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| 1 | Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission显示文摘Dear Editor,The occurrence of concentrated pneumonia cases in Wuhan city,Hubei province of China was first reported on December 30,2019 by the Wuhan Municipal Health Commission(WHO,2020).The pneumonia cases were found to be linked to a large seafood and animal market in Wuhan,and measures for sanitation and disinfection were taken swiftly by the local government agency.The Centers for Disease Control and Prevention(CDC)and Chinese health authorities later determined and announced that a novel coronavirus(CoV),denoted as 2019-nCoV,had caused the pneumonia outbreak in Wuhan city(CDC,2020).Scientists from multiple groups had obtained the virus samples from hospitalized patients(Normile,2020).The isolated viruses were morphologically identical when observed under electron microscopy. | Xintian Xu Ping Chen Jingfang Wang Jiannan Feng Hui Zhou Xuan Li Wu Zhong Pei Hao | 2020 | Science China(Life Sciences)2020，63，3： | 737 |
| 2 | Northernmost paleo-tethyan oceanic basin in Tibet:Geo-chronological evidence from ^(40)Ar/^(39)Ar age dating of Dur'ngoi ophiolite显示文摘Whole rock 40Ar/39Ar age dating has been conducted on a basalt sample from Dur’ngoi ophiolite, Qinghai Province, which was reported to be the northernmost pa-leo-tethyan oceanic basin in Tibet. A high temperature pla-teau age (345.3±7.9 Ma) with an isochorn age (336.6±7.1 Ma) has been obtained, representing the eruption time of oceanic crust Considering related geological settings, the new age provides constraints on the northernmost pa-leo-tethyan suture zone in Tibet and the tectonic evolution of Paleo-tethys in Northeast Tibet and adjacent areas. | CHEN Liang, SUN Yong, PEI Xianzhi, GAO Ming, FENG Tao, ZHANG Zhongqing & CHEN Wen1. Laboratory of Continental Dynamics, Northwest University, Xi’an 710069, China 2. Department of Geology, Northwest University, Xi’an, 710069, China 3. Institute of Geology, Chinese Academy of Geological Sciences, Beijing, 100037, China | 2001 | Chinese Science Bulletin2001，46，14： | 24 |
| 3 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 4 | An Integrated Analysis of Risk Factors of Cognitive Impairment in Patients with Severe Carotid Artery Stenosis显示文摘Objective To investigate cognitive dysfunction in patients with carotid artery stenosis(CAS) and potential risk factors related to cognitive-especially memory-dysfunction. Methods Forty-seven patients with carotid artery stenosis were recruited into our study cohort. The Mini-Mental State Examination(MMSE) and the Montreal Cognitive Assessment(MoCA) were adopted to assess cognitive function, the Wechsler Memory Scale(WMS) to assess memory function, high-resolution MRI and enhanced ultrasound to evaluate carotid plaques, and computed tomography perfusion(CTP) imaging to evaluate intracranial blood perfusion. Single-factor analysis and multiple-factor regression analysis were used to analyze potential risk factors of cognitive impairment. Results Mini-Mental State Examination test results showed that 22 patients had cognitive impairment, and MoCA test results showed that 10 patients had cognitive impairment. Analysis of various risk factors indicated that the average memory quotient of female patients was higher than that of males(P = 0.024). The cognitive and memory performance of those with an educational background above high school were significantly better than those of participants with high school or lower(P = 0.045). Patients with abnormal intracranial perfusion performed worse on the MMSE test(P = 0.024), and their WMS scores were significantly lower(P = 0.007). The MMSE scores and the memory quotients were significantly lower in patients with a history of cerebral infarction(MMSE, P = 0.047, memory quotient score, P = 0.018). Conclusion A history of cerebral infarction and abnormal cerebral perfusion are associated with decline in overall cognitive function and memory in patients with carotid stenosis. Being female and having an educational background above high school may be protective factors in the development of cognitive dysfunction. | LUO Ru Tao WANG Pei Jiong DENG Xiao Feng ZHOU Shu Jie ZHAO Meng QIAN Jing ZHANG Dong WANG Rong ZHANG Yan | 2018 | Biomedical and Environmental Sciences2018，31，11： | 17 |
