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| 1 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 2 | Epidemiological characteristics of thyroid nodules and risk factors for malignant nodules: a retrospective study from 6 304 surgical cases显示文摘 | Huan Qin Wang Kun Lou Fuchen Zhang Li Huang Qingxian Han Yunfeng Sun Hancheng Zhu Lei Lin Peng Song Jun Liu Fuqiang Wang Qian Hou Weikai | 2014 | Chinese Medical Journal2014，，12： | 20 |
| 3 | Effects of residual organics in municipal wastewater on hydrogenotrophic denitrifying microbial communities显示文摘Hydrogenotrophic denitrification is promising for tertiary nitrogen removal from municipal wastewater. To reveal the influence of residual organics in municipal wastewater on hydrogenotrophic denitrifiers, we adopted high-throughput 16 S r RNA gene amplicon sequencing to examine microbial communities in hydrogenotrophic denitrification enrichments. Using effluent from a municipal wastewater treatment plant as water source, COD,nitrate and p H were controlled the same except for a gradient of biodegradable carbon(i.e., primary effluent(PE), secondary effluent(SE), or combined primary and secondary effluent(CE)). Inorganic synthetic water(IW) was used as a control. Hydrogenophaga, a major facultative autotroph, accounted for 17.1%, 5.3%, 32.7% and 12.9% of the sequences in PE, CE,SE and IW, respectively, implicating that Hydrogenophaga grew well with or without organics.Thauera, which contains likely obligate autotrophic denitrifiers, appeared to be the most dominant genera(23.6%) in IW and accounted for 2.5%, 4.6% and 8.9% in PE, CE and SE,respectively. Thermomonas, which is related to heterotrophic denitrification, accounted for 4.2% and 7.9% in PE and CE fed with a higher content of labile organics, respectively.In contrast, Thermomonas was not detected in IW and accounted for only 0.6% in SE. Our results suggest that Thermomonas are more competitive than Thauera in hydrogenotrophic denitrification with biodegradable organics. Moreover, facultative autotrophic denitrifiers,Hydrogenophaga, are accommodating to residual organic in effluent wastewater, thus we propose that hydrogenotrophic denitrification is amenable for tertiary nitrogen removal. | Wei Xing Jinlong Li Peng Li Chong Wang Yanan Cao Desheng Li Yunfeng Yang Jizhong Zhou Jiane Zuo | 2018 | Journal of Environmental Sciences2018，30，3： | 16 |
| 4 | Hierarchical Manganese Oxide/Carbon Nanocomposites for Supercapacitor Electrodes显示文摘有装载的层次毛孔结构和可控制的 MnO2 的 MnO2/carbon nanocomposites 用一个自我限制的生长方法被综合了。这被 KMnO4 的氧化还原作用反应与包含层次毛孔的牺牲的碳底层完成。唯一的毛孔结构允许 nanocomposites 的合成,悦耳的 MnO2 装载直到 83 wt.% 。nanocomposites 的特定的电容增加了, MnO2 装载;在另一方面,电气化学的阻抗光谱学测量的传导性与增加装载的 MnO2 减少了。装载的 MnO2 的优化与高特定的电容和优秀的率能力导致了 nanocomposites。这个工作提供将为应用的一个大变化便于高效的 supercapacitor 材料的设计和制造的重要基本理解。 | Yiting Peng Zheng Chen Jing Wen Qiangfeng Xiao Ding Weng Shiyu He Hongbin Geng Yunfeng Lu | 2011 | Nano Research2011，4，2： | 8 |
| 5 | The characteristics and sources of natural gases from Ordovician weathered crust reservoirs in the Central Gas Field in the Ordos Basin显示文摘The Central Gas Field is a famous large-sized gas field in the Ordos Basin of China. However, identification of main gas sources of the Ordovician reservoirs in this gas field remains puzzling. On the basis of a lot of geochemical data and geological research on natural gases, the characteristics and sources of natural gases from Ordovician weathered crust reservoirs in the Central Gas Field in the Ordos Basin were studied. The results indicated that natural gases from Ordovician weathered crust reservoirs in the Central Gas Field in the Ordos Basin have similar chemical and isotopic compositions to highly mature and over-mature dry gases. Both coal-derived gases and oil-type gases coexist in the Central Gas Field in the Ordos Basin. The former was derived mainly from Carboniferous-Permian coal measures and the latter from Lower Paleozoic marine carbonates. It is suggested that coal-derived gases occur in the eastern part of the Central Gas Field while oil-type gases may be produced mainly in the northern, western and southern parts of the Central Gas Field in the Ordos Basin. | LI Xianqing HU Guoyi LI Jian HOU Dujie DONG Peng SONG Zhihong YANG Yunfeng | 2008 | Chinese Journal Of Geochemistry2008，27，2： | 7 |
