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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Fructus Broussonetae extract improves cognitive function and endoplasmic reticulum stress in Alzheimer's disease models显示文摘This study investigated the effects and possible targets of Fructus Broussonetiae extract,a traditional Chinese medicinal herb,on a model of Alzheimer's disease induced by beta-amyloid peptide 25-35 and D-galactose.The results revealed that intragastric administration of Fructus Broussonetiae significantly increased the expression of immunoglobulin-binding protein,a key factor in the endoplasmic reticulum stress-signaling pathway in rat hippocampus.In contrast,the treatment significantly decreased expression levels of PKR-like endoplasmic reticulum kinase and C/EBP homologous protein,and substantially improved learning,memory and spatial recognition dysfunction in rats.This evidence indicates that Fructus Broussonetiae extract improves spatial learning and memory abilities in rats by affecting the regulation of hippocampal endoplasmic reticulum stress and activation of the apoptosis pathway. | Yinghong Li Li Hu Zhengzhi Wu Zhiling Yu Meiqun Cao Kehuan Sun Yu Jin Anmin Wu Andrew CJ Huang | 2011 | Neural Regeneration Research2011，6，30： | 7 |
| 3 | Covalent organic frameworks functionalized carbon fiber paper for the capture and detection of hydroxyl radical in the atmosphere显示文摘Developing a fast,sensitive and convenient method for the detection of hydroxyl radicals(·OH) in the atmosphere could help us know the precursor levels of atmospheric species and control air pollution.In this work,the carbon fiber paper(CFP) functionalizing with a kind of covalent organic frameworks(COFs),formed from 1,3,5-triformylphloroglucinol(Tp) and benzidine(BD)(COF(TpBD)),was firstly used a new platform for ·OH trapping and detection.The COF(TpBD) modified CFP was acted as a filter to impregnate salicylic acid(SA) and a detector to detect 2,5-dihydroxybenzoic acid(2,5-DHBA) which was produced from the reaction between the impregnated SA and ’OH in the atmosphere.This method provided a linearity for 2,5-DHBA from 5.0×10^-14 mol/L 1.0×10^-9 mol/L with a detection limit of 6.9×10^-15 mol/L,which is corresponding to the amount of ·OH from 3.0×10^7 to 6.0×10^11 molecules/cm3 with the detection limit of 4.1×10^6 molecules/cm3.This COF(TpBD)-CFP platform has been successfully applied for the detection of ·OH concentration under different conditions of Yangzhou when the sampling time was shortened to 30 min.This work has provided a new method for atmospheric·OH detection with excellent sensitivity,simplicity,and high speed. | Zhiling Huang Qin Xu Xiaoya Hu | 2020 | Chinese Chemical Letters2020，31，9： | 2 |
| 4 | Compatibili- zation of Intumescent Flame Retardant/Polypropylene Composites Based on Alpha-methacrylic Acid Grafted Pol- ypropylene 显示文摘 | Ma Zhiling Zhao Min Hu Hanfang | 2002 | Journal of Applied Polymer Science2002，83，14： | 1 |
| 5 | Comprehensive chemical analysis of Venenum Bufonis by using liquid chromatog- raphy/electrospray ionization tandem mass spectrometry 显示文摘 | Hu Yongmei Yu Zhiling Yang Zhijun | 2011 | J Pharm Biomed Anal2011，56，： | 1 |
| 6 | Compati- bilization of Intumescent Flame Retardant/Polypropylene Composites Based on o-Methacrylic Acid Grafted Polypropylene显示文摘 | Ma Zhiling Zhao Min Hu Hanfang | 2002 | Journal of Applied Polymer Science2002，83，14： | 1 |
| 7 | Compatibilization of Intumesent flame retardant/polypropylene composites based on α-methacrylic acid grafted polypropylene 显示文摘 | Ma Zhiling Zhao Min Hu Hanfang | 2002 | J Appl Polym Sci2002，83，： | 1 |
| 8 | Comprehensive chemi- cal analysis of Venenum Bufonis by using liquid chromatography/ electrospray ionization tandem mass spectrometry 显示文摘 | Hu Yongmei Yu Zhiling Yang Z J | 2011 | J Pharm Bi- omed Anal2011，56，： | 1 |