| 5 | Bone biomaterials and interactions with stem cells显示文摘Bone biomaterials play a vital role in bone repair by providing the necessary substrate for cell adhesion,proliferation, and differentiation and by modulating cell activity and function. In past decades, extensive efforts have been devoted to developing bone biomaterials with a focus on the following issues:(1)developing ideal biomaterials with a combination of suitable biological and mechanical properties;(2)constructing a cell microenvironment with pores ranging in size from nanoscale to submicro-and microscale;and(3) inducing the oriented differentiation of stem cells for artificial-to-biological transformation. Here we present a comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells. Typical bone biomaterials that have been developed, including bioactive ceramics, biodegradable polymers, and biodegradable metals, are reviewed, with an emphasis on their characteristics and applications. The necessary porous structure of bone biomaterials for the cell microenvironment is discussed,along with the corresponding fabrication methods. Additionally, the promising seed stem cells for bone repair are summarized, and their interaction mechanisms with bone biomaterials are discussed in detail.Special attention has been paid to the signaling pathways involved in the focal adhesion and osteogenic differentiation of stem cells on bone biomaterials. Finally, achievements regarding bone biomaterials are summarized, and future research directions are proposed. | Chengde Gao Shuping Peng Pei Feng Cijun Shuai | 2017 | Bone Research2017，5，4： | 17 |
| 6 | VdPKS1 is required for melanin formation and virulence in a cotton wilt pathogen Verticillium dahliae显示文摘Verticillium dahliae is a soil-borne phytopathogenic fungus that causes vascular wilt disease in a broad range of hosts.This pathogen survives for many years in soil in the form of melanized microsclerotia.To investigate the melanin synthesis in V.dahliae,we identified a polyketide synthase gene in V.dahliae,namely VdPKS1.PKS1 is known to involve in the dihydroxynaphthalene melanin synthesis pathway in many fungi.We found that VdPKS1 was required for melanin formation but not for microsclerotial production in V dahliae.The VdPKS1 gene-disruption mutant (vdpksl) formed melanin-deficient albino microsclerotia,which did not affect the fungal colonization in host tissues but significantly reduced the disease severity.Gene transcription analysis in the wild-type and the vdpksl strains suggested that VdPKS1 gene-disruption influenced the expression of a series of genes involved in ethylene biosynthesis,microsclerotial formation and pathogenesis.Our results suggest that the VdPKS1-mediated melanin synthesis is important for virulence and developmental traits of V.dahliae. | Ting Zhang Bosen Zhang Chenlei Hua Pei Meng Sheng Wang Zhirong Chen Yejuan Du Feng Gao Jiafeng Huang | 2017 | Science China(Life Sciences)2017，60，8： | 14 |
| 7 | Geochemical Features, Age, and Tectonic Significance of the Kekekete Mafic-ultramafic Rocks, East Kunlun Orogen, China显示文摘The Kekekete mafic-ultramafic rocks are exposed in the Kekesha-Kekekete-Dawate area,which are in the eastern part of the East Kunlun Orogenic Belt.It outcrops as tectonic slices intruding tectonically in the Paleoproterozoic Baishahe Group and the Paleozoic Nachitai Group.The Kekekete mafic and ultramafic rocks is located near the central fault in East Kunlun and lithologically mainly consists of serpentinite,augite peridotite,and gabbro.The LA-ICP-MS zircon U-Pb age of the gabbro is 501±7 Ma,indicating that Kekekete mafic-ultramafic rocks formed in the Middle Cambrian.This rock assemblage is relatively poor in SiO2 and(Na2 O+K2 O) but rich in MgO and SFeO.The chondrite-normalized REE patterns of the gabbro dip slightly to the right;the primitive mantle and MORBnormalized spidergrams of trace elements show enrichment of large-ion lithophile elements(Cs,Rb,Ba,etc.) and no differentiation of high field strength elements.The general dominance of E-MORB features and the geochemical characteristics of OIB suggest that the Kekekete mafic-ultramafic rocks formed in an initial oceanic basin with slightly enriched mantle being featured by varying