|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 离子通道、磷酸化和哺乳动物精子获能显示文摘有性生殖动物需要精子和卵子之间进行精心协调的交流才能产生新的个体。精子获能是发生在女性生殖系统中的生殖细胞成熟的一个复杂现象,让精子能够和卵子联结并融合,是哺乳动物生育的必要条件。精子获能过程包括了质膜重组、离子渗透调节、胆固醇减少和许多蛋白质磷酸化状态的变化。研究精子离子通道的新工具能用更好的时空解析度将细胞内的离子变化和蛋白图像化,这些工具正在一步步阐明离子运输和磷酸化状态中的一系列调节是如何引起获能的。最近的证据表明有两条平行的通路调节引起获能的磷酸化发生。其中一条通路要求蛋白激酶A活化,另一条通路需要丝氨酸/苏氨酸磷酸酶失活。本文综述了精子获能所要求的离子运输参与和磷酸化信号处理。理解导致生育的分子机制,对于人们应对男性不育率升高、开发安全的以雄性配子为基础的避孕药、通过辅助生殖策略保持生物多样性都至关重要。 | Pablo E Visconti Dario Krapf Jose Luis de la Vega-Beltran Juan Jose Acevedo Alberto Darszon | 2011 | Asian Journal of Andrology2011，13，3： | 19 |
| 2 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 3 | Pulmonary vein stenosis:Etiology,diagnosis and management显示文摘Pulmonary vein stenosis(PVS) is rare condition characterized by a challenging diagnosis and unfavorable prognosis at advance stages. At present, injury from radiofrequency ablation for atrial fibrillation has become the main cause of the disease. PVS is characterized by a progressive lumen size reduction of one or more pulmonary veins that, when hemodynamically significant, may raise lobar capillary pressure leading to signs and symptoms such as shortness of breath, cough, and hemoptysis. Image techniques(transesophageal echocardiography, computed tomography, magnetic resonance and perfusion imaging) are essential to reach a final diagnosis and decide an appropriate therapy. In this regard, series from referral centers have shown that surgical and transcatheter interventions may improve prognosis. The purpose of this article is to review the etiology, assessment and management of PVS. | Pablo Pazos-López Cristina García-Rodríguez Alba Guitián-González Emilio Paredes-Galán María ángel De La Guarda álvarez-Moure Marta Rodríguez-álvarez José Antonio Baz-Alonso Elvis Teijeira-Fernández Francisco Eugenio Calvo-Iglesias Andrés íniguez-Romo | 2016 | World Journal of Cardiology2016，8，1： | 6 |
| 4 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 5 | The human olfactory system in two proteinopathies: Alzheimer’s and Parkinson’s diseases显示文摘Alzheimer’s and Parkinson’s diseases are the most prevalent neurodegenerative disorders.Their etiologies are idiopathic,and treatments are symptomatic and orientated towards cognitive or motor deficits.Neuropathologically,both are proteinopathies with pathological aggregates(plaques of amyloid-β peptide and neurofibrillary tangles of tau protein in Alzheimer’s disease,and Lewy bodies mostly composed of α-synuclein in Parkinson’s disease).These deposits appear in the nervous system in a predictable and accumulative sequence with six neuropathological stages.Both disorders present a long prodromal period,characterized by preclinical signs including hyposmia.Interestingly,the olfactory system,particularly the anterior olfactory nucleus,is initially and preferentially affected by the pathology.Cerebral atrophy revealed by magnetic resonance imaging must be complemented by histological analyses to ascertain whether neuronal and/or glial loss or neuropil remodeling are responsible for volumetric changes.It has been proposed that these proteinopathies could act in a prion-like manner in which a misfolded protein would be able to force native proteins into pathogenic folding(seeding),which then propagates through neurons and glia(spreading).Existing data have been examined to establish why some neuronal populations are vulnerable while others are resistant