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| 1 | Interleukin 17-Producing γδ T Cells Increased in Patients with Active Pulmonary Tuberculosis显示文摘Although it has been known that γδ T cells may play an important role in the immune response to infection of Mycobacterium tuberculosis (M. tb), the mechanisms by which the γδ T cells participate in the innate and/or acquired immunity to tuberculosis (TB) have not been full elucidated. In the present study, 27 patients with active pulmonary TB and 16 healthy donors (HD) were performed. We found that proportion of IL-17-producing cells among lymphocyte was similar between TB patients and HD, whereas the proportions of γδ T cells in IL-17-producing cells (59.2%) and IL-17-producing cells in γδ T cells (19.4%) in peripheral blood were markedly increased in TB patients when compared to those in HD (43.9% and 7.7%, respectively). In addition, the proportions of IFN-γ-producing γδ T cells in TB patients were obviously lower than that in HD. Upon re-stimulated with M. tb heat-treated antigen (M. tb-HAg) in vitro, fewer IL-17-producing γδ T cells were generated from HD and TB patients, whereas IFN-γ-producing γδ T cells were increased in TB patients compared to that in HD. Our findings in TB patients and healthy human were consistent with other murine investigation that the IL-17-producing γδ T cells were main source of IL-17 in mouse model of BCG infection, suggesting that γδ T cells might be involved in the formation of tubercular granuloma in pulmonary TB patients, but need further identification. | Meiyu Peng Zhaohua Wang Chunyan Yao Lina Jiang Qili Jin Jing Wang Baiqing Li | 2008 | Cellular & Molecular Immunology2008，5，3： | 28 |
| 2 | Introgression of qPE9-1 allele,conferring the panicle erectness,leads to the decrease of grain yield per plant in japonica rice(Oryza sativa L.)显示文摘圆锥花序建筑学是仔细与产量有关形成。qPE9-1 基因被证明了广泛地在产量很高的米饭栽培变种开发被过去常,授与在装饰用的梨树米饭的直立的圆锥花序特性。最近, qPE9-1 成功地被克隆;然而,谷物产量上的基因效果还每直立的圆锥花序等位基因 qPE9-1 的植物是争论的。在现在的学习,低垂的圆锥花序父母 Nongken 57,带 qpe9-1 等位基因,被用作周期性父母到连续地回交到从双 haploid (DH ) 的一根典型直立的圆锥花序线人口(Wuyunjing 8/Nongken 57 ) ,它以前被显示带 qPE9-1 等位基因。因此,一双 near-isogenic 线(无) 被开发。在无之间的农学的特点的比较证明当 qpe9-1 被 qPE9-1 代替时,圆锥花序建筑学从低垂树立被改变;而且,圆锥花序长度,植物高度, 1000 谷物重量和 tillers 显著地被减少,因而在 30% 每植物导致谷物产量的戏剧的减少。因此,我们断定 qPE9-1 是控制圆锥花序建筑学的一个主要因素,并且 qPE9-1 有多种的自然,与每植物的谷物产量上的否定效果。这结果强烈建议直立的圆锥花序等位基因 qPE9-1 应该在产量很高的繁殖实践和另外的有利基因被使用。另外,吃并且煮质量上的 qPE9-1 的效果也在现在的学习被讨论。 | Xiuhua Yi Zujian Zhang Shengyuan Zeng Chunyan Tian Juncheng Peng Min Li Yue Lu Qingcai Meng Minghong Gu Changjie Yan | 2011 | Journal of Genetics and Genomics2011，38，5： | 20 |
| 3 | Gearbox Fault Diagnosis using Adaptive Zero Phase Time-varying Filter Based on Multi-scale Chirplet Sparse Signal Decomposition显示文摘When used for separating multi-component non-stationary signals, the adaptive time-varying filter(ATF) based on multi-scale chirplet sparse signal decomposition(MCSSD) generates phase shift and signal distortion. To overcome this drawback, the zero phase filter is introduced to the mentioned filter, and a fault diagnosis method for speed-changing gearbox is proposed. Firstly, the gear meshing frequency of each gearbox is estimated by chirplet path pursuit. Then, according to the estimated gear meshing frequencies, an adaptive zero phase time-varying filter(AZPTF) is designed to filter the original signal. Finally, the basis for fault diagnosis is acquired by the envelope order analysis to the filtered signal. The signal consisting of two time-varying amplitude modulation and frequency modulation(AM-FM) signals is respectively analyzed by ATF and AZPTF based on MCSSD. The simulation results show the variances between the