| 6 | An Elastic-plastic Adhesion Model for Contacting Fractal Rough Surface and Perfectly Wetted Plane with Meniscus显示文摘The strong stiction of adjacent surfaces with meniscus is a major design concern in the devices with a micro-sized interface.Today, more and more research works are devoted to understand the adhesion mechanism.This paper concerns the elastic-plastic adhesion of a fractal rough surface contacting with a perfectly wetted rigid plane.The topography of rough surface is modeled with a two-variable Weierstrass-Mandelbrot fractal function.The Laplace pressure is dealt with the Dugdale approximation.Then the adhesion model of the plastically deformed asperities with meniscus can be established with the fractal microcontact model.According to the plastic flow criterion, the elastic-plastic adhesion model of the contacting rough surfaces with meniscus can be solved by combining the Maugis-Dugdale(MD) model and its extension with the Morrow method.The necessity for considering the asperities' plastic deformation has been validated by comparing the simulation result of the presented model with that of the elastic adhesion model.The stiction mechanism of rough surfaces with meniscus is also discussed. | PENG Yunfeng GUO Yinbiao | 2009 | Chinese Journal of Mechanical Engineering2009，22，1： | 6 |
| 7 | Fluid inclusion evidence for petroleum accumulation in northern Qaidam Basin显示文摘Based on the results of fluid inclusion study(microscopic characteristics,homogenization temperatures and grains with oil inclusions),the pool-forming time of the Nanbaxian and Mabei 1 oilfields in northern Qaidam Basin was discussed in this paper.Fluid inclusions in northern Qaidam Basin are relatively abundant,including aqueous inclusions and hydrocarbon inclusions.These inclusions are small(5-10 μm),and mainly distributed in quartz fissures,overgrowths and cementations.The abundances of grains with oil inclusions(GOI) are commonly low.The GOI values of most samples are between 2.0%-10.5%,and those of about 40 percent of total samples exceed 5%.The homogenization temperatures of fluid inclusions in different samples are markedly dissimilar,indicating that these inclusions were formed in different periods.According to the measured homogenization temperatures of fluid inclusions and in combination with burial history and thermal evolution history,the Nanbaxian and Mabei 1 oilfields are deduced,which have experienced two hydrocarbon charging periods,with the former of N1-N21 and N22-N23,and the latter of N1 and N1 end-N2,respectively. | YANG Yunfeng LI Xianqing FENG Songbao WANG Kangdong KONG Longxi DONG Peng XU Feng PENG Dehua CHEN Yan | 2010 | Chinese Journal Of Geochemistry2010，29，4： | 5 |
| 8 | Power-efficient RWA in dynamic WDM optical networks considering different connection holding times显示文摘The challenges imposed by environmental issues,such as global warming and the energy crisis,are demanding more responsible energy usage,including in the optical networking field.In optical transmission networks,most of the electrical power is consumed by the optical-electrical-optical conversion in optical repeaters.Modern optical network control plane technologies allow idle optical repeaters to be put into a low-power sleep mode.Inspired by this,we propose a novel power-efficient routing