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| 1 | Evaluation of magnifying colonoscopy in the diagnosis of serrated polyps显示文摘AIM:To elucidate the colonoscopic features of serrated lesions of the colorectum using magnifying colonoscopy.METHODS:Broad division of serrated lesions of the colorectum into hyperplastic polyps(HPs),traditional serrated adenomas(TSAs),and sessile serrated adenomas/polyps(SSA/Ps) has been proposed on the basis of recent molecular biological studies.However,few reports have examined the colonoscopic features of these divisions,including magnified colonoscopic findings.This study examined 118 lesions excised in our hospital as suspected serrated lesions after magnified observation between January 2008 and September 2011.Patient characteristics(sex,age),conventional colonoscopic findings(location,size,morphology,color,mucin) and magnified colonoscopic findings(pit pattern diagnosis) were interpreted by five colonoscopists with experience in over 1000 colonoscopies,and were compared with histopathological diagnoses.The pit patterns were categorized according to Kudo's classification,but a more detailed investigation was also performed using the subclassification [type Ⅱ-Open(type Ⅱ-O),type Ⅱ-Long(type Ⅱ-L),or type Ⅳ-Serrated(type Ⅳ-S)] proposed by Kimura T and Yamano H.RESULTS:Lesions comprised 23 HPs(23/118:19.5%),39 TSAs(39/118:33.1%:with cancer in one case),50 SSA/Ps(50/118:42.4%:complicated with cancer in three cases),and six others(6/118:5.1%).We excluded six others,including three regular adenomas,one hamartoma,one inflammatory polyp,and one juvenile polyp for further analysis.Conventional colonoscopy showed that SSA/Ps were characterized as larger in diameter than TSAs and HPs(SSA/P vs HP,13.62 ± 8.62 mm vs 7.74 ± 3.24 mm,P < 0.001;SSA/Ps vs TSA,13.62 ± 8.62 mm vs 9.89 ± 5.73 mm,P < 0.01);common in the right side of the colon [HPs,30.4%(7/23):TSAs,20.5%(8/39):SSA/P,84.0%(42/50),P < 0.001];flat-elevated lesion [HPs,30.4%(7/23):TSAs,5.1%(2/39):SSA/Ps,90.0%(45/50),P < 0.001];normal-colored or pale imucosa [HPs,34.8%(8/23):TSAs,10.3%(4/39):SSA/Ps,80%(40/50),P < 0.001];and with large amounts of mucin [HPs,21.7%(5/23):TSAs,17.9%(7/39):SSA/Ps,72.0%(36/50),P < 0.001].In magnified colonoscopic findings,17 lesions showed either type Ⅱ pit pattern alone or partial type Ⅱ pit pattern as the basic architecture,with 14 HPs(14/17,70.0%) and 3 SSA/Ps.Magnified colonoscopy showed the type Ⅱ-O pit pattern as characteristic of SSA/Ps [sensitivity 83.7%(41/49),specificity 85.7%(54/63)].Cancer was also present in three lesions,in all of which a type Ⅵ pit pattern was also present within the same lesion.There were four HPs and four TSAs each.The type Ⅳ-S pit pattern was characteristic of TSAs [sensitivity 96.7%(30/31),specificity 89.9%(72/81)].Cancer was present in one lesion,in which a type Ⅵ pit pattern was also present within the same lesion.In our study,serrated lesions of the colorectum also possessed the features described in previous reports of conventional colonoscopic findings.The pit pattern diagnosis using magnifying colonoscopy,particularly magnified colonoscopic findings using subclassifications of surface architecture,reflected the pathological characteristics of SSA/Ps and TSAs,and will be useful for colonoscopic diagnosis.CONCLUSION:We suggest