to pathology and to what extent glia prevent and/or facilitate proteinopathy spreading.Connectomic approaches reveal a number of hubs in the olfactory system(anterior olfactory nucleus,olfactory entorhinal cortex and cortical amygdala)that are key interconnectors with the main hubs(the entorhinal–hippocampal–cortical and amygdala–dorsal motor vagal nucleus)of network dysfunction in Alzheimer’s and Parkinson’s diseases. | Isabel Ubeda-Bañon Daniel Saiz-Sanchez Alicia Flores-Cuadrado Ernesto Rioja-Corroto Melania Gonzalez-Rodriguez Sandra Villar-Conde Veronica Astillero-Lopez Juan Pablo Cabello-de la Rosa Maria Jose Gallardo-Alcañiz Julia Vaamonde-Gamo Fernanda Relea-Calatayud Lucia Gonzalez-Lopez Alicia Mohedano-Moriano Alberto Rabano Alino Martinez-Marcos | 2020 | Translational Neurodegeneration2020，9，2： | 4 |
| 6 | Developing Flexible Dual Master's Degree Programs at UPAEP (Universidad Popular Autonoma del Estado de Puebla) and OSU (Oklahoma State University)显示文摘 | Mafia G. Fabregas-Janeiro Pablo Nuno de la Parra | 2012 | US-China Education Review(A)2012，2，2： | 2 |
| 7 | Treatment of Travelers’ Diarrhea: Randomized Trial Comparing Rifaximin, Rifaximin Plus Loperamide, and Loperamide Alone显示文摘 | Herbert L. Dupont Zhi–Dong Jiang Jaime Belkind–Gerson Pablo C. Okhuysen Charles D. Ericsson Shi Ke David B. Huang Margaret W. Dupont Javier A. Adachi F. Javier De La Cabada David N. Taylor Sridvya Jaini Francisco Martinez Sandoval | 2007 | Clinical Gastroenterology and Hepatology2007，，4： | 2 |
| 8 | Influence of thermal treatment on the ' in vitro' bioactivity of wollastonite materials显示文摘 | Miguel A de la Casa-Lillo Pablo Velasquez Piedad N De Aza | 2011 | Journal of Materials Science-Materials in Medicine2011，22，4： | 1 |
| 9 | Medicarpin, an anti- fungal compound identified in hexane extract of Dalbergia congestiflora Pittier heartwood 显示文摘 | Carmen MS Pablo LA Jos CL | 2012 | International Biodeterio- ration & Biodegradation2012，，69： | 1 |
| 10 | Monitoring of dissolved ciguatoxin and maitotoxin using solid-phase adsorption toxin tracking devices: Application to Gambierdiscus pacificus in culture显示文摘 | Amandine Caillaud Pablo de la Iglesia Esther Barber Helena Eixarch Normawaty Mohammad-Noor T. Yasumoto Jorge Diogène | 2011 | Harmful Algae2011，，5： | 1 |
| 11 | UPAEP High School Summer Academy at Oklahoma State University显示文摘 | Maria G. Fabregas Janeiro Pablo Nuno de la Parra Blanca Elena Lozano | 2013 | US-China Education Review(B)2013，3，10： | 1 |
| 12 | The developing CNS:a scenario for the action of proinsulin insulin and insulin - like growth factors显示文摘 | Pablo FD De La Rose EJ | 1995 | Trende Neurosci1995，18，： | 1 |
| 13 | In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor dur- ing early retinal neurogenesis 显示文摘 | Dfaz B Serna J De Pablo F de la Rosa E J | 2000 | Development2000，127，8： | 1 |
| 14 | Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients显示文摘BACKGROUND Life-long removal of gluten from the diet is currently the only way to manage celiac disease(CeD). Until now, no objective test has proven useful to objectively detect ingested gluten in clinical practice. Recently, tests that determine consumption of gluten by assessing excretion of gluten immunogenic peptides(GIP) in stool and urine have been developed. Their utility, in comparison with conventional dietary and analytical follow-up strategies, has not been fully established.AIM To assess the performance