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| 1 | Gd-EOB-DTPA-enhanced magnetic resonance imaging for focal liver lesions in Chinese patients:a multicenter,open-label,phase Ⅲ study显示文摘BACKGROUND:Contrast agents help to improve visibility in magnetic resonance(MR)imaging.However,owing to the large interstitial spaces of the liver,there is a reduction in the natural contrast gradient between lesions and healthy tissue.This study was undertaken to evaluate the efficacy and safety of the liverspecific MR imaging contrast agent gadoxetate disodium(GdEOB-DTPA)in Chinese patients.METHODS:This was a single-arm,open-label,multicenter study in patients with known or suspected focal liver lesions referred for contrast-enhanced MR imaging.MR imaging was performed in 234 patients before and after a single intravenous bolus of Gd-EOB-DTPA(0.025 mmol/kg body weight).Images were evaluated by clinical study investigators and three independent,blinded radiologists.The primary efficacy endpoint was sensitivity in lesion detection.RESULTS:Gd-EOB-DTPA improved sensitivity in lesion detection by 9.46%compared with pre-contrast imaging for the average of the three blinded readers(94.78%vs 85.32%for Gd-EOB-DTPA vs pre-contrast,respectively).Improvements in detection were more pronounced in lesions less than 1cm.Gd-EOB-DTPA improved diagnostic accuracy in lesion classification.CONCLUSIONS:This open-label study demonstrated that Gd-EOB-DTPA improves diagnostic sensitivity in liver lesions,particularly in those smaller than 1 cm.Gd-EOB-DTPA also significantly improves the diagnostic accuracy in lesion classification,and furthermore,Gd-EOB-DTPA is safe in Chinese patients with liver lesions. | Meng-Su Zeng Hui-Yi Ye Liang Guo Wei-Jun Peng Jian-Ping Lu Gao-Jun Teng Josy Breuer Yi Huan Ping Li Jian-Rong Xu Chang-Hong Liang | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 31 |
| 2 | Epidemiological characteristics of thyroid nodules and risk factors for malignant nodules: a retrospective study from 6 304 surgical cases显示文摘 | Huan Qin Wang Kun Lou Fuchen Zhang Li Huang Qingxian Han Yunfeng Sun Hancheng Zhu Lei Lin Peng Song Jun Liu Fuqiang Wang Qian Hou Weikai | 2014 | Chinese Medical Journal2014，，12： | 20 |
| 3 | 重复经颅磁刺激治疗抑郁症的机制研究进展(英文)显示文摘概述:抑郁障碍是目前最常见的心理健康问题之一。然而,对于该疾病的基于机制的治疗方法仍然是难以捉摸的。重复经颅磁刺激(rTMS)是一种非侵入性的程序,它可以以一种脉冲磁场来刺激大脑中的电活动,被认为是一种有效的抑郁症治疗方式。在这里,我们回顾了关于rTMS治疗抑郁症的临床和基础研究的主要发现,包括它的抗抑郁疗效,基本原理,调节神经回路、神经递质和脑网络、海马神经发生、和突出的功效,以及分子通路。 | Zhengwu PENG Cuihong ZHOU Shanshan XUE Jie BAI Shoufen YU Xiaosa LI Huaning WANG Qingrong TAN | 2018 | 上海精神医学2018，30，2： | 13 |
| 4 | Clinical outcomes of small incision lenticule extraction versus femtosecond laser-assisted LASIK for myopia: a Meta-analysis显示文摘AIM: To evaluate the possible differences in visual quality between small incision lenticule extraction(SMILE) and femtosecond laser in situ keratomileusis(FS-LASIK) for myopia.METHODS: A Meta-analysis was performed. Patients were from previously reported comparative studies treated with SMILE versus FS-LASIK. The Pub Med, EMBASE, Cochrane, Web of Science and Chinese databases(i.e. WANFANG and CNKI) were searched in Nov. of 2016 using Rev Man 5.1 version software. The differences in visual acuity, aberration and biomechanical effects within six months postoperatively were showed. Twenty-seven studies including 4223 eyes were included. RESULTS: No significant differences were observed between SMILE and FS-LASIK in terms of the proportion of eyes that lost one or more lines of corrected distance visual acuity after surgery(P=0.14), the proportion of eyes achieving an uncorrected distance visual acuity of 20/20 or better(P=0.43), the