that this system could be a good diagnostic tool for SSA/Ps using magnifying colonoscopy. | Shinya Ishigooka Masahito Nomoto Nobuyuki Obinata Yoshichika Oishi Yoshinori Sato Satoko Nakatsu Midori Suzuki Yoshiko Ikeda Tadateru Maehata Tomoaki Kimura Yoshiyuki Watanabe Takashi Nakajima Hiro-o Yamano Hiroshi Yasuda Fumio Itoh | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 2 | Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B显示文摘AIM To determine the role of hepatitis B virus X protein(HBx), HBx in regulating hepatic progenitor cell(HPC)-like features in hepatocellular carcinoma(HCC) and the underlying molecular mechanisms.METHODS We used a retrovirus vector to introduce wild type HBx or empty vector into Hep G2 cells. We then used these cells to analyze cell proliferation, senescence, transformation, and stem-like features. Gene expression profiling was carried out on Affymetrix GeneC hip Human U133A2.0 ver.2 arrays according to the manufacturer's protocol. Unsupervised hierarchical clustering analysis and Class Comparison analysis were performed by BRB-Array Tools software Version 4.2.2. A total of 238 hepatitis B virus(HBV)-related HCC patients' array data were used for analyzing clinical features.RESULTS The histone demethylase KDM5 B was significantlyhighly expressed in HBV-related HCC cases(P < 0.01). In HBV proteins, only HBx up-regulated KDM5 B by activating c-myc. Hepatic stem cell(Hp SC) markers(EpC AM, AFP, PROM1, and NANOG) were significantly highly expressed in KDM5B-high HCC cases(P < 0.01). KDM5 B played an important role in maintaining HpS Clike features and was associated with a poor prognosis. Moreover, inhibition of KDM5 B suppressed spheroid formation and cell invasion in vitro.CONCLUSION HBx activates the histone demethylase KDM5 B and induces HPC-like features in HCC. Histone demethylases KDM5 B may be an important therapeutic target against HBV-related HCC cases. | Xuyang Wang Naoki Oishi Tetsuro Shimakami Taro Yamashita Masao Honda Seishi Murakami Shuichi Kaneko | 2017 | World Journal of Gastroenterology2017，23，18： | 10 |
| 3 | Safety of hepatectomy for elderly patients with hepatocellular carcinoma显示文摘The number of elderly patients with hepatocellular carcinoma(HCC) has been increasing.Characteristics of elderly HCC patients are a higher proportion of females,a lower rate of positive hepatitis B surface antigen,and a higher rate of positive hepatitis C antibodies.Careful patient selection is vital for performing hepatectomy safely in elderly HCC patients.Treatment strategy should be decided by not only considering tumor stage and hepatic functional reserve,but also physiological status,including comorbid disease.Various assessment tools have been applied to predict the risk of hepatectomy.The reported mortality and morbidity rates after hepatectomy in elderly HCC patients ranged from 0% to 42.9% and from 9% to 51%,respectively.Overall survival rate after hepatectomy in elderly HCC patients at 5 years ranged from 26% to 75.9%.Both short-term and long-term results after hepatectomy for strictly selected elderly HCC patients are almost the same as those for younger patients.However,considering physiological characteristics and the high prevalence of comorbid disease in elderly patients,it is important to assess patients more meticulously and to select them strictly if scheduled to undergo major hepatectomy. | Koichi Oishi Toshiyuki Itamoto Toshihiko Kohashi Yasuhiro Matsugu Hideki Nakahara Mikiya Kitamoto | 2014 | World Journal of Gastroenterology2014，20，41： | 8 |
