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    题名 作者 年代 出处 被引量
1螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 2018中华高血压杂志2018,26,3:7
2Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa 2011The Lancet2011,,9809:3
3The complexities of proliferating cell nuclear antigen显示文摘McCormick D Hall PA 1992Histopathol1992,21,:2
4Interactionb etween primisulfuron and selected soil-applied insecticides in corn (Zea mays) 显示文摘Biediger D L Baumann PA WeaverDN 1992Weed Technol1992,6,:2
5卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景 缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 2017国际脑血管病杂志2017,25,5:2
6胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
7Hypoxia-induced tumour angiogenic pathway in head and neck cancer: An in vivo study显示文摘Kyzas PA Stefanou D Batistatou A 2005Cancer Lett2005,225,2:1
8The Role of DNA Methylation in mammalian epigenetics显示文摘Jones PA Takai D 2001Science2001,293,5532:1
9Phenotypic and functional separation of memory and effector human CD8+ T cells显示文摘Hamann D Baars PA Rep MHG 1997J Exp Med1997,186,:1
10Harmful molecular mechanisms in sepsis显示文摘RITTIRSCH D FLIERL MA WARD PA 2008Nat Rev Immunol2008,8,:1
11Age-related cataract显示文摘Asbell PA Dualan I Mindel J Brocks D Ahmad M Epstein S etal 2005Lancet2005,365,9459:1
12Classification of surgical complications:a new proposal with evaluation in a cohort of 6336 patients and results of a survey显示文摘Dindo D Demartines N Clavien PA 2004Ann Surg2004,240,:1
13Sexually transmitteddeses and gynecologic symptomsand signsin womenwith ahis-toryofinduced abartion显示文摘Hellberg D Mogilevkina I Mardh PA 0,,04:1
14An imperfect G2/M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells显示文摘Kremepler A Deckbar D Jeggo PA 0,,:1
15Understanding the limitations of radiation-induced cell cycle checkpoints显示文摘Deckbar D Jeggo PA L246 brich M 2011Crit Rev Biochem Mol Biol2011,46,4:1
16Efficacy and safety of antioxidant treatment with alpha-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial 显示文摘Ziegler D Low PA Litchy WJ 2011Diabe- tes Care2011,34,9:1
17Gene expression profiles and B-type natriuretic peptide elevation in heart transplantation: more than a hemodynamic marker显示文摘Mehra MR Uber PA Walther D 2006Circulation2006,114,1:1
18Genetic diversity ofthe Q fever agent,Coxiella burnetii?assessed by micro ar-ray-based whole-genome comparisons 显示文摘Beare PA Samuel JE* Howe D 2006J Bacteriol2006,188,7:1
19A novel hyaluronan-based gel in laparoscopic adhesion prevention:preclinical evaluation in an animal model显示文摘Deiaco PA Stefanetti M Pressato D 1998Fertiol Steril1998,69,2:1
20Gene transfer of endothelial NO synthase but not eNOS,plus inducible NOS regressed atherosclerosis in rabbits显示文摘Hayashi T Sumi D Juliet PA 2004Cardiovasc Res2004,61,2:1
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