| 9 | Clinical Analysis of GPT Alteration of Constructors for Qinghai-Tibetan Railroad at Different Altitude Areas显示文摘Objective: To observe the effect of hypoxia on the liver function of constructors at high altitude. Method: Select 221 constructors aged 23~42 as subjects, who had worked for 3~6 months at 4500 m. Collect venous blood from fasting subjects and determine GPT by new Lai’s Method from “The Nationwide Clinical Inspection Operating Rules'. Results: The study indicated that the GPT of 45 subjects among Group 1 were abnormal, with the proportion of 20.3%. The peak of GPT appeared when subjects exposed to high altitude of 4500m for 1 month, and the mean value was 83.76±9.23.The GPT of workers were higher than that of administers at different altitude (p<0.05). And the GPT of subjects at 4500 m were higher than those at 3500 m (p<0.05). We can find a degrading tendency with the increasing of working time (p<0.05). There was significantly statistic difference between two groups. Conclusions: The study confirmed that hypoxia could cause the change of liver function mildly and moderately. And there was a positive correlation between the degree of hypoxia and liver function. But, the change began to become a decreasing trend when people went on working longer. We also found that the change of liver structure and function at high altitude correlated with several factors else, including labor, individual difference, methods and sensitivity to the test. However, the explanation of its key mechanism deserves further investigation. | Peng Quansheng Yuan Zhengcai Wang Zhengjiang Wu Zhiling Zhang Xinxia Ge Rili Jin Guoen Hu Ying | 2006 | 工程科学(英文版)2006，4，2： | 0 |
| 10 | Flexible feeding patterns of copepod Centropages tenuiremis in fluctuating conditions: a possible survival strategy to cope with disturbance显示文摘Centropages tenuiremis is a species with a wide distribution range in disturbed coastal waters.However,due to a lack of dietary information,it remains unclear as to how they maintain such dominance in fluctuating conditions.In this study,C.tenuiremis was collected from the Daya Bay Nuclear Power Plant both in inlet and outfall regions at 06:00,12:00 and 18:00 on April 27,2011 and their in situ diet was analyzed using a PCR protocol targeting 18S ribosomal genes.Thirty-four species of prey organisms were identified totally,including Dinophyta,Baciliariophyta,Viridiplantae,Rhizaria,Apicomplexa,Chordata,Mollusca,Arthropoda and Fungi,indicating an obvious omnivorous feeding habit of C.tenuiremis.Centropages tenuiremis obviously exhibited spatial and temporal variations in diet composition.More plant prey(land plants and phytoplankton)were consumed in the morning(~50%),while more animal prey(metazoans and protozoans)were ingested at midday and night(60%–70%).Furthermore,a more diverse diet was detected in the outfall region(10–11 taxa),where the temperatures were relatively higher and more fluctuating,than in the control region(5–10 taxa).This finding indicated that C.tenuiremis could potentially expand its food spectrum under stressful condition.Specifically,C.tenuiremis exhibited phytoplankton preference(58.62%–67.64%)in the outfall region with a lower omnivory index(0.27–0.35)than in the control region(0.51–0.95).However,phytoplankton density was lower than that in the control region,suggesting a possible herbivorous tendency of C.tenuiremis under elevated temperatures to balance the energy acquirement and feeding effort.The flexible food choices of C.tenuiremis observed here could effectively buffer environmental fluctuations and might be an important survival strategy in coastal ecosystems. | Cuilian Xu Simin Hu Zhiling Guo Tao Li Hui Huang Leo Lai Chan Sheng Liu | 2020 | Acta Oceanologica Sinica2020，39，2： | 0 |
| 11 | The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells显示文摘In this study,we established cell models for Parkinson's disease using rotenone.An RNA interference vector targeting Parkin-associated endothelin receptor-like receptor(Pael-R) was transfected into the model cells.The results of reverse-transcription polymerase chain reaction and western blot analysis showed that Pael-R expression was decreased after RNA interference compared with the control group(no treatment) and the model group(rotenone treatment),while the rate of apoptosis and survival of dopaminergic cells did not differ significantly between groups,as detected by flow cytometry and an MTT assay.These experimental findings indicate that the Pael-R gene has no role in the changes in rotenone-induced Parkinson's disease model cells. | Ting Zou Xiangqi Tang Zhiling Huang Niangui Xu Zhiping Hu | 2014 | Neural Regeneration Research2014，9，4： | 0 |
