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| 1 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 2 | A general method of spatio-temporal clustering analysis显示文摘Spatio-temporal clustering has been a hot topic in the feld of spatio-temporal data mining and knowledge discovery.It can be employed to uncover and interpret developmental trends of geographic phenomenon in the real world.However,existing spatio-temporal clustering methods seldom consider both spatiotemporal autocorrelations and heterogeneities among spatio-temporal entities,and the coupling in space and time has not been well highlighted.In this paper,a unifed framework for the clustering analysis of spatio-temporal data is proposed,and a novel spatio-temporal clustering algorithm is developed by means of a spatio-temporal statistics methodology and intelligence computation technology.Our method is applied successfully to fnding spatio-temporal cluster in China’s annual temperature database for the period 1951 1992. | DENG Min LIU QiLiang WANG JiaQiu SHI Yan | 2013 | Science China(Information Sciences)2013，56，10： | 6 |
| 3 | Task Offloading Decision in Fog Computing System显示文摘Fog computing is an emerging paradigm of cloud computing which to meet the growing computation demand of mobile application. It can help mobile devices to overcome resource constraints by offloading the computationally intensive tasks to cloud servers. The challenge of the cloud is to minimize the time of data transfer and task execution to the user, whose location changes owing to mobility, and the energy consumption for the mobile device. To provide satisfactory computation performance is particularly challenging in the fog computing environment. In this paper, we propose a novel fog computing model and offloading policy which can effectively bring the fog computing power closer to the mobile user. The fog computing model consist of remote cloud nodes and local cloud nodes, which is attached to wireless access infrastructure. And we give task offloading policy taking into account executi+on, energy consumption and other expenses. We finally evaluate the performance of our method through experimental simulations. The experimental results show that this method has a significant effect on reducing the execution time of tasks and energy consumption of mobile devices. | Qiliang Zhu Baojiang Si Feifan Yang You Ma | 2017 | China Communications2017，14，11： | 5 |
| 4 | Geological and Geochemical Characteristics of Early Cretaceous Mafic Dikes in Northern Jiangxi Province, SE China and Their Geodynamic Implications显示文摘The development of Early Cretaceous mafic dikes in northern and southern Jiangxi allows an understanding of the geodynamic setting and characteristics of the mantle in southeast China in the Cretaceous. Geological and geochemical characteristics for the mafic dikes from the Wushan copper deposit and No. 640 uranium deposit are given in order to constrain the nature of source mantle, genesis and tectonic implications. According to the mineral composition, the mafic dikes in northern Jiangxi can be divided into spessartite and olive odinite types, which belong to slightly potassium-rich calc-alkaline lamprophyre characterized by enrichment in large ion lithophile elements (LILE) and light rare earth elements (LREE), large depletion in high strength field elements (HSFE) and with negative Nb, Ta and Ti anomalies, as well as 87Sr/86Sr ratios varying from 0.7055 to 0.7095 and 143Nd/144Nd ratios varying from 0.5119 to 0.5122. All features indicate that the magma responsible for the mafic dikes was derived mainly from metasomatic lithosphere mantle related to dehydration and/or upper crust melting during subduction. Differences in geochemical characteristics between the mafic dikes in northern Jiangxi and the Dajishan area, southern Jiangxi were also studied and they are attributed to differences in regional lithospheric mantle components and/or magma emplacement depth. Combining geological and geochemical characteristics with regional geological history, we argue that southeast China was dominated by an extensional tectonic setting in the Early Cretaceous, and the nature of the mantle source area was related to enrichment induced by asthenosphere upwelling and infiltration of upper crust-derived fluids responding to Pacific Plate subduction. | XIEGuiqing HURuizhong MAOJingwen LIRuiling CAOJinjian JIANGGuohao QILiang | 2005 | Acta Geologica Sinica(English Edition)2005，79，2： | 5 |
