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| 1 | Quality analysis of commercial samples of Ziziphi spinosae semen(suanzaoren) by means of chromatographic fingerprinting assisted by principal component analysis显示文摘Due to the scarcity of resources of Ziziphi spinosae semen(ZSS), many inferior goods and even adulterants are generally found in medicine markets. To strengthen the quality control, HPLC fingerprint common pattern established in this paper showed three main bioactive compounds in one chromatogram simultaneously. Principal component analysis based on DAD signals could discriminate adulterants and inferiorities. Principal component analysis indicated that all samples could be mainly regrouped into two main clusters according to the first principal component(PC1, redefined as Vicenin II)and the second principal component(PC2, redefined as zizyphusine). PC1 and PC2 could explain 91.42%of the variance. Content of zizyphusine fluctuated more greatly than that of spinosin, and this result was also confirmed by the HPTLC result. Samples with low content of jujubosides and two common adulterants could not be used equivalently with authenticated ones in clinic, while one reference standard extract could substitute the crude drug in pharmaceutical production. Giving special consideration to the well-known bioactive saponins but with low response by end absorption, a fast and cheap HPTLC methodfor quality control of ZSS was developed and the result obtained was commensurate well with that of HPLC analysis. Samples having similar fingerprints to HPTLC common pattern targeting at saponins could be regarded as authenticated ones. This work provided a faster and cheaper way for quality control of ZSS and laid foundation for establishing a more effective quality control method for ZSS. | Shuai Sun Hailing Liu Shunjun Xu Yuzhen Yan Peishan Xie | 2014 | Journal of Pharmaceutical Analysis2014，4，3： | 17 |
| 2 | A Geochemical Study of an REE-rich Carbonatite Dyke at Bayan Obo,Inner Mongolia,Northern China显示文摘An REE-rich carbonatite dyke was found in Dulahala, close to the Bayan Obo superlarge REE-Nb-Fe mineral deposit in Inner Mongolia, northern China. The REE content in the dyke varies greatly, from 1% up to 20% (wt), which might constitute rich REE ores. Light REEs in the carbonatite are enriched and highly fractionated relative to heavy REEs and there is no Eu anomaly. The REE and trace element distribution patterns of the carbonatite are identical to those of fine-grained dolomite marble which is the host rock of the Bayan Obo REE-Nb-Fe superlarge mineral deposit. This indicates a petrogenetic linkage between the REE-rich carbonatite and the mineralizations in this region. | YANG Xueming ZHENG Yongfei YANG Xiaoyong ZHANG Peishan M.J.LE BAS | 2000 | Acta Geologica Sinica(English Edition)2000，74，3： | 7 |
| 3 | Temperature increase impacts personality traits in aquatic non-native species: Implications for biological invasion under climate change显示文摘 | Dapeng ZHAO Peishan FENG | 2015 | Current Zoology2015，61，6： | 5 |
| 4 | Immunomodulatory properties of mesenchymal stem cells/dental stem cells and their therapeutic applications显示文摘Mesenchymal stem/stromal cells(MsCs)are widely distributed in the body and play essential roles in tissue regeneration and homeostasis.MsCs can be isolated from discarded tissues,expanded in vitro and used as therapeutics for autoimmune diseases and other chronic disorders.MsCs promote tissue regeneration and homeostasis by primarily acting on immune cells.At least six different types of MsCs have been isolated from postnatal dental tissues and have remarkable immunomodulatory properties.Dental stem cells(DsCs)have been demonstrated to have therapeutic effects on several systemic inflammatory diseases.Conversely,MsCs derived from nondental tissues such as the umbilical cord exhibit great benefits in the management of periodontitis in preclinical studies.Here,we discuss the main therapeutic uses of MSCs/DSCs,their mechanisms,extrinsic inflammatory cues and the intrinsic metabolic circuitries that govern the immunomodulatory functions of MSCs/DSCs.Increased understanding of the mechanisms underpinning the immunomodulatory functions of MSCs/DSCs is expected to aid in the development of more potent and precise MSC/DSC-based therapeutics. | Peishan Li Qianmin Ou Songtao Shi Changshun Shao | 2023 | Cellular & Molecular Immunology2023，20，6： | 4 |
