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| 1 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 2 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 3 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 4 | Osteogenic effects of D(+)β-3,4-dihydroxyphenyl lactic acid (salvianic acid A, SAA) on osteoblasts and bone marrow stromal cells of intact and prednisone-treated rats显示文摘 | Liao CUI Yu-yu LIU Tie WU Chun-mei AI Huai-qing CHEN | 2009 | Acta Pharmacologica Sinica2009，30，3： | 29 |
| 5 | Direct Transmission of Digital Message via Programmable Coding Metasurface显示文摘In modern wireless communications,digital information is frstly converted to analog signal by a digital-analog convertor,which is then mixed to high-frequency microwave to be transmitted through a series of devices including modulator,mixer,amplifer,flter,and antenna and is fnally received by terminals via a reversed process.Although the wireless communication systems have evolved signifcantly over the past thirty years,the basic architecture has not been challenged.Here,we propose a method to transmit digital information directly via programmable coding metasurface.Since the coding metasurface is composed of‘0’and‘1’digital units with opposite phase responses,the digital information can be directly modulated to the metasurface with certain coding sequences and sent to space under the illumination of feeding antenna.Te information,being modulated in radiation patterns of the metasurface,can be correctly received by multiple receivers distributed in diferent locations.Tis method provides a completely new architecture for wireless communications without using complicated digital-analog convertor and a series of active/passive microwave devices.We build up a prototype to validate the new architecture experimentally,which may fnd promising applications where information security is highly demanded. | Tie Jun Cui Shuo Liu Guo Dong Bai Qian Ma | 2019 | Research2019，，1： | 20 |
| 6 | Transurethral seminal vesiculoscopy for recurrent hemospermia: experience from 419 cases显示文摘 | Rui Chen Lei Wang Xia Sheng Shu-Guang Piao Xin-Wen Nian Xin Cheng Tie Zhou Hui-Zhen Li Ya-Wei Liu Guang-Hua Chen Chun-Lei Zhang De-Pei Kong Guang-An Xiao Xin Lu Zhen-Yu Jia Zhi-Yong Liu Ying-Hao Sun | 2018 | Asian Journal of Andrology2018，20，5： | 18 |
| 7 | Device related complications of the Coflex interspinous process implant for the lumbar spine显示文摘 | ZANG Lei DU Peng HAI Yong SU Qing-jun LU Shi-bao LIU Tie | 2013 | Chinese Medical Journal2013，，13： | 15 |
| 8 | Characterizing a large outbreak of dengue fever in Guangdong Province, China显示文摘Background:Dengue cases have been reported each year for the past 25 years in Guangdong Province,China with a recorded historical peak in 2014.This study aims to describe the epidemiological characteristics of this large outbreak in order to better understand its epidemic factors and to inform control strategies.Methods:Data for clinically diagnosed and laboratory-confirmed dengue fever cases in 2014 were extracted from the China Notifiable Infectious Disease Reporting System.We analyzed the incidence and characteristics of imported and indigenous cases in terms of population,temporal and spatial distributions.Results:A total of 45224 dengue fever cases and 6 deaths were notified in Guangdong Province in 2014,with an incidence of 47.3 per 100000 people.The elderly(65+years)represented 11.7%of total indigenous cases with the highest incidence(72.3 per 100000).Household workers and the unemployed accounted for 23.1%of indigenous cases.The majority of indigenous cases occurred in the 37th to 44th week of 2014(September and October)and almost all(20 of 21)prefecture-level cities in Guangdong were affected.Compared to the non-Pearl River Delta Region,the Pearl River Delta Region accounted for the majority of dengue cases and reported cases earlier in 2014.Dengue virus serotypes 1(DENV-1),2(DENV-2)and 3(DENV-3)were detected and DENV-1 was predominant(88.4%).Conclusions:Dengue fever is a serious public health problem and is emerging as a continuous threat in Guangdong Province.There is an urgent need to enhance dengue surveillance and control,especially for the high-risk populations in high-risk areas. | Jian-Peng Xiao Jian-Feng He Ai-Ping Deng Hua-Liang Lin Tie Song Zhi-Qiang Peng Xiao-Cheng Wu Tao Liu Zhi-Hao Li Shannon Rutherford Wei-Lin Zeng Xing Li Wen-Jun Ma Yong-Hui Zhang | 2016 | Infectious Diseases of Poverty2016，5，1： | 13 |