original signals and the filtered signals yielded by AZPTF based on MCSSD are 13.67 and 41.14, which are far less than variances (323.45 and 482.86) between the original signals and the filtered signals obtained by ATF based on MCSSD. The experiment results on the vibration signals of gearboxes indicate that the vibration signals of the two speed-changing gearboxes installed on one foundation bed can be separated by AZPTF effectively. Based on the demodulation information of the vibration signal of each gearbox, the fault diagnosis can be implemented. Both simulation and experiment examples prove that the proposed filter can extract a mono-component time-varying AM-FM signal from the multi-component time-varying AM-FM signal without distortion. | WU Chunyan LIU Jian PENG Fuqiang YU Dejie LI Rong | 2013 | Chinese Journal of Mechanical Engineering2013，26，4： | 16 |
| 4 | Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4显示文摘补充 32 的反应基因(RGC-32 ) 是涉及房间的增长,区别和迁居的一个房间周期管理者并且也在 angiogenesis 被含有。这里,我们证明在巨噬细胞的那 RGC-32 表情被 IL-4 导致并且由 LPS 减少了,显示在 RGC-32 表示和 M2 极化之间的一个连接。我们证明 RGC-32 的增加的表示或者激活的巨噬细胞,这蛋白质在压制支持 inflammatory cytokine IL-6 的生产并且支持反煽动性的调停人 TGF-β 的生产是特征的;。与一致在 vitro,数据, RGC-32 高级的联系肿瘤的巨噬细胞(TAM ) 快车,和这个表达式被导出肿瘤的腹水的液体以一种 M-CSF- 或 IL-4-dependent 方式导致。一起,这些结果为 M2 巨噬细胞极化作为一个标记建立 RGC-32 并且显示这蛋白质是为癌症免疫疗法的一个潜在的目标,指向联系肿瘤的巨噬细胞。 | Peng Zhao Daiqing Gao Qingjie Wang Bingfeng Song Qianqian Shao Jintang Sun Chunyan Ji Xingang Li Peng Li Xun Qu | 2015 | Cellular & Molecular Immunology2015，12，6： | 12 |
| 5 | Catalytic oxidation of benzene over nanostructured porous Co_3O_4-CeO_2 composite catalysts显示文摘Mesostructured Co3O4-CeO2 composite was found to be an effective catalytic material for the complete oxidation of benzene. The Co3O4-CeO2 catalysts with different Co/Ce ratios (mol/mol) were prepared via the nanocasting method and the mesostructure was replicated from two-dimensional (2D) hexagonal SBA-15 and three-dimensional (3D) cubic KIT-6 silicas, respectively. All the obtained Co3O4-CeO2 catalysts exhibited the similar symmetry with the parent silicas and well ordered mesostructures. The Co3O4- CeO2 catalysts with 2D mesostructure showed lower catalytic activities than the corresponding 3D materials. The Co3O4-CeO2 catalyst nanocasted from KIT-6 and with the Co/Ce ratio of 16/1 possessed the best catalytic benzene oxidation activity due to larger quantities of surface hydroxyl groups and surface oxygenated species. The mesostructured Co3O4-CeO2 material thus shows great potential as a promising eco-environmental catalyst for benzene effective elimination. | Chunyan Ma Zhen Mu Chi He Peng Li Jinjun Li Zhengping Hao | 2011 | Journal of Environmental Sciences2011，23，12： | 9 |
| 6 | Identification of differentially expressed genes in rat silicosis model by suppression subtractive hybridization analysis显示文摘在肺的纤维变性的发展的批评分子的机制仍然保持未知,让有差的预后的病人诊断。孤立在肺的纤维变性明确地起来调整的基因,我们建立了一个老鼠矽肺模型在有水晶的硅石暂停的治疗以后的 360 d。胸的拍证明一些散布高密度的阴影出现在肺地里。典型显微镜的小谎 rosing silicotic 小瘤在肺,牙槽的上皮的房间和支气管的上皮的房间形成了,特别地在部分 fibrosing silicotic 小瘤附近;他们中的一些显示出建议了在矽肺和肺癌症之间的关联的不正常的增生。抑制减少性的杂交分析被执行在肺织物把基因表示与矽肺和正常的肺织物作比较。反向的抄写聚合酶链反应证明七个新奇 cDNA 序列的表情由在有矽肺的肺织物的减少性的杂交不同于的抑制识别了正常的肺织物。生物信息学分析证明 47 积极克隆代表了包含二通常认为的蛋白质的 35 基因,四预言了类似的蛋白质。分析也证明一些在矽肺屏蔽了基因,例如 prolyl 4-hydroxylases,肌动朊相关的 protein-2/3 建筑群和酸的哺乳动物的 chitinase,以前没被报导。这些基因可以为在肺的纤维变性的发展调查分子的机制提供新线索。 | Zhongyuan Jin Baoan Liu Deyun Feng Chen Chen Xiang Li Yongbin Hu Jinwu Peng Yu Liu Jing Du Chunyan Fu Jifang Wen | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 6 |