final refractive spherical equivalent(P=0.89), the refractive spherical equivalent within ±1.00 diopter of the target values(P=0.80), vertical coma(P=0.45) and horizontal coma(P=0.06). Compared with the FSLASIK group, total higher-order aberration(P<0.001) and spherical aberration(P<0.001) were higher and the decrease in corneal hysteresis(P=0.0005) and corneal resistance factor(P=0.02) were lower in the SMILE group. CONCLUSION: SMILE and FS-LASIK are comparable in efficacy, safety and predictability for correcting myopia.However, the aberration in the SMILE group is superior to that in the FS-LASIK group, and the loss of biomechanical effects may occur less frequently after SMILE than after FS-LASIK. | Huan Yan Li-Yan Gong Wei Huang Yan-Li Peng | 2017 | International Journal of Ophthalmology(English edition)2017，10，9： | 12 |
| 5 | High quality reference genome of drumstick tree(Moringa oleifera Lam.), a potential perennial crop显示文摘The drumstick tree(Moringa oleifera Lam.) is a perennial crop that has gained popularity in certain developing countries for its high-nutrition content and adaptability to arid and semi-arid environments. Here we report a high-quality draft genome sequence of M. oleifera. This assembly represents 91.78% of the estimated genome size and contains 19,465 protein-coding genes. Comparative genomic analysis between M. oleifera and related woody plant genomes helps clarify the general evolution of this species, while the identification of several species-specific gene families and positively selected genes in M. oleifera may help identify genes related to M. oleifera's high protein content, fast-growth, heat and stress tolerance. This reference genome greatly extends the basic research on M. oleifera, and may further promote applying genomics to enhanced breeding and improvement of M. oleifera. | TIAN Yang ZENG Yan ZHANG Jing YANG Cheng Guang YAN Liang WANG XuanJun SHI ChongYing XIE Jing DAI TianYi PENG Lei ZENG HUAN Yu XU An Ni HUANG YeWei ZHANG JiaJin MA Xiao DONG Yang HAO ShuMei SHENG Jun | 2015 | Science China(Life Sciences)2015，58，7： | 10 |
| 6 | GW5-Like, a homolog of GW5, negatively regulates grain width, weight and salt resistance in rice显示文摘Grain size is an important determinant of yield potential in crops. We previously demonstrated that natural mutations in the regulatory sequences of qSW5/GW5 confer grain width diversity in rice. However, the biological function of a GW5 homolog, named GW5-Like(GW5 L), remains unknown. In this study, we report on GW5 L knockout mutants in Kitaake, a japonica cultivar(cv.)considered to have a weak gw5 variant allele that confers shorter and wider grains. GW5 L is evenly expressed in various tissues, and its protein product is localized to the plasma membrane. Biochemical assays verified that GW5 L functions in a similar fashion to GW5. It positively regulates brassinosteroid(BR) signaling through repression of the phosphorylation activity of GSK2. Genetic data show that GW5 L overexpression in either Kitaake or a GW5 knockout line, Kasaorf3(indica cv. Kasalath background), causes more slender, longer grains relative to the wild-type. We also show that GW5 L could confer salt stress resistance through an association with calmodulin protein OsCa M1-1. These findings identify GW5 L as a negative regulator of both grain size and salt stress tolerance, and provide a potential target for breeders to improve grain yield and salt stress resistance in rice. | Peng Tian Jiafan Liu Changling Mou Cuilan Shi Huan Zhang Zhichao Zhao Qibing Lin Jie Wang Jiulin Wang Xin Zhang Xiuping Guo Zhijun Cheng Shanshan Zhu Yulong Ren Cailin Lei Haiyang Wang Jianmin Wan | 2019 | Journal of Integrative Plant Biology2019，61，11： | 9 |