degrees of mixing of N-MORB depleted mantle and a similar-OIB-type source.From a comprehensive study of the previous data,the author believes that the tectonic history of the East Kunlun region was controlled by a geodynamic system of rifting and extension in the late stages of the Neoproterozoic to early stages of the Early Paleozoic and this formed the paleo-oceanic basin or rift system now represented by the ophiolites along the central fault in East Kunlun,the Kekekete mafic-ultramafic rocks and Delisitan ophiolite. | LI Ruibao PEI Xianzhi LI Zuochen SUN Yu FENG Jianyong PEI Lei CHEN Guochao LIU Chengjun CHEN Youxin | 2013 | Acta Geologica Sinica(English Edition)2013，87，5： | 13 |
| 8 | Analysis of sedimentary-geomorphologic variation and the living environment of hominids at the Shuidonggou Paleolithic site显示文摘Shuidonggou is one of the most important Upper Paleolithic sites in North China. Due to the presence of rich human remains,animal fossils,abundant sporopollen and unique geological sequence,it is the type site for Late Pleistocene to Holocene human occupation and environmental change in the Ningxia-Inner Mongolia region. Many scholars suggest that the site should be named the 'Shuidong-gou Formation' of Late Pleistocene in North China. Dating results indicate that ancient human activities at the site took place 30―24 ka (Marine Isotope Stage MIS 3). The climate at that time was warmer and moister than present day,and adequate precipitation led to the formation of water pack depressions where broad-leaf trees and sparse forest vegetations,as well as herbivorous animals flourished,mak-ing the area suitable for early human hunting,gathering and survival. The Neolithic human occupation happened 9―5 ka at the site,while similar environmental conditions with MIS3 occurred. The absence of human activity record in the region during the Last Glacial Maximum (MIS2) suggests that the envi-ronment was too harsh for humans to live there. | GAO Xing YUAN BaoYin PEI ShuWen WANG HuiMin CHEN FuYou FENG XingWu | 2008 | Chinese Science Bulletin2008，53，13： | 12 |
| 9 | Microstructure, biodegradation, antibacterial and mechanical properties of ZK60-Cu alloys prepared by selective laser melting technique显示文摘Magnesium(Mg) alloys are receiving increasing attention for body implants owing to their good biocompatibility and biodegradability. However, they often suffer from bacterial infections on account of their insufficient antibacterial ability. In this study, ZK60-x Cu(x = 0, 0.2, 0.4, 0.6 and 0.8 wt%) alloys were prepared by selective laser melting(SLM) with alloying copper(Cu) to enhance their antibacterial ability.Results showed that ZK60-Cu alloys exhibited strong antibacterial ability due to combination of release of Cu ions and alkaline environment which could kill bacteria by destroying cellular membrane structure,denaturing enzymes and inhibiting deoxyribonucleic acid(DNA) replication. In addition, their compressive strength increased due to grain refinement and uniformly dispersing of short-bar shaped MgZnCu phases. Moreover, ZK60-Cu alloys also exhibited good cytocompatibility. In summary, ZK60-Cu alloys with antibacterial ability may be promising implants for biomedical applications. | Cijun Shuai Long Liu Mingchun Zhao Pei Feng Youwen Yang Wang Guo Chengde Gao Fulai Yuan | 2018 | Journal of Materials Science & Technology2018，34，10： | 12 |
| 10 | Biochemical Mechanism of Chlorantraniliprole Resistance in the Diamondback Moth, Plutella xylostella Linnaeus显示文摘The insecticide chlorantraniliprole exhibits good efficacy and plays an important role in controlling the diamondback moth, Plutella xylostella Linnaeus. However, resistance to chlorantraniliprole has been observed recently in some field populations. At present study, diamondback moths with resistance to chlorantraniliprole(resistant ratio(RR) was 82.18) for biochemical assays were selected. The assays were performed to determine potential resistance mechanisms. The results showed that the selected resistant moths(GDLZ-R) and susceptible moth could be synergized by known metabolic inhibitors such as piperonyl butoxide(PBO), triphenyl phosphate(TPP) and diethyl-maleate(DEM) at different levels(1.68-5.50-fold and 2.20-2.89-fold, respectively), and DEM showed the maximum