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| 1 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 2 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 3 | De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation显示文摘Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence-a662-bp intronic insertion in the SCUBE2 gene-is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies. | Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su | 2020 | National Science Review2020，7，2： | 4 |
| 4 | Selective adsorption of silver ions from aqueous solution using polystyrene-supported trimercaptotriazine resin显示文摘Trimercaptotriazine-functionalized polystyrene chelating resin was prepared and employed for the adsorption of Ag(I)from aqueous solution.The adsorbent was characterized according to the following techniques:Fourier transform infrared spectroscopy,elemental analysis,scanning electron microscopy and the Brunauer-Emmet-Teller method.The effects of initial Ag(I)concentration,contact time,solution pH and coexisting ions on the adsorption capacity of Ag(I)were systematically investigated.The maximum adsorption capacity of Ag(I)was up to 187.1 mg/g resin at pH 0.0 and room temperature.The kinetic experiments indicated that the adsorption rate of Ag(I)onto the chelating resin was quite fast in the first 60 min and reached adsorption equilibrium after 360min.The adsorption process can be well described by the pseudo second-order kinetic model and the equilibrium adsorption isotherm was closely fitted by the Langmuir model.Moreover,the chelating resin could selectively adsorb more Ag(I)ions than other heavy metal ions including:Cu(II),Zn(II),Ni(II),Pb(II)and Cr(III)during competitive adsorption in the binary metal species systems,which indicated that it was a highly selective adsorbent of Ag(I)from aqueous solution. | Shiming Wang Hongling Li Xiaoya Chen Min Yang Yanxing Qi | 2012 | Journal of Environmental Sciences2012，24，12： | 4 |
| 5 | Subjective tinnitus: lesion-induced pathological central homeostasis remodeling显示文摘Subjective tinnitus is the most common type of tinnitus, which is the manifestation of pathologicalactivities in the brain. It happens in a substantial portion of the general population and brings significantburden to the society. Severe subjective tinnitus can lead to depression and insomnia and severely affectspatients’ quality of life. However, due to poor understanding of its etiology and pathogenesis, treatmentof subjective tinnitus remains challenging. In recent decades, a growing number of studies have shownthat subjective tinnitus is related to lesion-induced neural plasticity of auditory and non-auditory centralsystems. This article reviews cellular mechanisms of neural plasticity in subjective tinnitus to providefurther understanding of its pathogenesis. | Qi Zhang Lidong Zhao Weidong Shen Shiming Yang | 2021 | Journal of Otology2021，16，4： | 2 |
| 6 | Thermogravimetric analysis of co-combustion of biomass and biochar显示文摘 | Qiguo Yi Fangjie Qi Gong Cheng Yongguang Zhang Bo Xiao Zhiquan Hu Shiming Liu Haiyan Cai Shan Xu | 2013 | Journal of Thermal Analysis and Calorimetry2013，，3： | 1 |
| 7 | A Simulation Study on A Solar Heat Pump Heating System with Seasonal Latent Heat Storage 显示文摘 | Qi Qi Shiming Deng Yiqiang Jiang | 2008 | Solar Energy2008，8，： | 1 |
| 8 | A simulation study on a solar heat pump heating system with sea- sonal latent heat storage 显示文摘 | Qi Qi Deng Shiming Jiang Yiqiang | 2008 | Solar Energy2008，82，： | 1 |
| 9 | Assessment on contaminations in sediments of an intake and the inflow canals in Taihu Lake, China显示文摘作为在中国的第二个最大的淡水湖,泰胡·莱克在湖附近提供水供应给约 3200 万个居民。然而,戏剧性地增加了污染威胁了在最近的年里喝水供应的安全。在现在的学习,我们在 Gonghu 海湾在吸入和流入运河的沉积调查了营养素和重金属的污染,泰胡·莱克。而且,我们也在污染的空间分发特征上检验了人的活动的影响。我们的结果证明吸入与流入运河相比介绍了磷和氮的相对更低的集中。然而,在吸入的沉积的 Cr, Ni, Cu, Zn 和 Pb 的集中超过了最低效果水平(LEL ) 价值,显示潜在的风险到喝水资源。另外,在 Tianji 运河和 Jinshu 运河的沉积的 Ni 的集中超过了严重效果水平(SEL ) 价值。更重要地,在 Tianji 运河的沉积的 Cu 的集中超过了价值三次 SEL。Multivariate 统计分析证实国内污水首先贡献了滋养的累积,并且电子垃圾的漏在沉积统治了金属的丰富。一起拿,更多的努力应该被作在泰胡·莱克保证水资源的安全,特别为国内污水和工业废水的处理。 | Xiaolong WANG Shiming DING Qi ZHANG Weiping HU | 2015 | Frontiers of Environmental Science & Engineering2015，9，4： | 1 |