| 7 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 8 | How does Helicobacter pylori cause gastric cancer through connexins: An opinion review显示文摘Helicobacter pylori (H. pylori) is a Gram-negative bacterium with a number of virulence factors, such as cytotoxin-associated gene A, vacuolating cytotoxin A, its pathogenicity island, and lipopolysaccharide, which cause gastrointestinal diseases. Connexins function in gap junctional homeostasis, and their downregulation is closely related to gastric carcinogenesis. Investigations into H. pylori infection and the fine-tuning of connexins in cells or tissues have been reported in previous studies. Therefore, in this review, the potential mechanisms of H. pylori-induced gastric cancer through connexins are summarized in detail. | Huan Li Can-Xia Xu Ren-Jie Gong Jing-Shu Chi Peng Liu Xiao-Ming Liu | 2019 | World Journal of Gastroenterology2019，25，35： | 9 |
| 9 | A LysM Receptor Heteromer Mediates Perception of Arbuscular Mycorrhizal Symbiotic Signal in Rice显示文摘Symbiotic microorganisms improve nutrient uptake by plants.To initiate mutualistic symbiosis with arbus-cular mycorrhizal(AM)fungi,plants perceive Myc factors,including lipochitooligosaccharides(LCOs)and short-chain chitooligosaccharides(CO4/CO5),secreted by AM fungi.However,the molecular mechanism of Myc factor perception remains elusive.In this study,we identified a heteromer of LysM receptor-like kinases consisting of OsMYR1/OsLYK2 and OsCERK1 that mediates the perception of AM fungi in rice.CO4 directly binds to OsMYR1,promoting the dimerization and phosphorylation of this receptor complex.Compared with control plants,Osmyr1 and Oscerk1 mutant rice plants are less sensitive to Myc factors and show decreased AM colonization.We engineered transgenic rice by expressing chimeric receptors that respectively replaced the ectodomains of OsMYR1 and OsCERK1 with those from the homologous Nod factor receptors MtNFP and MtL YK3 of Medicago truncatula.Transgenic plants displayed increased cal-cium oscillations in response to Nod factors compared with control rice.Our study provides significant mechanistic insights into AM symbiotic signal perception in rice.Expression of chimeric Nod/Myc recep-tors achieves a potentially important step toward generating cereals that host nitrogen-fixing bacteria. | Jiangman He Chi Zhang Huiling Dai Huan Liu Xiaowei Zhang Jun Yang Xi Chen Yayun Zhu Dapeng Wang Xiaofeng Qi Weichao Li Zhihui Wang Guoyong An Nan YU Zuhua He Yong-Fei Wang Youli Xiao Peng Zhang Ertao Wang | 2019 | Molecular Plant2019，12，12： | 9 |
| 10 | Preparation and Characterization of Flame Retardant and Low Smoke Releasing Oil-resistant EVA/NBR Blends显示文摘Nano-Si O2 and/or Mo O3 were introduced to ethylene-vinyl acetate/nitrile butadiene rubber(EVA/NBR) blends containing magnesium hydroxide(MH) and red phosphorus(RP) to further improve the mechanical properties, oil resistance, smoke suppression and flame retardancy. The results indicated that the tensile strength and oil resistance were significantly improved by incorporating nano-Si O2. Smoke suppression tests for EVA/NBR blend samples showed that both nano-Si O2 and Mo O3 can significantly reduce smoke release amount. The flammability characterization indicated that the blended sample with an LOI value of 33.0 could achieve V-0 level in the UL-94 test. Cone calorimetry test data showed the peak heat release rate was 67% lower than that for pure EVA/NBR. Thermal analysis showed that the presence of both nano-Si O2 and Mo O3 was beneficial to promoting char formation of the EVA/NBR blends. Char residual analysis suggested that Mo O3 aggregated in solid phase during combustion. | Huan Zou Jun Sun Xiao-yu Gu Peng Jiang Xi-shan Liu 张胜 | 2015 | Chinese Journal of Polymer Science2015，33，4： | 8 |