| 5 | Stereotactic body radiotherapy combined with transarterial chemoembolizationfor hepatocellular carcinoma with portal vein tumor thrombosis显示文摘 | Jingbo Kang Qing Nie Rui Du Liping Zhang Jun Zhang Qiliang Li Jianguo Li Wenjie Qi | 2014 | Molecular and Clinical Oncology2014，，1： | 4 |
| 6 | Influences of alternate partial root-zone irrigation and urea rate on water-and nitrogen-use efficiencies in tomato显示文摘Traditional water and fertilizer inputs are often much higher than the actual demands of tomato,which causes a reduction in water-and fertilizer-use efficiencies.To investigate the advantage of alternate partial root-zone irrigation(AI)on water-and nitrogen(N)-use efficiencies of tomato modified by water and N management,taking conventional irrigation(CI)as the control,the effects of AI on root morphology and activity,fruit yield and water and N use efficiency were studied using pot experiments.There were four combinations of irrigation levels and growing stages of tomato for AI,i.e.AI_(1)(high water(W_(H))from blooming to harvest stage(BHS)),AI_(2)(W_(H)from blooming to fruit setting stage(BFS)and low water(W_(L))at the harvest stage(HS)),AI_(3)(W_(L)at BFS and W_(H)at HS)and AI_(4)(W_(L)at BHS)at three urea rates,i.e.low urea rate(NL),middle urea rate(N_(M))and high urea rate(N_(H))in the form of urea.Irrigation quotas for W_(H)and W_(L)in AI at BFS or HS were 80%and 60%of that in CI,respectively.Compared to CI,AI decreased water consumption by 16.0%-33.1%and increased water use efficiency of yield(WUE_(y))and dry mass(WUE_(d))by 6.7%-11.9%and 10.2%-15.9%,respectively.AI_(1)did not decline yield,total N uptake(TNU)and N use efficiency(NUE)significantly.Compared to NL,N_(M)enhanced tomato yield,TNU,WUE_(y)and WUE_(d)by 28.5%,35.3%,22.6%and 16.3%,respectively.Compared to CINL,AI_(1)N_(M)reduced water consumption by 12.5%,but increased tomato yield,TNU,WUE_(y)and WUE_(d)by 35.5%,58.4%,54.4%and 53.7%,respectively.Therefore,AI_(1)can improve water use efficiency and total N uptake of tomato simultaneously at medium urea rate. | Liu Xiaogang Li Fusheng Zhang Fucang Cai Huanjie Yang Qiliang | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 4 |
| 7 | Assessment of potential dermal and inhalation exposure of workers to the insecticide imidacloprid using whole-body dosimetry in China显示文摘In China, although improvements to the pesticide registration process have been made in la thirty years, no occupational exposure data are required to obtain a commercial license for pesticide product. Consequently, notably little research has been conducted to establish a exposure assessment procedure in China. The present study monitored the potential derm operator exposure from knapsack electric sprayer wheat field application of imidacloprid Liaocheng City, Shandong Province and in Xinxiang City, Henan Province, China, usin whole-body dosimetry. The potential inhalation exposure was determined using a person air pump and XAD-2 sample tubes. The analytical method was developed and validate including such performance parameters as limits of detection and quantification, linear rang recovery and precision. The total potential dermal and inhalation exposures were 14.20, 16.815.39 and 20.78 m L/hr, respectively, for the four operators in Liaocheng and Xinxian corresponding to 0.02% to 0.03% of the applied volume of spray solution. In all trials, the low part(thigh, lower leg) of the body was the most contaminated, accounting for approximate76% to 88% of the total exposure. The inhalation exposure was less than 1% of the tot exposure. Such factors as the application pattern, crop type, spray equipment, operat experience and climatic conditions have been used to explain the exposure distribution ov the different parts of the body. As indicated by the calculated Margin of Exposure, the typic wheat treatment scenarios when a backpack sprayer was used are considered to be safe terms of imidacloprid exposure. | Lidong Cao Bo Chen Li Zheng Dongwei Wang Feng Liu Qiliang Huang | 2015 | Journal of Environmental Sciences2015，27，1： | 4 |