| 9 | Negative reflection and negative surface wave conversion from obliquely incident electromagnetic waves显示文摘Complete control of spatially propagating waves(PWs)and surface waves(SWs)is an ultimate goal that scientists and engineers seek for,in which negative reflection of PW and negative surface wave are two exotic phenomena.Here,we experimentally demonstrate an anisotropic digital coding metasurface capable of controlling both PWs and SWs with a single coding pattern.On the basis of the digital description of coding metasurfaces,a simple coding method is proposed to allow dual functionalities(either PW or SW manipulations)under two orthogonal polarizations at arbitrarily oblique incidences,thus improving the adaptability of digital coding metasurfaces in more practical circumstances.With elaborately designed ellipse-shaped coding particles,we experimentally demonstrate various functions under oblique incidences,including the negative reflection of PW,negative SW,anomalous reflection and their arbitrary combinations,all having good agreements with theoretical and numerical predictions.We believe that the proposed method may enable the digital coding metasurfaces to have broad applications in radar detections,wireless communications and imaging. | Shuo Liu Tie Jun Cui Ahsan Noor Zui Tao Hao Chi Zhang Guo Dong Bai Yan Yang Xiao Yang Zhou | 2018 | Light(Science & Applications)2018，7，1： | 10 |
| 10 | Analysis of the causes of heavy aerosol pollution in Beijing,China:A case study with the WRF-Chem model显示文摘The causes and variability of a heavy haze episode in the Beijing region was analyzed.During the episode,the PM2.5 concentration reached a peak value of 450 μg/kg on January 18,2013 and rapidly decreased to100 μg/kg on January 19,2013,characterizing a large variability in a very short period.This strong variability provides a good opportunity to study the causes of the haze formation.The in situ measurements(including surface meteorological data and vertical structures of the winds,temperature,humidity,and planetary boundary layer(PBL)) together with a chemical/dynamical regional model(WRF-Chem) were used for the analysis.In order to understand the rapid variability of the PM2.5 concentration in the episode,the correlation between the measured meteorological data(including wind speed,PBL height,relative humidity,etc.) and the measured particle concentration(PM2.5 concentration) was studied.In addition,two sensitive model experiments were performed to study the effect of individual contribution from local emissions and regional surrounding emissions to the heavy haze formation.The results suggest that there were two major meteorological factors in controlling the variability of the PM2.5 concentration,namely,surface wind speed and PBL height.During high wind periods,the horizontal transport of aerosol particles played an important role,and the heavy haze was formed when the wind speeds were very weak(less than 1 m/s).Under weak wind conditions,the horizontal transport of aerosol particles was also weak,and the vertical mixing of aerosol particles played an important role.As a result,the PBL height was a major factor in controlling the variability of the PM_(2.5) concentration.Under the shallow PBL height,aerosol particles were strongly confined near the surface,producing a high surface PM_(2.5) concentration.The sensitivity model study suggests that the local emissions(emissions from the Beijing region only)were the major cause for the heavy haze events.With only local emissions,the calculated peak value of the PM_(2.5) concentration was 350 μg/kg,which accounted for 78%of the measured peak value(450 μg/kg).In contrast,without the local emissions,the calculated peak value of the PM_(2.5) concentration was only100 μg/kg,which accounted for 22%of the measured peak value. | Hui He Xuexi Tie Qiang Zhang Xiange Liu Qian Gao Xia Li Yang Gao | 2015 | Particuology2015，13，3： | 9 |
| 11 | Circulating miRNA and cancer diagnosis显示文摘miRNAs are a class of small RNA molecules with regulatory function, and play an important role in tumor development and progression. It has been demonstrated that tumor-derived miRNAs exist in the circulating nucleic acids of cancer patients. This phenomenon implies that detection of the circulating miRNA may be an effective method for non-invasive diagnosis of cancer. In this review, we summarize the applications of the circulating miRNA as biomarkers in cancer diagnosis, as well as the latest research progress in this area. | TIE Yi1, LIU BinDong2, FU HanJiang1 & ZHENG XiaoFei1· 1 Beijing Institute of Radiation Medicine, Bejing 100850, China 2 Health Disparities/HIV Immed Ofc, Meharry Medical College, Nashville TN 37208, USA | 2009 | Science China(Life Sciences)2009，52，12： | 9 |