| 11 | Magnetic nanoparticles based cancer therapy: current status and applications显示文摘Nanotechnology holds a promising potential for developing biomedical nanoplatforms in cancer therapy. The magnetic nanoparticles, which integrate uniquely appealing features of magnetic manipulation, nanoscale heat generator, localized magnetic field and enzyme-mimics, prompt the development and application of magnetic nanoparticles-based cancer medicine. Considerable success has been achieved in improving the magnetic resonance imaging(MRI) sensitivity, and the therapeutic function of the magnetic nanoparticles should be given adequate attention. This work reviews the current status and applications of magnetic nanoparticles based cancer therapy. The advantages of magnetic nanoparticles that may contribute to improved therapeutics efficacy of clinic cancer treatment are highlighted here. | Huan Zhang Xiao Li Liu Yi Fan Zhang Fei Gao Ga Long Li Yuan He Ming Li Peng Hai Ming Fan | 2018 | Science China(Life Sciences)2018，61，4： | 8 |
| 12 | Polymorphisms of three gene-derived STS on pig chromosome 13q41 are associated with susceptibility to enterotoxigenic Escherichia coli F4ab/ac in pigs显示文摘Neonatal diarrhea caused by enterotoxigenic Escherichia coli(ETEC)F4 is a common and serious disease,resulting in significant economical loss in the pig industry.The locus encoding ETEC F4 receptor has been mapped to pig chromosome(SSC)13q41,and one of the most significantly linked markers is S0075.In this study,we selected three genes including SLC12A8,MYLK and KPNA1 from a chromosomal region flanking S0075 on SSC13 to develop pig specific sequence tagged sites(STS). Seven single nucleotide polymorphisms were identified in the three pig STS using DNA of four full-sib susceptible and resistant animals in a White Duroc×Erhualian intercross.All grandparents,parents and 755 offspring in the intercross were genotyped for three polymorphisms,including SLC12A8 g.159A>G,MYLK g.1673A>G and KPNA1 g.306A>G.Family-based transmission disequilibrium test(TDT) revealed that all polymorphisms and the corresponding haplotypes are significantly associated with ETEC F4ab/ac(especially F4ac)brush border adhesion phenotypes,indicating that these polymor- phism are in linkage disequlibrium with causal mutation(s)of the gene encoding ETEC F4ab/ac receptor. Our results strengthen the evidence for the involvement of SSC13q41 in high acquiring risk of ETEC F4ab/ac infection,and provide novel polymorphic markers for fine mapping of the ETEC F4ab/ac receptor locus. | HUANG Xiang 1 ,REN Jun 1 ,YAN XueMing 1,2 ,PENG QiuLing 1 ,TANG Huan 1 ,ZHANG Bo 1 ,JI HuaYuan 1 , YANG ShuJin1&HUANG LuSheng 1 1Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China,Jiangxi Agricultural University, Nanchang 330045,China 2Department of Biology,Nanchang University of Science and Technology,Nanchang 330038,China | 2008 | Science China(Life Sciences)2008，51，7： | 8 |