| 8 | Space solar telescope in soft X-ray and EUV band显示文摘In this paper we have reviewed our achievements in soft X-ray and extreme ultraviolet (EUV) optics. Up to now, the research system of soft X-ray and EUV optics has been established, including light sources, detectors, calibrations, optical testing and machining of super smooth mirrors, and fabrications of multilayer film mirrors. Based on our achievements, we have developed two types of solar space telescopes for the soft X-ray and EUV space solar observations. One is an EUV multilayer normal incident telescope array including 4 different operation wavelength telescopes. The operation wavelengths of the EUV telescope are 13.0, 17.1, 19.5 and 30.4 nm. The other is a complex space solar telescope, which is composed of an EUV multilayer normal incident telescope and a soft X-ray grazing incident telescope. The EUV multilayer normal incident telescope stands in the central part of the soft X-ray grazing incident telescope. The normal incident telescope and the grazing incident telescope have a common detector. The different operation wavelengths can be changed by rotating a filter wheel. | CHEN Bo LIU Zhen YANG Lin GAO Liang HE Fei WANG XiaoGuang NI QiLiang | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 3 |
| 9 | Evolving a core-periphery pattern of manufacturing industries across Chinese provinces显示文摘有关在中国的不平的开发,这篇论文以经验为主地分析越过省生产工业的核心圆周坡度(自治区域,自治市) ,并且估计这些省在最近的年里改变了到的程度。自从瓷器改革和洞起来,经济的空间结构介绍了一个重要核心圆周模式,显然向东方沿海的区域扭曲的核心。与加深市场改革和全球化的扩大,工业地点是逐渐地与省的发展优点一致。核心省专攻强壮的前面、向后的连接,以及高消费比率描绘的那些工业,增加的高度回到规模,和劳动或人首都的紧张。然而,另外,它是关于外部省的反面集中的工业逐渐地在这些区域正在集中的精力。到某个度,比较优点理论和新经济地理识别决定在中国生产工业的空间分发的内在的力量。这份报纸显示沿着不同坡度的区域的工业化成为 unsynchronized 将是一个长期的趋势。在某个时期以内,区域肯定与他们的各自的特征和开发舞台一致开发工业扇区。工业的一个核心圆周模式也显示因为工业的不平的分发而且工业结构的不一致的演变趋势,越过区域的工业发展 differentials 为每个省产生不仅。 | MAO Qiliang WANG Fei LI Jun DONG Suocheng | 2014 | Journal of Geographical Sciences2014，24，5： | 3 |
| 10 | In situ stress state and seismic hazard in the Dayi seismic gap of the Longmenshan thrust belt显示文摘In the Longmenshan thrust belt,the Dayi seismic gap,an area with few earthquakes,is located between the ruptures of the 2008 Wenchuan Earthquake and the 2013 Lushan Earthquake,with a length of approximately 40–60 km.To date,however,the extent of the seismic hazard of the Dayi seismic gap and whether this gap is under high stress are still hotly debated.To further evaluate the seismic hazard of the Dayi seismic gap with regard to stress,two boreholes(1,000 and 500 m deep)were arranged to carry out hydraulic fracturing in situ stress measurement on either side of the Shuangshi-Dachuan fault zone.This zone has a high seismic hazard and the capacity to undergo surface rupture.Through the analogy of this new data with stability analysis using Byerlee’s Law and existing stress measurement data collected before strong earthquakes,the results show that the area surrounding the Shuangshi-Dachuan fault zone in the Dayi seismic gap(Dachuan Town)is in a state of high in situ stress,and has the conditions necessary for friction slip,with the potential hazard of moderate to strong earthquakes.Our results are the first to reveal the in situ stress profile at a depth of 1,000 m in the Dayi seismic gap,and provide new data for comprehensive evaluation of the seismic hazard in this seismic gap,which is of great significance to explore the mechanism of earthquake occurrence and to help mitigate future disaster. | Bing LI Furen XIE Jinshui HUANG Xiwei XU Qiliang GUO Guangwei ZHANG Junshan XU Jianxin WANG Dawei JIANG Jian WANG Lifeng DING | 2022 | Science China Earth Sciences2022，65，7： | 3 |
| 11 | Effects of drip irrigation modes on growth and physiological characteristics of Arabica coffee under different N levels显示文摘The objective of this study was to obtain the water-saving and efficient production mode of Arabica coffee. The effects of three drip irrigation modes,conventional drip irrigation( CDI),alternate drip irrigation( ADI) and fixed drip irrigation( FDI) on growth,photosynthetic characteristics,biomass accumulation and irrigation water use efficiency of Arabica coffee were investigated under three nitrogen levels,high nitrogen( NH),middle nitrogen( NM) and low nitrogen( NL). The results show that there was a significant Logistic curve between the plant height,the stem diameter of Arabica coffee and growth days. Compared with CDI,ADI had no significant effects on leaf net photosynthetic rate,stomatal conductance,instantaneous water use efficiency and biomass accumulation above ground of Arabica coffee,while FDI decreased significantly,ADI and FDI increased irrigation water use efficiency by 50. 59% and 32. 85%,respectively. Compared with NH,with the reduction of N application rate,net photosynthetic rate,stomatal conductance,biomass accumulation above ground and irrigation water use efficiency decreased by 6. 81%-12. 30%,13. 70%-22. 69%,9. 61%-16. 67% and 9. 78%-15. 64%,respectively. Compared with CDINH,ADINHdecreased net photosynthesis rate and the stomatal conductance not significantly,other treatments decreased by 9. 16%-19. 22%,14. 49%-32. 91%,and decreased biomass accumulation above ground by 8. 26%-27. 34% except ADINH,and increased irrigation water use efficiency by 16. 46%-60. 95% except CDINMand CDINL. Therefore,alternate drip irrigation under high N level( ADINH) is the best water and nitrogen coupling mode of young Arabica coffee tree for water efficiency. | HAO Kun LIU Xiaogang HAN Zhihui WU Helin YU Ning LIU Yanwei YANG Qiliang | 2017 | 排灌机械工程学报2017，35，10： | 3 |