synergism in both strains. In enzymes assays, a high level of glutathione-S-transferase(GST) was observed in the resistant moth, in contrast, moths that are susceptible to the insecticide had only 1/3 the GST activity of the resistant moths. The analysis of short-term exposure of chlorantraniliprole on biochemical response in the resistant strain also showed that GST activity was significantly elevated after exposure to a sub-lethal concentration of chlorantraniliprole(about 1/3 LC50, 12 mg L-1) 12 and 24 h, respectively. The results show that there is a strong correlation between the enzyme activity and resistance, and GST i s likely the main detoxification mechanism responsible for resistance to chlorantraniliprole in P. xylostella L., cytochrome P450 monooxygenase(P450) and carboxy-lesterase(Car E) are involved in to some extent. | HU Zhen-di FENG Xia LIN Qing-sheng CHEN Huan-yu LI Zhen-yu YIN Fei LIANG Pei GAO Xi-wu | 2014 | Journal of Integrative Agriculture2014，13，11： | 12 |
| 11 | Association of CYP3A polymorphisms with the pharmacokinetics of cyclosporine A in early post- renal transplant recipients in China显示文摘目的: 回顾地评估细胞色素 P450 3A (CYP3A ) 和 ATP 有约束力的盒子亚科 B 的协会成员 1 (ABCB1 ) 有用汉语的 cyclosporine A (CsA ) 的 pharmacokinetics 的基因多型性肾移植病人。 | Xiang-guang MENG Cheng-xian GUO Guo-qing FENG Ying-chun ZHAO Bo-ting ZHOU Jian-le HAN Xin CHEN Yong SHI Hong-yao SHI Ji-ye YIN Xiang-dong PENG Qi PEI Wei ZHANG Guo WANG Meng HE Min LIU Jing-ke YANG Hong-hao ZHOU | 2012 | Acta Pharmacologica Sinica2012，33，12： | 11 |
| 12 | Severe burn injury alters intestinal microbiota composition and impairs intestinal barrier in mice显示文摘Background:The intestinal barrier integrity is crucial for maintaining intestinal homeostasis,and the mechanisms of intestinal barrier disruption induced by burn injury remain obscure.This study was aimed to investigate the changes of intestinal microbiota and barrier function in burned mice to further comprehend the mechanisms of burn-induced intestinal barrier dysfunction.Methods:Samples were from mice inflicted with 30%total body surface area(TBSA)full-thickness burns.The intestinal permeability,tight junction proteins expressions,zonula occludens-1(ZO-1)localization,inflammatory cytokines expressions,and short-chain fatty acids(SCFAs)contents were determined.The microbial community was assessed via 16S rDNA Illumina sequencing.Results:The intestinal permeability was increased after severe burn injury,peaking at 6 h post-burn,with approximately 20-folds of the control(p<0.001).The expression of tight junction proteins(ZO-1,occludin,claudin-1,and claudin-2)was significantly altered(p<0.05).The ZO-1 morphology was dramatically changed following burn injury.The fecal SCFAs’contents(acetate,propionate,butyrate,isobutyrate,and isovalerate)were noticeably declined after burn injury(p<0.05).The expressions of pro-inflammatory cytokines(interleukin(IL)-1βand IL-6)in ileal mucosa were increased,whereas the expressions of anti-inflammatory cytokines(IL-4 and IL-13)were decreased following burn injury(p<0.05).In addition,burned mice showed an alteration of intestinal microbial community,such as decreased diversity,reduced Bacteroidetes abundance,and increased Firmicutes abundance.Conclusions:The severe burn-induced intestinal barrier dysfunction is along with the alterations of microbial community. | Yanhai Feng Yalan Huang Yu Wang Pei Wang Fengjun Wang | 2019 | Burns & Trauma2019，7，1： | 11 |
| 13 | Emergency medicine in China: present and future显示文摘BACKGROUND: Emergency medicine was inaugurated, as an official specialty in China, only25 years ago, and its growth in clinical practice and academic development since that time have beenremarkable.METHODS: This paper is a critical and descriptive review on current situations in emergencymedicine in China, based on the literature review, personal observations, interviews with manyChinese emergency medicine doctors and experts, and personal experience in both China and USA.RESULTS: The current practice of emergency medicine in China encompasses three areas: prehospitalmedicine, emergency medicine, and critical care medicine. Most tertiary emergency departments(EDs) are structurally and functionally divided into several clinical areas, allowing the ED itself to functionas a small