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| 1 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | Long-term survival after intraluminal brachytherapy for inoperable hilar cholangiocarcinoma: A case report显示文摘Surgical resection with a tumor-free margin is the onlycurative treatment for hilar cholangiocarcinoma (Klatskin tumor). However, over half of the patients present late with unresectable tumors. Radiotherapy using external beamirradiation or intraluminal brachytherapy (ILBT) has been used to treat unresectable hilar cholangiocarcinoma with satisfactory outcome. We reported a patient with unresectable hilar cholangiocarcinoma surviving more than 6 years after combined external beam irradiation and ILBT. | Siu-Yin Chan Ronnie T. Poon Kelvin K. Ng Chi-Leung Liu Raymond T. Chan Sheung-Tat Fan | 2005 | World Journal of Gastroenterology2005，11，20： | 7 |
| 3 | Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients显示文摘Dear Editor,The ongoing coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2(SARSCoV-2)is a serious threat to global public health,and is imposing severe burdens on human society.Several candidate vaccines against SARS-CoV-2 are now undergoing clinical trials.The Spike(S)protein of SARS-CoV-2 is widely considered as a promising antigen.However. | Bao-zhong Zhang Ye-fan Hu Lin-lei Chen Thomas Yau Yi-gang Tong Jing-chu Hu Jian-piao Cai Kwok-Hung Chan Ying Dou Jian Deng Xiao-lei Wang Ivan Fan-Ngai Hung Kelvin Kai-Wang To Kwok Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，8： | 5 |
| 4 | A case of laparoscopic hepatectomy for recurrent hepatocellular carcinoma显示文摘Conventional hepatectomy is an effective way to treat hepatocellular carcinoma.However,it is invasive and stressful.The use of laparoscopy in hepatectomy,while technically demanding,reduces surgical invasiveness and stressfulness but still achieves complete resection with adequate margins.Compared with conventional hepatectomy,laparoscopic hepatectomy provides a better chance and situation for further surgery in the case of recurrence of hepatocellular carcinoma.Even aged patients can successfully endure repeated hepatectomy using laparoscopy,as shown in the present report.This report presents a case of repeated laparoscopic hepatectomy treating hepatocellular carcinoma and its recurrence in an aged patient having cirrhosis,a disease causing extra difficulty for performing laparoscopic hepatectomy.The report also describes techniques of the operation and displays characteristic results of laparoscopic hepatectomy such as smaller wounds,less blood loss,less pain,less scars and adhesion,shorter postoperative hospital stay,and faster recovery. | Tan To Cheung Kelvin Kwok-chai Ng Ronnie Tung-ping Poon See Ching Chan Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，4： | 5 |
| 5 | Investigation of Radix Achyranthis Bidentatae Phytochemistry and Pharmacology显示文摘Radix achyranthis bidentatae(RAB), a member of the Amaranthaceae family, has been widely used in Traditional Chinese Medicine for1000 s of years. Increasing interest in RAB-derived medicinal has led to the discovery of additional triterpenoid saponins, phytoecdysones,polysaccharides, and many other compounds, as well as investigations into their pharmacology. A large number of pharmacological studies have shown RAB and its active components possess a range of pharmacological activities, including anti-tumor, anti-fertility, anti-senile, and anti?inflammatory effects. This review is an up?to?date summary and synthesis of the uses of RAB from phytochemical and pharmacological perspectives. | Liu Yang A-Jiao Hou Mei-Ling Yan Xu-Dong Xing Xin-Yue Guo Hai Jiang Bing-You Yang Kelvin Chan Qiu-Hong Wang Hai-Xue Kuang | 2019 | World Journal of Traditional Chinese Medicine2019，5，1： | 4 |
| 6 | Hepatitis B Virus Screening Before Chemotherapy for Lymphoma: A Cost-Effectiveness Analysis显示文摘 | Urszula Zurawska Lisa K. Hicks Gloria Woo Chaim M. Bell Murray Krahn Kelvin K. Chan Jordan J. Feld | 2012 | Journal of Clinical Oncology2012，，26： | 3 |