| 12 | SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice显示文摘Establishment of the primordial follicle(PF)pool is pivotal for the female reproductive lifespan;however,the mechanism of primordial folliculogenesis is poorly understood.Here,the transcription factor SP1 was shown to be essential for PF formation in mice.Our results showed that SP1 is present in both oocytes and somatic cells during PF formation in the ovary.Knockdown of Sp1 expression,especially in pregranulosa cells,significantly suppressed nest breakdown,oocyte apoptosis,and PF formation,suggesting that SP1 expressed by somatic cells functions in the process of primordial folliculogenesis.We further demonstrated that SP1 governs the recruitment and maintenance of Forkhead box L2-positive(FOXL2^+)pregranulosa cells using an Lgr5-EGFP-IRES-CreER^T2(Lgr5-KI)reporter mouse model and a FOXL2^+ cell-specific knockdown model.At the molecular level,SP1 functioned mainly through manipulation of NOTCH2 expression by binding directly to the promoter of the Notch2 gene.Finally,consistent with the critical role of granulosa cells in follicle survival in vitro,massive loss of oocytes in SP1 knockdown ovaries was evidenced before puberty after the ovaries were tranSP1anted under the renal capsules.Conclusively,our results reveal that SP1 controls the establishment of the ovarian reserve by regulating pregranulosa cell development in the mammalian ovary. | Han Cai Bingying Liu Huarong Wang Guanghong Sun Lizhao Feng Ziqi Chen Jiaqi Zhou Jiawei Zhang Tuo Zhang Meina He Tingting Yang Qirui Guo Zhen Teng Qiliang Xin Bo Zhou Hua Zhang Guoliang Xia Chao Wang | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 13 | An ethnobotanical study of forage plants in Zhuxi County in the Qinba mountainous area of central China显示文摘In the Qinba mountainous area of Central China,pig farming has a significant impact on the growth of the rural economy and has substantially increased farmer incomes.Traditional knowledge plays an important role in the selection of forage plant species for pig farming by local people.This study aimed to identify the forage plants used for pig feeding and to catalog indigenous knowledge regarding their use.During 2016 and 2017,ethnobotanical surveys and inventories were conducted in Zhuxi County,Hubei Province,China.Data were collected using semi-structured interviews,key informant reports,free listings,guided field walks,and participatory observations with 77 households in 16 villages in 13 towns/townships.The obtained data were analyzed using a relative frequency citation(RFC)index.Overall,145 wild forage plants from 91 genera and 31 families were recorded.The most cited families were Asteraceae,Polygonaceae,Urticaceae,Amaranthaceae,Fabaceae,Cruciferae,Caryophyllaceae,and Lamiaceae.Whole plants(75.9%)and tender leaves(12.4%)were the most frequently used parts of the plants.Most of the forage plants were herbaceous(88.9%).Almost all forage plants could be collected throughout the year(62.7%).Raw and cooked were the two main preparation methods.The most frequently cited species were Taraxacum mongolicum,Bidens pilosa,Sonchus oleraceus,Pilea verrucosa,and Pilea pumila var.obtusifolia.A total of 14 species were identified as the top forage plants in Zhuxi County based on their RFC values(RFC value greater than 0.5).Local people possess rich traditional knowledge about the utilization and management of forage plants for pig feeding.However,the maintenance of this traditional knowledge may be seriously threatened by changes in pig feeding modes and the lack of successors.Appropriate strategies and action plans have been suggested for the conservation of traditional knowledge associated with biodiversity and the sustainable use of forage species resources.These include 1)taking targeted measures to protect forage resources and associated traditional knowledge;2)strengthening research on the forage plants with the highest RFC values for nutritional value,digestibility,other functions,and ecological status;and 3)enhancing the identification of poisonous forage plants. | Jun Yang Jifeng Luo Qiliang Gan Leiyu Ke Fengming Zhang Hairu Guo Fuwei Zhao Yuehu Wang | 2021 | Plant Diversity2021，43，3： | 3 |