and wavelength assignment(RWA) algorithm,called HTAPE.The HTAPE algorithm exploits the knowledge of the connection holding times to minimize the number of optical repeaters in the active mode,and hence reduce the total electricity consumption of the optical network.We test the new algorithm on the typical CERNET and USNET networks.Compared with traditional RWA algorithms without holding-time-awareness,it is observed that the HTAPE algorithm yields significant reductions in power consumption. | DU Shu ZHANG ShengFeng PENG YunFeng LONG KePing | 2013 | Science China(Information Sciences)2013，56，4： | 4 |
| 9 | Integration of nanoscale light emitters:an efficient ultraviolet and blue random lasing from NaYF_4:Yb/Tm hexagonal nanocrystals显示文摘Near infrared light-controlled release of payloads from ultraviolet-sensitive(UV-sensitive) polymer hydrogels or nanocarriers is one of the most promising strategies for biotherapy. Here, we propose the concept of light activation of NaYF_4:20%Yb, 2%Tm nanocrystals(NCs). NaYF_4:20%Yb, 2%Tm NCs are synthesized by a solvothermal method. Effective upconversion luminescence from NaYF_4:20%Yb, 2%Tm NCs excited by a continuous wave(CW) 980 nm laser is obtained. The NaYF_4:20%Yb, 2%Tm NCs are then used as a laser gain medium and sandwiched between Al and quartz reflectors to form laser microcavities. UV and blue upconverted random lasing is obtained from the laser microcavities. Hence, we verify explicitly that the NaYF_4:Yb, Tm NCs support UV and blue upconversion random lasing via a 980 nm nanosecond laser excitation. Our work provides what we believe is a new concept for precision and localized cancer therapy by external light excitation. | YA-PEI PENG WEI LU PENGPENG REN YIQUN NI YUNFENG WANG LONG ZHANG YU-JIA ZENG WENFEI ZHANG SHUANGCHEN RUAN | 2018 | Photonics Research2018，6，10： | 4 |
| 10 | Tetrahedral Framework Nucleic Acid-Based Delivery of Resveratrol Alleviates Insulin Resistance:From Innate to Adaptive Immunity显示文摘Obesity-induced insulin resistance is the hallmark of metabolic syndrome,and chronic,low-grade tissue inflammation links obesity to insulin resistance through the activation of tissue-infiltrating immune cells.Current therapeutic approaches lack efficacy and immunomodulatory capacity.Thus,a new therapeutic approach is needed to prevent chronic inflammation and alleviate insulin resistance.Here,we synthesized a tetrahedral framework nucleic acid(tFNA)nanoparticle that carried resveratrol(RSV)to inhibit tissue inflammation and improve insulin sensitivity in obese mice.The prepared nanoparticles,namely tFNAs-RSV,possessed the characteristics of simple synthesis,stable properties,good water solubility,and superior biocompatibility.The tFNA-based delivery ameliorated the lability of RSV and enhanced its therapeutic efficacy.In high-fat diet(HFD)-fed mice,the administration of tFNAs-RSV ameliorated insulin resistance by alleviating inflammation status.tFNAs-RSV could reverse M1 phenotype macrophages in tissues to M2 phenotype macrophages.As for adaptive immunity,the prepared nanoparticles could repress the activation of Th1 and Th17 and promote Th2 and Treg,leading to the alleviation of insulin resistance.Furthermore,this study is the first to demonstrate that tFNAs,a nucleic acid material,possess immunomodulatory capacity.Collectively,our findings demonstrate that tFNAs-RSV alleviate insulin resistance and ameliorate inflammation in HFD mice,suggesting that nucleic acid materials or nucleic acid-based delivery systems may be a potential agent for the treatment of insulin resistance and obesity-related metabolic diseases. | Yanjing Li Shaojingya Gao Sirong Shi Dexuan Xiao Shuanglin Peng Yang Gao Ying Zhu Yunfeng Lin | 2021 | Nano-Micro Letters2021，13，6： | 4 |