| 12 | Simulating hydrological responses to climate change using dynamic and statistical downscaling methods: a case study in the Kaidu River Basin, Xinjiang, China显示文摘Climate change may affect water resources by altering various processes in natural ecosystems. Dynamic and statistical downscaling methods are commonly used to assess the impacts of climate change on water resources. Objectively, both methods have their own advantages and disadvantages. In the present study, we assessed the impacts of climate change on water resources during the future periods (2020–2029 and 2040–2049) in the upper reaches of the Kaidu River Basin, Xinjiang, China, and discussed the uncertainties in the research processes by integrating dynamic and statistical downscaling methods (regional climate models (RCMs) and general circulation modes (GCMs)) and utilizing these outputs. The reference period for this study is 1990–1999. The climate change trend is represented by three bias-corrected RCMs (i.e., Hadley Centre Global Environmental Model version 3 regional climate model (HadGEM3-RA), Regional Climate Model version 4 (RegCM4), and Seoul National University Meso-scale Model version 5 (SUN-MM5)) and an ensemble of GCMs on the basis of delta change method under two future scenarios (RCP4.5 and RCP8.5). We applied the hydrological SWAT (Soil and Water Assessment Tool) model which uses the RCMs/GCMs outputs as input to analyze the impacts of climate change on the stream flow and peak flow of the upper reaches of the Kaidu River Basin. The simulation of climate factors under future scenarios indicates that both temperature and precipitation in the study area will increase in the future compared with the reference period, with the largest increase of annual mean temperature and largest percentage increase of mean annual precipitation being of 2.4°C and 38.4%, respectively. Based on the results from bias correction of climate model outputs, we conclude that the accuracy of RCM (regional climate model) simulation is much better for temperature than for precipitation. The percentage increase in precipitation simulated by the three RCMs is generally higher than that simulated by the ensemble of GCMs. As for the changes in seasonal precipitation, RCMs exhibit a large percentage increase in seasonal precipitation in the wet season, while the ensemble of GCMs shows a large percentage increase in the dry season. Most of the hydrological simulations indicate that the total stream flow will decrease in the future due to the increase of evaporation, and the maximum percentage decrease can reach up to 22.3%. The possibility of peak flow increasing in the future is expected to higher than 99%. These results indicate that less water is likely to be available in the upper reaches of the Kaidu River Basin in the future, and that the temporal distribution of flow may become more concentrated. | BA Wulong DU Pengfei LIU Tie BAO Anming LUO Min Mujtaba HASSAN QIN Chengxin | 2018 | Journal of Arid Land2018，10，6： | 8 |
| 13 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 14 | Effects of uniconazole with or without micronutrient on the lignin biosynthesis,lodging resistance,and winter wheat production in semiarid regions显示文摘Lodging stress results in grain yield and quality reduction in wheat. Uniconazole, a potential plant growth regulator significantly enhances lignin biosynthesis and thus provides mechanical strength to plants in order to cope with lodging stress. A field study was conducted during the 2015–2016 and 2016–2017 growing seasons, to investigate the effects of uniconazole sole application or with micronutrient on the lignin biosynthesis, lodging resistance, and production of winter wheat. In the first experiment, uniconazole at concentrations of 0(CK), 15(US1), 30(US2), and 45(US3) mg L^-1 was applied as sole seed soaking, while in the second experiment with manganese(Mn) at concentration of 0.06 g L^-1 Mn, 0.06 g L^-1 Mn+ 15 mg L^-1 uniconazole(UMS1), 0.06 g L^-1 Mn+30 mg L^-1 uniconazole(UMS2), and 0.06 g L^-1 Mn+45 mg L^-1 uniconazole(UMS3), respectively. Uniconazole sole application or with micronutrient significantly increased the lignin content by improving the lignin-related enzyme activities of phenylalanine ammonia-lyase, cinnamyl