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| 1 | Palaeogeomorphology and its control on the development of sequence stratigraphy and depositional systems of the Early Silurian in the Tarim Basin显示文摘The Silurian in the Tarim Basin was deposited on the basement deformed by the Caledonian tectonic movements at the end of the Late Ordovician. The development and distribution of sedimentary sequences of the Early Silurian have been clearly controlled by the palaeogeomorphology of the Late Ordovician. Based on unconformity characteristics and distribution of erosion, several zones can be differentiated including a high uplifted erosion zone, a transitional slope zone and a depression zone. The central and west Tabei Uplift zones show high angular unconformity and intense erosion. The Tarim Basin in the late Ordovician shows characteristics of higher in the west, lower in the east while higher in the south, lower in the north. The Early Silurian mainly developed transgressive and highstand systems tracts on the whole, while the lowstand systems tract only developed partly below the slope break. The palaeogeomorphology controlled the clastic source supply and deposit distribution. Braided delta system and tidal flat–estuary system were deposited. The duration of uplifting of the Tazhong paleouplift was longer than that of the Tabei paleo-uplift, and deposition was later. This led to the lower and middle members of the Kepingtage Formation missing in that area. As a large-scale transgression occurred during the deposition period of the upper member of the Kepingtage Formation, sediment from the west of the basin was transported and deposited by tides and waves, forming tidal–marine debris systems above the uplift. Proximal alluvial fan and fan delta coarse clastic deposits developed in proximal uplift zone in the east and southeast of the basin, and braided delta put forward to the transitional zone between the edge of uplift and the sea. Large-scale tidal channel, sub-distributary channel and mouth bar of the delta front can form favorable reservoirs, and they are primary targets for oil and gas exploration. This research on sequence–depositional systems development and distribution controlled by palaeogeomorphology is significant in guiding the prediction of reservoir sandstones. | Liu Jingyan Lin Changsong Cai Zhenzhong Zhu Yongfeng Yang Yongheng Peng Li Si Baoling Huang Zhen Li Huanpu Xu Yingcai Su Zhenzhen | 2010 | Petroleum Science2010，7，3： | 13 |
| 2 | Influence of alloying elements on hot tearing susceptibility of Mg-Zn alloys based on thermodynamic calculation and experimental显示文摘Based on the hot tearing index|△T/△(fs)^(0.5)|recently proposed by Kou and the thermodynamic calculations of Pandat software,Al,Cu,and Mn elements were picked up and their influence on hot tearing susceptibility of Mg-x Zn(x=6,8,10,wt%)alloys was studied by experiments.The results indicate that Al addition can significantly reduce the hot tearing susceptibility of Mg-Zn alloys.Either 0.5Cu or 0.3Mn addition individually can reduce the HTS of the Mg-6Zn-(1,4)Al alloys,while adding together increases the susceptibility.The addition of 0.5Cu and 0.3Mn both individually and together increases the HTS of Mg-8/10Zn-1Al alloys.Based on the experimental and calculation results,the index can be modified to|△T/△(fs)^(0.5)|(d)^(2)for more accurate prediction on the hot tearing resistance of Mg-Zn based alloys.Grain refinement significantly improves the hot tearing resistance of Mg-Zn based alloys. | Zhenzhen Yang Ke Wang Penghuai Fu Liming Peng Bin Hu Ming Liu Anil K.Sachdev | 2018 | Journal of Magnesium and Alloys2018，6，1： | 6 |
| 3 | Introduction of a multicenter online database for non-metastatic breast cancer in China显示文摘Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016). | Yaping Yang Jieqiong Liu Min Peng Fengxi Su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen Su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song | 2020 | Science China(Life Sciences)2020，63，9： | 4 |