| 5 | Epitaxy of rare earth element fluorcarbonate minerals from carbonatite dyke at Bayan Obo, Inner Mongolia, China显示文摘Rare earth element fluorocarbonate minerals such as bastnaesite and parisite are firstly discovered in carbonatite dykes from Bayan Obo, Inner Mongolia, China. Bastnaesite rarely occurs as homogeneously single crystal, but contains microfine phase of parisite. They form regular intergrowth along (0001) plane net, which is identified as epitaxy. This eptactic texture results from the variation of chemical composition of crystallizing agents of those minerals that crystallize directly from carbonatite magma. | Xueming Yang Peishan Zhang Kejie Tao Xiaoyong Yang Shuangxi Chen Minglong Zou M. J. Le Bas R. N. Wilson R. Ranson L. S. Campbell et al. | 1998 | Chinese Science Bulletin1998，43，13： | 2 |
| 6 | CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription显示文摘Toll-like receptors (TLRs) play critical roles in innate immunity and inflammation. The molecular mechanisms by which TLR signaling is fine-tuned remain to be completely elucidated. Cullin 4B (CUL4B), which assembles the CUL4B-RING E3 ligase complex (CRL4B), has been shown to regulate diverse developmental and physiological processes by catalyzing monoubiquitination for histone modification or polyubiquitination for proteasomal degradation. Here, we identified the role of CUL4B as an intrinsic negative regulator of the TLR-triggered inflammatory response. Deletion of CUL4B in macrophages increased the production of proinflammatory cytokines and decreased anti-inflammatory cytokine IL-10 production in response to pathogens that activate TLR3, TLR4, or TLR2. Myeloid cell-specific Cul4b knockout mice were more susceptible to septic shock when challenged with lipopolysaccharide, polyinosinic-polycytidylic acid or Salmonella typhimurium infection. We further demonstrated that enhanced TLR-induced inflammatory responses in the absence of CUL4B were mediated by increased GSK3β activity. Suppression of GSK3β activity efficiently blocked the TLR-triggered increase in proinflammatory cytokine production and attenuated TLR-triggered death in Cul4b mutant mice. Mechanistically, CUL4B was found to negatively regulate TLR-triggered signaling by epigenetically repressing the transcription of Pten, thus maintaining the anti-inflammatory PI3K-AKT-GSK3β pathway. The upregulation of PTEN caused by CUL4B deletion led to uncontrolled GSK3β activity and excessive inflammatory immune responses. Thus, our findings indicate that CUL4B functions to restrict TLR-triggered inflammatory responses through regulating the AKT-GSK3β pathway. | Yu Song Peishan Li Liping Qin Zhiliang Xu Baichun Jiang Chunhong Ma Changshun Shao Yaoqin Gong | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 7 | Information theory, applied to chromatographic fingerprint of herbal medicine for quality control显示文摘 | Gong Fan Liang Yizeng Xie Peishan | 2003 | Joumal of Chromatography A2003，1002，12： | 1 |
| 8 | Quality control of herbal medicines显示文摘 | Xie Peishan Chan Kelvin | 2004 | J Chromatogr B2004，812，： | 1 |
| 9 | Ordered microstructure induced by orientation behavior of liquid-crystal polythiophene for performance improvement of hybrid solar cells显示文摘 | Wei Chen Yiwang Chen Fan Li Lie Chen Kai Yuan Kai Yao Peishan Wang | 2011 | Solar Energy Materials and Solar Cells2011，，： | 1 |
| 10 | The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement 显示文摘 | Alyssa R Peishan LS Thomas JW | 2008 | Int J Nanomedicine2008，3，1： | 1 |