| 13 | Interaction effect of nitrogen form and planting density on plant growth and nutrient uptake in maize seedlings显示文摘High planting density is essential to increasing maize grain yield.However,single plants suffer from insufficient light under high planting density.Ammonium(NH_4^+)assimilation consumes less energy converted from radiation than nitrateIt is hypothesized that a mixed NO_3~–/NH_4^+supply is more important to improving plant growth and population productivity under high vs.low planting density.Maize plants were grown under hydroponic conditions at two planting densities(low density:only).A significant interaction effect was found between planting density and N form on plant biomass.Compared to nitrate only,75/25NO_3~–/NH_4^+increased per-plant biomass by 44%under low density,but by 81%under high density.Treatment with 75/25NO_3~–/NH_4^+increased plant ATP,photosynthetic rate,and carbon amount per plant by 31,7,and 44%under low density,respectively,but by 51,23,and 95%under high density.Accordingly,carbon level per plant under 75/25NO_3~–/NH_4^+was improved,which increased leaf area,specific leaf weight and total root length,especially for high planting density,increased by 57,17 and 63%,respectively.Furthermore,under low density,75/25NO_3~–/NH_4^+increased nitrogen uptake rate,while under high density,75/25NO_3~–/NH_4^+increased nitrogen,phosphorus,copper and iron uptake rates.By increasing energy use efficiency,an optimum NO_3~–/NH_4^+ratio can improve plant growth and nutrient uptake efficiency,especially under high planting density.In summary,an appropriate supply of NH_4^+in addition to nitrate can greatly improve plant growth and promote population productivity of maize under high planting density,and therefore a mixed N form is recommended for high-yielding maize management in the field. | WANG Peng WANG Zhang-kui SUN Xi-chao MU Xiao-huan CHEN Huan CHEN Fan-jun Yuan Li-xing MI Guo-hua | 2019 | Journal of Integrative Agriculture2019，18，5： | 8 |
| 14 | A new pathotype characterization of Daxing and Huangyuan populations of cereal cyst nematode(Heterodera avenae) in China显示文摘The cereal cyst nematode(CCN, Heteroder aavenae) causes serious yield loss on cereal crops, especially wheat, worldwide. Daxing population in Beijing City and Huangyuan population in Qinghai Province, China, are two CCN populations. In this study, the CCN pathotypes of Daxing and Huangyuan populations were characterized by tests on 23 standard 'International Test Assortment' with the local species Wenmai 19 as the susceptible control. Tested materials were grouped by three nematode populations' virulence on resistant genes(Rha1, Rha2, Rha3, Cre1) and nonresistant genes, varieties and lines. Both Daxing and Huangyuan populations were avirulent to Ortolan(Ha1). Barley cvs. Ortolan, Siri, Morocco, Bajo Aragon 1-1, and Martin 403-2 were all resistant to both populations. Cultivars Herta, Harlan 43 and wheat Iskamish-K-2-light were all susceptible to Huangyuan population, all of them, however, were resistant to Daxing population. The other five oats were all resistant to the two tested CCN populations. Except Iskamisch K-2-light, all the other wheat cultivars(Capa, Loros×Koga, AUS 10894, and Psathias) were susceptible to Daxing population. Because the pathotypes of the two tested CCN populations in Beijing and Qinghai were not identical to any of the 13 pathotypes previously characterized by the test assortment, we classified Daxing and Huangyuan populations as the new pathotypes, named Ha91. | CUI Jiang-kuan HUANG Wen-kun PENG Huan LIU Shi-ming WANG Gao-feng KONG Lin-an PENG De-liang | 2015 | Journal of Integrative Agriculture2015，14，4： | 8 |