of enzyme-linked immunosorbent assay(ELISA) and point-of-care tests(PoCTs) for GIP excretion in CeD patients on gluten-free diet(GFD).METHODS We conducted an observational, prospective, cross-sectional study in patients following a GFD for at least two years. Using the Gastrointestinal Symptom Rating Scale questionnaire, patients were classified at enrollment as asymptomatic or symptomatic. Gluten consumption was assessed twice by 3-d dietary recall and GIP excretion(by ELISA in stool and PoCTs(commercial kits for stool and urine) in two consecutive samples. These samples and dietary reports were obtained 10 day apart one from the other. Patients were encouraged to follow their usual GFD during the study period.RESULTS Forty-four patients were enrolled, of which 19(43.2%) were symptomatic despite being on a GFD. Overall, 83 sets of stool and/or urine samples were collected.Eleven out of 44 patients(25.0%) had at least one positive GIP test. The occurrence of at least one positive test was 32% in asymptomatic patients compared with 15.8% in symptomatic patients. GIP was concordant with dietary reports in 65.9% of cases(Cohen′s kappa: 0.317). PoCT detected dietary indiscretions. Both ELISA and PoCT in stool were concordant(concomitantly positive or negative) in 67 out of 74(90.5%) samples. Excretion of GIP was detected in 7(8.4%) stool and/or urine samples from patients considered to be strictly compliant with the GFD by dietary reports.CONCLUSION GIP detects dietary transgressions in patients on long-term GFD, irrespective of the presence of symptoms. PoCT for GIP detection constitutes a simple homebased method for self-assessment of dietary indiscretions. | Ana Florencia Costa Emilia Sugai María de la Paz Temprano Sonia Isabel Niveloni Horacio Vázquez María Laura Moreno M.Remedios Domínguez-Flores Alba Mu?oz-Suano Edgardo Smecuol Juan Pablo Stefanolo Andrea F González Angel Cebolla-Ramirez Eduardo Mauri?o Elena F Verdú Julio César Bai | 2019 | World Journal of Gastroenterology2019，25，11： | 1 |
| 15 | Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis显示文摘 | Ian R van Driel Alan G Baxter Karen L Laurie Tricia D Zwar Nicole L La Gruta Louise M Judd Katrina L Scarff Pablo A Silveira Paul A Gleeson | 2002 | Autoimmunity Reviews2002，，5： | 1 |
| 16 | Effects of window size and thermal mass on building comfort using an intelligent ventilation controller 显示文摘 | Pablo La Roche Murray Milne | 2004 | Solar Energy2004，77，： | 1 |
| 17 | Assessment of nutri- tional status on hospital admission: nutritional scores显示文摘 | PABLO AMR IZAGA MA ALDAY LA | 2003 | Eur J Clin Nutr2003，57，7： | 1 |
| 18 | Proinsulin/insulin is synthesized locally and prevents caspase- and cathepsin-mediated cell death in the embryonic mouse retina 显示文摘 | Valenciano AI Corrochano S de Pablo F de la Villa P de la Rosa E | 2006 | J Neurochem2006，99，2： | 1 |
| 19 | Comparative study of the electronic structure of alkaline-earth borides(MeB2;Me=Mg,Al,Zr,Nb,and Ta)and their normal-state conductivity显示文摘 | Pablo de la Mora Miguel Castro Gustavo Tavizon | 2002 | Journal of Solid State Chemistry2002，169，： | 1 |
| 20 | Enzymatic recycling-based amperometric immunosensor for the ultrasensitive detection of okadaic acid in shellfish显示文摘 | Mònica Campàs Pablo de la Iglesia Marie Le Berre Marian Kane Jorge Diogène Jean-Louis Marty | 2008 | Biosensors and Bioelectronics2008，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员