independent hospital. While Chinese emergency physicians receive specialty training througha number of pathways, national standards in training and certifi cation have not yet been developed. As aresult, the scope of practice for emergency physicians and the quality of clinical care vary greatly betweenindividual hospitals. Physician recruitment, diffi cult working conditions, and academic promotion remain asmajor challenges in the development of emergency medicine in China.CONCLUSION: To further strengthen the specialty advancement, more government leadershipis needed to standardize regional training curriculums, elucidate practice guidelines, provide fundingopportunities for academic development in emergency medicine, and promote the development of asystem approach to emergency care in China. | Y.Veronica Pei Feng Xiao | 2011 | World Journal of Emergency Medicine2011，2，4： | 10 |
| 14 | Choice for graphene as conductive additive for cathode of lithium-ion batteries显示文摘Graphene is a promising conductive additive for the lithium-ion batteries(LIBs) and shows great potential especially with its fast development of the large scale fabrication technology. This work has explored the influence of the incorporation of graphenes prepared by three typical methods on the electrochemical performance of the LiCoO_2-based cathode focusing on the choice for the effective graphene as conductive additive for the cathode of LIBs. Through the comparison of the intrinsic characteristics of graphenes and the electrochemical performance of electrodes with graphene, it is found that graphene with low disorder degree and large size is not suitable for LiCoO_2 cathodes as conductive additive. Conversely, the graphene with oxygen functional groups, relatively low surface area and proper size displays much better electrochemical performance when it is used as conductive additive. This work also demonstrates the transmission mechanism for different graphenes as conductive additives in the LiCoO_2 materials, and further reveals that the conductivity of graphene is not the only factor as conductive additives, surface chemistry and sheet size of the graphene are also essential factors which greatly influence the electrochemical performance of electrode. In addition, when combined with Super P, only 1% graphene is enough to construct an efficient conductive network in the electrode. This study also gives a new sight on the practical application of graphene as conductive additive for high performance LIBs. | Ying Shi Lei Wen Songfeng Pei Minjie Wu Feng Li | 2019 | Journal of Energy Chemistry2019，28，3： | 10 |
| 15 | Modern human behaviors during the late stage of the MIS3 and the broad spectrum revolution:Evidence from a Shuidonggou Late Paleolithic site显示文摘The last glacial period was vital for the distribution and evolution of early modern humans in Asia. The Shuidonggou Late Paleolithic site, dated at 30-20 ka BP, accumulated cultural remains during the important late stage of MIS 3 period in the last glacial. These remains represent characteristics of typical Late Paleolithic conditions in North China:high degree of standardization and morphological variability of tool types, exploitation of bone materials, systematic use of body decorations, extensive use of earth-pit hearths, distinct functional spatial organization within habitations, and conversion of subsistence patterns. These characteristics illustrate early modern human behaviors during the late MIS3 period, and provide clues and perspectives for the analysis of early modern human origins in China. At the same time, the conversion of subsistence patterns is considered to be a combination of multiple early modern human behaviors, as well as the result of the Broad Spectrum Revolution. In this paper, we argue for the dynamic mechanism of Broad Spectrum Revolution from a human behavioral and ecological perspective. | GUAN Ying GAO Xing LI Feng PEI ShuWen CHEN FuYou ZHOU ZhenYu | 2012 | Chinese Science Bulletin2012，57，4： | 10 |