| 4 | Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p 15^INK4B, p 16^INK4A, and p57^KIP2 transcription显示文摘 | Qingping Zheng Hongjia Fan Zhenzhen Meng Lin Yuan Cuicui Liu You Peng Weiwei Zhao Lulu Wang Jing Li Jing Feng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 5 | A core-shell structured COYID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity显示文摘Although inoculation of COVID-19 vaccines has rolled out globally,there is still a critical need for safe and effective vaccines to ensure fair and equitable supply for all countries.Here,we report on the development of a highly efficacious mRNA vaccine,SW0123 that is composed of sequence-modified mRNA encoding the full-length SARS-CoV-2 Spike protein packaged in core-shell structured lipopolyplex(LPP)nanoparticles.SWOT 23 is easy to produce using a large-scale microfluidics-based apparatus.The unique core-shell structured nanoparticle facilitates vaccine uptake and demonstrates a high colloidal stability,and a desirable biodistribution pattern with low liver targeting effect upon intramuscular administration.Extensive evaluations in mice and nonhuman primates revealed strong immunogenicity of SW0123,represented by induction of Th1-polarized T cell responses and high levels of antibodies that were capable of neutralizing not only the wild-type SARS-CoV-2,but also a panel of variants including D614G and N501Y variants.In addition,SW0123 conferred effective protection in both mice and non-human primates upon SARS-CoV-2 challenge.Taken together,SW0123 is a promising vaccine candidate that holds prospects for further evaluation in humans. | Ren Yang Yao Deng Baoying Huang Lei Huang Ang Lin Yuhua Li Wenling Wang Jingjing Liu Shuaiyao Lu Zhenzhen Zhan Yufei Wang Ruhan A Wen Wang Peihua Niu Li Zhao Shiqiang Li Xiaopin Ma Luyao Zhang Yujian Zhang Weiguo Yao Xingjie Liang Jincun Zhao Zhongmin Liu Xiaozhong Peng Hangwen Li Wenjie Tan | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 3 |
| 6 | Differentiation of Induced Pluripotent Stem Cells into Male Germ Cells In Vitro through Embryoid Body Formation and Retinoic Acid or Testosterone Induction显示文摘 | Peng Li Hongliang Hu Shi Yang Ruhui Tian Zhenzhen Zhang Wei Zhang Meng Ma Yong Zhu Xizhi Guo Yiran Huang Zuping He Zheng Li Xuan Jin | 2012 | BioMed Research International2012，，： | 2 |
| 7 | The complete mitochondrial genome of the Epinephelus tukula(Perciformes,Serranidae)显示文摘 | YUQING YANG ZHENZHEN XIE CHENG PENG | 2016 | Mitochondrial DNA Part A2016，27，1： | 1 |
| 8 | Development of the zebrafish mesonephros显示文摘 | Cuong Q. Diep Zhenzhen Peng Tobechukwu K. Ukah Paul M. Kelly Renee V. Daigle Alan J. Davidson | 2015 | genesis . 2015 (3-4)2015，，3： | 1 |
| 9 | Genome sequence of Gossypium anomalum facilitates interspecific introgression breeding显示文摘Crop wild relatives are an important reservoir of natural biodiversity. However, incorporating wild geneticdiversity into breeding programs is often hampered by reproductive barriers and a lack of accurate genomicinformation. We assembled a high-quality, accurately centromere-anchored genome of Gossypium anomalum, a stress-tolerant wild cotton species. We provided a strategy to discover and transfer agronomicallyvaluable genes from wild diploid species to tetraploid cotton cultivars. With a (Gossypium hirsutum 3 G.anomalum)2 hexaploid as a bridge parent, we developed a set of 74 diploid chromosome segment substitution lines (CSSLs) of the wild cotton species G. anomalum in the G. hirsutum background. This set of CSSLsincluded 70 homozygous substitutions and four heterozygous substitutions, and it collectively containedabout 72.22% of the G. anomalum genome. Twenty-four quantitative trait loci associated with plant height,yield, and fiber qualities were detected on 15 substitution segments. Integrating the reference genome withagronomic trait evaluation of the CSSLs enabled location and cloning of two G. anomalum genes thatencode peroxiredoxin and putative callose synthase 8, respectively, conferring drought tolerance andimproving fiber strength. We have demonstrated the power of a high-quality wild-species reference genomefor identifying agronomically valuable alleles to facilitate interspecific introgression breeding in crops. | Zhenzhen Xu Jiedan Chen Shan Meng Peng Xu Caijiao Zhai Fang Huang Qi Guo Liang Zhao Yonggang Quan Yixin Shangguan Zhuang Meng Tian Wen Ya Zhang Xianggui Zhang Jun Zhao Jianwen Xu Jianguang Liu Jin Gao Wanchao Ni Xianglong Chen Wei Ji Nanyi Wang Xiaoxi Lu Shihong Wang Kai Wang Tianzhen Zhang Xinlian Shen | 2022 | Plant Communications2022，3，5： | 1 |
