fuping Yuan Xiaolei Wu | 2023 | Journal of Materials Science & Technology2023，，1： | 0 |
| 12 | Boosting chemical looping combustion performances of red mud with transition metal oxides显示文摘Red mud(RM)is industrial solid waste that severely threatens environmental safety,and its resource utilization is significant both economically and ecologically.The presence of ferric oxides(Fe_(2)O_(3))makes RM potential oxygen carriers(OC)for chemical looping combustion(CLC),which is a promising,novel and low-carbon combustion technology.This work examined the CLC performance of two kinds of RM using gaseous and solid fuels.Both Fe_(2)O_(3) and alkali and alkaline-earth metals(AAEM)species within RM enhance carbon conversion during CLC.Nevertheless,the reactivity of original RM is unsatisfactory due to its low oxygen transporting capacity(R_(0),lower than 0.1),carbon conversion(X_(C),less than 0.8),CO_(2) selectivity(Y_(CO_(2)),less than 0.9)and instable performance.Transition metal oxides including CuO and NiO were used to modify the RM through wet impregnation.Both oxides notably improve RM performances,i.e.,X_(C) and Y_(CO_(2)) are notably increased.Still,deteriorations during redox cycles are observed because of particle agglomeration and sintering,especially for the RM modified with NiO.Considering the cost,potential environmental risk and efficacy,CuO is superior to NiO thanks to the enhanced performances of the modified RM-based OC including higher X_(C)(about 0.9),Y_(CO_(2))(approximately 1)and stronger sintering resistance. | Jingchong Yan Li Zhang Jing He Muxin Liu Zhiping Lei Zhanku Li Zhicai Wang Shibiao Ren Hengfu Shui | 2022 | Carbon Resources Conversion2022，5，2： | 0 |
| 13 | Assessing the cost reduction potential of CCUS cluster projects of coal-fired plants in Guangdong Province in China显示文摘Carbon capture, utilization, and storage (CCUS) have garnered extensive attention as a target of carbon neutrality in China. The development trend of international CCUS projects indicates that the cluster construction of CCUS projects is the main direction of future development. The cost reduction potential of CCUS cluster projects has become a significant issue for CCUS stakeholders. To assess the cost reduction potential of CCUS cluster projects, we selected three coal-fired power plants in the coastal area of Guangdong as research targets. We initially assessed the costs of building individual CCUS projects for each plant and subsequently designed a CCUS cluster project for these plants. By comparing individual costs and CCUS cluster project costs, we assessed the cost reduction potential of CCUS cluster projects. The results show that the unit emission reduction cost for each plant with a capacity of 300 million tonnes per year is 392.34, 336.09, and 334.92 CNY/tCO_(2). By building CCUS cluster project, it could save 56.43 CNY/tCO_(2) over the average cost of individual projects (354.45 CNY/tCO_(2)) when the total capture capacity is 9 million tonnes per year (by 15.92%). Furthermore, we conducted a simulation for the scenario of a smaller designed capture capacity for each plant. We found that as the capture scale increases, the cost reduction potential is higher in the future. | Muxin LIU Yueze ZHANG Hailin LAN Feifei HUANG Xi LIANG Changyou XIA | 2023 | Frontiers of Earth Science2023，17，3： | 0 |
| 14 | Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency显示文摘As an important enzyme for gluconeogenesis, mitochondrial phosphoenolpyruvate carboxykinase(PCK2) has further complex functions beyond regulation of glucose metabolism. Here, we report that conditional knockout of Pck2 in osteoblasts results in a pathological phenotype manifested as craniofacial malformation, long bone loss, and marrow adipocyte accumulation. Ablation of Pck2 alters the metabolic pathways of developing bone, particularly fatty acid metabolism. However, metformin treatment can mitigate skeletal dysplasia of embryonic and postnatal heterozygous knockout mice, at least partly via the AMPK signaling pathway.Collectively, these data illustrate that PCK2 is pivotal for bone development and metabolic homeostasis, and suggest that regulation of metformin-mediated signaling could provide a novel and practical strategy for treating metabolic skeletal dysfunction. | Zheng Li Muxin Yue Boon Chin Heng Yunsong Liu Ping Zhang Yongsheng Zhou | 2022 | International Journal of Oral Science2022，14，4： | 0 |
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