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| 1 | IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines显示文摘 | Jochen Schmitz Alexander Owyang Elizabeth Oldham Yaoli Song Erin Murphy Terril K. McClanahan Gerard Zurawski Mehrdad Moshrefi Jinzhong Qin Xiaoxia Li Daniel M. Gorman J. Fernando Bazan Robert A. Kastelein | 2005 | Immunity2005，，5： | 6 |
| 2 | Rifaximin Alters Intestinal Bacteria and Prevents Stress-Induced Gut Inflammation and Visceral Hyperalgesia in Rats显示文摘 | Dabo Xu Jun Gao Merritt Gillilland Xiaoyin Wu Il Song John Y. Kao Chung Owyang | 2014 | Gastroenterology2014，，2： | 4 |
| 3 | IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines显示文摘 | Jochen Schmitz Alexander Owyang Elizabeth Oldham Yaoli Song Erin Murphy Terril K. McClanahan Gerard Zurawski Mehrdad Moshrefi Jinzhong Qin Xiaoxia Li Daniel M. Gorman J. Fernando Bazan Robert A. Kastelein | 2005 | Immunity2005，，5： | 3 |
| 4 | Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation显示文摘Accumulating evidence shows that agents targeting gut dysbiosis are effective for improving symptoms of irritable bowel syndrome(IBS).However,the potential mechanisms remain unclear.In this study we investigated the effects of berberine on the microbiota-gut-brain axis in two rat models of visceral hypersensitivity,i.e.,specific pathogen-free SD rats subjected to chronic water avoidance stress(WAS)and treated with berberine(200 mg·kg^(−1)·d^(−1),ig,for 10 days)as well as germ-free(GF)rats subjected to fecal microbiota transplantation(FMT)from a patient with IBS(designated IBS-FMT)and treated with berberine(200 mg·kg^(−1)·d^(−1),ig,for 2 weeks).Before the rats were sacrificed,visceral sensation and depressive behaviors were evaluated.Then colonic tryptase was measured and microglial activation in the dorsal lumbar spinal cord was assessed.The fecal microbiota was profiled using 16S rRNA sequencing,and short chain fatty acids(SCFAs)were measured.We showed that berberine treatment significantly alleviated chronic WAS-induced visceral hypersensitivity and activation of colonic mast cells and microglia in the dorsal lumbar spinal cord.Transfer of fecal samples from berberine-treated stressed donors to GF rats protected against acute WAS.FMT from a patient with IBS induced visceral hypersensitivity and pro-inflammatory phenotype in microglia,while berberine treatment reversed the microglial activation and altered microbial composition and function and SCFA profiles in stools of IBS-FMT rats.We demonstrated that berberine did not directly influence LPS-induced microglial activation in vitro.In both models,several SCFA-producing genera were enriched by berberine treatment,and positively correlated to the morphological parameters of microglia.In conclusion,activation of microglia in the dorsal lumbar spinal cord was involved in the pathogenesis of IBS caused by dysregulation of the microbiota–gut–brain axis,and the berberine-altered gut microbiome mediated the modulatory effects of the agent on microglial activation and visceral hypersensitivity,providing a potential option for the treatment of IBS. | Jin-dong Zhang Jiao Liu Shi-wei Zhu Yuan Fang Ben Wang Qiong Jia Hui-feng Hao John YKao Qi-hua He Li-jin Song Fei Liu Bao-li Zhu Chung Owyang Li-ping Duan | 2021 | Acta Pharmacologica Sinica2021，42，11： | 2 |
| 5 | IL-33,an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines显示文摘 | Schmitz J Owyang A Oldham E | 2005 | Immunity2005，23，5： | 1 |
| 6 | IL-33,an intedeukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines显示文摘 | Schmitz J Owyang A Oldham E | 2005 | Immunity2005，23，5： | 1 |
| 7 | IL-33, an interleukin-1-likecytokine that signals via the IL-1 receptor-related protein ST2 andinduces T helper type 2-associated cytokines显示文摘 | Schmitz J Owyang A Oldham E | 2005 | Immunity2005，23，5： | 1 |
| 8 | State and the Business Cycle 显示文摘 | Owyang M T Rapach D E Wall H J | 2009 | Journal of Urban Economics2009，65，2： | 1 |
| 9 | The economic performance of cities:A Markov-switching approach显示文摘 | OWYANG M T | 2008 | Journal of Urban Economics2008，64，3： | 1 |
| 10 | IL-33,an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines显示文摘 | Schmitz J Owyang A Oldham E | 2005 | Immunity2005，23，5： | 1 |
| 11 | IL-33, an interleukin-l-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines 显示文摘 | Schmitz J Owyang A Oldham E | 2005 | Immunity2005，23，5： | 1 |
| 12 | Serum glucose concentration as a nodular of interdigestive motility显示文摘 | Barnet JL Owyang C | 1998 | Gastroenterology1998，94，12： | 1 |
| 13 | IL - 33, an interleukin - 1 - like cytokine that signals via the IL - 1 receptor - related protein ST2 and induces T helper type 2 - associated cytokines 显示文摘 | Sehmitz J Owyang A Oldham E Song Y Murphy E McClanahan TK | 2005 | Immunity2005，23，： | 1 |
| 14 | Interleukin25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract显示文摘 | OWYANG A M ZAPH C WILSON E H | | 0，，04： | 1 |
| 15 | 1L-33, an inter4eukin- 1-1ike cytokine that signals via the IL-1 receptor-related pro- tein ST2 and induces T helper type 2-associated cytokines显示文摘 | Schmitz J Owyang A Oldham E | 2005 | Immunity2005，23，5： | 1 |
| 16 | High-affinity CCK-A receptors on the vagus nerve mediate CCK-stimulated pancreatic secretion in rats显示文摘 | Li Y Had Y Owyang C | 1997 | Am J Physiol1997，273，31： | 1 |
| 17 | IL-33, an interleukin-1 - like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines 显示文摘 | Sehmitz J Owyang A Oldham E | 2005 | Immunity2005，23，5： | 1 |
| 18 | Seismic design of a gargantuan under- ground pump station显示文摘 | Wongkaew K Owyang M S | 2004 | Tunneling and Underground Space Technology2004，19，： | 1 |
| 19 | Pancreatic secretion evoked by cholecystokinin and non-cholecystokinin-dependent duodenal stimuli via vagal afferent fibres in the rat显示文摘 | Li Y Owyang C | 1996 | J Physiol1996，494，3： | 1 |
| 20 | XOMA 052,an anti- IL-1 { beta} monoclonal antibody, improves glucose control and { beta }-cell function in the diet-induced obesity mouse model显示文摘 | Owyang AM Maedler K Gross L | 2010 | Endocrinology2010，151，6： | 1 |
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