| 12 | Synthesis, Structural Characterization,and Electrochemical Properties of Binuclear Copper(Ⅱ) Complexes Containing Tetradentate Schiff Base Ligand显示文摘Two binuclear copper(Ⅱ) complexes, [Cu2(saloph)2 (μ-O)2]-2(DMF)[H2saloph=N,N′-o-phenylenebis(salicylideneaminato)] (a) and [Cu2(salen)2(μ-O)2] [H2salen=N,N′-bis(salicylic-deneaminato) ethylene] (b)were synthesized and characterized by X-ray crystallography. Both of them have distorted rectangular pyramidal geometry around Cu(Ⅱ). The complete series of complexes show bridging phenoxo groups between the copper centers, together with hydroxo-bridges in these complexes. The complexes have also been characterized by elemental analysis, IR, TG-DTA, and electrochemical results. | DING Yu HU Xiaoxia SUN Xiaoli ZUO Zhiling | 2010 | Wuhan University Journal of Natural Sciences2010，15，2： | 0 |
| 13 | Formulation and Antioxidant Activity Evaluation of Theaflavin Effervescent Tablet显示文摘Theaflavins(TFs),as the major polyphenolic components of fermented tea,possess beneficial effects on human health.In this study,the effervescent tablets based on theaflavins were developed.The optimal formulation of TF effervescent tablets was obtained by response surface methodology with the Box-Behnken design.Then,the physiochemical properties were evaluated,including hardness,friability,effervescent time and pH of the solution.At last,the antioxidant ability of TF effervescent tablets was studied through DPPH and ABTS radical scavenging assay.According to the results,the optimal formulation of the tablets contained TF powder 9.09%,disintegrating agent 43.80%(the weight ratio of citric acid and sodium bicarbonate was 1:1),aspartame 1.86%,PEG-6003%,and mannitol in balance.With the wet granulation method,the TF effervescent tablets displayed suitable hardness,fast disintegration time,good color,pleasant taste and high antioxidant activity.This study demonstrated that the TF effervescent tablets could be a valuable product for the supplement market and contribute to promoting practical application of TFs. | Wenjing QI Xueying WANG Zhiling HU Qi ZHENG Qiyuan MAO Shiming LI Chang LIU | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
| 14 | Transfer Behavior of Carbendazim from Dried Yingshan Yunwu Tea Leaves into Tea Infusions显示文摘Tea infusion is the main route of human exposure to pollutants in tea,and it is vital to investigate the transfer rate of pollutants from tea leaves to infusion.Carbendazim is a commonly used systemic fungicide,the transfer behavior of which in Yingshan Yunwu tea is not clear.Hence,this study firstly established the analytical method for determination of carbendazim with great accuracy and precision via modified QuEChERS method and ultra-performance liquid chromatography-fluorescence detection(UPLC-FLD).Then,the transfer behavior of carbendazim from tea leaves and infusion was systematically investigated.Results indicated that water temperature and proportion of tea to water ration would obviously increase the transfer rate of carbendazim,but times of infusion repetition showed negative correlation with the transfer rate of carbendazim.In addition,brewing time seemed to have lesser impact on the transfer rate.This study will be helpful for the risk assessment of carbendazim residue and provide the guidance for tea brewing. | Xinyu LIU Yuchao TIAN Haijian LIU Qingling ZHU Nan LUO Zhiling HU Chang LIU | 2023 | Agricultural Biotechnology2023，12，5： | 0 |