| 7 | Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells显示文摘The restriction of immunoglobulin(Ig)expression to B lymphocytes is well established.However,several reports have confirmed that the Ig gene can be expressed in many non-B cancer cells and/or some normal cells.Our aim is to determine whether the Ig gene promoter can be activated in non-B cancer cells and to identify the regulatory mechanism for Ig gene expression.Our results show that the Ig promoter of VH4-59 was activated in several non-B cancer cell lines.Moreover,two novel positive regulatory elements,an enhancer-like element at 2800 to 2610 bp and a copromoter-like element at 2610 to 2300 bp,were identified in two epithelial cancer cell lines,HeLa S3 and HT-29.The octamer element(59-ATGCAAAT-39)located in the Ig promoter,a crucial element for B-cell-derived Ig gene transcription,was also very important for non-B-cell-derived Ig gene transcription.More importantly,we confirmed that octamer-related protein-1(Oct-1),but not Oct-2,was a crucial transcriptional factor for Ig gene transcription due to its ability to bind to the octamer element of the Ig promoter in epithelial cancer cells.These results suggested the presence of a distinct regulatory mechanism for Ig gene expression in non-B cancer cells. | Xiaohui Zhu Lina Wu Li Zhang Peng Hao Shuai Zhang Jing Huang Jie Zheng Yinan Liu Wenjun Li Yingmei Zhang Chunyan Zhou Youhui Zhang C Cameron Yin Xiaoyan Qiu | 2010 | Cellular & Molecular Immunology2010，7，4： | 5 |
| 8 | Validation of the Nanjing Criteria for Diagnosing Pyrrolizidine Alkaloids-induced Hepatic Sinusoidal Obstruction Syndrome显示文摘Background and Aims:Hepatic sinusoidal obstruction syndrome(HSOS)is caused by toxic injury to sinusoidal endothelial cells in the liver.The intake of pyrrolizidine alkaloids(PAs)in some Chinese herbal remedies/plants remains the major etiology for HSOS in China.Recently,new diagnostic criteria for PA-induced HSOS(i.e.PA-HSOS)have been developed;however,the efficacy has not been clinically validated.This study aimed to assess the performance of the Nanjing criteria for PA-HSOS.Methods:Data obtained from consecutive patients in multiple hospitals,which included 86 PA-HSOS patients and 327 patients with other liver diseases,were retrospectively analyzed.Then,the diagnostic performance of the Nanjing criteria and simplified Nanjing criteria were evaluated and validated.The study is registered in www.chictr.org.cn(ID:ChiCTR1900020784).Results:The Nanjing criteria have a sensitivity and specificity of 95.35%and 100%,respectively,while the simplified Nanjing criteria have a sensitivity and specificity of 96.51%and 96.33%,respectively,for the diagnosis of PA-HSOS.Notably,a proportion of patients with Budd-Chiari syndrome(11/49)was misdiagnosed as PA-HSOS on the basis of the simplified Nanjing criteria,and this was mainly due to the overlapping features in the enhanced computed tomography/magnetic resonance imaging examinations.Furthermore,most of these patients(10/11)had occlusion or thrombosis of the hepatic vein,and communicating vessels in the liver were found in 8/11 patients,which were absent in PA-HSOS patients.Conclusions:The Nanjing criteria and simplified Nanjing criteria exhibit excellent performance in diagnosing PA-HSOS.Thus,both could be valuable diagnostic tools in clinical practice. | Wei Zhang Lu Liu Ming Zhang Feng Zhang Chunyan Peng Bin Zhang Jun Chen Lin Li Jian He Jiangqiang Xiao Yanhong Feng Xunjiang Wang Aizhen Xiong Li Yang Xiaoping Zou Yuecheng Yu Yuzheng Zhuge | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 4 |