| 14 | Synergistic effect between expandable graphite and ammonium polyphosphate on flame retarded polylactide显示文摘 | Hongfang Zhu Qiliang Zhu Juan Li Kang Tao Lixin Xue Qing Yan | 2010 | Polymer Degradation and Stability2010，，2： | 2 |
| 15 | Sent2Agri System Based Crop Type Mapping in Yellow River Irrigation Area显示文摘Agricultural monitoring is essential for adequate management of food production and distribution.Crop land and crop type classification,using remote sensing time series,form an important tool to capture the agricultural production information.The recently launched Sentinel-2 satellites provide unprecedented monitoring capacities in terms of spatial resolution,swath width,and revisit frequency.The Sentinel-2 for Agriculture(Sen2-Agri)system has been developed to fully exploit those capacities,by providing four relevant earth observation products for agricultural monitoring.Under the Dragon 4 Program,the crop mapping with various satellite images and a specific focus on the Yellow River irrigated agricultural area in the Ningxia Hui Autonomous Region in China was carried out with the Sentinel-2 for Agriculture system(Sent2Agri).9 types of crops were classified and the crop type map in 2017 was produced based on 35 scenes Sentinel 2A/B images.The overall accuracy computed from the error confusion matrix is 88%,which includes the cropped and uncropped types.After the removal of the uncropped area,the overall accuracy for a cropped decrease to 73%.In order to further improve the crop classification accuracy,the training dataset should be further improved and tuned. | Jinlong FAN Pierre DEFOURNY Qinghan DONG Xiaoyu ZHANG Mathilde De VROEY Nicolas BELLEMANS Qi XU Qiliang LI Lei ZHANG Hao GAO | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 16 | Regulating bifunctional flower-like NiFe_(2)O_(4)/graphene for green EMI shielding and lithium ion storage显示文摘Environment and energy are the eternal hot topics in the world,multiloculated microscale materials have attracted great attention in the field of electromagnetic interference(EMI)shielding and lithium ions storage.Herein,a novel flower-like NiFe_(2)O_(4)/graphene composite with adjustable structure was fabricated as EMI shielding material and anode material of lithium-ion batteries.NiFe_(2)O_(4)/graphene composite is a potential green EMI shielding material.The EMI shielding effectiveness(SE)increases with the increase of graphene content in NiFe_(2)O_(4)/graphene composite,and the total EMI SE of NiFe_(2)O_(4)/graphene with 73.6 wt.%graphene increases from 26.5 to 40.6 d B with the increase of frequency in 2–18 GHz.Furthermore,it exhibits long-life and large capacity lithium storage performance at high current density.The capacity reaches 732.79 m Ah g^(-1)after 100 cycles at 0.1 A g^(-1),recovering to more than 139%from the minimum capacity value.After 300 cycles at 0.5 A g^(-1),the capacity increases to 688.5 mAh g^(-1).The initial capacities at 2 and 5 A g^(-1)are 704.9 and 717.8 mAh g^(-1),and remain 297.9 and 203.2 m Ah g^(-1)after 1000 cycles.The distinguished EMI shielding performance and electrochemical performance are mainly ascribed to the structure regulation of NiFe_(2)O_(4)/graphene composite,as well as the synergistic effect of graphene and NiFe_(2)O_(4).This research opens up infinite opportunities for the application of multifunctional and interdisciplinary materials. | Lihua Yao Wenqiang Cao Jianguo Zhao Qi Zheng Yuchang Wang Shang Jiang Qiliang Pan Jie Song Youqi Zhu Maosheng Cao | 2022 | Journal of Materials Science & Technology2022，，32： | 2 |