| 15 | Effects of Househould Cleaning Methods on Carbendazim Residue in Apples显示文摘Carbendazim,belonging to fungicides,was commonly used for controlling crop diseases,resulting in frequent residues in fruits and vegetables.Washing was the initial step of household fruit processing for cleaning and reducing pollutant contents.However,the effect of washing on the removal of carbendazim in apples was not systemically studied.Thus,in this study,an analytical method was firstly established for the determination of carbendazim with great accuracy and precision through quick,simple,cheap,effective and safe(QuEChERS)method and ultra-performance liquid chromatography-fluorescence detection(UPLC-FLD).Then,the influencing factors were systematically researched to unveil their effects on the carbendazim residue in apples.The results indicated that water temperature,washing products and washing method could obviously affect the carbendazim content in apples.In addition,the best cleaning scheme for removal of carbendazim was soaking apples for 5 min in a cleaning solution,which was prepared by dissolving 8 g of commercial fruit washing soup with 500 ml of water at 45℃.Under this condition,the removal rate of carbendazim in the washing step reached 73.91%.This study will be helpful for providing guidance for household cleaning methods for controlling pesticide residues. | Zhiling HU Yuchao TIAN Qingling ZHU Haijian LIU Nan LUO Fan WANG Ziyi ZHANG Furong LIU Chang LIU Mengrong CHENG | 2023 | Agricultural Biotechnology2023，12，6： | 0 |
| 16 | Novel biomarkers identifying hypertrophic cardiomyopathy and its obstructive variant based on targeted amino acid metabolomics显示文摘Background:Hypertrophic cardiomyopathy(HCM)is an underdiagnosed genetic heart disease worldwide.The management and prognosis of obstructive HCM(HOCM)and non-obstructive HCM(HNCM)are quite different,but it also remains challenging to discriminate these two subtypes.HCM is characterized by dysmetabolism,and myocardial amino acid(AA)metabolism is robustly changed.The present study aimed to delineate plasma AA and derivatives profiles,and identify potential biomarkers for HCM.Methods:Plasma samples from 166 participants,including 57 cases of HOCM,52 cases of HNCM,and 57 normal controls(NCs),who first visited the International Cooperation Center for HCM,Xijing Hospital between December 2019 and September 2020,were collected and analyzed by high-performance liquid chromatography-mass spectrometry based on targeted AA metabolomics.Three separate classification algorithms,including random forest,support vector machine,and logistic regression,were applied for the identification of specific AA and derivatives compositions for HCM and the development of screening models to discriminate HCM from NC as well as HOCM from HNCM.Results:The univariate analysis showed that the serine,glycine,proline,citrulline,glutamine,cystine,creatinine,cysteine,choline,and aminoadipic acid levels in the HCM group were significantly different from those in the NC group.Four AAs and derivatives(Panel A;proline,glycine,cysteine,and choline)were screened out by multiple feature selection algorithms for discriminating HCM patients from NCs.The receiver operating characteristic(ROC)analysis in Panel A yielded an area under the ROC curve(AUC)of 0.83(0.75-0.91)in the training set and 0.79(0.65-0.94)in the validation set.Moreover,among 10 AAs and derivatives(arginine,phenylalanine,tyrosine,proline,alanine,asparagine,creatine,tryptophan,ornithine,and choline)with statistical significance between HOCM and HNCM,3 AAs(Panel B;arginine,proline,and ornithine)were selected to differentiate the two subgroups.The AUC values in the training and validation sets for Panel B were 0.83(0.74-0.93)and 0.82(0.66-0.98),respectively.Conclusions:The plasma AA and derivatives profiles were distinct between the HCM and NC groups.Based on the differential profiles,the two established screening models have potential value in assisting HCM screening and identifying whether it is obstructive. | Lanyan Guo Bo Wang Fuyang Zhang Chao Gao Guangyu Hu Mengyao Zhou Rutao Wang Hang Zhao Wenjun Yan Ling Zhang Zhiling Ma Weiping Yang Xiong Guo Chong Huang Zhe Cui Fangfang Sun Dandan Song Liwen Liu Ling Tao | 2022 | Chinese Medical Journal2022，135，16： | 0 |
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