| 15 | Mesozoic basins and associated palaeogeographic evolution in North China显示文摘In North China, the Mesozoic terrestrial basins, sedimentary palaeogeography and tectonic settings involved five evolutionary stages:(1) the Early-Middle Triassic,(2) the Late Triassic to Early-Middle Jurassic,(3) the Late Jurassic to early Early Cretaceous,(4) the middle-late Early Cretaceous and(5) the Late Cretaceous. The regional punctuated tectonic events occurred during these evolutionary stages. During the Early-Middle Triassic(stage 1), the Xingmeng Orogenic Belt(XMOB, i.e., eastern part of Central Asia Orogenic Belt, CAOB) of the northern North China was settled in the transition of tectonic environment from syn-orogenic compression to post-orogenic extension with intensive uplifting. It is a main provenance in the unified Ordos-North China Basin.The united continental plate of China and the Qinling-Dabie-Sulu Orogenic Belt formed due to convergence and collision between the North China Plate and the Yangtze Plate along two suture zones of the Mianlue and the Shangdan in the terminal Middle Triassic. During the Late Triassic to the Early-Middle Jurassic(stage 2), the Late Triassic mafic or alkaline rocks and intrusions occurred on the northern and southern margins of North China Craton(NCC) and XMOB, implying that intensified extension happened all over the North China(early phase of stage 2). Additionally, in the late phase of stage 2, the basic volcanicfilling faulted basins were widely distributed in the northeastern North China during the EarlyMiddle Jurassic, including a series of small- to medium-sized basins with coal-bearing strata and some volcanic rocks in other areas of North China, which was the result of subduction of the Palaeo-Pacific Plate during the Early-Middle Jurassic. An active continental margin with accretionary complex developed in the eastern Heilongjiang of China, Japan and the Far East of Russia at that time. However, in the end of the Early-Middle Jurassic, because of the Yanshanian orogeny characterized by complicated thrust and fold, the previous unified OrdosNorth China Basin was separated by the northeast-oriented Great Xing'an Range and Taihang Mountain uplifted linearment. The differential evolution of basins and sedimentary palaeogeography between eastern and western North China was initiated, and was interpreted to result in the closure of Okhotsk Ocean and the subduction of Palaeo-Pacific Plate(late stage 2). During the Late Jurassic(the early phase of stage 3), a variety of faulted basins occurred in the Yanshan and Yinshan areas in the northeastern North China. In Yanshan area, basins were filled with thickened intermediate volcanic rocks and purple-red coarse-grained clastic rocks. In contrast, only thick layered sedimentary rocks with rare volcanic rocks developed in the Yinshan faulted basins, the Ordos Basin and basins in sourthern North China. XMOB wasthe main provenance of the Early Mesozoic basins in the North China, while the Ordos Basin and the Hefei Basin were partly supplied by the northern Qinling Orogenic Belt. During the Late Jurassic-early Early Cretaceous(the late phase of stage 3), the northern and northeastern North China experienced extensional movement after the subduction of the Palaeo-Pacific Plate, the closure of the Mongolia-Okhotsk Ocean and the subsequent Yanshanian orogeny. At the same time, a NE-oriented, giant rift basin system(NE Asia Rift) extended from the Yanshan to the western Great Xing'an Range, where rift basins were filled with the regional, NE-oriented, thick coarse-grained clastic rocks and a belt of volcanic rocks. In the meantime, the eastern and northeastern China and most areas of NCC were presented as highland terrains. During the middle-late Early Cretaceous(stage 4), rift basins developed and accumulated alluvial sediments and interbedded alkaline volcanic rocks in the western and northern North China, including Yingen, Ejinaqi and Erlian regions. Basins were formed on both sides of the Tan-Lu Fault Zone under a striking-slipping force. Furthermore, faulted basins developed in the Yishu Fault Zone of Shandong(central Tan-Lu Fault