| 16 | Comparison of phylobetadiversity indices based on community data from Gutianshan forest plot显示文摘Phylobetadiversity incorporates phylogenetic information and beta diversity,and can account for the ecological similarities between communities with a phylogenetic perspective.Although different phylobetadiversity indices reflect differences in different characteristics between communities,the results of different phylobetadiversity indices are not comparable.In this study we examined phylobetadiversity indices for a 24-hm 2 plot in the Gutianshan National Nature Reserve.It was found the abundanceweighted D pw was almost identical to Rao's D of Rao's quadratic entropy.PhyloSor had a similar ecological meaning and algorithm to UniFrac.Although Dnn was different in definition from UniFrac and PhyloSor,they were all strongly correlated.The effect of species abundance on phylobetadiversity was not significant when scales were relatively small,but was significant at larger scales.These contrasts likely resulted from reductions in evenness in communities as scales increased.P ST and Rao's H better reflected the distance-decay changes caused by spatial and habitat variation than other indices at larger scales,whereas AW-D nn and D nn better reflected these changes at small scales. | FENG Gang ZHANG JinLong PEI NanCai RAO MiDe MI XiangCheng REN HaiBao MA KePing | 2012 | Chinese Science Bulletin2012，57，6： | 9 |
| 17 | A phase I study on pharmacokinetics and pharmacodynamics of higenamine in healthy Chinese subjects显示文摘瞄准: 调查 higenamine 的 pharmacokinetics,药效学,和安全,乌头属植物根的活跃成分,在健康中国志愿者。 | Sheng FENG Ji JIANG Pei HU Jian-yan ZHANG Tao LIU Qian ZHAO Bi-lu LI | 2012 | Acta Pharmacologica Sinica2012，33，11： | 9 |
| 18 | Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson’s disease显示文摘Parkinson’s disease(PD),known as one of the most universal neurodegenerative diseases,is a serious threat to the health of the elderly.The current treatment has been demonstrated to relieve symptoms,and the discovery of new small-molecule compounds has been regarded as a promising strategy.Of note,the homeostasis of the autolysosome pathway(ALP)is closely associated with PD,and impaired autophagy may cause the death of neurons and thereby accelerating the progress of PD.Thus,pharmacological targeting autophagy with small-molecule compounds has been drawn a rising attention so far.In this review,we focus on summarizing several autophagy-associated targets,such as AMPK,m TORC1,ULK1,IMPase,LRRK2,beclin-1,TFEB,GCase,ERRα,C-Abelson,and as well as their relevant small-molecule compounds in PD models,which will shed light on a clue on exploiting more potential targeted small-molecule drugs tracking PD treatment in the near future. | Kai Zhang Shiou Zhu Jiamei Li Tingting Jiang Lu Feng Junping Pei Guan Wang Liang Ouyang Bo Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 9 |
| 19 | MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling显示文摘发信号的 BMP 怎么集成到并且使动摇人的 pluripotent 干细胞(hPSCs ) 的 pluripotency 电路开始区别进单个细菌层是一个长期的难题。这里,我们报导肌肉片断 homeobox 2 (MSX2 ) , msh 家庭的一个 homeobox 抄写因素, BMP 发信号的直接目标基因和 hPSC 到 mesendoderm 的区别的一个主人调停人。MSX2 的强制表示足够废除 pluripotency 并且导致 hPSCs 的指导 mesendoderm 区别,当 MSX2 弄空损害 mesendoderm 正式就职时。MSX2 是在 hPSCs 的 BMP 小径的直接目标基因,并且能被 Wnt 信号 synergistically 在 mesendoderm 正式就职期间经由 LEF1 激活。而且, MSX2 使动摇通过到 SOX2 倡导者和 SOX2 抄写的压抑的直接绑定的 pluripotency 电路,当 MSX2 通过节的倡导者的直接绑定和激活由 SOX2 的同时的抑制和节的表示的正式就职控制 mesendoderm 系承诺时。有趣地, SOX2 能支持 MSX2 蛋白质的降级,建议在在干细胞命运的控制的二个指定系的因素之间的相互的对抗。一起,我们的调查结果揭示使动摇的关键新机制在 hPSCs 的 pluripotency 和指导系承诺。 | Qingqing Wu Leisheng Zhang Pei Su Xiaohua Lei Xin Liu Hongtao Wang Lisha Lu Yang Bai Tao Xiong Dong Li Zhengmao Zhu Enkui Duan Erlie Jiang Sizhou Feng Mingzhe Hang Yuanfu Xu Fei Wang Jiaxi Zhou | 2015 | Cell Research2015，25，12： | 8 |
| 20 | Machine learning assisted design of γ′-strengthened Co-base superalloys with multi-performance optimization显示文摘Designing a material with multiple desired properties is a great challenge,especially in a complex material system.Here,we propose a material design strategy to simultaneously optimize multiple targeted properties of multi-component Co-base superalloys via machine learning.The microstructural stability,γ′solvus temperature,γ′volume fraction,density,processing window,freezing range,and oxidation resistance were simultaneously optimized. | Pei Liu Haiyou Huang Stoichko Antonov Cheng Wen Dezhen Xue Houwen Chen Longfei Li Qiang Feng Toshihiro Omori Yanjing Su | 2020 | npj Computational Materials2020，，1： | 8 |
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