| 4 | A potent chemotherapeutic strategy in prostate cancer: S-(methoxytrityl)-L-cysteine, a novel Eg5 inhibitor显示文摘基于 Docetaxel 的联合化疗为阉割抵抗的前列腺癌症仍然是占优势的治疗。然而, taxane 相关的药抵抗和 neurotoxicity 提示了我们开发代用品治疗策略。Eg5 (kinesin 锭子蛋白质) 为双极的锭子形成关键并且在有丝分裂的早阶段期间复制染色体分离,为癌症化疗作为一个吸引人的目标出现了。这研究的目的是调查 S-(methoxytrityl )-L-cysteine (S (MeO ) TLC ) 的 anticancer 功效,在前列腺癌症的一个新奇 Eg5 禁止者。Eg5 表示在人的前列腺癌症房间线被检验,织物 microarrays 从临床的标本被构造。在前列腺癌症房间的 S (MeO ) TLC 的 Antiproliferative 活动被房间生存能力试金估计。anticancer 效果和在前列腺癌症房间的 S (MeO ) TLC 的禁止的机制被 Hoechst 染色,流动 cytometry 和 immunofluorescence 进一步探索。另外,下的异种皮移植模型上的 S (MeO ) TLC 的 antitumor 效果被估计。Eg5 表示在 PC3, DU145 和 LNCaP 房间被识别。多于前列腺癌症的一半,临床的标本显示了 Eg5 表示。S (MeO ) TLC 与测试的另外的四个 Eg5 禁止者相比在前列腺癌症房间展出了更多的强大的 anticancer 活动。S (MeO ) TLC 在逮捕与不同 monopolar 锭子形成在有丝分裂划分房间以后导致了房间死亡。S (MeO ) TLC 展出了它的重要禁止的活动(P < 0.05 ) 通过有丝分裂的拘捕的正式就职也在下的异种皮移植上当模特儿。我们断定 Eg5 是为前列腺癌症化疗的一个好目标,并且 S (MeO ) TLC 是在前列腺癌症答应 anticancer 代理人的一个有势力。 | Nai-Dong Xing Sen-Tai Ding Ryoichi Saito Koji Nishizawa Takashi Kobayashi Takahiro Inoue Shinya Oishi Nobutaka Fujii Jia-Jv Lv Osamu Ogawax Hiroyuki Nishiyama | 2011 | Asian Journal of Andrology2011，13，2： | 4 |
| 5 | Performance Improvements in Raman Distributed Temperature Sensor显示文摘 | Toru FUKUZAWA Hideo SHIDA Kazushi OISHI Nobuaki TAKEUCHI Shoj i ADACHI | 2013 | Photonic Sensors2013，3，4： | 3 |
| 6 | Medial tibial plateau morphology and stress fracture location:A magnetic resonance imaging study显示文摘AIM To determine the location of medial tibial plateau stress fractures and its relationship with tibial plateau morphology using magnetic resonance imaging(MRI).METHODS A retrospective review of patients with a diagnosis of stress fracture of the medial tibial plateau was performed for a 5-year period. Fourteen patients [three female and 11 male, with an average age of 36.4 years(range, 15-50 years)], who underwent knee MRI, were included. The appearance of the tibial plateau stress fracture and the geometry of the tibial plateau were reviewed and measured on MRI.RESULTS Thirteen of 14 stress fractures were linear, and one of them stellated on MRI images. The location of fractures was classified into three types. Three fractures were located anteromedially(AM type), six posteromedially(PM type), and five posteriorly(P type) at the medial tibial plateau. In addition, tibial posterior slope at the medial tibial plateau tended to be larger when the fracture was located more posteriorly on MRI.CONCLUSION We found that MRI showed three different localizations of medial tibial plateau stress fractures, which were associated with tibial posterior slope at the medial tibial plateau. | Kiminori Yukata Issei Yamanaka Yuzuru Ueda Sho Nakai Hiroyoshi Ogasa Yosuke Oishi Jun-ichi Hamawaki | 2017 | World Journal of Orthopedics2017，8，6： | 2 |