Zone) as well, where dinosaur fauna flourished. Basic volcanic rocks and fluvial-lacustrine sediments were deposited in small- or medium-sized rift basins in the northeastern China. The Songliao Basin was a typical giant basin that was mainly filled with late Early Cretaceous lacustrine sediments. A group of rift basins occurred in the Sanjiang area, central Heilongjiang Province, northeastern China. From the middle-late Early Cretaceous to the Late Cretaceous(stage 5), depositional and subsiding center of the basins constantly shifted southeastwards in Heilongjiang Province. The tectonic setting changed into the Palaeo-Pacific continental margin in north and northeastern China. Besides, during the Late Mesozoic, a huge terrestrial biota, mainly dinosaur fauna, dominated in North China. The Yanliao biota of the Middle-Late Jurassic and the Jehol biota of the Early Cretaceous are characterized by feathered dinosaurs, primitive birds, mammals, pterosaur, insects and plants(angiosperms). In northeastern Asia, this Late Mesozoic tectonic background, palaeogeoraphy and palaeoecology were shared by East China, Korean Peninsula, Japan and the Far East of Russia. | Yong-Qing Liu Hong-Wei Kuang Nan Peng Huan Xu Peng Zhang Neng-Sheng Wang Wei An | 2015 | Journal of Palaeogeography2015，4，2： | 7 |
| 16 | Controlled synthesis of single-crystal SnSe nanoplates显示文摘二维的分层的 IVVI chalcogenides 在下一代的 optoelectronic 为应用正在吸引大兴趣,光电、热电的设备。然而,在高质量的 IVVI chalcogenide nanostructures 的可控制的合成的大挑战迄今为止妨碍了他们的深入的研究和实际应用。第一次,这里,我们由蒸汽运输免职在云母底层上以一种控制方式报导单个水晶的 IVVI SnSe nanoplates 的可行合成。成长得当的 SnSe nanoplates 有近似方形的形状,可控制的方面长度从 1 ~ 6 m 变化。电的运输和 optoelectronic 大小证明同样获得的 SnSe nanoplates 显示 p 类型电导率和高 photoresponsivity。 | Shuli Zhao Huan Wang Yu Zhou Lei Liao Ying Jiang Xiao Yang Guanchu Chen Min Lin Yong wang Hailin Peng Zhongfan Liu | 2015 | Nano Research2015，8，1： | 7 |
| 17 | Molecular and functional characterization of sulfiredoxin homologs from higher plants显示文摘由在氧化 peroxiredoxin 减少 cysteine-sulfinic 酸, sulfiredoxin (Srx ) 在酵母和人的房间在氧化压力抵抗起一个重要作用。这里,我们从更高的植物报导 Srx 相当或相同的事物的第一分子、功能的描述。生物信息的分析揭示了把序列编码为两张单音的简易窄床和 dicot 植物种类的潜在的 Srx 的存在。通常认为的植物 Srx 蛋白质从酵母和人展出了重要身份到他们的 orthologs,并且为催化作用包含了保存签名顺序和残余必需品。然而,植物 Srxs 不同于酵母和人的 orthologs,都被预言在他们的主要结构拥有叶绿体运输肽。从 Arabidopsis 和米饭的 Srx 蛋白质(指定了为 AtSrx 和 OsSrx,分别地) 在 SRX1 删除酵母房间的 Srx 的补充功能的缺乏。AtSrx 的 GFP 熔化蛋白质在 Arabidopsis 叶肉原物被指向到叶绿体。AtSrx 抄写在植物、繁殖的机关发生了,并且最高的抄本水平在叶子被检测。在氧化应力下面, AtSrx 抄本水平实质地被增加,哪个有在维持被发现必要的 2-Cys peroxiredoxins 的提高的抄写的 paralleled 叶绿体氧化还原作用平衡。除了氧化应力, osmotic/water 赤字或冷处理也提起了 AtSrx 抄本水平。与上面的调查结果一致, AtSrx 的猛烈异种是显著地,产生氧化的更多比野类型 Arabidopsis 强调植物。总起来说,这个工作的结果在是必要的让工厂应付氧化应力的更高的工厂显示功能的 Srx 相当或相同的事物的存在。 | Xian Peng Liu Xue Ying Liu Juan Zhang Zong Liang Xia Xin Liu Huan Ju Qin Dao Wen Wang | 2006 | Cell Research2006，16，3： | 7 |
| 18 | Effect of miniscalpel-needle on relieving the pain of myofascial pain syndrome: a systematic review显示文摘OBJECTIVE: To evaluate the effect and safety of miniscalpel-needle(MSN) on reducing the pain of myofascial pain syndrome(MPS).METHODS: We reviewed the available literatures inception up to February 2014 using Pubmed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure Database, Chinese Biomedical Database and Wanfang Database.RESULTS: Eight randomized controlled trials were finally identified. The main controls involved acupuncture, medications, injection, massage and cupping. We found that all of the studies agreed on the potential benefit of MSN as a strategy for MPS and the superiority compared to the controls, however,randomized methods applied in most of the trials could be criticized for their high or unclear risk of bias. Further research is also needed to clarify questions around the appropriate frequency and number of treatment sessions of MSN.CONCLUSION: This review shows that MSN might have the effect on MPS, even though there were some limitations in the studies included in the review. Studies with robust methodology are warranted to further test its pain-relieving effect on MPS. | Liu Tong Peng Yuanyuan Zhu Shipeng Chen Huan Li Fuyun Hong Peixin Cao Bingyan Peng Bo Fan Yifan Chen Yupei Zhang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 6 |