| 9 | Image retrieval based on multi-concept detector and semantic correlation显示文摘With the rapid development of future network, there has been an explosive growth in multimedia data such as web images. Hence, an efficient image retrieval engine is necessary. Previous studies concentrate on the single concept image retrieval, which has limited practical usability. In practice, users always employ an Internet image retrieval system with multi-concept queries, but, the related existing approaches are often ineffective because the only combination of single-concept query techniques is adopted. At present semantic concept based multi-concept image retrieval is becoming an urgent issue to be solved. In this paper, a novel Multi-Concept image Retrieval Model(MCRM) based on the multi-concept detector is proposed, which takes a multi-concept as a whole and directly learns each multi-concept from the rearranged multi-concept training set. After the corresponding retrieval algorithm is presented, and the log-likelihood function of predictions is maximized by the gradient descent approach. Besides, semantic correlations among single-concepts and multiconcepts are employed to improve the retrieval performance, in which the semantic correlation probability is estimated with three correlation measures, and the visual evidence is expressed by Bayes theorem, estimated by Support Vector Machine(SVM). Experimental results on Corel and IAPR data sets show that the approach outperforms the state-of-the-arts. Furthermore, the model is beneficial for multi-concept retrieval and difficult retrieval with few relevant images. | XU HaiJiao HUANG ChangQin PAN Peng ZHAO GanSen XU ChunYan LU YanSheng CHEN Deng WU JiYi | 2015 | Science China Chemistry2015，58，12： | 3 |
| 10 | Effect of Lamb Age and in vitro Culture System of Oocytes on JIVET Technology显示文摘[Objectives] This study was conducted to investigate the effects of lamb age and in vitro culture system of oocytes on the results of juvenile in vitro embryo transfer( JIVET). [Methods]Ten Dorper × small-tailed Han lambs aged 5 to 10 weeks were induced to superovulate via i. p. injection of pregnant mare's serum gonadotropin( PMSG). The oocytes were matured in basal maturation solution or modified maturation solution,which was prepared by adding 200 μmol/L cysteine to the basal maturation solution. Then,the oocytes were fertilized in fertilization medium I containing 2% estrus sheep serum( ESS) or fertilization medium II containing 3 mg/ml bull serum albumin( BSA). Finally,the number of oocytes,oocyte maturation rate and cleavage rate of the lambs of different ages were determined. [Results]The average number of oocytes recovered per lamb was( 111. 00 ± 16. 97),( 139. 50 ± 28. 99),( 108. 50 ± 17. 68) and( 42. 00 ± 11. 31) for5-,7-,8-and 10-week-old Dorper × small-tailed Han lambs,respectively. The number of oocytes obtained from 5-,7-and 8-week-old lambs was significantly higher than that from 10-week-old lambs( P < 0. 05),but there was no significant difference among 5-,7-and 8-week-old lambs( P > 0. 05). The maturation rate of oocytes cultured in modified maturation solution was 3. 64% higher than that in basal maturation solution. The cleavage rate of oocytes in fertilization medium I was very significantly higher than that in fertilization medium II( P < 0. 01). [Conclusions] The results of JIVET can be improved by harvesting oocytes from lambs aged 5-8 weeks,adding a certain amount of cysteine into oocyte maturation solution,and a certain amount of ESS into fertilization medium. | Yangyi MAO Huidi LUO Guanwu ZHANG Zhiwu WANG Peng ZHAO Jun LI Hongyu GUO Shenghua ZHOU Huihui GUO Chunyan LI | 2019 | Agricultural Biotechnology2019，8，1： | 3 |