| 11 | Gene expression of vascular endothelial growth factor A and hypoxic adaptation in Tibetan pig显示文摘Background: Vascular endothelial growth factor A(VEGFA) can induce endothelial cell proliferation, promote cell migration, and inhibit apoptosis. These processes play key roles in physiological blood vessel formation and pathological angiogenesis.Methods: In this study, we examined VEGFA gene expression in the heart, liver, and kidney of Tibetan pigs(TP), Yorkshire pigs that migrated to high altitudes(YH), and Yorkshire pigs that lived at low altitudes(YL).We used PCR and Sanger sequencing to screen for single nucleotide polymorphisms(SNPs) in 5'-flanking DNA and exons of the VEGFA gene. Quantitative real-time PCR and western blots were used to measure expression levels and PCR products were sequenced.Results: Results showed that the VEGFA m RNA and protein expression in heart, liver and kidney of TP was higher than that in YH and YL. In addition, the m RNA sequence of the pig VEGFA gene was conserved among pig breeds, and only five SNPs were found in the 5'-flanking region of the VEGFA gene, the allele frequency distributions of the 5 SNPs were not significantly different between the TP, Yorkshire(YL), and Diannan small-ear(DN) pig populations.Conclusion: In conclusion, the Tibetan pig showed high levels of VEGFA gene expression in several hypoxic tissues, which suggests that the VEGFA gene may play a major functional role in hypoxic adaptation. | Bo Zhang Yangzong Qiangba Peng Shang Yunfeng Lu Yuzeng Yang Zhixiu Wang Hao Zhang | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 4 |
| 12 | Study on the AVO forward modeling of coal bearing strata显示文摘Based on the AVO theoretical modeling of the coalbed, this paper analyzes the AVO characteristics and influencing factors of the coalbed P-P reflection wave. On the top interface of the coalbed, the P-P reflection wave absolute value of reflective coefficient decreases when the incidence angle increases between 0 and 60 degrees, and then increases gradually. On the bottom interface of the coalbed, the total reflection occurs rather strikingly because the incident wave propagates from low impendence media to high one. And for the soft and fractured coal in particular, such a phenomenon takes place even at an incidence angle less than 15 degrees. So the reflection characteristics of the coalbed bottom interface are not conducive to AVO analysis. AVO response is closely relative to the coal structure, and AVO intercept and gradient of top interface of the coalbed reflection wave increases when the coal structure is destroyed severely. For coalbeds of the same coal structure, AVO intercept and gradient of the coalbed top interface with the sandstone roof is greater than that with the mudstone one. The tuning of coal-bed thickness has adverse influence on coalbed AVO attributes analysis obviously. Those AVO characteristics of coalbed are shown further by modeling from Well 9-10-15 and Well 10-E-3 in Huainan coalfield, China. | Suping Peng Yunfeng Gao | 2005 | Chinese Science Bulletin2005，50，S1： | 4 |
| 13 | Experimentai Research on Saturated-Gain for Soft X-Ray Laser from Neon-Like Germanium Plasma显示文摘AmpliHcation of spontaneous emissions at 19.6,23.2 and 23.6 nm have been observed by a “ultiple-Target Series Coupling”design in Ge plasma,.The combined length for four targets is up to 56mm.The gain length product(GL)of small signal is up to 18 for both lines at 23.2 and 23.6 nmt and the effective GL is 16.4 and 15.7 for these two lines respectively.This two lines are obviously tending to saturation.The divergence of x-ray laser beam is about 4 mrad. | WANG Shiji GU Yuan ZHOU GuanUn NI Yuanlong YU Songyu FU Sizu MAO Chusheng TAO Zucong CHEN Wannian LIN Zunqi FAN Dianyuan ZHANG Guoping SHENG Jiatian YANG Minglun ZHANG Tanxin SHAO Yunfeng PENG Huimin HE Xiantu YU Min | 1991 | Chinese Physics Letters1991，8，12： | 3 |