| 19 | Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway显示文摘Taxus,commonly known as yew,is a well-known gymnosperm with great ornamental and medicinal value.In this study,by assembling a chromosome-level genome of the Himalayan yew(Taxus wallichiana)with 10.9 Gb in 12 chromosomes,we revealed that tandem duplication acts as the driving force of gene family evolution in the yew genome,resulting in the main genes for paclitaxel biosynthesis,i.e.those encoding the taxadiene synthase,P450s,and transferases,being clustered on the same chromosome.The tandem duplication may also provide genetic resources for the nature to sculpt the core structure of taxoids at different positions and subsequently establish the complex pathway of paclitaxel by neofunctionalization.Furthermore,we confirmed that there are two genes in the cluster encoding isoenzymes of a known enzyme in the paclitaxel biosynthetic pathway.The reference genome of the Himalayan yew will serve as a platform for decoding the complete biosynthetic pathway of paclitaxel and understanding the chemodi-versity of taxoids in gymnosperms. | Jian Cheng Xiao Wang Xiaonan Liu Xiaoxi Zhu Zihe Li Huanyu Chu Qian Wang QianQian Lou Bijun Cai Yiqun Yang Xiaoyun Lu Kai Peng Dingyu Liu Yuwan Liu Lina Lu Huan Liu Ting Yang Qijin Ge Chengcheng Shi Guichun Liu Zhiwei Dong Xun Xu Wen Wang Huifeng Jiang Yanhe Ma | 2021 | Molecular Plant2021，14，7： | 6 |
| 20 | Thermodynamic modeling and phase diagram prediction of salt lake brine systemsⅡ.Aqueous Li^(+)-Na^(+)-K^(+)-SO_(4)^(2-) and its subsystems显示文摘It is still a challenging task to accurately and temperature-continuously express the thermodynamic properties and phase equilibrium behaviors of the salt-lake brine with multi-component,multitemperature and high concentration.The essential subsystem of sulfate type brine,aqueous Li^(+)-Na^(+)-K^(+)-SO_(4)^(2-) and its subsystems across a temperature range from 250 K to 643 K are investigated with the improved comprehensive thermodynamic model.Liquid parameters(Δg_(IJ),Δh_(IJ),and ΔC_(p,IJ))associated with the contributions of Gibbs energy,enthalpy,and heat capacity to the binary interaction parameters,i.e.the temperature coefficients of eNRTL parameters formulated with a Gibbs Helmholtz expression,are determined via multi-objective optimization method.The solid constantsΔ_(f)G_(k)°^((298.15))andΔ_(f)H_(k)°^((298.15))of11 solid species occurred in the quaternary system are rebuilt from multi-temperature solubilities.The modeling results show the accurate representation of(1)solution properties and binary phase diagram at temperature ranges from eutectic points to 643 K;(2)isothermal phase diagrams for Li_(2)SO_(4)-Na_(2)SO_(4)-H_(2)O,Li_(2)SO_(4)-K_(2)SO_(4)-H_(2)O and Na_(2)SO_(4)-K_(2)SO_(4)-H_(2)O ternary systems.The predicted results of complete structure and polythermal phase diagram of ternary systems and the isothermal phase diagrams of quaternary system excellently match with the experimental data. | Huan Zhou Peng Wu Wenxuan Li Xingfan Wang Kuo Zhou Qing Hao | 2021 | Chinese Journal of Chemical Engineering2021，34，6： | 6 |
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