| 11 | Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study显示文摘The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown.This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai,China.Oral glucose tole3rance test was conducted during baseline and follow-up visits.Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk.A total of 613(10.3%)incident diabetes cases were identified during the follow-up visit after 4.5 years.Fasting plasma glucose,postload glucose,and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid(all Ps<0.05).The incidence rate of diabetes increased across the quartiles of serum uric acid(7.43%,8.77%,11.47%,and 13.43%).Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid(odds ratio(95%confidence interval)=1.36(1.06−1.73)).Stratified analysis indicated that the association was only observed in women.Accordingly,serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women. | Di Cheng Chunyan Hu Rui Du Hongyan Qi Lin Lin Xueyan Wu Lina Ma Kui Peng Mian Li Min Xu Yu Xu Yufang Bi Weiqing Wang Yuhong Chen Jieli Lu | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 12 | Role of nitric oxide and vascular endothelial growth factor in fluoride-induced goitrogenesis in rats显示文摘 | Guoyan Liu Weidong Zhang Peng Jiang Xinhong Li Chunyan Liu Chunyan Chai | 2012 | Environmental Toxicology and Pharmacology2012，，2： | 2 |
| 13 | Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip显示文摘EGFR mutations companion diagnostics have been proved to be crucial for the efficacy of tyrosine kinase inhibitor targeted cancer therapies. To uncover multiple mutations occurred in minority of EGFR-mutated cells,which may be covered by the noises from majority of unmutated cells, is currently becoming an urgent clinical requirement. Here we present the validation of a microfluidic-chip-based method for detecting EGFR multimutations at single-cell level. By trapping and immunofluorescently imaging single cells in specifically designed silicon microwells, the EGFR-expressed cellswere easily identified. By in situ lysing single cells, the cell lysates of EGFR-expressed cells were retrieved without cross-contamination. Benefited from excluding the noise from cells without EGFR expression, the simple and cost-effective Sanger's sequencing, but not the expensive deep sequencing of the whole cell population, was used to discover multi-mutations. We verified the new method with precisely discovering three most important EGFR drugrelated mutations from a sample in which EGFR-mutated cells only account for a small percentage of whole cell population. The microfluidic chip is capable of discovering not only the existence of specific EGFR multi-mutations,but also other valuable single-cell-level information: on which specific cells the mutations occurred, or whether different mutations coexist on the same cells. This microfluidic chip constitutes a promising method to promote simple and cost-effective Sanger's sequencing to be a routine test before performing targeted cancer therapy. | Ren Li Mingxing Zhou Jine Li Zihua Wang Weikai Zhang Chunyan Yue Yan Ma Hailin Peng Zewen Wei Zhiyuan Hu | 2018 | Nano-Micro Letters2018，10，1： | 2 |
| 14 | A Superhydrophobic/Electrothermal/Photothermal Synergistically Anti-icing Strategy with Excellent Self-healable and Anti-abrasion Property显示文摘Unexpected ice accumulation tends to cause many problems or even disasters in our daily life.Based on the superior electrothermal and photothermal function of the carbon nanotubes,we introduced a superhydrophobic/electrothermal/photothermal synergistically anti-icing strategy.When a voltage of 15 V was applied to the superhydrophobic sample,the surface could rapidly melt the ice layer(~3 mm thickness)within 530 s at the environmental temperature of-25℃.When the near-infrared light(808 nm)irradiates on the superhydrophobic sample,the ice