| 14 | Parallel lightpath provisioning under wavelength continuity constraint in multi-domain optical networks based on hierarchical path computation element显示文摘Inter-domain path provision under a wavelength continuity constraint(WCC),including path computation and resource reservation procedures,is a major challenge in multi-domain wavelength division multiplexing(WDM) optical networks,because of the requirement for confidentiality between the domains.Based on the hierarchical path computation element(PCE) architecture,this work proposed a path establishment scheme under a WCC to provide a fast inter-domain path establishment solution and decrease the influence of the WCC.The hierarchical PCE architecture consists of a single parent PCE serving as the arbitrator and multiple child PCEs responsible for the child domains.By cooperation between the parent PCE and the child PCEs,both inter-domain path computation and inter-domain wavelength reservation can be processed in parallel to accelerate and optimize WCC lightpath provisioning and thus to reduce the blocking probability.The effectiveness of this solution has been evaluated through simulations.The simulation results show that the proposed solution can achieve lower computation and reservation delays and thus lead to lower blocking probabilities on the multi-domain WCC paths. | SUN Jian WANG ZongWei CHEN Zhen PENG YunFeng | 2013 | Science China(Information Sciences)2013，56，3： | 2 |
| 15 | Performance Analysis of Intelligent CR-NOMA Model for Industrial IoT Communications显示文摘Aiming for ultra-reliable low-latency wireless communications required in industrial internet of things(IIoT)applications,this paper studies a simple cognitive radio non-orthogonal multiple access(CR-NOMA)downlink system.This system consists of two secondary users(SUs)dynamically interfered by the primary user(PU),and its performance is characterized by the outage probability of the SU communications.This outage probability is calculated under two conditions where,a)the transmission of PU starts after the channel state information(CSI)is acquired,so the base station(BS)is oblivious of the interference,and b)when the BS is aware of the PU interference,and the NOMA transmission is adapted to the more comprehensive knowledge of the signal to interference plus noise ratio(SINR).These results are verified by simulations,and their good agreement suggests our calculations can be used to reduce the complexity of future analysis.We find the outage probability is reduced when the SUs move further away from the primary transmitter or when the signal from PU is less powerful,and the BS always has better performance when it is aware of the interference.The findings thus emphasize the importance of monitoring the channel quality and realtime feedback to optimize the performance of CR-NOMA system. | Yinghua Zhang Jian Liu Yunfeng Peng Yanfang Dong Changming Zhao | 2020 | Computer Modeling in Engineering & Sciences2020，，10： | 2 |
| 16 | Kinetic Parameters of Methane Generated from Source Rocks in the Kuqa Depression of Tarim Basin and Their Application显示文摘摘要:在金试管的一个热模拟实验靠近系统,用 KINETICS 和 GOR 同位素动力学软件,煤气的产生的运动参数和从 TriassicJurassic 烃来源的同位素的分别在 Tarim 盆的 Kuqa 消沉摇的甲烷碳计算被获得。分别地,在 Kuqa 消沉从侏罗记煤,侏罗记 mudstone 和三叠纪的 mudstone 产生的甲烷的激活精力是 197268 kJ/mol, 180260 kJ/mol 和 214289 kJ/mol,他们的频率因素是 5.265times1013s ? 1, 9.761times1011s ? 1 并且 2.270times1014s ? 1。这反映他们烃产生行为的差别。甲烷碳的运动参数同位素的分别在侏罗记煤,侏罗记 mudstone 和三叠纪的 mudstone 也是不同的,谁的平均激活精力,分别地是 228 kJ/mol, 205 kJ/mol 和 231 kJ/mol。与地质的背景结合了,在 Yinan-2 煤气的水池的天然气的起源被讨论,并且天然气的一个累积模型因此被建立。Yinan-2 气体首先在 Yangxia 从侏罗记忍受煤的来源岩石被导出下垂。主要煤气的累积时间是 50 妈,相应 Ro 在从 1.25%1.95% 的范围。天然气的损失率是 25%30% 。 | LI Xianqing XIAO Xianming MI Jingkui TANG Yongchun XIAO Zhongyao LIU Dehan SHEN Jiagui YANG Yunfeng WANG Yan DONG Peng | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 2 |