| 11 | NAD^(+) salvage governs the immunosuppressive capacity of mesenchymal stem cells显示文摘Mesenchymal stem/stromal cells(MSCs)possess robust immunoregulatory functions and are promising therapeutics for inflammatory disorders.This capacity is not innate but is activated or‘licensed’by inflammatory cytokines.The licensing mechanism remains unclear.Here,we examined whether inflammatory cytokines metabolically reprogrammed MSCs to confer this immunoregulatory capacity.In response to stimulation by inflammatory cytokines,MSCs exhibited a dramatic increase in the consumption of glucose,which was accompanied by an enhanced use of nicotinamide adenine dinucleotide(NAD^(+))and increased expression of nicotinamide phosphoribosyltransferase(NAMPT),a central enzyme in the salvage pathway for NAD^(+) production.When NAD^(+) synthesis was blocked by inhibiting or depleting NAMPT,the immunosuppressive function of MSCs induced by inflammatory cytokines was greatly attenuated.Consequently,when NAD^(+) metabolism in MSCs was perturbed,their therapeutic benefit was decreased in mice suffering from inflammatory bowel disease and acute liver injury.Further analysis revealed that NAMPT-driven production of NAD^(+) was critical for the inflammatory cytokine-induced increase in glycolysis in MSCs.Furthermore,the increase in glycolysis led to succinate accumulation in the tricarboxylic acid cycle,which led to hypoxia-inducible factor 1α(HIF-1α)stabilization and subsequently increased the transcription of key glycolytic genes,thereby persistently maintaining glycolytic flux.This study demonstrated that unlike its proinflammatory role in immune cells,NAD^(+) metabolism governs the anti-inflammatory function of MSCs during inflammation. | Jiankai Fang Pengbo Hou Shisong Liu Muqiu Zuo Zhanhong Liu Wangwang Chen Yuyi Han Yanan Li Tingting Wang Chao Feng Peishan Li Changshun Shao Yufang Shi | 2023 | Cellular & Molecular Immunology2023，20，10： | 1 |
| 12 | Targeted core-shell nanoparticles for precise CTCF gene insert in treatment of metastatic breast cancer显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)technology emerges a remarkable potential for cure of refractory cancer like metastatic breast cancer.However,how to efficiently deliver the CRISPR system with non-viral carrier remains a major issue to be solved.Here,we report a kind of targeted core-shell nanoparticles(NPs)carrying dual plasmids(pHR-pCas9)for precise CCCTC-binding factor(CTCF)gene insert to circumvent metastatic breast cancer.The targeted core-shell NPs carrying pHR-pCas9 can accomplishγGTP-mediated cellular uptake and endosomal escape,facilitate the precise insert and stable expression of CTCF gene,inhibit the migration,metastasis,and colonization of metastatic breast cancer cells.Besides,the finding further reveals that the inhibitory mechanism of metastasis could be associated with up-regulating CTCF protein,followed by down-regulating stomatin(STOM)protein.The study offers a universal nanostrategy enabling the robust non-viral delivery of gene-editing system for treatment of severe illness. | Jialun Duan Chunjie Bao Ying Xie Haitao Guo Yixuan Liu Jianwei Li Rui Liu Peishan Li Jing Bai Yan Yan Limin Mu Xueqi Li Guiling Wang Wanliang Lu | 2022 | Bioactive Materials2022，7，5： | 1 |
| 13 | Optimization of the TLC of protoberberine alkaloids and fingerprint valuation of the coptidis rhizome显示文摘 | Xie Peishan Yan Yuzhen | 1992 | Journal of Planar Chromatography Modern TLC1992，5，5： | 1 |
| 14 | Carbonatite dykes at bayan Obo, inner Mongolia, China显示文摘 | M. J. Bas J. Kellere Tao Kejie F. Wall C. T. William Zhang Peishan | 1992 | Mineralogy and Petrology1992，，3： | 1 |
| 15 | Fingerprint Identification of Ginseng Drugs显示文摘 | Xie Peishan Yuan Yuzhen | 1987 | Journal of High Resolution Chromatography Communication1987，10，11： | 1 |
| 16 | Differentiation &Evaluation of commercial Ginseng& their products by Means of HPTLC Fingerprint Analysis显示文摘 | Xie Peishan Yuan Yuzhen | 1998 | Journal of Planal Chromatography Modern TLC1998，1，1： | 1 |
| 17 | Quantification relations between the sourc eparameters显示文摘 | Peishan Chen Tongxia Bai | 1992 | Acta Seismologica Sinica1992，，3： | 1 |
| 18 | Reaction relationships in the Bayan Obo Fe-REE-Nb deposit Inner Mongolia, China: implications for the relative stability of rare-earth element phosphates and fluorocarbonates显示文摘 | M. P. Smith P. Henderson Zhang Peishan | 1999 | Contributions to Mineralogy and Petrology (-)1999，，2： | 1 |
| 19 | Carbonatite dykes at bayan Obo, inner Mongolia, China显示文摘 | M. J. Bas J. Kellere Tao Kejie F. Wall C. T. William Zhang Peishan | 1992 | Mineralogy and Petrology1992，，3： | 1 |
| 20 | Scaling law and its application to earthquake statistical relations 显示文摘 | Chen Peishan Chen Haitong | 1989 | Tectonophvsics1989，，166： | 1 |
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