| 17 | Manipulation of the host cell membrane by humanγ-herpesviruses EBV and KSHV for pathogenesis显示文摘The cell membrane regulates many physiological processes including cellular communication,homing and metabolism. It is therefore not surprising that the composition of the host cell membrane is manipulated by intracellular pathogens. Among these, the human oncogenic herpesviruses Epstein–Barr virus(EBV) and Kaposi's sarcoma-associated herpesvirus(KSHV)exploit the host cell membrane to avoid immune surveillance and promote viral replication.Accumulating evidence has shown that both EBV and KSHV directly encode several similar membrane-associated proteins, including receptors and receptor-specific ligands(cytokines and chemokines), to increase virus fitness in spite of host antiviral immune responses. These proteins are expressed individually at different phases of the EBV/KSHV life cycle and employ various mechanisms to manipulate the host cell membrane. In recent decades, much effort has been made to address how these membrane-based signals contribute to viral tumorigenesis. In this review, we summarize and highlight the recent understanding of how EBV and KSHV similarly manipulate host cell membrane signals, particularly how remodeling of the cell membrane allows EBV and KSHV to avoid host antiviral immune responses and favors their latent and lytic infection. | Fang Wei Qing Zhu Ling Ding Qing Liang Qiliang Cai | 2016 | Virologica Sinica2016，31，5： | 2 |
| 18 | Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration显示文摘The circadian clock participates in maintaining homeostasis in peripheral tissues,including intervertebral discs(IVDs).Abnormal mechanical loading is a known risk factor for intervertebral disc degeneration(IDD).Based on the rhythmic daily loading pattern of rest and activity,we hypothesized that abnormal mechanical loading could dampen the IVD clock,contributing to IDD.Here,we investigated the effects of abnormal loading on the IVD clock and aimed to inhibit compression-induced IDD by targeting the core clock molecule brain and muscle Arnt-like protein-1(BMAL1).In this study,we showed that BMAL1 KO mice exhibit radiographic features similar to those of human IDD and that BMAL1 expression was negatively correlated with IDD severity by systematic analysis based on 149 human IVD samples.The intrinsic circadian clock in the IVD was dampened by excessive loading,and BMAL1 overexpression by lentivirus attenuated compression-induced IDD.Inhibition of the RhoA/ROCK pathway by Y-27632 or melatonin attenuated the compression-induced decrease in BMAL1 expression.Finally,the two drugs partially restored BMAL1 expression and alleviated IDD in a diurnal compression model.Our results first show that excessive loading dampens the circadian clock of nucleus pulposus tissues via the RhoA/ROCK pathway,the inhibition of which potentially protects against compression-induced IDD by preserving BMAL1 expression.These findings underline the importance of the circadian clock for IVD homeostasis and provide a potentially effective therapeutic strategy for IDD. | Dong Wang Pandi Peng Michal Dudek Xueyu Hu Xiaolong Xu Qiliang Shang Di Wang Haoruo Jia Han Wang Bo Gao Chao Zheng Jianxin Mao Chu Gao Xin He Pengzhen Cheng Huanbo Wang Jianmin Zheng Judith A.Hoyland Qing-Jun Meng Zhuojing Luo Liu Yang | 2022 | Bone Research2022，10，2： | 2 |
| 19 | Synergistic effect between expandable graphite and ammonium polyphosphate on flame retarded polylactide显示文摘 | Hongfang Zhu Qiliang Zhu Juan Li Kang Tao Lixin Xue Qing Yan | 2010 | Polymer Degradation and Stability2010，，2： | 2 |
| 20 | Effects of an ultra-high magnetic field up to 25 T on the phase transformations of undercooled Co-B eutectic alloy显示文摘While there have been multiple recent reports in the literature focusing on the effects of magnetic field on the phase transformation behaviors,the research conducted with an ultra-high magnetic field greater than 20 T is still preliminary.In the current study,the structure evolution of Co-B alloys are experimentally studied with undercooling.The effects of a 25 T magnetic field on the solidification behavior and the subsequent solid-state phase transformation behavior have been investigated.The 25 T magnetic field is confirmed to have little effect on the homogeneous nucleation,but have some influence on the heterogeneous nucleation of Co_(3) B and Co_(23)B6 phases by modifying the wetting angleθ.The decomposition of Co_(23)B6 phase in the subsequent cooling process can be effectively suppressed by applying the 25 T magnetic field.The present work might be helpful for not only theoretically understanding the influence of ultra-high magnetic field on the phase transformation behaviors but a potential technology of field-manipulation of magnetic materials. | Yixuan He Yuhao Wua Fan Bu Chengxiong Zou Zhangchi Bian Qiliang Huang Tie Liu Qiang Wang Jun Wang Jinshan Li Eric Beaugnon | 2021 | Journal of Materials Science & Technology2021，，34： | 2 |
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