| 10 | A simulation study on a solar heat pump heating system with seasonal latent heat storage显示文摘 | Qi Qi Deng Shiming Jiang Yiqiang | 2008 | Solar Energy2008，82，8： | 1 |
| 11 | THE CITY'S PICTURESQUE COUNTRYSIDE显示文摘In recent years,Beijing has been implementing President Xi Jinping's instruction,stating,'Lucid waters and lush mountains are invaluable assets'Many important efforts are being made to promote the all-around enhancement of the city's countryside areas.By carrying out a range of projects,Bejing has improved the living environments of its 3,254 villages.More and more of the city's beautiful villages are becoming popular attractions,highlighting Beijing's harmonious and sustainable nature. | Wang Wei Brad Green Huang Guanhai Li Guizhen Qi Shiming Song Jianguo Xiao Xinjia Zhang Guangmin Zhao Shusheng | 2021 | Beijing2021，，27： | 0 |
| 12 | Identification of Styryl Sulfonyl Fluoride as a Near-Perfect Michael Acceptor for Diversified Protein Bioconjugations显示文摘Cysteine(Cys)-specific bioconjugation has widespread applications in the synthesis of protein conjugates,particularly for the functionalization of antibodies.Here,we report the discovery of transstyryl sulfonyl fluoride(SSF)as a near-perfect Michael acceptor for Cys-specific protein bioconjugation.Compared to maleimides,which are predominantly used,SSF exhibited better chemoselectivity,selfstability,and conjugate stability while maintaining comparable reactivity.Using SSF-derived probes,proteins can be readily modified on the Cys residue(s)to install functionalities,for example,fluorescent dyes,toxins,and oligonucleotides,without influencing the activity.Further applications of SSF-derived serum-stable antibody-drug conjugates and PD-L1 nanobody-oligo conjugates demonstrate the great translational value of SSF-based bioconjugation in drug development and single-cell sequencing. | Qingsong Wu Qi Xue Ji Li Qinheng Zheng Xinlu Zhao Wannan Li Shiming Sun Wanxing Sha Yang Yang Yi Yang Jie P.Li | 2023 | CCS Chemistry2023，5，10： | 0 |
| 13 | REVIVING THE CITY'S RIVERS显示文摘0n September 27,with the opening of the Qujiadian hydro-junction,the 865-kilometre(km)channel of the Yongding River was replenished with water and connected once again to the Bohai Sea.In recent times,Beijing has been carrying out ecological water replenishment for the channels of various rivers throughout the city.In addition to the Yongding River,the entire channels of the Chaobai,Beiyunhe,Juhe and Juma rivers have already been reflled with water and connected to the Bohai Sea.These five major rivers in the city do not flow into Bohai Sea at the same location.Using multiple sources,basins and approaches,these rivers,with their replenished water,are now connected to the sea for the first time. | Wang Wei(Translated) Brad Green Feng Yongguo(Photos) Hu Shengli(Photos) Qi Shiming(Photos) Wei Zheng(Photos) Xiao Zhuang(Photos) | 2021 | Beijing2021，，43： | 0 |
| 14 | THE CITY'S MOUNTAINS AND WATER显示文摘Aselection of excellent photos from the 12th'Love Beijing,Focus on Beijing'public photography event are on display at the Capital Museum.The 2021 event,with its theme of'Beijing:A Happy and Prosperous City'has attracted scores of photography enthusiasts and audiences who are eager to enjoy Beijing's highlights through the medium of photography.Attendees at the museum's exhibit were thilled about what they have seen.'This is Beijing through the lens of ordinary people who love the city'one attendee commented.'These photographs enable us to see the latest,the best and the most beautiful version of Beijing,'said another.He continued,'Because these photos so perfectly reflect the spirit of the city,they could have only been shot by photographers with a real passion for Beijing' | Wang Wei An Xiufang Chen Limin Li Jintao LI Zhiming QI Shiming Tian Jun Zhao Guangming | 2021 | Beijing2021，，25： | 0 |