could be rapidly removed after 460 s.It was found that the superhydrophobicity helps the melted water to roll off immediately,and then solves the re-freeze problem the traditional surfaces facing.Moreover,the ice can be completely melted with 120 s when the superhydrophobic/electrothermal/photothermal synergistically anti-icing strategy was utilized.To improve the mechanical robustness for practical application,both nanoscale carbon nanotubes and microscale carbon powders were utilized to construct hierarchical structure.Then these dual-scale fillers were sprinkled onto the semi-cured elastomer substrate to prepare partially embedded structure.Both hierarchical structure and partially embedded structure were obtained after completely curing the substrate,which imparts excellent abrasion resistance(12.50 kPa,16.00 m)to the prepared sample.Moreover,self-healable poly(urea–urethane)elastomer was introduced as the substrate.Thus,the cutted superhydrophobic sample can be mended by simply contacting at room temperature. | Peng Wang Jian Wang Wei Duan Chunyan Li Huilong Han Qing Xie | 2021 | Journal of Bionic Engineering2021，18，5： | 2 |
| 15 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 16 | Crystal structure of histidine-containing phosphocarrier protein from Thermoanaerobacter tengcongensis MB4 and the implications for thermostability显示文摘Protein thermostability is an inherent characteristic of proteins from thermophilic microorganisms,and therefore enables these organisms to survive at extreme temperatures.Although it is well-known that thermostable proteins are critical for the growth of thermophilic organisms,the structural basis of protein thermostability is not yet fully understood.The histidine-containing phosphocarrier (HPr) protein,a phosphate shuttle protein in the phosphoenolpyruvate-dependent sugar transport system (PTS) of bacterial species,is an ideal model for investigating protein thermostability with respect to its small size and deficiency in disulphide bonds or cofactors.In this study,the HPr protein from Thermoanaerobacter tengcongensis (TtHPr) is cloned and purified.Crystal structure with good quality has been determined at 2.3 resolution,which provides a firm foundation for exploring the thermostable mechanism.However,it shows that the crystal structure is conserved and no clue can be obtained from this single structure.Furthermore,detailed comparison of sequence and structure with the homologs from mesoor thermophilic bacteria shows no obvious rule for thermostability,but the extra salt-bridge existing only in thermophilic bacteria might be a better explanation for thermostability of HPr.Thus,mutations are performed to interrupt the salt-bridge in HPrs in thermophilic bacteria.Using site-directed mutations and the circular dichroism method,thermostability is evaluated,and the mutational variations are shown to have a faster denaturing rate than for wild-type viruses,indicating that mutations cause instability in the HPrs.Understanding the higher-temperature resistance of thermophilic and hyperthermophilic proteins is essential to studies on protein folding and stability,and is critical in engineering efficient enzymes that can work at a high temperature. | FENG ChunYan GAO Feng LIU YiWei WANG GuiHua PENG Hao MA YanHe YAN JingHua GAO George Fu | 2011 | Science China(Life Sciences)2011，54，6： | 2 |