| 7 | The influence of quality characteristics of aquatic products on its price determination in China-A case of salmon products in supermarkets of Shanghai显示文摘The relationship between salmon prices and attributes were explored using the samples collected in supermarkets in Shanghai,China.The results showed that the price of the salmon did not have a significant relationship with the depth of orange color of salmon,unlike the results of stated preferences of western consumers in the previous studies.Whereas,smoked products had a positive relationship with price in the linear model form,and as the main importing country,Norway has the strongest positive relationship with price.In China salmon demand is expected to increase in future,salmon attributes highly appreciated in the market are different from western countries and salmon exporters need to recognize China as a special market for effective market. | Ya Du Xiaobo Lou Taro Oishi Yiyang Liu | 2020 | Aquaculture and Fisheries2020，5，6： | 2 |
| 8 | A thickened or indistinct junctional zone on T2-weighted MR images in patients with endometrial carcinoma: pathologic consideration based on microcirculation显示文摘 | Yumiko Oishi Tanaka Masato Nishida Hajime Tsunoda Yoshihito Ichikawa Yukihisa Saida Yuji Itai | 2003 | European Radiology2003，，8： | 2 |
| 9 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 10 | SJES14121200034992显示文摘 | Sha Sha Zeng Taro Yamashita Mitsumasa Kondo Kouki Nio Takehiro Hayashi Yasumasa Hara Yoshimoto Nomura Mariko Yoshida Tomoyuki Hayashi Naoki Oishi Hiroko Ikeda Masao Honda Shuichi Kaneko | 2014 | Journal of Hepatology2014，，1： | 2 |
| 11 | Hindlimb suspension induces the expression of multiple myosin heavy chain isoforms in single fibres of the rat soleus muscle显示文摘 | Oishi Y Ishihara A Yamamoto H | 1998 | Acta Physiol Scand1998，162，2： | 2 |
| 12 | 左心房结构和功能改变可早期预测无症状高血压患者左心室功能不全显示文摘该研究旨在探索无症状高血压患者左心房结构和功能改变与左心室功能不全之间的关系。入选左心室射血分数(1eft ventricular ejection fraction,LVEF)≥60%的无症状高血压患者126例。应用常规脉冲组织多普勒及二维斑点追踪超声心动图(two-dimensional speckle—tracking echocardiography,2DSTE)检测和分析左心房结构与功能改变的独立影响因素。 | Miyoshi H Oishi Y Mizuguchi Y Iuchi A Nagase N Ara N Oki T 刘莉 叶鹏 | 2013 | 中华高血压杂志2013，21，5： | 2 |
| 13 | PERSONALITY, CULTURE, AND SUBJECTIVE WELL-BEING: Emotional and Cognitive Evaluations of Life显示文摘 | Ed Diener Shigehiro Oishi Richard E. Lucas | 2003 | Annual Review of Psychology2003，，： | 2 |
| 14 | Effects of environmental factors on toxicity of a eyanobacterium ( Microcystis aeruginosa ) under culture conditions 显示文摘 | Watanabe M F Oishi S | 1985 | Appl Environ Microbiol1985，49，： | 1 |
| 15 | Effect of 6-Dioetylamino-1,3,5- triazine-2,4-dithiol Concentration on the Polymer Plating on Iron Plates显示文摘 | Mori K Kang Z X Oishi Y | 2005 | PolymJ2005，37，11： | 1 |
| 16 | Developmental changes in the ex- pression of growth-associated protein-43 mRNA in the monkey thala- mus:northern blot and in situ hybridization studies 显示文摘 | Murata Y Higo N Oishi T | 2005 | Neuro- science2005，136，2： | 1 |
| 17 | Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome显示文摘 | Diaz GA Banikazemi M Oishi K | 1999 | Nat Genet1999，22，3： | 1 |
| 18 | Effects of butyl paraben on the male reproductive system in mice显示文摘 | Oishi S | 2002 | Arch Toxicol2002，76，7： | 1 |
| 19 | Determination of Porosity of TiO: Films from Reflection Spectra显示文摘 | Matsubara T Oishi T Katagiri A | 2002 | Journal of The Electrochemi- cal Society2002，149，2： | 1 |
| 20 | Imaging and uptake mechanism of 131I-meta-iodobenzylguanidine in medullary thyroid carcinoma显示文摘 | Oishi S Sasaki M Sato T | 1986 | Endocrinol Jpn1986，33，3： | 1 |
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