alcohol dehydrogenase, tyrosine ammonialyase, and peroxidase, ameliorating basal internode characteristics, and breaking strength. The spike length, spike diameter, spikes/plant, weight/spike, yield/spike, and grain yield increased and then decreased with uniconazole application at a higher concentration, where their maximum values were recorded with UMS2 and US2 treatments. The lignin accumulation was positively correlated with lignin-related enzyme activities and breaking strength while, negatively correlated with lodging rate. Uniconazole significantly improved the lignin biosynthesis, lodging resistance, and grain yield of winter wheat and the treatments which showed the greatest effects were uniconazole seed soaking with micronutrient at a concentration of 30 mg L^-1 and 0.06 g L^-1 , and uniconazole sole seed soaking at a concentration of 30 mg L^-1 . | Irshad AHMAD MENG Xiang-ping Muhammad KAMRAN Shahzad ALI Shakeel AHMAD LIU Tie-ning CAI Tie HAN Qing-fang | 2020 | Journal of Integrative Agriculture2020，19，1： | 8 |
| 15 | Intelligent coding metasurface holograms by physics-assisted unsupervised generative adversarial network显示文摘Intelligent coding metasurface is a kind of information-carrying metasurface that can manipulate electromagnetic waves and associate digital information simultaneously in a smart way.One of its widely explored applications is to develop advanced schemes of dynamic holographic imaging.By now,the controlling coding sequences of the metasurface are usually designed by performing iterative approaches,including the Gerchberg–Saxton(GS)algorithm and stochastic optimization algorithm,which set a large barrier on the deployment of the intelligent coding metasurface in many practical scenarios with strong demands on high efficiency and capability.Here,we propose an efficient non-iterative algorithm for designing intelligent coding metasurface holograms in the context of unsupervised conditional generative adversarial networks(cGANs),which is referred to as physics-driven variational auto-encoder(VAE)cGAN(VAE-cGAN).Sharply different from the conventional cGAN with a harsh requirement on a large amount of manual-marked training data,the proposed VAE-cGAN behaves in a physics-driving way and thus can fundamentally remove the difficulties in the conventional cGAN.Specifically,the physical operation mechanism between the electric-field distribution and metasurface is introduced to model the VAE decoding module of the developed VAE-cGAN.Selected simulation and experimental results have been provided to demonstrate the state-of-the-art reliability and high efficiency of our VAE-cGAN.It could be faithfully expected that smart holograms could be developed by deploying our VAE-cGAN on neural network chips,finding more valuable applications in communication,microscopy,and so on. | Che Liu Wen Ming Yu Qian Ma Lianlin Li Tie Jun Cui | 2021 | Photonics Research2021，9，4： | 7 |
| 16 | Study on novel eco-friendly anti-creasing agents for natural silk fabric显示文摘三个新奇 eco 友好的弄皱反的代理人被设计了并且综合。与他们一起对待的自然丝绸织物比与 1,2,3,4 钢瓶煤气 tetracarboxylic 酸(BTCA ) 完成的那些展出更高的皱纹恢复度,力量保留率和白色。与综合混合物和 BTCA 对待的织物的洗的耐久性是类似的。在综合结构和丝绸织物的表面粗糙的氯原子, carboxyl 和 s-triazine 戒指都对丝绸的缝隙抵抗的改进贡献。 | Xiao Shan Liu Tie Ling Xing Dong Mei Xu Guo Qiang Chen | 2012 | Chinese Chemical Letters2012，23，6： | 7 |
| 17 | Intelligent metasurfaces:control,communication and computing显示文摘Controlling electromagnetic waves and information simultaneously by information metasurfaces is of central importance in modern society.Intelligent metasurfaces are smart platforms to manipulate the wave-information-matter interactions without manual intervention by synergizing engineered ultrathin structures with active devices and algorithms,which evolve from the passive composite materials for tailoring wave-matter interactions that cannot be achieved in nature.Here,we review the recent progress of intelligent metasurfaces in wave-information-matter controls by providing the historical background and underlying physical mechanisms.Then we explore the application of intelligent metasurfaces in developing novel wireless communication architectures,with particular emphasis on metasurface-modulated backscatter wireless communications.We also explore the wave-based computing by using the intelligent metasurfaces,focusing on the emerging research direction in intelligent sensing.Finally,we comment on the challenges and highlight the potential routes for the further developments of the intelligent metasurfaces for controls,communications and computing. | Lianlin Li Hanting Zhao Che Liu Long Li Tie Jun Cui | 2022 | eLight2022，2，1： | 7 |