| 15 | Characteristics of distribution of heavy metals insediment of Le An River显示文摘Heavy metals in core samples of Caijiawan and Hushan of Jiangxi Province, China were studied.The results indicated that the sediments of Caijiawan and Hushan were heavily polluted by Cu , Zn, Cd, Pb.Almost all of the elements have the similar profile shap | Li Qi (Research Center for Eco - Environmental Sciences,Chinese Academy of Sciences , BeiJing 100085 , China)Chen Shiming (Nanchang Institute of Aeronautical Technology . Nanchang 330034 , China) A. Yahya (Institute for Sedimentology, University of Heid | 1995 | Journal of Environmental Sciences1995，7，2： | 0 |
| 16 | Potential application of proteolysis targeting chimera(PROTAC)modification technology in natural products for their targeted protein degradation显示文摘There are numerous evaluations of natural products,of which majority are food bioactives,performed up to date for their various health beneficial activities via targeting specific proteins.However,the direct identification of a targeted protein remains unexplored for natural occurring compounds.Proteolysis targeting chimera(PROTAC)is a type of bifunctional chimeric molecules that can directly degrade the binding proteins targeted by bioactive molecules in an ubiquitin-proteasome pathway.As the agents in protein degradation dependent on ubiquitin ligase,the bifunctional molecule connects the target protein ligand and E3 ligase ligand together via an appropriate linker.It is highly selective and efficient to induce the ubiquitin-mediated degradation of targeted binding proteins.Therefore,it has been demonstrated that the PROTAC technology has broad application in the modulation of the target protein level.In this review,we outlined the advances in PROTAC combined molecule compounds,summarized its quantitative structure-activity relationship,and finally reviewed the methods applied in identifying the target proteins of natural products.We hope it will provide an insightful application of PROTAC techniques in the target protein identification of natural products including food bioactive molecules. | Guliang Yang Haiyan Zhong Xinxin Xia Zhiwen Qi Chengzhang Wang Shiming Li | 2022 | Food Science and Human Wellness2022，11，2： | 0 |
| 17 | Bilateral Filter for the Optimization of Composite Structures显示文摘In the present study,we propose to integrate the bilateral filter into the Shepard-interpolation-based method for the optimization of composite structures.The bilateral filter is used to avoid defects in the structure that may arise due to the gap/overlap of adjacent fiber tows or excessive curvature of fiber tows.According to the bilateral filter,sensitivities at design points in the filter area are smoothed by both domain filtering and range filtering.Then,the filtered sensitivities are used to update the design variables.Through several numerical examples,the effectiveness of the method was verified. | Yuhang Huo Ye Tian Shiming Pu Tielin Shi Qi Xia | 2021 | Computer Modeling in Engineering & Sciences2021，，6： | 0 |
| 18 | Formulation and Antioxidant Activity Evaluation of Theaflavin Effervescent Tablet显示文摘Theaflavins(TFs),as the major polyphenolic components of fermented tea,possess beneficial effects on human health.In this study,the effervescent tablets based on theaflavins were developed.The optimal formulation of TF effervescent tablets was obtained by response surface methodology with the Box-Behnken design.Then,the physiochemical properties were evaluated,including hardness,friability,effervescent time and pH of the solution.At last,the antioxidant ability of TF effervescent tablets was studied through DPPH and ABTS radical scavenging assay.According to the results,the optimal formulation of the tablets contained TF powder 9.09%,disintegrating agent 43.80%(the weight ratio of citric acid and sodium bicarbonate was 1:1),aspartame 1.86%,PEG-6003%,and mannitol in balance.With the wet granulation method,the TF effervescent tablets displayed suitable hardness,fast disintegration time,good color,pleasant taste and high antioxidant activity.This study demonstrated that the TF effervescent tablets could be a valuable product for the supplement market and contribute to promoting practical application of TFs. | Wenjing QI Xueying WANG Zhiling HU Qi ZHENG Qiyuan MAO Shiming LI Chang LIU | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