| 17 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hnnqucofp0u5x6wnf.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 18 | ELASTIC-PLASTIC ADHESION MODEL FOR SINGLE ASPERICAL ASPERITY MICROCONTACT显示文摘The adhesion of single asperity contacting with a rigid flat is investigated. The microcontact model of the deformable asperity is established utilizing fractal geometry, which makes the resulted adhesion model to relate with the surface characteristics that the asperity belongs to. The Dugdale approximation is utilized to consider the adhesive interaction within and outside the contact area. Then the model for solving the elastic-plastic adhesion of single asperity is presented by combing the Maugis-Dugdale(MD) model. To illustrate the necessity of considerin8 the plastic deformation in microcontact, simulations of the relationship between the adhesive contact load and the interference of the asperity are performed. The result shows that the presented model is more suitable for the solution of the elastic-plastic mierocontact of spherical asperity due to intermolecular adhesive interactions. | PENG Yunfeng GUO Yinbiao | 2008 | Chinese Journal of Mechanical Engineering2008，21，4： | 2 |
| 19 | Advances in Antimicrobial Peptides and Expression Strategy显示文摘Antimicrobial peptides are widely distributed in nature,existing in organisms of plants,insects,and vertebrates.It has been approved that antimicrobial peptides have broad spectrum antimicrobial activities,and play a key modulatory role in the innate immune response and tumor inhibiting activity.Due to the special action mechanism,the antimicrobial peptides become a hot field of genetic engineering.In the present paper,the general properties,mechanism of action,application value,existing problems,the latest progress and the expression strategy were discussed. | SUN Yan WANG Yunfeng CHEN Hongyan SHI Xingming WANG Mei HUANG Tingting SUN Peng YANG Guihua | 2011 | Journal of Northeast Agricultural University(English Edition)2011，18，1： | 2 |
| 20 | LINC00891 regulated by miR-128-3p/GATA2 axis impedes lung cancer cell proliferation,invasion and EMT by inhibiting RhoA pathway显示文摘Long non-coding RNA(lncRNA)LINC00891 knockdown is associated with poor prognosis of lung adenocarcinoma,but the underlying mechanism remains to be further explored.Here,we found that LINC00891 expression is downregulated in lung cancer tissues and cell lines compared with that in adjacent normal tissues and normal lung epithelial cells.LINC00891 overexpression impedes cell proliferation,invasion,migration and epithelial-to-me-senchymal transition(EMT)process in lung cancer cells.Mechanistic research showed that GATA2 directly binds to LINC00891 promoter and transcriptionally regulates LINC00891 expression.Meanwhile,GATA2 was identified as a target of miR-128-3p,and it is negatively regulated by miR-128-3p.Moreover,overexpression of GATA2 suppresses lung cancer cell proliferation,invasion,migration,and EMT process.Furthermore,LINC00891 restrains the RhoA pathway activity,and treatment with CCG-1423(a specific RhoA pathway inhibitor)antagonizes the promoting effect of LINC00891 knockdown on cell malignant behaviors.Additionally,silencing of LINC00891 promotes xenograft tumor growth,which can be reversed by administration with CCG-1423.In summary,LINC00891 regulated by the miR-128-3p/GATA2 axis restrains lung cancer cell malignant progression and hinders xenograft tumor growth by suppressing the RhoA pathway. | Yunfeng Zhang Dingli Song Ziyang Peng Rui Wang Kai Li Hong Ren Xin Sun Ning Du Shou-Ching Tang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，3： | 2 |
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