| 7 | Continuous Improvement of Survival Outcomes of Resection of Hepatocellular Carcinoma: A 20-Year Experience显示文摘 | Sheung Tat Fan Chung Mau Lo Ronnie T. P. Poon Chun Yeung Chi Leung Liu Wai Key Yuen Chi Ming Lam Kelvin K. C. Ng See Ching Chan | 2011 | Annals of Surgery2011，，4： | 3 |
| 8 | Liver transplantation for acute-on-chronic liver failure显示文摘 | Albert C. Chan Sheung Tat Fan Chung Mau Lo Chi Leung Liu See Ching Chan Kelvin K. Ng Boon Hun Yong Alexander Chiu Banny K. Lam | 2009 | Hepatology International2009，，4： | 2 |
| 9 | Continuous Improvement of Survival Outcomes of Resection of Hepatocellular Carcinoma: A 20-Year Experience显示文摘 | Sheung Tat Fan Chung Mau Lo Ronnie T. P. Poon Chun Yeung Chi Leung Liu Wai Key Yuen Chi Ming Lam Kelvin K. C. Ng See Ching Chan | 2011 | Annals of Surgery2011，，4： | 2 |
| 10 | Better Survival in Female Patients With Hepatocellular Carcinoma: Oral Contraceptive Pills Related?显示文摘 | Chi Ming Lam Jamy L Yong Annie O Chan Kelvin K Ng Ronnie T Poon Chi Leung Liu Chung Mau Lo Sheung Tat Fan | 2005 | Journal of Clinical Gastroenterology2005，，6： | 1 |
| 11 | Pharmaco- kinetic interaction of paeoniflorin and sinomenine: pharmacoki- netic parameters and tissue distribution characteristics in rats and protein binding ability in vitro显示文摘 | Zhong Qiu Liu Zhi Hong Jiang Kelvin Chan | 2005 | Journal of Pharmacolog- ical Sciences2005，99，： | 1 |
| 12 | Changing Paradigm in the Management of Hepatocellular Carcinoma Improves the Survival Benefit of Early Detection by Screening显示文摘 | Albert C. Y. Chan Ronnie T. P. Poon Kelvin K. C. Ng Chung Mau Lo Sheung Tat Fan John Wong | 2008 | Annals of Surgery2008，，4： | 1 |
| 13 | Emergence in China of human disease due to avian influenza A(H10N8)-cause for concern显示文摘 | To K K Tsang A K Chan J F Kelvin K W Alan K L | 2014 | J Infect2014，68，： | 1 |
| 14 | Application of Mid-Infrared Spectroscopy in the Quality Control of Traditional Chinese Medicines显示文摘 | Suqin Sun Jianbo Chen Qun Zhou Guanghua Lu Kelvin Chan | 2010 | Planta Med2010，，17： | 1 |
| 15 | Comparison of Pyrosequencing, Sanger Sequencing, and Melting Curve Analysis for Detection of Low-Frequency Macrolide-Resistant Mycoplasma pneumoniae Quasispecies in Respiratory Specimens显示文摘 | Kwok-Hung Chan Kelvin K. W. To Betsy W. K. Chan Clara P. Y. Li Susan S. Chiu Kwok-Yung Yuen Pak-Leung Ho | 2013 | Journal of Clinical Microbiology2013，，8： | 1 |
| 16 | Good practice in reviewing and publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine and Chinese materia medica显示文摘 | Kelvin Chan Debbie Shaw Monique S.J. Simmonds Christine J. Leon Qihe Xu Aiping Lu Ian Sutherland Svetlana Ignatova You-Ping Zhu Rob Verpoorte Elizabeth M. Williamson Pierre Duez | 2012 | Journal of Ethnopharmacology2012，，3： | 1 |
| 17 | Assay of free ferulic acid and total ferulic acid for quality assessment of An geliea sinensis 显示文摘 | Guang -Hua Lu Kelvin Chan Kelvin Leung | 2005 | Journal of Chromatography2005，1068，： | 1 |
| 18 | Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial显示文摘 | Jeremy Chataway Nadine Schuerer Ali Alsanousi Dennis Chan David MacManus Kelvin Hunter Val Anderson Charles R M Bangham Shona Clegg Casper Nielsen Nick C Fox David Wilkie Jennifer M Nicholas Virginia L Calder John Greenwood Chris Frost Richard Nicholas | 2014 | The Lancet2014，，： | 1 |
| 19 | Reirradiation of Locally Recurrent Nasopharynx Cancer With External Beam Radiotherapy With or Without Brachytherapy显示文摘 | Lawrence Koutcher Nancy Lee Michael Zelefsky Kelvin Chan Gilad Cohen David Pfister Dennis Kraus Suzanne Wolden | 2010 | International Journal of Radiation Oncology Biology Physics2010，，1： | 1 |
| 20 | Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectrometry 显示文摘 | Lu Guang-hua Chan Kelvin Chan Chi-leng | 2004 | J Chromatogr A2004，1046，2004： | 1 |
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