| 19 | Assessing spatiotemporal variations of forest carbon density using bi-temporal discrete aerial laser scanning data in Chinese boreal forests显示文摘Assessing the changes in forest carbon stocks over time is critical for monitoring carbon dynamics,estimating the balance between carbon uptake and release from forests,and providing key insights into climate change mitigation.In this study,we quantitatively characterized spatiotemporal variations in aboveground carbon density(ACD)in boreal natural forests in the Greater Khingan Mountains(GKM)region using bi-temporal discrete aerial laser scanning(ALS)data acquired in 2012 and 2016.Moreover,we evaluated the transferability of the proposed design model using forest field plot data and produced a wall-to-wall map of ACD changes for the entire study area from 2012 to 2016 at a grid size of 30 m.In addition,we investigated the relationships between carbon dynamics and the dominant tree species,age groups,and topography of undisturbed forested areas to better understand ACD variations by employing heterogeneous forest canopy structural characteristics.The results showed that the performance of the temporally transferable model(R^(2)=0.87,rRMSE=18.25%),which included stable variables,was statistically equivalent to that obtained from the model fitted directly by the 2016 field plots(R^(2)=0.87,rRMSE=17.47%).The average rate of change in carbon sequestration across the entire study region was 1.35 Mg⋅ha^(-1)⋅year^(-1) based on the changes in ALS-based ACD values over the course of four years.The relative change rates of ACD decreased as the elevation increased,with the highest and lowest ACD growth rates occurring in the middle-aged and mature forest stands,respectively.The Gini coefficient,which represents forest canopy surface structure heterogeneity,is sensitive to carbon dynamics and is a reliable predictor of the relative change rate of ACD.This study demonstrated the applicability of bi-temporal ALS for predicting forest carbon dynamics and fine-scale spatial change patterns.Our research contributed to a better understanding of the in-fluence of remote sensing-derived environmental variables on forest carbon dynamic patterns and the development of context-specific management approaches to increase forest carbon stocks. | Zhiyong Qi Shiming Li Yong Pang Guang Zheng Dan Kong Zengyuan Li | 2023 | Forest Ecosystems2023，10，5： | 0 |
| 20 | Anti-apoptotic effects of recombinant human granulocyte colony-stimulating factor in focal cerebral ischemic rats显示文摘The neuroprotective effects of granulocyte colony-stimulating factor in cerebral ischemia/reperfusion injury are currently contentious. The present study examined the effects of subcutaneous injection of recombinant human granulocyte colony-stimulating factor (50 μg/kg) over 5 days in a model of cerebral ischemia/reperfusion with intraluminal filament occlusion in rats. The results indicated that recombinant human granulocyte colony-stimulating factor reduced brain infarct volume following cerebral ischemia/reperfusion injury in rats, down-regulated the expression of caspase-3 mRNA (a key protease for apoptosis in the cerebral ischemia zone), lowered the rate of neuronal apoptosis in the cerebral ischemia zone, and notably ameliorated neurological function. These results indicate that recombinant human granulocyte colony-stimulating factor has anti-apoptotic effects on neurons following focal cerebral ischemia/reperfusion injury, and exerts neuroprotective effects. | Xia Yuan Shiming Zhang Wanli Dong Qi Fang | 2011 | Neural Regeneration Research2011，6，11： | 0 |
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