| 10 | Linear polyketides produced by co-culture of Penicillium crustosum and Penicillium fellutanum显示文摘Two new polyketides, penifellutins A (1) and B (2), possessing a 22 carbon linear skeleton, were isolated from a co-culture of the deep-sea-derived fungi Penicillium crustosum PRB-2 and Penicillium fellutanum HDN14-323. Meanwhile, two esterification products of 1, penifellutins C (3) and D (4), were obtained because compound 1 could be esterified spontaneously when stored in methanol. Their configurations were difficult to determine because of chiral central crowdedness, structural flexibility and instability. As such, we solved this issue by comprehensively using Mo2(OAc)4-based CD experiments, density functional theory calculation of 13C NMR, DP4 + probability analysis and many chemical reactions, including making acetonide derivative, Mosher’s method, PGME method, etc. Compounds 1 and 2 show obvious inhibitory activity on the liver hyperplasia of zebrafish larvae at a concentration of 10 μmol/L, while 3 and 4 show no activity, indicating that two carboxyls in the structure are important active sites. | Guihong Yu Peng Sun Reyilamu Aierken Chunxiao Sun Zhenzhen Zhang Qian Che Guojian Zhang Tianjiao Zhu Qianqun Gu Mingyu Li Dehai Li | 2022 | Marine Life Science & Technology2022，4，2： | 1 |
| 11 | Solidification Microstructure and Mechanical Properties of Cast Magnesium-Aluminum-Tin Alloys显示文摘 | Alan A. Luo Penghuai Fu Liming Peng Xiaoyu Kang Zhenzhen Li Tianyu Zhu | 2012 | Metallurgical and Materials Transactions A2012，，1： | 1 |
| 12 | Differentiation of Induced Pluripotent Stem Cells into Male Germ Cells In Vitro through Embryoid Body Formation and Retinoic Acid or Testosterone Induction显示文摘 | Peng Li Hongliang Hu Shi Yang Ruhui Tian Zhenzhen Zhang Wei Zhang Meng Ma Yong Zhu Xizhi Guo Yiran Huang Zuping He Zheng Li Xuan Jin | 2012 | BioMed Research International2012，，： | 1 |
| 13 | RNF126 Quenches RNF168 Function in the DNA Damage Response显示文摘DNA damage response(DDR) is essential for maintaining genome stability and protecting cells from tumorigenesis. Ubiquitin and ubiquitin-like modi?cations play an important role in DDR, from signaling DNA damage to mediating DNA repair. In this report, we found that the E3 ligase ring ?nger protein 126(RNF126) was recruited to UV laser micro-irradiation-induced stripes in a RNF8-dependent manner. RNF126 directly interacted with and ubiquitinated another E3 ligase, RNF168. Overexpression of wild type RNF126, but not catalytically-inactive mutant RNF126(CC229/232 AA), diminished ubiquitination of H2 A histone family member X(H2AX),and subsequent bleomycin-induced focus formation of total ubiquitin FK2, TP53-binding protein1(53 BP1), and receptor-associated protein 80(RAP80). Interestingly, both RNF126 overexpression and RNF126 downregulation compromised homologous recombination(HR)-mediated repair of DNA double-strand breaks(DSBs). Taken together, our ?ndings demonstrate that RNF126 negatively regulates RNF168 function in DDR and its appropriate cellular expression levels are essential for HR-mediated DSB repair. | Lianzhong Zhang Zhenzhen Wang Ruifeng Shi Xuefei Zhu Jiahui Zhou Bin Peng Xingzhi Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，6： | 1 |
| 14 | Real-time evolution of up-conversion nanocrystals from tailored metastable intermediates显示文摘In-situ observation of the growth and decomposition processes is significantly important for guiding the fabrication of upconversion nanocrystals(UCNCs)with high performance.However,the high crystallization energy and rapid nucleation rate of the corresponding crystals make real-time observation still a huge challenge.Herein,the in-situ nucleation-growth-degradation processes of the UCNCs are investigated by employing tailored metastable intermediates,which possess a slowing-down nucleation rate under electron beam irradiation.The non-classical nucleation processes of the UCNCs,containing the coalescence of clusters and the subsequent crystallization,are demonstrated.Moreover,the Ostwald ripening and oriented attachment processes,which determine the particle size and morphology,are unambiguously recorded.Furthermore,the degrading process of the UCNCs is observed to be triggered by surface defects.Our work provides an insight into the real-time evolution dynamics of the UCNCs,which further sheds light on the fabrication of nano-sized up-conversion phosphors. | Peng Zhang Xue Yu Ping Xia Zhenzhen Cui Jianhong Yi Caiju Li Peng Song Feng Zhao Ting Wang Jianbei Qiu Xuhui Xu | 2023 | Nano Research2023，16，1： | 0 |