| 17 | Hierarchical Code Assignment Algorithm and StateBased CDMA Protocol for UWSN显示文摘The characteristics of underwater acoustic channel such as long propagation delay and low bit rate cause the MAC(Medium Access Control) protocols designed for radio channels to be either inapplicable,or have low efficiency for UWSN(Underwater Sensor Network).We propose a hierarchical and distributed code assignment algorithm based on divisive probability function which can avoid conflict between spread codes with high probability,and provide a statebased MAC protocol for UWSN.Without RTS/CTS(Request To Send/Clear To Send) handshaking,each node maintains a neighbor table including state field,and packages are forwarded according to the state of the receiver,so it can avoid the interference caused by transmitting to a sending node in a half-duplex system and improve channel utilization.The design of power control minimizes the nearfar effect inherent in CDMA.Simulation results reveal that state-based CDMA protocol shows outstanding performance in throughput,delivery ratio and resource-consumption. | DU Xiujuan PENG Chunyan LIU Xiuxiu LIU Yuchi | 2015 | China Communications2015，12，3： | 2 |
| 18 | Combination of two multiplex genome-edited soybean varieties enables customization of protein functional properties显示文摘Dear Editor,Soybean(Glycine max)is a major source of plant-based protein for people worldwide,providing a healthy,affordable,and environmentally friendly alternative to animal-based protein(Montgomery,2003).It has been estimated that there are currently over 12000 food products that contain soy protein(Montgomery,2003).Different food applications of soy protein require distinct properties that affect its function and sensory features.For instance,the sensory quality of soymilk is significantly affected by protein emulsibility,whereas tofu quality is determined by protein-gelling ability(Kinsella,1979). | Mengyan Bai Cuicui Yuan Huaqin Kuang Qian Sun Xinchen Hu Luning Cui Wenxin Lin Chunyan Peng Peng Yue Shikui Song Zebin Guo Yuefeng Guan | 2022 | Molecular Plant2022，15，7： | 1 |
| 19 | Zinc quin-olates through styryl substitution in a~position via acetoxyexchange reaction显示文摘 | Chen Liuqing Tao Peng Sun Chunyan | 2011 | Synth Met2011，161，： | 1 |
| 20 | Eastern Ancient Terrane of the North China Craton显示文摘Based on the spatial distribution of ancient rocks and zircons, three ancient terranes older than ca. 2.6 Ga have recently been identified in the North China Craton, namely the Eastern, Southern, and Central Ancient Terranes. The Eastern Ancient Terrane is the best studied and understood of the three ancient terranes. It has a long geological history back to ca. 3.8 Ga ago and includes the areas of Anshan-Benxi, eastern Hebei, eastern Shandong and western Shandong. In Anshan-Benxi, several different types of 3.8 Ga rocks were discovered together with 3.1-3.7 Ga rocks, whereas 2.9-3.0 Ga K-rich granites and 2.5 Ga syenogranite occur on larger scales. In eastern Hebei, 3.0-3.4 Ga rocks and older detrital and xenocrystic zircons were identified. In eastern Shandong, there are a large volumes of 2.7 Ga and 2.9 Ga rocks. In western Shandong, early Neoarchean(2.6-2.7 Ga) intrusive and supracrustal rocks are widely distributed. Whole-rock Nd and zircon Hf isotope data suggest that both mantle additions and crustal recycling played important roles within the Eastern Ancient Terrane during almost every tectono-magmatic event. Most BIFs in the North China Craton are late Neoarchean in age and are distributed on continental crust along the western margin of the Eastern Ancient Terrane, probably suggesting that a stable environment was one of the key factors for the formation of large-scale BIFs. | WAN Yusheng LIU Shoujie Alfred KRONER DONG Chunyan XIE Hangqiang XIE Shiwen BAI Wenqian REN Peng MA Mingzhu LIU Dunyi | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 1 |
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