| 18 | Research on carbon and oxygen isotopes in phosphorus-bearing rock series of the Late Neoproteroic-Early Cambrian Taozichong Formation in Qingzhen City, Guizhou Province, Southwest China显示文摘In the study of the phosphate-bearing stratum at the bottom of the Cambrian system, the authors found that there occurred carbon isotope negative anomalies in the Taozichong section phosphate-bearing stratum in Qingzhen, Guizhou Province; they can be correspondingly compared with other synsedimentary carbon isotope negative anomalies both at home and abroad. The results showed that there occurred three negative anomalies of carbon isotopes in the Neoproterozoic-Early Cambrian Taozichong Formation, indicating that the temporal palaeo-oceanographical environment changed significantly, in which there happened two times of intensive carbon isotope variation, corresponding to creature extinction. Meanwhile, it is believed that the carbon isotope negative anomalies in phosphorites were caused by the ascending water mass of ocean current with the negative carbon isotopic composition of deep-ocean hydrothermal deposits. | MAO Tie YANG Ruidong MAO Jiaren YE Chun LIU Kun GAO Junbo | 2014 | Chinese Journal Of Geochemistry2014，33，4： | 6 |
| 19 | Breast Cancer Subtypes and Survival in Chinese Women with Operable Primary Breast Cancer显示文摘Objective: To investigate the associations between the different breast cancer subtypes and survival in Chinese women with operable primary breast cancer. Methods: A total of 1538 Chinese women with operable primary breast cancer were analyzed in this study, the median follow-up was 77 months. Estrogen receptor (ER), progesterone receptor (PR), and HER2 status were available for these patients. Results: Luminal A (ER+ and/or PR+, HER2-) had a favorable disease-free survival (DFS) and overall survival (OS) compared with other subtypes in the entire cohort. Using the luminal A as a reference, among the patients with lymph node positive disease, HER2+ (ER-, PR-, HER2+) had the worst DFS (hazard ratio, HR=1.80, 95% CI 1.11 to 2.91, P=0.017) and luminal B (ER+ and/or PR+, HER2+) had the worst OS (HR=2.27, 95% CI 1.50 to 3.45, P<0.001); among the patients with lymph node negative disease, triple-negative (ER-, PR-, HER2-) had the worst DFS (HR=2.21, 95% CI 1.43 to 3.41, P<0.001), whereas no significant difference in DFS between HER2+ and luminal B or luminal A was observed. Conclusion: As compared with luminal A, luminal B and HER2+ have the worst survival in patients with lymph node positive disease, but this is not the case in patients with lymph node negative disease; triple-negative subtype has a worse survival in both lymph node positive and lymph node negative patients. | Zhao-sheng Li Lu Yao Yi-qiang Liu Tao Ouyang Jin-feng Li Tian-feng Wang Zhao-qing Fan Tie Fan Ben-yao Lin Yun-tao Xie | 2011 | Chinese Journal of Cancer Research2011，23，2： | 6 |
| 20 | Topologically Protected Edge State in Two-Dimensional Su–Schrieffer–Heeger Circuit显示文摘Topological circuits,an exciting feld just emerged over the last two years,have become a very accessible platform for realizing and exploring topological physics,with many of their physical phenomena and potential applications as yet to be discovered.In this work,we design and experimentally demonstrate a topologically nontrivial band structure and the associated topologically protected edge states in an RF circuit,which is composed of a collection of grounded capacitors connected by alternating inductors in the x and y directions,in analogy to the Su–Schriefer–Heeger model.We take full control of the topological invariant(i.e.,Zak phase)as well as the gap width of the band structure by simply tuning the circuit parameters.Excellent agreement is found between the experimental and simulation results,both showing obvious nontrivial edge state that is tightly bound to the circuit boundaries with extreme robustness against various types of defects.Te demonstration of topological properties in circuits provides a convenient and fexible platform for studying topological materials and the possibility for developing fexible circuits with highly robust circuit performance. | Shuo Liu Wenlong Gao Qian Zhang Shaojie Ma Lei Zhang Changxu Liu Yuan Jiang Xiang Tie Jun Cui Shuang Zhang | 2019 | Research2019，，1： | 6 |
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