| 15 | Carbon nanotube-based photothermal membrane for efficient cold air heating and removal of particulate matter and airborne bacteria显示文摘Indoor heating results in high energy consumption and severe atmospheric pollution.Although the development of solar air heaters provides a sustainable route for indoor thermal comfort,such heaters still face challenges in terms of adequate heat exchange and filtering of atmospheric pollutants.Inspired by solar-driven interfacial evaporation,we propose a multifunctional carbon nanotube-based photothermal membrane for efficient cold air heating and purification via ventilation.Carbon nanotubes endow the membrane with high light absorption and thermal conversion capabilities,thereby sufficiently heating the approaching cold air.With the hierarchical structure formed by phase inversion,the thin upper skin of the composite membrane intercepts micropollutants via the size-sieving effect,whereas the finger-like pores and interpenetrating macrovoids inside the membrane ensure that the heated clear air passes through quickly.A proof-of-principle experiment indicated a cold airflow of 1 L/min across the membrane,yielding a temperature increase of ca.37°C as well as a PM 2.5 rejection always higher than 93%.Further antibacterial experiments demonstrated that the membrane effectively removed airborne bacteria.This multifunctional carbon nanotube-based photothermal membrane with specific microstructures not only improves the indoor living quality but also provides a sustainable development scheme to coordinate the relationship among energy utilization,building heating,and air purification. | Weichao Dong Lina Huang Xiangju Song Yan Zhang Mengke Liu Zhenzhen Ren Long Pang Hui Peng Heqing Jiang | 2024 | Green Carbon2024，2，1： | 0 |
| 16 | Analytical Models of Passive Linear Structures in Printed Circuit Boards显示文摘Analytical models for passive linear structures,like metallic traces,vias,are proposed for simulations at the package and Printed circuit board(PCB)levels.In the proposed method,traces are modeled based on the transmission line theory,whereas the vias are described by the parallel-plate impedance and several equivalent circuits elements.The proposed models can be applied to efficiently simulate composed passive linear structures.Several scenarios are analyzed including traces with two or three width,traces routed into different layers and interconnects commonly used in PCBs.The results of the models are compared with those from the fullwave simulations and experiments.An improvement on the computation speed has been observed with respect to the full-wave simulations at the effective range of models.In our measurements,a compensation approach of impedance mismatch in parameter measurements is analyzed and calculated,which could significantly simplify the experimental process. | PENG Zhenzhen SU Donglin | 2021 | Chinese Journal of Electronics2021，30，2： | 0 |
| 17 | Outcomes of allograft from donor kidney microthrombi and secondary recipient thrombotic microangiopathy: should we consider loosening the belt?显示文摘There is currently a huge worldwide demand for donor kidneys for organ transplantation.Consequently,numerous marginal donor kidneys,such as kidneys with microthrombi,are used to save patients'lives.While some studies have shown an association between the presence of microthrombi in donor kidneys and an increased risk for delayed graft function(DGF)(McCall et al.,2003;Gao et al.,2019),other studies have demonstrated that microthrombi negatively impact the rate of DGF(Batra et al.,2016;Hansen et al.,2018),but not graft survival rate(McCall et al.,2003;Batra et al.,2016;Gao et al.,2019).In contrast,Hansen et al.(2018)concluded that fibrin thrombi were not only associated with reduced graft function six months posttransplantation but also with increased graft loss within the first year of transplantation.On the other hand,Batra et al.(2016)found no significant differences in the DGF rate or one-year graft function between recipients in diffuse and focal microthrombi groups.To date,however,the overall influence of donor kidney microthrombi and the degree of influence on prognosis remain controversial,necessitating further research. | Yamei CHENG Luying GUO Xue REN Zhenzhen YANG Junhao LV Huiping WANG Wenhan PENG Hongfeng HUANG Jianyong WU Jianghua CHEN Rending WANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，6： | 0 |
| 18 | Bionic immunoactivator copresenting autophagy promoting and costimulatory molecules for synergistic cancer immunotherapy显示文摘Immunotherapy has great promise in improving malignant tumor treatment.However,the efficacy of existing strategies is often limited by the immunosuppressive environment.Here,we demonstrate an in situ bionic immunoactivator,PLT-Bec1/DTA-1,with possessed natural advantages of platelets for tumor recruitment and activation,on which DTA-1(CD357 monoclonal antibody)and Bec1 were tethered as combined immune boosters.PLT-Bec1/DTA-1,as a self-triggered release repository,can deliver the pre-tethered Bec1 and DTA-1 deeply through the secretion of platelet microparticles(PMPs),thereby cooperate tacitly and exhibit superiority in immune activation of dendritic cells(DCs)and T cells via autophagy inducibility,coupled with glucocorticoid-induced tumor necrosis factor receptor(GITR)-triggered T_(Reg) suppression,remodeled the immunosuppressive network of tumor microenvironment.PLT-Bec1/DTA-1 promoted antigen presentation and T cell proliferation,and alleviated the low activity state of bone marrow-derived dendritic cells(BMDCs)in tumor suppressive environment.PLT-Bec1/DTA-1 inhibited tumor recurrence(5-and 13-fold lower of control group in tumor volume)and CD8^(+)T/T_(Reg) ratio(6.3-and 8.8-fold vs.control group)in mouse tumor model after intravenous or subcutaneous administration.Also,PLT-Bec1/DTA-1 prevented tumor colonization in lung through in situ immune activation,and was slightly superior to the combined of Bec1 and PD-L1.Our findings highlight the promise of delivering immunostimulatory payloads via bionic carriers,eliciting automatic in situ activation of effector immune cells in tumor microenvironment for tumor eradication.All these results provide promising prospects into the application of immunoactivator in improving cancer synergistic immunotherapy to overcome the bottlenecks in clinic. | Yiwei Peng Yiliang Yang Zhenzhen Yang Datong Gao Jiajia Li Qi Sun Yitian Du Meng Lin Xianrong Qi | 2024 | Nano Research2024，17，3： | 0 |
| 19 | The first chromosome-level Fallopia multiflora genome assembly provides insights into stilbene biosynthesis显示文摘Fallopia multiflora(Thunb.)Harald,a vine belonging to the Polygonaceae family,is used in traditional medicine.The stilbenes contained in it have significant pharmacological activities in anti-oxidation and anti-aging.This study describes the assembly of the F.multiflora genome and presents its chromosome-level genome sequence containing 1.46 gigabases of data(with a contig N50 of 1.97 megabases),1.44 gigabases of which was assigned to 11 pseudochromosomes.Comparative genomics confirmed that F.multiflora shared a whole-genome duplication event with Tartary buckwheat and then underwent different transposon evolution after separation.Combining genomics,transcriptomics,and metabolomics data to map a network of associated genes and metabolites,we identified two FmRS genes responsible for the catalysis of one molecule of p-coumaroyl-CoA and three molecules of malonyl-CoA to resveratrol in F.multiflora.These findings not only serve as the basis for revealing the stilbene biosynthetic pathway but will also contribute to the development of tools for increasing the production of bioactive stilbenes through molecular breeding in plants or metabolic engineering in microbes.Moreover,the reference genome of F.multiflora is a useful addition to the genomes of the Polygonaceae family. | Yujiao Zhao Zhengyang Yang Zhongren Zhang Minzhen Yin Shanshan Chu Zhenzhen Tong Yuejian Qin Liangping Zha Qingying Fang Yuan Yuan Luqi Huang Huasheng Peng | 2023 | Horticulture Research2023，10，5： | 0 |
| 20 | Synthesis of furan from allenic sulfide derivatives显示文摘In this paper, we report the synthesis of furan derivatives from allenic sulfides. By the reaction with NaH, β-Hydroxyl allenic sulfides were found to generate furan products in excellent yields with the removal of phenylthio group. β-Aldehyde allenic sulfides were found to give similar furan products with one more substituent when treated with additional nucleophilic reagents. β-ketone allenic sulfides can also cyclize to give furan derivatives with the promotion of P2O5. | PENG LingLing ZHANG Xiu MA Jie ZHONG ZhenZhen ZHANG Zhe ZHANG Yan WANG JianBo | 2009 | Science China Chemistry2009，52，10： | 0 |
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